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1. 发明授权

US06890482B2 Apparatus for blood oxygenation 有权
标题翻译：血氧合仪
公开(公告)号：US06890482B2
公开(公告)日：2005-05-10
申请号：US10424031
申请日：2003-04-25
申请人： Vincent Divino, Jr. , Jeffrey L. Creech , William R. Patterson , Stephen E. Myrick
发明人： Vincent Divino, Jr. , Jeffrey L. Creech , William R. Patterson , Stephen E. Myrick
IPC分类号： A61M1/16 , A61M1/36 , A61M25/00 , A61M1/14 , A61M37/00
CPC分类号： A61M1/3621 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/325 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3626 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , C01B13/02 , Y10S128/03 , Y10S261/28 , A61M2202/0007
摘要： An apparatus and method for blood oxygenation are provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly. The liquid-to-liquid oxygenation assembly includes a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The mixed fluid exits the chamber via an outlet for delivery to a patient.
摘要翻译：提供了一种用于血氧的装置和方法。该装置有利地包括液体 - 液体氧合装置。液体 - 液体氧合组件包括具有用于第一气体过饱和流体和第二流体（例如血液）的入口的可加压室。入口有利地定位在混合室中，使得第一流体和第二流体通常彼此进入混合室以促进混合和液体 - 液体气体转移。混合流体通过出口离开室以输送给患者。

2. 发明授权

US06811750B2 Apparatus for blood oxygenation 有权
标题翻译：血氧合仪
公开(公告)号：US06811750B2
公开(公告)日：2004-11-02
申请号：US10071702
申请日：2002-02-08
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： Apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了用于血氧合的装置和方法。该装置包括具有用于接收流体例如生理盐水的第一入口的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。耦合到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到该液体中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其它类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成氧合血液，再次输送到患者或其他部位。

3. 发明授权

US06602468B2 Method of blood oxygenation 有权
标题翻译：血氧合法
公开(公告)号：US06602468B2
公开(公告)日：2003-08-05
申请号：US09469261
申请日：1999-12-21
申请人： William R. Patterson , Jeffrey L. Creech
发明人： William R. Patterson , Jeffrey L. Creech
IPC分类号： A61M134
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S261/27
摘要： A method for a bubble-free oxygenated blood delivery is provided. The method includes a step of selecting a delivery system having a tubular elongated member with a lumen. The selecting step comprises determining an effective diameter of the lumen needed to achieve a bubble-free delivery of the oxygenated blood based on a specified oxygenated blood flow rate and a desired target oxygen partial pressure in the oxygenated blood. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion. In another embodiment, the delivery system includes a generally tubular elongated member having a proximal end portion and a distal end portion with a plurality of holes.
摘要翻译：提供了一种无气泡氧合血液输送的方法。该方法包括选择具有管腔的细长构件的输送系统的步骤。选择步骤包括基于指定的氧化血流速度和氧合血液中期望的目标氧分压来确定实现氧合血液的无气泡递送所需的内腔的有效直径。输送系统包括具有近端部分，远端部分和位于近端部分和远端部分之间的过渡部分的大致管状细长部件。过渡部分与近端部分相比是相对柔性的，并且与远端部分相比是相对较硬的。在另一个实施例中，输送系统包括大致管状的细长构件，其具有近端部分和具有多个孔的远端部分。

4. 发明授权

US06596235B2 Method for blood oxygenation 失效
公开(公告)号：US06596235B2
公开(公告)日：2003-07-22
申请号：US09778433
申请日：2001-02-07
申请人： Vincent Divino, Jr. , Paul J. Zalesky , William R. Patterson
发明人： Vincent Divino, Jr. , Paul J. Zalesky , William R. Patterson
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758
摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

5. 发明授权

US5061236A Venous reservoir with improved inlet configuration and integral screen for bubble removal 失效
标题翻译：具有改进的入口配置的静脉储存器和用于除气的整体屏幕
公开(公告)号：US5061236A
公开(公告)日：1991-10-29
申请号：US554759
申请日：1990-07-16
申请人： Karl M. Sutherland , William R. Patterson
发明人： Karl M. Sutherland , William R. Patterson
IPC分类号： A61J1/10 , A61M1/14 , A61M1/34 , A61M1/36 , A61M39/02
CPC分类号： A61M1/3627 , A61M2039/0202 , A61M2206/11
摘要： A blood reservoir device comprising a generally flexible blood collection chamber having an inlet portion and a main portion. The inlet portion is preferably sized and configured such that blood entering the inlet portion will avoid turbulence and will undergo generally laminar flow through the inlet portion, into the main portion of the chamber. A vent tube is provided for venting coalesced or collected gas bubbles from the top edge of the chamber. Additionally, one or more filter elements may be positioned within the chamber to further facilitate removal of air bubbles from blood passing through the chamber.
摘要翻译：一种血液储存装置，包括具有入口部分和主要部分的大体柔性的血液收集室。优选地，入口部分的尺寸和构造使得进入入口部分的血液将避免湍流并且通常通过入口部分层流流入腔室的主要部分。提供排气管用于从腔室的顶部边缘排出聚结或收集的气泡。此外，一个或多个过滤器元件可以被定位在腔室内以进一步便于从通过腔室的血液中去除气泡。

6. 发明授权

US4127357A Variable shroud for a turbomachine 失效
标题翻译：涡轮机可变护罩
公开(公告)号：US4127357A
公开(公告)日：1978-11-28
申请号：US809582
申请日：1977-06-24
申请人： William R. Patterson
发明人： William R. Patterson
IPC分类号： F01D11/08 , F01D11/10 , F01D11/22 , F04D29/08
CPC分类号： F01D11/22
摘要： A turbine shroud segment is supported by a pair of eccentric shafts which are rotated in response to the engine operating temperatures to selectively vary the radial position of the shroud segment so as to minimize the radial clearance between the shroud segment and the rotatable blades circumscribed therein during variable operating conditions. The bimetal actuator moves in response to changes in the temperature of the cooling air to rotate a ring gear which in turn rotates the eccentric shafts to modulate the radial position of the shroud segment. By proper selection of component design specification and operating parameters, the radial clearance can be minimized during steady-state operating conditions without attendant rubbing during transient operating conditions.
摘要翻译：涡轮机护罩段由一对偏心轴支撑，所述一对偏心轴响应于发动机工作温度而旋转，以选择性地改变护罩段的径向位置，以便最小化护罩区段与其间限制的可旋转叶片之间的径向间隙可变运行条件。双金属致动器响应于冷却空气的温度变化而移动，以旋转环形齿轮，该环形齿轮又旋转偏心轴以调节护罩段的径向位置。通过适当选择部件设计规范和操作参数，在稳态运行条件下可以使径向间隙最小化，而不需要在瞬态运行条件下进行摩擦。

7. 发明授权

US3966354A Thermal actuated valve for clearance control 失效
标题翻译：用于间隙控制的热致动阀
公开(公告)号：US3966354A
公开(公告)日：1976-06-29
申请号：US534551
申请日：1974-12-19
申请人： William R. Patterson
发明人： William R. Patterson
IPC分类号： F01D11/10 , F01D11/18 , F01D11/24 , G05D23/08 , F01D25/12 , F01D25/14
CPC分类号： F01D11/24 , F01D11/18 , G05D23/08
摘要： A shroud closely surronding a high thermal inertia rotor is provided with a support structure having low thermal inertia characteristics. The support structure is selectively exposed to different temperature mediums during transient operation by way of a thermal actuated valve so as to cause a rapid growth thereof during periods of engine acceleration and a slow shrinkage thereof during periods of deceleration of the engine. In this manner the clearance relationship between the shroud and enclosed rotor is maintained at a minimum during periods of steady-state and transitional operation to thereby increase the efficiency of the combination.
摘要翻译：紧密地缠绕高热惯性转子的护罩设置有具有低热惯性特性的支撑结构。在通过热致动阀的瞬态操作期间，支撑结构选择性地暴露于不同的温度介质，以便在发动机加速期间及其在发动机减速期间的缓慢收缩期间使其快速增长。以这种方式，在稳态和过渡操作期间，护罩和封闭转子之间的间隙关系保持最小，从而提高组合的效率。

8. 发明授权

US08267955B2 Metallic coils enlaced with fibers for embolization of a body cavity 有权
标题翻译：金属线圈与用于体腔栓塞的纤维一起放置
公开(公告)号：US08267955B2
公开(公告)日：2012-09-18
申请号：US13010671
申请日：2011-01-20
申请人： William R. Patterson , Earl Slee , Tom Wilder , Thomas McCarthy , Brian Strauss , Hermann Monstadt , Hans Henkes
发明人： William R. Patterson , Earl Slee , Tom Wilder , Thomas McCarthy , Brian Strauss , Hermann Monstadt , Hans Henkes
IPC分类号： A61M29/00
CPC分类号： A61L31/18 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00004 , A61B2017/00526 , A61L31/022 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/606 , A61L2430/36
摘要： A vaso-occlusive device is provided for reducing blood flow in a patient. The device can include a coil, a stretch resistant member, and a plurality of fibers. The coil can define a lumen and be sized for insertion to a point of use in a vascular network of the patient. The stretch resistant member can have a first end fixedly attached to the first end of the coil. Further, the plurality of fibers can be configured with each of the fibers in direct contact with the stretch resistant member.
摘要翻译：提供了一种用于减少患者血液流量的血管闭塞装置。该装置可以包括线圈，抗拉构件和多根纤维。线圈可以限定内腔，并且其尺寸适于插入患者血管网络中的使用点。抗拉伸构件可以具有固定地附接到线圈的第一端的第一端。此外，多根纤维可以配置成与抗拉伸构件直接接触的每个纤维。

9. 发明授权

US07896899B2 Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity 有权
标题翻译：金属线圈与生物或生物可降解的或合成的聚合物或纤维一起放置，用于体腔栓塞
公开(公告)号：US07896899B2
公开(公告)日：2011-03-01
申请号：US11134998
申请日：2005-05-23
申请人： William R. Patterson , Earl Slee , Tom Wilder , Thomas McCarthy , Brian Strauss , Herman Monstadt , Hans Henkes
发明人： William R. Patterson , Earl Slee , Tom Wilder , Thomas McCarthy , Brian Strauss , Herman Monstadt , Hans Henkes
IPC分类号： A61M29/00
CPC分类号： A61L31/18 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00004 , A61B2017/00526 , A61L31/022 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/606 , A61L2430/36
摘要： The invention provides for vaso-occlusive coils comprising fibers.
摘要翻译：本发明提供了包含纤维的血管闭塞线圈。

10. 发明授权

US06936221B1 Method of forming gas-enriched fluid 失效
标题翻译：形成富集气体的方法
公开(公告)号：US06936221B1
公开(公告)日：2005-08-30
申请号：US09468471
申请日：1999-12-21
申请人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
发明人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
IPC分类号： A61M1/16 , A61M1/36 , A61M25/00 , A61M1/34 , A61M37/00
CPC分类号： A61M1/3626 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , B01F3/04758 , C01B13/02 , Y10S261/28 , A61M2202/0007
摘要： A method for forming a gas-enriched fluid is provided. The method includes a step of providing a mixing chamber having a first inlet, a second inlet, and an outlet. A first fluid is delivered into the mixing chamber via the first inlet and flows vertically. A second fluid having a liquid phase supersaturated with a gas is delivered to the mixing chamber via the second inlet to mix with the first fluid and from the gas-enriched fluid.
摘要翻译：提供了一种形成富含气体的流体的方法。该方法包括提供具有第一入口，第二入口和出口的混合室的步骤。第一流体经由第一入口输送到混合室中并垂直流动。具有用气体过饱和的液相的第二流体经由第二入口输送到混合室，以与第一流体和富含气体的流体混合。

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