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1. 发明授权

US07013703B2 System and method of evaluating or calibrating a bubble detector 有权
标题翻译：评估或校准气泡检测器的系统和方法
公开(公告)号：US07013703B2
公开(公告)日：2006-03-21
申请号：US10750428
申请日：2003-12-31
申请人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
发明人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
IPC分类号： G06K9/00
CPC分类号： G01N35/08 , A61M1/32 , A61M1/3626 , A61M2202/0476 , A61M2209/02 , G01N2291/015 , G01N2291/02433 , G01N2291/02466
摘要： A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time exceeds a desired maximum volume, the bubble detector may initiate a system shut down. A bubble detector can be evaluated or calibrated by introducing bubbles into a conduit, detecting the bubbles introduced into the conduit using visual inspection or a bubble detector of known resolution and comparing the results with the examination of a bubble detector under evaluation.
摘要翻译：气泡检测器利用超声波换能器在气泡通过传感器时进行取样。分析返回信号的包络线以确定每个采样气泡的体积。如果在一定时间内采样的气泡的总体积超过所需的最大体积，则气泡检测器可能会启动系统关闭。气泡检测器可以通过将气泡引入管道中进行评估或校准，使用目视检查或者已知分辨率的气泡检测器检测导入导管的气泡，并将结果与正在评估的气泡检测器进行比较。

2. 发明授权

US06843099B2 Bubble detector and method of evaluation or calibration thereof 有权
标题翻译：气泡检测器及其评估或校准方法
公开(公告)号：US06843099B2
公开(公告)日：2005-01-18
申请号：US10610084
申请日：2003-06-30
申请人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
发明人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
IPC分类号： G01N29/02 , A61H33/02 , A61M1/36 , G01N35/08
CPC分类号： G01N35/08 , A61M1/32 , A61M1/3626 , A61M2202/0476 , A61M2209/02 , G01N2291/015 , G01N2291/02433 , G01N2291/02466
摘要： A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time exceeds a desired maximum volume, the bubble detector may initiate a system shut down. A bubble detector can be evaluated or calibrated by introducing bubbles into a conduit, detecting the bubbles introduced into the conduit using visual inspection or a bubble detector of known resolution and comparing the results with the examination of a bubble detector under evaluation.
摘要翻译：气泡检测器利用超声波换能器在气泡通过传感器时进行取样。分析返回信号的包络线以确定每个采样气泡的体积。如果在一定时间内采样的气泡的总体积超过所需的最大体积，则气泡检测器可能会启动系统关闭。气泡检测器可以通过将气泡引入管道中进行评估或校准，使用目视检查或者已知分辨率的气泡检测器检测导入导管的气泡，并将结果与正在评估的气泡检测器进行比较。

3. 发明授权

US06582387B2 System for enriching a bodily fluid with a gas 有权
公开(公告)号：US06582387B2
公开(公告)日：2003-06-24
申请号：US09813068
申请日：2001-03-20
申请人： Daw J. Derek , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
发明人： Daw J. Derek , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
IPC分类号： A61M3700
CPC分类号： A61M1/3663 , A61M1/32 , A61M1/3626
摘要： A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages various aspects of the system, such as the production of gas-enriched fluids, flow rates, bubble detection, and automatic operation and shut down.

4. 发明授权

US06622542B2 Bubble detector and method of use thereof 有权
标题翻译：气泡检测器及其使用方法
公开(公告)号：US06622542B2
公开(公告)日：2003-09-23
申请号：US09813072
申请日：2001-03-20
申请人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
发明人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
IPC分类号： G01N2900
CPC分类号： G01N35/08 , A61M1/32 , A61M1/3626 , A61M2202/0476 , A61M2209/02 , G01N2291/015 , G01N2291/02433 , G01N2291/02466
摘要： A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time exceeds a desired maximum volume, the bubble detector may initiate a system shut down. A bubble detector can be evaluated or calibrated by introducing bubbles into a conduit, detecting the bubbles introduced into the conduit using visual inspection or a bubble detector of known resolution and comparing the results with the examination of a bubble detector under evaluation.
摘要翻译：气泡检测器利用超声波换能器在气泡通过传感器时进行取样。分析返回信号的包络线以确定每个采样气泡的体积。如果在一定时间内采样的气泡的总体积超过所需的最大体积，则气泡检测器可能会启动系统关闭。气泡检测器可以通过将气泡引入管道中进行评估或校准，使用目视检查或者已知分辨率的气泡检测器检测导入导管的气泡，并将结果与正在评估的气泡检测器进行比较。

5. 发明授权

US06936221B1 Method of forming gas-enriched fluid 失效
标题翻译：形成富集气体的方法
公开(公告)号：US06936221B1
公开(公告)日：2005-08-30
申请号：US09468471
申请日：1999-12-21
申请人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
发明人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
IPC分类号： A61M1/16 , A61M1/36 , A61M25/00 , A61M1/34 , A61M37/00
CPC分类号： A61M1/3626 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , B01F3/04758 , C01B13/02 , Y10S261/28 , A61M2202/0007
摘要： A method for forming a gas-enriched fluid is provided. The method includes a step of providing a mixing chamber having a first inlet, a second inlet, and an outlet. A first fluid is delivered into the mixing chamber via the first inlet and flows vertically. A second fluid having a liquid phase supersaturated with a gas is delivered to the mixing chamber via the second inlet to mix with the first fluid and from the gas-enriched fluid.
摘要翻译：提供了一种形成富含气体的流体的方法。该方法包括提供具有第一入口，第二入口和出口的混合室的步骤。第一流体经由第一入口输送到混合室中并垂直流动。具有用气体过饱和的液相的第二流体经由第二入口输送到混合室，以与第一流体和富含气体的流体混合。

6. 发明授权

US06855291B2 Method of blood oxygenation 失效
标题翻译：血氧合法
公开(公告)号：US06855291B2
公开(公告)日：2005-02-15
申请号：US10384301
申请日：2003-03-07
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M1/16 , A61M1/36 , A61M1/14 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membranes(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有第一入口以容纳气体过饱和流体例如生理盐水的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。联接到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到其中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成含氧血液，再次输送到患者或其他部位。

7. 发明授权

US06602467B1 Apparatus and method for blood oxygenation 失效
标题翻译：用于血氧的设备和方法
公开(公告)号：US06602467B1
公开(公告)日：2003-08-05
申请号：US09410344
申请日：1999-09-30
申请人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
发明人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
IPC分类号： A61M114
CPC分类号： A61M1/3626 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , B01F3/04758 , C01B13/02 , Y10S261/28 , A61M2202/0007
摘要： An apparatus and method for blood oxygenation are provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly. The liquid-to-liquid oxygenation assembly includes a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The mixed fluid exits the chamber via an outlet for delivery to a patient.
摘要翻译：提供了一种用于血氧的装置和方法。该装置有利地包括液体 - 液体氧合装置。液体 - 液体氧合组件包括具有用于第一气体过饱和流体和第二流体（例如血液）的入口的可加压室。入口有利地位于混合室中，使得第一流体和第二流体通常彼此进入混合室，以促进混合和液体 - 液体气体的转移。混合流体通过出口离开室以输送给患者。

8. 发明授权

US07172727B2 Apparatus for blood oxygenation 失效
标题翻译：血氧合仪
公开(公告)号：US07172727B2
公开(公告)日：2007-02-06
申请号：US10953747
申请日：2004-09-29
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M1/34 , A61M1/36 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有用于接收流体例如生理盐水的第一入口的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。耦合到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到该液体中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成氧合血液，再次输送到患者或其他部位。

9. 发明授权

US06974435B2 Method for enriching a bodily fluid with a gas 有权
标题翻译：用气体浓缩体液的方法
公开(公告)号：US06974435B2
公开(公告)日：2005-12-13
申请号：US10279507
申请日：2002-10-24
申请人： Derek J. Daw , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
发明人： Derek J. Daw , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
IPC分类号： A61M1/14 , A61M1/10 , A61M1/32 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3663 , A61M1/32 , A61M1/3626
摘要： A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages various aspects of the system, such as the production of gas-enriched fluids, flow rates, bubble detection, and automatic operation and shut down.
摘要翻译：系统利用氧合装置产生气体富集的生理流体并将其与体液结合以产生富含气体的体液。氧合装置可以采取放置在外壳内的一次性药筒的形式。电子控制器管理系统的各个方面，例如生产富含气体的流体，流速，气泡检测和自动操作和关闭。

10. 发明授权

US06759008B1 Apparatus and method for blood oxygenation 有权
标题翻译：用于血氧的设备和方法
公开(公告)号：US06759008B1
公开(公告)日：2004-07-06
申请号：US09410179
申请日：1999-09-30
申请人： William R. Patterson , Jeffrey L. Creech
发明人： William R. Patterson , Jeffrey L. Creech
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S261/27
摘要： An apparatus for blood oxygenation and delivery is provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly with a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The apparatus also includes a delivery system coupled to the blood oxygenation assembly. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion. In another embodiment, the delivery system includes a generally tubular elongated member having a proximal end portion and a distal end portion with a plurality of holes.
摘要翻译：提供了用于血氧和输送的装置。该装置有利地包括液体至液体氧合组件，其具有用于第一气体过饱和流体和第二流体（例如血液）的入口的可加压室。入口有利地位于混合室中，使得第一流体和第二流体通常彼此进入混合室，以促进混合和液体 - 液体气体的转移。该装置还包括耦合到血液氧合组件的递送系统。输送系统包括具有近端部分，远端部分和位于近端部分和远端部分之间的过渡部分的大致管状细长部件。过渡部分与近端部分相比是相对柔性的，并且与远端部分相比是相对较硬的。在另一个实施例中，输送系统包括大致管状的细长构件，其具有近端部分和具有多个孔的远端部分。

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