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21. 发明授权

US06673804B1 Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US06673804B1
公开(公告)日：2004-01-06
申请号：US09678294
申请日：2000-10-02
申请人： Tomio Kimura , Shoujiro Miyazaki , Keiji Ueda , Kazuhiko Tanzawa , Shigeru Ushiyama , Wataru Takasaki
发明人： Tomio Kimura , Shoujiro Miyazaki , Keiji Ueda , Kazuhiko Tanzawa , Shigeru Ushiyama , Wataru Takasaki
IPC分类号： C07D20946
CPC分类号： C07D209/48 , C07C311/29 , C07D209/66 , C07D233/78 , C07D239/54 , C07D239/70 , C07D239/96 , C07D275/06 , C07D277/34 , C07D401/12 , C07D401/14 , C07D471/04 , C07D473/04 , C07D475/02 , C07D495/04
摘要： A compound of the formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof: R1 is H or NHOH. R2 is H, optionally substituted alkyl, cycloalkyl or a group —AR6. A is an alkylene which may be optionally interrupted by O, —S(O)m— or —N(R9). R6 is a group (II), (III), (IV) X is O, S, —N(R10)—, —C(R11)(R12)—. Y is O, CO, —S(O)n—, —N(R10)—, —C(R11)(R12)—. Each of R7 and R8 is H, alkyl, COOH, optionally substituted alkyl, etc. Each of R9, R10, R11, and R12 is H, alkyl, etc. Each of m and n is 0 to 2. R3 is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl. R4 is optionally substituted (hetero)arylene. R5 is optionally substituted alkyl, optionally substituted (hetero)aryl. These compounds have matrixmetalloproteinase—13 inhibitory activity and aglycanase inhibitory activity.
摘要翻译：式（I）的化合物或其药理学上可接受的盐，酯或其它衍生物：R 1是H或NHOH。 R 2是H，任选取代的烷基，环烷基或基团-AR 6 .A是可以任选被O，-S（O）m - 或-N（R 9）间隔的亚烷基。 R 6为（II），（III），（IV）X为O，S，-N（R 10） - ， - C（R 11）（R 12） Y是O，CO，-S（O）n - ， - N（R 10） - ， - C（R 11）（R 12） - 。 R 7和R 8中的每一个是H，烷基，COOH，任选取代的烷基等。R 9，R 10，R 11和R 12中的每一个是H，烷基等等。m和n各自为0至2.R 3为H，任选取代的烷基，任选取代的环烷基，任选取代的烯基，任选取代的炔基。 R 4是任选取代的（杂）亚芳基。 R 5是任选取代的烷基，任选取代的（杂）芳基。这些化合物具有基质金属蛋白酶-13抑制活性和糖苷连结酶抑制活性。

22. 发明授权

US5688791A Aryl group-or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-hiv agent 失效
标题翻译：芳基或芳族杂环基取代的氨基喹诺酮衍生物和抗-Hiv剂
公开(公告)号：US5688791A
公开(公告)日：1997-11-18
申请号：US526225
申请日：1995-09-11
申请人： Tomio Kimura , Tetsushi Katsube
发明人： Tomio Kimura , Tetsushi Katsube
IPC分类号： C07D487/04 , A61K31/4375 , A61K31/47 , A61K31/535 , A61P31/18 , C07D215/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/06 , C07D487/14 , C07D498/06 , C07D513/04 , C07D513/06 , A61K31/54 , C07D401/02 , C07D403/02
CPC分类号： C07D215/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/06 , C07D513/04 , C07D513/06 , Y10S514/934
摘要： Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.
摘要翻译：公开了由式（Ia），（Ib）或（Ic）表示的芳基或杂环基取代的氨基喹诺酮化合物：（Ia）取代基在说明书中定义，或化合物的盐，和含有该有效成分的AIDS固化剂。

23. 发明授权

US4481362A Process for preparing optically active tryptophanes 失效
标题翻译：光学活性色氨酸的制备方法
公开(公告)号：US4481362A
公开(公告)日：1984-11-06
申请号：US494692
申请日：1983-05-17
申请人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
发明人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
IPC分类号： C12N9/80 , C12P13/04 , C12P13/22 , C12P41/00 , C12R1/025 , C12R1/05 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/145 , C12R1/20 , C12R1/225 , C12R1/265 , C12R1/32 , C12R1/365 , C12R1/38 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/65 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/78 , C12R1/80 , C12R1/84 , C12R1/845 , C12R1/85 , C12R1/88 , C12R1/885 , C07D209/20
CPC分类号： C12N9/80 , C12P13/04 , C12P13/227
摘要： Biochemical optical resolution of DL-tryptophanes in which DL-tryptophane amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-tryptophane amides in racemic DL-tryptophane amides are asymmetrically hydrolyzed to form optically active L-tryptophanes at a high yield and almost all D-tryptophane amides remain without being subjected to hydrolysis. The resultant D-tryptophane amides are readily hydrolyzed, after separating L-tryptophanes, to form optically active D-tryptophanes at a high yield.
摘要翻译：描述DL-色氨酰胺与能够产生酰胺酶的微生物或其处理产物相互作用的DL-色氨酸的生物化学光学拆分。外消旋的DL-色氨酰胺中的L-色氨酰胺不对称地水解，以高产率形成光学活性的L-色氨酸，并且几乎所有的D-色氨酸酰胺保持不被水解。得到的D-色氨酰胺在分离L-色氨酸后容易水解，以高产率形成光学活性的D-色氨酸。

24. 发明授权

US08344029B2 Substituted propanamide derivative and pharmaceutical composition containing the same 失效
标题翻译：取代丙酰胺衍生物和含有它们的药物组合物
公开(公告)号：US08344029B2
公开(公告)日：2013-01-01
申请号：US11996268
申请日：2006-07-18
申请人： Kazumasa Aoki , Koji Suda , Kentoku Gotanda , Tomio Kimura
发明人： Kazumasa Aoki , Koji Suda , Kentoku Gotanda , Tomio Kimura
IPC分类号： A01N37/18 , A01N33/02 , A01N33/18 , A01N33/24 , A61K31/165 , A61K31/135 , A61K31/04
CPC分类号： C07C237/22
摘要： It is an object of the present invention to provide a substituted propanamide derivative or a pharmacologically acceptable salt thereof that is useful as a prophylactic or therapeutic agent for a bone metabolic disease. The present invention relates to a pharmaceutical composition comprising a compound having General Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 represents a C6-C10 aryl group that may be substituted by a group selected from Substituent Group α, for example; R2 represents a C6-C10 aryl group that may be substituted by a group selected from Substituent Group α, for example; and X represents a hydroxyl group or a C1-C6 alkoxy group, for example].
摘要翻译：本发明的目的是提供可用作骨代谢疾病的预防或治疗剂的取代丙酰胺衍生物或其药理学上可接受的盐。本发明涉及含有通式（I）的化合物或其药理学上可接受的盐作为活性成分的药物组合物[其中，R 1表示可以被选自取代基的基团取代的C6-C10芳基 α，例如; R2表示可以被选自取代基组α的基团取代的C6-C10芳基; X表示羟基或C 1 -C 6烷氧基。

25. 发明授权

US08170752B2 Parking assistance apparatus, vehicle-side apparatus of parking assistance apparatus, parking assist method, and parking assist program 失效
标题翻译：停车辅助装置，停车辅助装置的车辆侧装置，停车辅助方法和停车辅助程序
公开(公告)号：US08170752B2
公开(公告)日：2012-05-01
申请号：US12670713
申请日：2008-07-04
申请人： Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Masami Tomioka , Hideo Yanagisawa
发明人： Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Masami Tomioka , Hideo Yanagisawa
IPC分类号： A01B69/00 , B62D6/00 , B62D12/00 , G05D1/02
CPC分类号： G08G1/168 , B60R1/00 , B60R2300/108 , B60R2300/302 , B60R2300/50 , B60R2300/70 , B60R2300/8026 , B60R2300/806 , B60W30/095 , B60W40/02 , B60W2420/403 , B62D15/028
摘要： A parking assistance apparatus makes it easy for a driver to grasp a relative positional relation between a vehicle and a target parking position and makes it possible to park the vehicle at the target parking position in a parking space with accuracy.An image of a mark M in a parking space S is taken by a vehicle-side camera 7. A relative position calculation portion 8 calculates a relative positional relation between the vehicle and a target parking position T based on the taken image of the mark M. A backward locus calculation portion 9 calculates an expected locus when the vehicle moves based on the relative positional relation and based on a steering angle detected by a steering angle sensor 15. An image of the parking space S is taken by a parking-space-side camera 3 and transmitted to a vehicle-side apparatus 1. An image composition portion 12 composes the image of the parking space S from the parking-space-side camera 3 and the expected locus calculated by the backward locus calculation portion 9. The composed image is displayed on the monitor 14 located in the vicinity of a drivers seat of the vehicle.
摘要翻译：停车辅助装置使驾驶员容易掌握车辆与目标停车位置之间的相对位置关系，并且能够准确地将车辆停放在停车位置的目标停车位置。停车空间S中的标记M的图像由车辆侧照相机7拍摄。相对位置计算部8基于拍摄到的标记M的图像计算车辆与目标停车位置T之间的相对位置关系反向轨迹计算部9基于相对位置关系，基于由转向角传感器15检测到的转向角来计算车辆移动时的预期轨迹。停车位S的图像由停车位 - 图像合成部12从停车位侧摄像机3构成停车空间S的图像，由向后轨迹计算部9计算出的预期轨迹构成。图像显示在位于车辆驾驶员座位附近的监视器14上。

26. 发明授权

US07755511B2 Parking assistance apparatus 失效
标题翻译：停车辅助设备
公开(公告)号：US07755511B2
公开(公告)日：2010-07-13
申请号：US11885858
申请日：2006-02-28
申请人： Satoshi Yamamoto , Kazunori Shimazaki , Tomio Kimura
发明人： Satoshi Yamamoto , Kazunori Shimazaki , Tomio Kimura
IPC分类号： G08G1/14
CPC分类号： B62D15/028 , B62D15/0275
摘要： In a parking assistance apparatus disclosed herein, a position and a yaw angle of a vehicle are acquired continuously from an initial stop position A, and a vehicle mark C2′ in moving the vehicle backwards with a steering angle maintained during a backward movement operation from a backward movement start position B in parking the vehicle in a target parking space S is displayed on a display. The vehicle mark C2′ is displayed in a shifting manner on the display such that the target parking space S is traced based on a momentary steering angle and a momentary yaw angle of the vehicle, which result from backward movement of the vehicle. When the vehicle mark C2′ deviates from the target parking space S during the backward movement operation, a driver adjusts the steering angle. The vehicle mark C2′ is shifted on the display based on a change in the steering angle to be turned into a vehicle mark C4 at a suitable position corresponding to the target parking space S.
摘要翻译：在本文所公开的停车辅助装置中，从初始停止位置A连续地获取车辆的位置和偏航角，并且在向后移动操作期间保持的转向角从车辆向后移动的车辆标记C2' 将车辆停放在目标停车位S中的向后运动开始位置B显示在显示器上。车辆标记C2'以显示器的移动方式显示，使得基于车辆的后向移动导致的车辆的瞬时转向角和瞬时偏航角来追踪目标停车位S。当车辆标记C2'在向后移动操作期间偏离目标停车位S时，驾驶员调节转向角。基于在与目标停车空间S对应的适当位置处转向车辆标记C4的转向角的变化，车辆标记C2'在显示器上移动。

27. 发明申请

US20090118199A1 SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：取代的丙烯酰胺衍生物和药物组合物
公开(公告)号：US20090118199A1
公开(公告)日：2009-05-07
申请号：US11914209
申请日：2006-05-11
申请人： Kazumasa Aoki , Koji Suda , Toshio Kaneko , Tomio Kimura
发明人： Kazumasa Aoki , Koji Suda , Toshio Kaneko , Tomio Kimura
IPC分类号： A61K38/05 , C07D295/15 , A61K31/195 , C07C229/36 , C07C237/20 , A61K31/165 , A61P19/08
CPC分类号： A61K31/166 , C07C237/22 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2602/08 , C07D207/327 , C07D277/30 , C07D295/13 , C07D307/54 , C07D317/54 , C07D333/16 , C07D407/04 , C07D409/04 , Y02P20/55
摘要： A pharmaceutical composition comprising a compound having Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 is, for example, a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group α; R2 is, for example, a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group α; and X is, for example, a hydroxyl group or a C1-C6 alkoxy group].
摘要翻译：一种药物组合物，其包含具有式（I）的化合物或其药理学上可接受的盐作为活性成分：[其中，R 1为例如可以被一个或多于一个基团取代的C 6 -C 10芳基来自取代基组α; R2是例如可以被一个或多于一个选自取代基组α的一个基团取代的C 6 -C 10芳基; X是例如羟基或C1-C6烷氧基]。

28. 发明申请

US20080174452A1 Parking Assistance Apparatus 失效
标题翻译：停车辅助设备
公开(公告)号：US20080174452A1
公开(公告)日：2008-07-24
申请号：US11885858
申请日：2006-02-28
申请人： Satoshi Yamamoto , Kazunori Shimazaki , Tomio Kimura
发明人： Satoshi Yamamoto , Kazunori Shimazaki , Tomio Kimura
IPC分类号： B60Q1/48
CPC分类号： B62D15/028 , B62D15/0275
摘要： In a parking assistance apparatus disclosed herein, a position and a yaw angle of a vehicle are acquired continuously from an initial stop position A, and a vehicle mark C2′ in moving the vehicle backwards with a steering angle maintained during a backward movement operation from a backward movement start position B in parking the vehicle in a target parking space S is displayed on a display. The vehicle mark C2′ is displayed in a shifting manner on the display such that the target parking space S is traced based on a momentary steering angle and a momentary yaw angle of the vehicle, which result from backward movement of the vehicle. When the vehicle mark C2′ deviates from the target parking space S during the backward movement operation, a driver adjusts the steering angle. The vehicle mark C2′ is shifted on the display based on a change in the steering angle to be turned into a vehicle mark C4 at a suitable position corresponding to the target parking space S.
摘要翻译：在本文公开的停车辅助装置中，从初始停止位置A连续地取得车辆的位置和偏航角，并且在向后移动操作期间保持的转向角向后移动车辆的车辆标记C 2' 将车辆停放在目标停车位S中的向后移动开始位置B显示在显示器上。车辆标记C 2'以显示器的移动方式显示，使得目标停车位S基于由车辆的后向运动引起的车辆的瞬时转向角和瞬时偏航角而被跟踪。当车辆标记C 2'在向后移动操作期间偏离目标停车位S时，驾驶员调节转向角。车辆标记C 2'基于在对应于目标停车空间S的适当位置处转向车辆标记C 4的转向角的变化而在显示器上移动。

29. 发明授权

US07024286B2 Parking assisting device 失效
标题翻译：停车辅助装置
公开(公告)号：US07024286B2
公开(公告)日：2006-04-04
申请号：US10797334
申请日：2004-03-09
申请人： Tomio Kimura , Kazunori Shimazaki
发明人： Tomio Kimura , Kazunori Shimazaki
IPC分类号： G06F17/00 , B60Q1/48
CPC分类号： G06T7/60 , B60T2201/10 , B62D15/028 , G06T2207/30264
摘要： Disclosed is a parking assisting device, including: a camera for capturing an image behind a vehicle; a display provided to a dashboard of the vehicle; passage width measurement device that measures a width of a passage; and a controller for displaying the image captured with the camera on the display. Also disclosed is a device for calculating an initial stopping position required for parking the vehicle in-parallel into a target parking space perpendicular to the passage on the basis of the passage width measured, with the passage width measurement device, to superimpose on a screen of the display a displayed image for guidance used for guiding the vehicle to the initial stopping position.
摘要翻译：公开了一种停车辅助装置，包括：摄像机，用于拍摄车辆后方的图像; 提供给车辆仪表板的显示器; 测量通道宽度的通道宽度测量装置; 以及用于在显示器上显示用相机拍摄的图像的控制器。还公开了一种用于计算基于通过测量的通道宽度而将车辆并行停放在与通道垂直的目标停车位所需的初始停止位置的装置，以将通道宽度测量装置叠加在显示用于将车辆引导到初始停止位置的用于引导的显示图像。

30. 发明申请

US20050283006A1 Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses 审中-公开
标题翻译：杂芳基取代的吡咯衍生物，其制备及其治疗用途
公开(公告)号：US20050283006A1
公开(公告)日：2005-12-22
申请号：US10411061
申请日：2003-04-10
申请人： Tomio Kimura , Kazumasa Aoki , Akira Nakao , Shigeru Ushiyama , Takaichi Shimozato , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
发明人： Tomio Kimura , Kazumasa Aoki , Akira Nakao , Shigeru Ushiyama , Takaichi Shimozato , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
IPC分类号： C07D401/04 , C07D401/14 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04 , C07D491/20 , C07D41/14 , C07D43/02
CPC分类号： C07D451/02 , C07D401/04 , C07D401/14 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04
摘要： Compounds having activity against production of inflammatory cytokines of formula (I)′: A′ is pyrrole; R1′ is aryl or heteroaryl; R2′ is heteroaryl having at least one nitrogen atom; R3′ is (IIa)′, (IIb)′ or (IIc)′: m′ is 1 or 2; one of D′ and E′ is nitrogen and the other is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 4- to 7-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′: hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′: alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′: oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.
摘要翻译：具有抗式产生式（I）的炎性细胞因子的化合物的化合物：A'是吡咯; R 1是芳基或杂芳基; R 2是具有至少一个氮原子的杂芳基; （IIa）'，（IIb）'或（IIc）'：m'为1或2; D'和E'之一是氮，另一个是> C（R 5'） - ，R 5'是氢，取代基α'或取代基β'; B'是含氮的4-至7-元杂环; R 4'是1至3个取代基α'，取代基β'和取代基γ'的取代基; R 1'和R 3'连接到与R 2'连接的吡咯原子相邻的吡咯的两个原子上; 取代基α'：羟基，硝基，氰基，卤素，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基或-NR a R b b。 R a，O和R b'是氢，烷基，烯基，炔基，芳烷基或烷基磺酰基，或者R a'和R“ b'与氮原子形成杂环基; 取代基β'：烷基，烯基，炔基，芳烷基或环烷基; 取代基γ'：氧代，羟基亚氨基，烷氧基亚氨基，亚烷基，亚烷基二氧基，烷基亚磺酰基，烷基磺酰基，芳基，芳氧基，亚烷基或芳烷基。

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