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1. 发明申请

US20050283006A1 Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses 审中-公开
标题翻译：杂芳基取代的吡咯衍生物，其制备及其治疗用途
公开(公告)号：US20050283006A1
公开(公告)日：2005-12-22
申请号：US10411061
申请日：2003-04-10
申请人： Tomio Kimura , Kazumasa Aoki , Akira Nakao , Shigeru Ushiyama , Takaichi Shimozato , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
发明人： Tomio Kimura , Kazumasa Aoki , Akira Nakao , Shigeru Ushiyama , Takaichi Shimozato , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
IPC分类号： C07D401/04 , C07D401/14 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04 , C07D491/20 , C07D41/14 , C07D43/02
CPC分类号： C07D451/02 , C07D401/04 , C07D401/14 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04
摘要： Compounds having activity against production of inflammatory cytokines of formula (I)′: A′ is pyrrole; R1′ is aryl or heteroaryl; R2′ is heteroaryl having at least one nitrogen atom; R3′ is (IIa)′, (IIb)′ or (IIc)′: m′ is 1 or 2; one of D′ and E′ is nitrogen and the other is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 4- to 7-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′: hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′: alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′: oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.
摘要翻译：具有抗式产生式（I）的炎性细胞因子的化合物的化合物：A'是吡咯; R 1是芳基或杂芳基; R 2是具有至少一个氮原子的杂芳基; （IIa）'，（IIb）'或（IIc）'：m'为1或2; D'和E'之一是氮，另一个是> C（R 5'） - ，R 5'是氢，取代基α'或取代基β'; B'是含氮的4-至7-元杂环; R 4'是1至3个取代基α'，取代基β'和取代基γ'的取代基; R 1'和R 3'连接到与R 2'连接的吡咯原子相邻的吡咯的两个原子上; 取代基α'：羟基，硝基，氰基，卤素，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基或-NR a R b b。 R a，O和R b'是氢，烷基，烯基，炔基，芳烷基或烷基磺酰基，或者R a'和R“ b'与氮原子形成杂环基; 取代基β'：烷基，烯基，炔基，芳烷基或环烷基; 取代基γ'：氧代，羟基亚氨基，烷氧基亚氨基，亚烷基，亚烷基二氧基，烷基亚磺酰基，烷基磺酰基，芳基，芳氧基，亚烷基或芳烷基。

2. 发明授权

US07122666B2 Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses 失效
标题翻译：杂芳基取代的吡咯衍生物，其制备及其治疗用途
公开(公告)号：US07122666B2
公开(公告)日：2006-10-17
申请号：US10354648
申请日：2003-01-30
申请人： Tomio Kimura , Akira Nakao , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
发明人： Tomio Kimura , Akira Nakao , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
IPC分类号： C07D207/00 , C07D209/00
CPC分类号： C07D451/02 , C07D401/04 , C07D401/14 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04
摘要： Compounds having activity against production of an inflammatory cytokine of formula (I)′: A′ is pyrrole; R1′ is phenyl or naphthyl; R2′ is pyridyl or pyrimidinyl; R3′ is (IIa)′, (IIb)′ or (IIc)′: m′ is 1; E′ is nitrogen; D′ is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 5-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′ is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′ is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′ is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.
摘要翻译：具有抗式产生式（I）的炎性细胞因子的活性化合物的化合物：A'是吡咯; R 1是苯基或萘基; R 2是吡啶基或嘧啶基; （IIa）'，（IIb）'或（IIc）'：m'为1; E'是氮; D'是> C（R 5'） - ，R 5'是氢，取代基α'或取代基β'; B'是含氮5元杂环; R 4'是1至3个取代基α'，取代基β'和取代基γ'的取代基; R 1'和R 3'连接到与R 2'连接的吡咯原子相邻的吡咯的两个原子上; 取代基α'是羟基，硝基，氰基，卤素，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基或-NR a R b B。 R a，O和R b'是氢，烷基，烯基，炔基，芳烷基或烷基磺酰基，或者R a'和R“ b'与氮原子形成杂环基; 取代基β'是烷基，烯基，炔基，芳烷基或环烷基; 取代基γ'是氧代，羟基亚氨基，烷氧基亚氨基，亚烷基，亚烷基二氧基，烷基亚磺酰基，烷基磺酰基，芳基，芳氧基，亚烷基或芳亚烷基。

3. 发明授权

US08809684B2 Insulated wire 有权
标题翻译：绝缘电线
公开(公告)号：US08809684B2
公开(公告)日：2014-08-19
申请号：US13075286
申请日：2011-03-30
申请人： Takanori Yamazaki , Kiyoshi Watanabe , Junichi Abe , Hideyuki Kikuchi , Daisuke Hino
发明人： Takanori Yamazaki , Kiyoshi Watanabe , Junichi Abe , Hideyuki Kikuchi , Daisuke Hino
IPC分类号： H01B7/00
CPC分类号： H01B3/305 , H01B3/301
摘要： There is provided an insulated wire including a wire conductor and an insulation coating formed on the wire conductor by extrusion coating a resin composition. The resin composition is a mixture of a polyphenylene sulfide-based resin (A) and a polyamide-based resin (B), in which a ratio of parts by mass of the resin (B) to that of the resin (A), i.e. (B)/(A), is not less than 5/95 and not more than 30/70.
摘要翻译：提供了一种绝缘电线，其包括线导体和通过挤出涂覆树脂组合物形成在导线导体上的绝缘涂层。树脂组合物是聚苯硫醚类树脂（A）和聚酰胺类树脂（B）的混合物，其中树脂（B）与树脂（A）的质量份的比例，即（B）/（A），不小于5/95且不大于30/70。

4. 发明申请

US20140140416A1 OFFSET DECODING DEVICE, OFFSET CODING DEVICE, IMAGE FILTERING DEVICE, AND DATA STRUCTURE 有权
标题翻译：偏移解码装置，偏移编码装置，图像滤波装置和数据结构
公开(公告)号：US20140140416A1
公开(公告)日：2014-05-22
申请号：US14127889
申请日：2012-06-22
申请人： Takanori Yamazaki , Tomohiro Ikai , Tomoyuki Yamamoto , Yukinobu Yasugi
发明人： Takanori Yamazaki , Tomohiro Ikai , Tomoyuki Yamamoto , Yukinobu Yasugi
IPC分类号： H04N19/117 , H04N19/44
CPC分类号： H04N19/117 , H04N19/14 , H04N19/182 , H04N19/184 , H04N19/44 , H04N19/463 , H04N19/70 , H04N19/82 , H04N19/96
摘要： An adaptive offset filter (60) adds an offset to the pixel value of each pixel forming an input image. The adaptive offset filter (60) refers to offset-type specifying information, sets offset attributes for a subject unit area of the input image, decodes an offset having a bit width corresponding to an offset value range included in the set offset attributes, and adds the offset to the pixel value of each pixel forming the input image.
摘要翻译：自适应偏移滤波器（60）对形成输入图像的每个像素的像素值添加偏移。自适应偏移滤波器（60）是指偏移型指定信息，设置输入图像的主体单位区域的偏移属性，对具有与设定的偏移属性中包含的偏移值范围相对应的位宽的位移进行解码，与形成输入图像的每个像素的像素值的偏移。

5. 发明授权

US08609688B2 Substituted imidazopyridinyl-aminopyridine compounds 有权
公开(公告)号：US08609688B2
公开(公告)日：2013-12-17
申请号：US13529459
申请日：2012-06-21
申请人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Kenichi Yoshida , Takanori Yamazaki , Takahiro Kitamura , Takeshi Isoyama
发明人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Kenichi Yoshida , Takanori Yamazaki , Takahiro Kitamura , Takeshi Isoyama
IPC分类号： A01N43/42 , A61K31/44 , C07D515/02
CPC分类号： C07D471/04 , C07D451/02 , C07D491/08 , C07D498/08
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

6. 发明授权

US08568547B2 Molded product and manufacturing method thereof 失效
标题翻译：成型品及其制造方法
公开(公告)号：US08568547B2
公开(公告)日：2013-10-29
申请号：US12768794
申请日：2010-04-28
申请人： Takanori Yamazaki , Naofumi Chiwata , Takenori Taki
发明人： Takanori Yamazaki , Naofumi Chiwata , Takenori Taki
IPC分类号： B32B37/06
CPC分类号： B29C45/14811 , B29C43/18 , B29C43/203 , B29C45/14221 , B29K2105/256 , B29K2705/00 , B29K2715/006 , B32B37/04 , B32B2307/206 , B32B2311/00 , Y10T156/1043 , Y10T156/1044 , Y10T428/239 , Y10T428/24942 , Y10T428/31678
摘要： A molded product and a method of manufacturing the same are disclosed, in which the insulating layer of uniform thickness is formed in a narrow clearance between plural metal bodies. Surroundings of metal plates spaced at specified intervals are covered with insulating polymer to insulate them electrically. A spacer polymer which consists of insulating polymer whose melting point is T1 is arranged between the metal plates, and a molded part which consists of insulating polymer whose melting point is T2 (
摘要翻译：公开了一种成型品及其制造方法，其中均匀厚度的绝缘层形成在多个金属体之间的窄间隙中。以规定间隔隔开的金属板的周围用绝缘聚合物覆盖，以使它们电绝缘。熔点为T1的由绝缘聚合物组成的间隔聚合物布置在金属板之间，由熔点为T2（

7. 发明授权

US08476253B2 Amide derivative 失效
标题翻译：酰胺衍生物
公开(公告)号：US08476253B2
公开(公告)日：2013-07-02
申请号：US13234514
申请日：2011-09-16
申请人： Takuya Ikeda , Takanori Yamazaki , Hiroshi Tsuchida
发明人： Takuya Ikeda , Takanori Yamazaki , Hiroshi Tsuchida
IPC分类号： C07D401/04 , A61K31/438
CPC分类号： C07D413/14 , C07D417/14
摘要： Compounds or pharmacologically acceptable salts thereof are provided. In various embodiments the compounds have an antagonistic effect on a neurokinin NK1 receptor, a neurokinin NK2 receptor, and a muscarine M3 receptor. The compounds are useful as therapeutic agents for bronchial asthma, chronic obstructive pulmonary disease, or the like.
摘要翻译：提供化合物或其药理学上可接受的盐。在各种实施方案中，化合物对神经激肽NK1受体，神经激肽NK2受体和毒蕈碱M3受体具有拮抗作用。这些化合物可用作支气管哮喘，慢性阻塞性肺病等的治疗剂。

8. 发明授权

US08270116B2 Magnetic disk drive and magnetic head slider with stabilized flying 失效
标题翻译：磁盘驱动器和磁头滑块具有稳定的飞行
公开(公告)号：US08270116B2
公开(公告)日：2012-09-18
申请号：US11522117
申请日：2006-09-14
申请人： Yuki Shimizu , Junguo Xu , Jianhua Li , Takanori Yamazaki
发明人： Yuki Shimizu , Junguo Xu , Jianhua Li , Takanori Yamazaki
IPC分类号： G11B5/60
CPC分类号： G11B5/6005
摘要： A magnetic disk drive includes a magnetic recording medium and a magnetic head slider adapted to fly over a surface of a magnetic recording medium and read or write information. The magnetic head slider includes a slider air bearing surface and a magnetic transducer. The slider air bearing surface includes a front pad having front rail surfaces and front step bearing surfaces, a rear pad having a rear rail surface and a rear step bearing surface, and a negative-pressure groove interposed between the front pad and the rear pad. A vibration suppressing groove is formed in the rear rail surface so as to be deeper than the rear rail surface and to be closed at its periphery. The vibration suppressing groove quickly damps out translational and pitching vibrations in the flying height direction of the magnetic head slider while stabilizing its flying.
摘要翻译：磁盘驱动器包括磁记录介质和适于在磁记录介质的表面上飞越并读取或写入信息的磁头滑块。磁头滑块包括滑块空气支承表面和磁换能器。滑块空气轴承表面包括具有前导轨表面和前阶梯支承表面的前垫，具有后轨表面和后台阶支承表面的后垫，以及插入在前垫和后垫之间的负压槽。在后轨面上形成振动抑制槽，使其比后轨面更深，并在其周边封闭。振动抑制槽在稳定其飞行的同时快速地减小磁头滑块的飞行高度方向上的平移和俯仰振动。

9. 发明申请

US20120071467A1 AMIDE DERIVATIVE 失效
公开(公告)号：US20120071467A1
公开(公告)日：2012-03-22
申请号：US13234514
申请日：2011-09-16
申请人： Takuya Ikeda , Takanori Yamazaki , Hiroshi Tsuchida
发明人： Takuya Ikeda , Takanori Yamazaki , Hiroshi Tsuchida
IPC分类号： A61K31/551 , C07D417/14 , A61K31/4545 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/496 , A61P11/00 , A61P11/14 , A61P11/06 , A61P29/00 , A61P1/04 , A61P1/08 , A61P35/00 , A61P25/08 , A61P25/24 , A61P25/22 , A61P25/16 , C07D413/14
CPC分类号： C07D413/14 , C07D417/14
摘要： Compounds or pharmacologically acceptable salts thereof are provided. In various embodiments the compounds have an antagonistic effect on a neurokinin NK1 receptor, a neurokinin NK2 receptor, and a muscarine M3 receptor. The compounds are useful as therapeutic agents for bronchial asthma, chronic obstructive pulmonary disease, or the like.
摘要翻译：提供化合物或其药理学上可接受的盐。在各种实施方案中，化合物对神经激肽NK1受体，神经激肽NK2受体和毒蕈碱M3受体具有拮抗作用。这些化合物可用作支气管哮喘，慢性阻塞性肺病等的治疗剂。

10. 发明授权

US08105540B2 Method of treating polymer compound and treatment system for the same 失效
标题翻译：处理高分子化合物和处理系统的方法相同
公开(公告)号：US08105540B2
公开(公告)日：2012-01-31
申请号：US12821788
申请日：2010-06-23
申请人： Toshiharu Goto , Takanori Yamazaki , Yoshihiko Iwamoto , Jun Kakizaki
发明人： Toshiharu Goto , Takanori Yamazaki , Yoshihiko Iwamoto , Jun Kakizaki
IPC分类号： B01J19/18 , B01J19/00 , B01J19/20 , B28B17/00 , B29B13/00 , B29C47/92 , B29C47/38 , B29C47/78
CPC分类号： B29C47/50 , B29B17/02 , B29B17/04 , B29B2017/0293 , B29B2017/046 , B29C47/0004 , B29C47/0011 , B29C47/0014 , B29C47/0066 , B29C47/366 , B29C47/822 , B29C47/8815 , B29C47/92 , B29C2947/92019 , B29C2947/92104 , B29C2947/924 , B29C2947/92466 , B29C2947/92514 , B29C2947/926 , B29C2947/92704 , B29C2947/92895 , B29C2947/92961 , B29K2023/06 , C08J11/08 , Y02W30/622 , Y02W30/625 , Y02W30/701
摘要： A method of treating a polymer compound has the steps of: mixing and agitating the polymer compound and a chemical agent in an extruder while controlling the inside of the extruder to be kept at a high temperature and a high pressure to have a reaction mixture containing a polymer treated product; supplying the reaction mixture continuously into a high-pressure container disposed following the extruder and retaining the reaction mixture at the high temperature and high pressure for a predetermined time; then supplying the reaction mixture continuously to a chemical agent separator to separate the polymer treated product; and supplying the separated polymer treated product continuously to a molding means to form it into a molded material.
摘要翻译：处理高分子化合物的方法具有以下步骤：在挤出机内混合搅拌高分子化合物和化学试剂，同时控制挤出机的内部保持在高温和高压下，使含有聚合物处理产品; 将反应混合物连续地供入设置在挤出机后面的高压容器中，并将反应混合物保持在高温高压下一段预定时间; 然后将反应混合物连续供给到化学试剂分离器以分离聚合物处理产物; 并将分离的聚合物处理产物连续地供给到模制装置中以将其形成为模制材料。

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