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11. 发明授权

US06956205B2 Means and method for guiding ions in a mass spectrometer 有权
标题翻译：在质谱仪中引导离子的方法和方法
公开(公告)号：US06956205B2
公开(公告)日：2005-10-18
申请号：US09882361
申请日：2001-06-15
申请人： Melvin A. Park
发明人： Melvin A. Park
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/063 , H01J49/107
摘要： A multipole ion guide capable of incorporating a plurality of ion sources (i.e., MALDI, ESI, EI/CI, etc.) to provide and analyze ions in a mass analyzer (i.e., ICR, TOF, quadrupole, etc.) has been designed. Such multipole ion guides comprise an array of pairs of parallel conducting rods (i.e., 3 pair, 4 pair, 5 pair, etc.), each pair being equally spaced from one another, with the array being bound on its top and bottom as well as its ends by DC electrodes. The ion guide then utilizes RF/DC potentials to accept ions from any of a multitude of ion sources to facilitate their transmission through differentially pumped regions to a high pressure mass analysis region.
摘要翻译：已经设计了能够并入多个离子源（即，MALDI，ESI，EI / CI等）以提供和分析质量分析器（即ICR，TOF，四极杆等）中的离子的多极离子导向器。这样的多极离子导向器包括一对平行的导电棒（即，3对，4对，5对等），每对彼此间隔相等，阵列也在其顶部和底部被结合作为其末端由直流电极。离子导向器然后利用RF / DC电位接受来自多个离子源中的任何一个的离子，以促进它们通过差分泵浦区域传输到高压质量分析区域。

12. 发明授权

US6130426A Kinetic energy focusing for pulsed ion desorption mass spectrometry 失效
标题翻译：脉冲离子解吸质谱的动能聚焦
公开(公告)号：US6130426A
公开(公告)日：2000-10-10
申请号：US32510
申请日：1998-02-27
申请人： Frank H. Laukien , Melvin A. Park
发明人： Frank H. Laukien , Melvin A. Park
IPC分类号： H01J49/16 , H01J49/40 , B01D59/44 , H01J49/00
CPC分类号： H01J49/164
摘要： The present invention relates to a means and method for decreasing the energy distribution of ions produced from solid or liquid samples by pulsed desorption method. More particularly, the present invention discloses a method wherein the kinetic energies of ions are related to their locations at a given time after the excitation event which caused their desorption. Based on this relationship between ion position and energy, an accelerating electric field is applied at a predetermined time after the excitation event. The magnitude of the applied electric field and the time of its application are such that the kinetic energy distribution of the ions is substantially reduced or eliminated.
摘要翻译：本发明涉及通过脉冲解吸法降低由固体或液体样品产生的离子的能量分布的方法和方法。更具体地说，本发明公开了一种方法，其中离子的动能与它们在引发它们的解吸附的激发事件之后给定时间的位置有关。基于离子位置和能量之间的关系，在激发事件之后的预定时间施加加速电场。所施加的电场的大小和其应用的时间使得离子的动能分布显着减少或消除。

13. 发明授权

US08841607B2 Atmospheric pressure ion source with exhaust system 有权
标题翻译：带排气系统的大气压离子源
公开(公告)号：US08841607B2
公开(公告)日：2014-09-23
申请号：US13602249
申请日：2012-09-03
申请人： Zicheng Yang , Roy P Moeller , Stephen Zanon
发明人： Zicheng Yang , Roy P Moeller , Stephen Zanon
IPC分类号： H01J49/26
CPC分类号： H01J49/044 , H01J49/165 , H01J49/168 , H01J49/24
摘要： An atmospheric pressure ion source, employing the principle of electrospray ionization, chemical ionization, or photo-ionization, comprises a spray probe for spraying a liquid into an ionization chamber and has an exhaust port through which residual spray mist and waste gas, such as evaporated solvent, are extracted. The ion source further comprises an exhaust system comprising a conduit which is connected to the exhaust port. The conduit has a transition from a first cross-section to a second cross section at a point downstream of the exhaust port wherein the second cross section is reduced in relation to the first cross section. Gas is injected via a gas injector into the conduit in a region of the transition to create a low pressure region that removes unwanted material from the chamber.
摘要翻译：使用电喷雾电离，化学电离或光电离原理的大气压离子源包括用于将液体喷射到电离室中的喷射探针，并具有排气口，残留的喷雾和废气如蒸发溶剂，萃取。离子源还包括排气系统，其包括连接到排气口的导管。导管在排气口下游的点处具有从第一横截面到第二横截面的过渡，其中第二横截面相对于第一横截面减小。气体通过气体注入器在过渡区域中被注入导管，以产生从腔室去除不需要的材料的低压区域。

14. 发明授权

US08809769B2 Apparatus and method for cross-flow ion mobility spectrometry 有权
标题翻译：交叉流离子迁移谱法的装置和方法
公开(公告)号：US08809769B2
公开(公告)日：2014-08-19
申请号：US13688594
申请日：2012-11-29
申请人： Bruker Daltonics, Inc.
发明人： Melvin Andrew Park
IPC分类号： H01J49/00
CPC分类号： G01N27/622 , H01J49/004 , H01J49/36
摘要： A cross-flow ion mobility spectrometer consists of two parallel plates defining a volume between them. Analyte ions flow along an axis from an entrance end to an exit end through the volume. An RF confining field tends to guide ions along the axis. An analytical gas flow is established orthogonal to the axis. A DC electrostatic analytical field is oriented in opposition to the analytical gas flow such that the “drag force” on ions of the selected mobility due to the analytical gas flow is balanced by the force on the ions due to the electrostatic analytical field. The selected ions are thereby able to follow a stable path to the exit end of the cross-flow mobility analyzer. However, the force on ions of other than the selected mobility is unbalanced and these ions are deflected and lost.
摘要翻译：交叉流离子迁移谱仪由两个平行的板组成，在它们之间限定体积。分析离子沿着一个轴线从入口端到出口端流过体积。 RF限制场趋向于沿着轴引导离子。建立与轴正交的分析气流。 DC静电分析场与分析气体流动相对取向，使得由于分析气体流动而选择的迁移率的离子上的“阻力”由于静电分析场而由离子上的力平衡。所选择的离子因此能够遵循到交叉流动迁移率分析仪的出口端的稳定路径。然而，除选择的迁移率之外的离子力是不平衡的，并且这些离子被偏转和损失。

15. 发明授权

US08759758B2 Gas chromatograph-mass spectrometer transfer line 有权
标题翻译：气相色谱 - 质谱仪传输线
公开(公告)号：US08759758B2
公开(公告)日：2014-06-24
申请号：US13418743
申请日：2012-03-13
申请人： Urs Steiner , Felician Muntean , Bert D. Egley
发明人： Urs Steiner , Felician Muntean , Bert D. Egley
IPC分类号： H01J49/04 , G01N30/72
CPC分类号： H01J49/0422 , G01N30/7206 , H01J49/04
摘要： A transfer line for conveying the column effluent from a gas chromatograph to an ion source of a mass spectrometer has a transfer line body and a mechanism for moving the transfer line body either towards or away from the mass spectrometer. A gas seal between the housing of the mass spectrometer and the transfer line body prevents vacuum leak when the transfer line body is moved. In one embodiment, the transfer line body outer periphery is threaded and a hand wheel engages the transfer line body threads via complementary threads in order to move the body. When the transfer line is moved towards the mass spectrometer, the body presses an ion source, which is not rigidly fixed to the housing of the mass spectrometer, into a recess seat of the housing, and aligns the ion source in an operating position.
摘要翻译：用于将柱流出物从气相色谱仪输送到质谱仪的离子源的输送管线具有输送管线主体和用于使输送管线体朝向或远离质谱仪移动的机构。质量分析仪的壳体与传输线体之间的气体密封防止输送线主体移动时的真空泄漏。在一个实施例中，输送线主体外周是带螺纹的，并且手轮通过互补螺纹与传输线主体线接合，以便移动主体。当传送线向质谱仪移动时，身体将没有刚性地固定到质谱仪的壳体上的离子源按压到壳体的凹座中，并将离子源对准在操作位置。

16. 发明授权

US08680462B2 Curved heated ion transfer optics 有权
标题翻译：弯曲加热离子转移光学
公开(公告)号：US08680462B2
公开(公告)日：2014-03-25
申请号：US13370513
申请日：2012-02-10
申请人： Stephen Zanon , Roy P Moeller , Urs Steiner , Felician Muntean
发明人： Stephen Zanon , Roy P Moeller , Urs Steiner , Felician Muntean
IPC分类号： H01J49/06
CPC分类号： H01J37/04 , H01J49/0468 , H01J49/063 , H01J49/068 , H01J2237/053 , H01J2237/057 , H01J2237/1516
摘要： An ion optics assembly is formed by four quarter-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a quarter-circular channel with quarter-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. Quarter-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer. A heater is provided at the entrance to the ion transfer optics, to prevent accumulation of ions on the poles. A thermal break is provided in the quad, so as to enable maintaining the front of the quad heated and the rest of the quad cooler.
摘要翻译：离子光学组件由四个四分之一圆形的轮廓元件形成，所有元件都附着在相同的参考板上。因此，所有四个元件保持与相同的参考板对准。四个元件形成四分之一圆形四通道四通道。四极电极接收电势以形成将离子聚焦并保持在通道中心所需的场。在通道的所有侧面都设有四分之一圆形的绝缘体，以便从质谱仪的内部将通道密封在其长度上。在离子转移光学器件的入口处设置加热器，以防止离子在极上的积聚。在四边形中提供热断裂，以便能够保持四边形的前部被加热并且四分之一冷却器的其余部分。

17. 发明授权

US08637811B2 Stabilized electron multiplier anode 有权
标题翻译：稳定的电子倍增器阳极
公开(公告)号：US08637811B2
公开(公告)日：2014-01-28
申请号：US13184022
申请日：2011-07-15
申请人： Urs Steiner , Roy P Moeller , David Deford
发明人： Urs Steiner , Roy P Moeller , David Deford
IPC分类号： B01D59/44
CPC分类号： H01J3/36 , H01J43/30 , H01J49/02 , H01J49/26
摘要： Methods and systems to compensate for distortions created by dynamic voltage applied to an electron multiplier used in mass spectrometry. An electron multiplier has a cathode end accepting ion flow, an opposite emitter end and an interior surface. The electron multiplier produces an electron output from ions colliding with the interior surface. A variable power supply has a voltage output coupled to the cathode end and the emitter end of the electron multiplier. The voltage output changes dynamically to adjust the electron output from the electron multiplier. An anode is located in proximity to the electron multiplier. An electrometer is coupled to the anode in proximity to the electron multiplier to measure the current generated by the electron output. A low pass filter circuit is coupled to the emitter end to the ground of the electrometer to attenuate emitter voltage changes. A bias circuit is coupled to the emitter end to stabilize emitter to anode voltage difference.
摘要翻译：用于补偿由施加到质谱仪中使用的电子倍增器的动态电压产生的失真的方法和系统。电子倍增器具有阴极端接受离子流，相对的发射极端和内表面。电子倍增器产生离子与内表面碰撞的电子输出。可变电源具有耦合到电子倍增器的阴极端和发射极端的电压输出。电压输出动态变化，以调整电子倍增器的电子输出。阳极位于电子倍增器附近。靠近电子倍增器的静电计耦合到阳极，以测量由电子输出产生的电流。低通滤波器电路被耦合到发射极端到静电计的地面以衰减发射极电压变化。偏置电路耦合到发射极端以稳定发射极与阳极的电压差。

18. 发明申请

US20140014747A1 ASSEMBLY FOR AN ELECTROSPRAY ION SOURCE 有权
标题翻译：组装电沉积源
公开(公告)号：US20140014747A1
公开(公告)日：2014-01-16
申请号：US13550061
申请日：2012-07-16
申请人： Roy P. MOELLER , Rohan THAKUR , Felician MUNTEAN , Maurizio A. SPLENDORE , Stephen ZANON
发明人： Roy P. MOELLER , Rohan THAKUR , Felician MUNTEAN , Maurizio A. SPLENDORE , Stephen ZANON
IPC分类号： F23D11/32
CPC分类号： H01J49/10 , H01J49/165 , H01J49/167
摘要： An assembly for use in an electrospray ion source includes a capillary for guiding a flow of liquid generally containing analyte(s) of interest, which is to be electrosprayed into an ionization chamber, a first tube at least partially encasing the capillary such that a first conduit for guiding a first heatable gas is created proximate the capillary and a hollow member that has an internal evacuated space and is located at the outer circumference of the capillary such that heat transfer from the first heatable gas flowing proximate the capillary to the liquid in the capillary is impeded. The assembly provides a simple and lean/compact way of preventing excessive heat transfer to the liquid in the capillary of an electrospray ion source.
摘要翻译：用于电喷雾离子源的组件包括毛细管，用于引导通常含有目标分析物的液体流，所述分析物将被电喷雾到电离室中，第一管至少部分地封装毛细管，使得第一在毛细管附近产生用于引导第一可加热气体的导管，以及具有内部抽真空空间并位于毛细管外周的中空构件，使得来自第一可加热气体的热量传递到毛细管附近流到液体中毛细管受阻。该组件提供了一种简单且精益/紧凑的方法来防止电喷雾离子源的毛细管中的液体过度传热。

19. 发明申请

US20130277570A1 METHOD AND DEVICE FOR GAS-PHASE ION FRAGMENTATION 有权
标题翻译：用于气相离子化的方法和装置
公开(公告)号：US20130277570A1
公开(公告)日：2013-10-24
申请号：US13449436
申请日：2012-04-18
申请人： Melvin Andrew PARK , Desmond Allen KAPLAN
发明人： Melvin Andrew PARK , Desmond Allen KAPLAN
IPC分类号： H01J27/20
CPC分类号： H01J49/0054
摘要： The invention relates to a device for performing electron capture dissociation on multiply charged cations. Provided is an electron emitter which, upon triggering, emits a plurality of low energy electrons suitable for efficient electron capture reactions to occur. Further, the device contains a particle emitter being located proximate to the electron emitter and being capable, upon triggering, to emit a plurality of high energy charged particles substantially in a direction towards the electron emitter in order that the electron emitter receives a portion of the emitted plurality of high energy charged particles and emission of the plurality of low energy electrons is triggered. A volume capable of containing a plurality of multiply charged cations is located in opposing relation to the electron emitter such that the volume receives the plurality of low energy electrons upon emission as to allow electron capture dissociation to occur.
摘要翻译：本发明涉及用于在多电荷阳离子上进行电子捕获离解的装置。提供了一种电子发射器，其在触发时发射适于发生有效电子捕获反应的多个低能电子。此外，该器件包含位于电子发射器附近的粒子发射器，并且能够在触发时基本上沿朝向电子发射器的方向发射多个高能量带电粒子，以使电子发射器接收一部分发射多个高能量带电粒子并发射多个低能电子。能够容纳多个多电荷阳离子的体积位于与电子发射体相对的关系中，使得体积在发射时接收多个低能电子以允许发生电子俘获解离。

20. 发明授权

US08481929B2 Lens free collision cell with improved efficiency 有权
标题翻译：镜头免费碰撞电池，提高效率
公开(公告)号：US08481929B2
公开(公告)日：2013-07-09
申请号：US13406767
申请日：2012-02-28
申请人： Urs Steiner , Felician Muntean , Roy P Moeller , Thinh M Ha
发明人： Urs Steiner , Felician Muntean , Roy P Moeller , Thinh M Ha
IPC分类号： H01J49/06 , G01N27/00 , H01J49/00 , G01N27/62
CPC分类号： H01J49/068 , G01N27/622 , H01J49/005 , H01J49/063 , H01J49/066 , Y10T29/49117
摘要： An ion collision cell is fabricated by four semi-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a semi-circular channel with a semi-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. semi-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer.
摘要翻译：离子碰撞单元由四个半圆形轮廓元件制成，所有这些元件都附着在相同的参考板上。因此，所有四个元件保持与相同的参考板对准。四个元件形成具有半圆形四边形电极的半圆形通道。四极电极接收电势以形成将离子聚焦并保持在通道中心所需的场。在通道的所有侧面上都设有半圆形绝缘体，以便将密度从质谱仪内部的通道密封在其长度上。

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