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1. 发明授权

US09355832B2 Reflectrons and methods of producing and using them 有权
标题翻译：反射器及其制造和使用方法
公开(公告)号：US09355832B2
公开(公告)日：2016-05-31
申请号：US14289822
申请日：2014-05-29
申请人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
发明人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
IPC分类号： H01J49/06 , H01J49/40
CPC分类号： H01J49/067 , H01J49/405
摘要： Certain embodiments described herein are directed to reflectron assemblies and methods of producing them. In some configurations, a reflectron comprising a plurality of lenses each comprising a planar body and comprising a plurality of separate and individual conductors spanning a central aperture from a first side to a second side of a first surface of the planar body is described. In some instances, the plurality of conductors are each substantially parallel to each other and are positioned in the same plane.
摘要翻译：本文描述的某些实施例涉及反射器组件及其制造方法。在一些配置中，描述了包括多个透镜的反射器，每个透镜都包括平面主体，并且包括多个分离的和单独的导体，跨越从平面主体的第一表面的第一侧到第二侧的中心孔。在一些情况下，多个导体各自基本上彼此平行并且位于同一平面中。

2. 发明授权

US09236235B2 Curved ion guide and related methods 有权
标题翻译：弯曲离子指导及相关方法
公开(公告)号：US09236235B2
公开(公告)日：2016-01-12
申请号：US12277198
申请日：2008-11-24
申请人： Felician Muntean , Urs Steiner
发明人： Felician Muntean , Urs Steiner
IPC分类号： H01J49/06
CPC分类号： H01J49/063
摘要： An ion guide includes a plurality of curved electrodes and an ion deflecting device. The electrodes are arranged in parallel with each other and with a central curved axis, the curved central axis being co-extensive with an arc of a circular section having a radius of curvature, each electrode being radially spaced from the curved central axis, wherein the plurality of electrodes define a curved ion guide region arranged about the curved central axis and between opposing pairs of the electrodes. The ion deflecting device may include a device for applying a DC electric field to two or more of the electrodes in a radial direction. The ion deflecting device may include a pair of curved, parallel ion deflecting electrodes, which are in addition to curved electrodes utilized for applying an RF ion guiding field.
摘要翻译：离子导向器包括多个弯曲电极和离子偏转装置。电极彼此平行并具有中心的弯曲轴线，弯曲的中心轴与具有曲率半径的圆形截面的弧共同延伸，每个电极与弯曲的中心轴径向间隔开，其中，多个电极限定围绕弯曲的中心轴线布置并且在相对的电极对之间布置的弯曲离子引导区域。离子偏转装置可以包括用于沿径向向两个或更多个电极施加DC电场的装置。离子偏转装置可以包括一对弯曲的平行离子偏转电极，这些电极除了用于施加RF离子引导场的弯曲电极之外。

3. 发明申请

US20140151529A1 OPTICAL DETECTORS AND METHODS OF USING THEM 审中-公开
标题翻译：光学检测器及其使用方法
公开(公告)号：US20140151529A1
公开(公告)日：2014-06-05
申请号：US14082685
申请日：2013-11-18
申请人： Urs Steiner , Daniel Robert Marshak
发明人： Urs Steiner , Daniel Robert Marshak
IPC分类号： G01J1/44
CPC分类号： H01J43/20 , G01J1/44 , G01J2001/4453
摘要： Certain embodiments described herein are directed to optical detector and optical systems. In some examples, the optical detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In other configurations, each dynode can be coupled to a respective electrometer. Methods using the optical detectors are also described.
摘要翻译：本文描述的某些实施例涉及光学检测器和光学系统。在一些示例中，光学检测器可以包括多个倍增电极，其中一个或多个倍增电极耦合到静电计。在其他配置中，每个倍增极可以耦合到相应的静电计。还描述了使用光学检测器的方法。

4. 发明申请

US20130015342A1 Fixed Connection Assembly For an RF Drive Circuit in a Mass Spectrometer 有权
标题翻译：用于质谱仪中RF驱动电路的固定连接组件
公开(公告)号：US20130015342A1
公开(公告)日：2013-01-17
申请号：US13184225
申请日：2011-07-15
申请人： Urs Steiner , Lawrence B. Jones
发明人： Urs Steiner , Lawrence B. Jones
IPC分类号： H01J49/26 , H01J49/00
CPC分类号： H01J49/4255 , H01J49/02 , H01J49/022 , H01J49/22 , H01J49/36 , H01J49/42 , H01J49/4215 , Y10T307/391 , Y10T307/461
摘要： In one embodiment, a mass spectrometer includes an RF drive circuit for generating RF signals, a quadrupole mass filter, and a fixed connection assembly for delivering RF signals from the RF drive circuit to the quadrupole mass filter, the fixed connection assembly representing the entire delivery path of RF signals from the RF drive circuit to the quadrupole mass filter. By avoiding flexible components such as a freestanding wires or flexible circuit boards, the need for retuning when parts are removed or disturbed for testing or servicing is reduced, and a modular instrument in which components and connections are standardized and therefore interchangeable is realized.
摘要翻译：在一个实施例中，质谱仪包括用于产生RF信号的RF驱动电路，四极质量过滤器和用于将RF信号从RF驱动电路传送到四极质量过滤器的固定连接组件，固定连接组件代表整个输送从RF驱动电路到四极质量过滤器的RF信号的路径。通过避免诸如独立电线或柔性电路板的柔性部件，减少零件被拆除或干扰以进行测试或维修时的重新调整的需要，以及实现标准化和可互换的组件和连接的模块化仪器。

5. 发明申请

US20130015340A1 MULTIPOLE ASSEMBLY HAVING A MAIN MASS FILTER AND AN AUXILIARY MASS FILTER 审中-公开
标题翻译：具有主质量过滤器和辅助过滤器的多组件
公开(公告)号：US20130015340A1
公开(公告)日：2013-01-17
申请号：US13366897
申请日：2012-02-06
申请人： Urs STEINER
发明人： Urs STEINER
IPC分类号： H01J49/26
CPC分类号： H01J3/40 , H01J49/068 , H01J49/4215 , H01J49/4255
摘要： A multipole rod assembly for use in a mass spectrometer has a plurality of rods aligned around and parallel to a common ion optical axis. Each rod consists of two rod pieces that are collinear with one another. Each rod piece has an opposing face that is perpendicular to the axis and faces the other rod. One rod piece has a recess is its face. The rod pieces are physically connected together with an insulating piece located between the two rod pieces to electrically de-couple the rod pieces. The insulating piece has a shape and size that allows it to fit entirely within the recess so that, during operation of the mass spectrometer, the insulating piece is substantially screened from the ion optical axis.
摘要翻译：用于质谱仪的多极杆组件具有多个杆，其围绕并平行于公共离子光轴对准。每个杆由两个彼此共线的杆件组成。每个杆件具有垂直于轴线并面对另一个杆的相对面。一个杆件的凹面是其表面。杆件通过位于两个杆件之间的绝缘件物理连接在一起，以电连接杆件。绝缘片具有允许其完全配合在凹部内的形状和尺寸，使得在质谱仪的操作期间绝缘片基本上从离子光轴上筛选。

6. 发明授权

US07745781B2 Real-time control of ion detection with extended dynamic range 有权
标题翻译：离子检测的实时控制具有扩展的动态范围
公开(公告)号：US07745781B2
公开(公告)日：2010-06-29
申请号：US12130182
申请日：2008-05-30
申请人： Urs Steiner
发明人： Urs Steiner
IPC分类号： H01J49/26
CPC分类号： H01J49/025
摘要： In a method controlling an ion detector, one or more ion input signals are received at the ion detector. A data point indicative of an intensity of at least one of the received ion input signals is acquired. Asynchronously with acquiring the data point, a drive voltage applied to the ion detector is regulated to operate the ion detector at a gain optimal for the intensity of at least one of the received ion input signals. An ion detector for implementing the method is also provided.
摘要翻译：在控制离子检测器的方法中，在离子检测器处接收一个或多个离子输入信号。获取指示所接收的离子输入信号中的至少一个的强度的数据点。与获取数据点异步地，调节施加到离子检测器的驱动电压以使离子检测器以对于所接收的离子输入信号中的至少一个的强度最佳的增益进行操作。还提供了一种用于实现该方法的离子检测器。

7. 发明申请

US20090045330A1 Sample ionization at above-vacuum pressures 有权
标题翻译：在高于真空压力下进行样品电离
公开(公告)号：US20090045330A1
公开(公告)日：2009-02-19
申请号：US11893308
申请日：2007-08-15
申请人： Mingda Wang , Charles A. Fancher , Felician Muntean , Urs Steiner
发明人： Mingda Wang , Charles A. Fancher , Felician Muntean , Urs Steiner
IPC分类号： H01J49/26
CPC分类号： H01J49/0477 , H01J49/0404 , H01J49/044
摘要： Sample material ionized in a sample receiving chamber is flowed into a sample conduit. Drying gas may also flow into the sample conduit and may be heated. The pressure and length of the sample conduit may be provided according to the product 50 or greater Torr-cm. The sample conduit may include a turn. The sample conduit may lead to an ion extraction chamber at which a sampling orifice may lead to a mass spectrometer. The diameter of the sample conduit may be larger than the diameter of the sampling orifice. An electrical field may be applied in the ion extraction chamber to slow incoming ions. A voltage jump may be applied to the sample conduit.
摘要翻译：在样品接收室中离子化的样品材料流入样品导管。干燥气体也可以流入样品管道并且可以被加热。样品导管的压力和长度可以根据产品50或更大的Torr-cm提供。样品管道可以包括转弯。样品导管可导致离子提取室，采样孔可以在该离子提取室处导致质谱仪。样品导管的直径可以大于采样孔的直径。可以在离子提取室中施加电场以减慢入射离子。电压跳变可以施加到样品导管。

8. 发明授权

US06599410B1 Device for rehydration and electrophoresis of gel strips and method of using the same 有权
标题翻译：凝胶条的再水化和电泳装置及其使用方法
公开(公告)号：US06599410B1
公开(公告)日：2003-07-29
申请号：US09819061
申请日：2000-09-01
申请人： Urs Steiner , Mohammed Rezaul Islam , Eric R. Hungerman
发明人： Urs Steiner , Mohammed Rezaul Islam , Eric R. Hungerman
IPC分类号： G01N27447
CPC分类号： G01N27/44795 , G01N27/44704 , G01N27/44713
摘要： The present invention involves a gel strip carrier module for a gel strip that reduces the handling of the gel strip and the hands-on-time during preparation of the gel strip for isoelectric focusing. The gel carrier module includes a gel strip chamber that serves as both a rehydration and focusing chamber, and allows the sample to be applied either throughout the entire gel or in a defined zone. The gel carrier module includes a pair of electrodes near opposite ends of the chamber that the gel strip rests on, gel side facing down. The gel carrier module includes a cover with hold-down blocks or pressure blocks to assure reliable, light contact between the gel and the electrodes during focusing. A rehydration buffer is added into the chamber, and the gel strip is gently placed in the chamber, gel side down, for rehydration. The rehydration buffer may include the sample, or, in the event that the sample needs to be applied after rehydration, the gel carrier module includes sample application wells between the electrodes that the sample can be added to after rehydration of the gel strip.
摘要翻译：本发明涉及一种用于凝胶条的凝胶带载体模块，其减少了在制备用于等电聚焦的凝胶条时凝胶条的处理和手动接触时间。凝胶载体模块包括用作再水化和聚焦室两者的凝胶条带，并允许将样品施用于整个凝胶或限定区域。凝胶载体模块包括一对电极，其位于腔室的相对端附近，凝胶条位于其上，凝胶面朝下。凝胶载体模块包括具有压紧块或压块的盖，以确保在聚焦期间凝胶和电极之间可靠的轻微接触。将补液缓冲液加入到室中，并将凝胶条轻轻地放置在腔室中，凝胶侧向下放置，用于补液。再补充缓冲液可以包括样品，或者在再水合后需要应用样品的情况下，凝胶载体模块包括在电极之间的样品施加孔，在凝胶条的再水合之后可以加入样品。

9. 发明授权

US5843295A Gel electrophoresis well-forming and loading-guide comb 失效
标题翻译：凝胶电泳形成和加载导向梳
公开(公告)号：US5843295A
公开(公告)日：1998-12-01
申请号：US992928
申请日：1997-12-18
申请人： Urs Steiner , Tim O. Lau , Terry A. Landers
发明人： Urs Steiner , Tim O. Lau , Terry A. Landers
IPC分类号： G01N27/447 , G01N27/26 , C12M3/00
CPC分类号： G01N27/44743
摘要： A well-forming and loading-guide comb for electrophoresis gels. The comb includes a comb body, to which well-forming teeth and a loading guide are attached in an opposing fashion. The comb can be used with the teeth pointing downward into the gel to form sample wells in either vertical or horizontal electrophoresis gels. Upon hardening of the gel, the comb is once removed from the gels, leaving sample wells therein. The comb is then rotated 180 degrees, and notches (in the case of vertical electrophoresis gels) or L-shaped extensions (in the case of horizontal electrophoresis gels) of the loading guide are aligned with the sample wells so as to provide for easy guided access of a sample delivering instrument during the loading of samples into the wells.
摘要翻译：电泳凝胶的成型和加载导向梳。梳子包括梳体，成形齿和装载导向器以相对的方式附接到该梳体上。梳子可以与牙齿向下指向凝胶一起使用，以在垂直或水平电泳凝胶中形成样品孔。凝胶固化后，将梳子从凝胶中取出，留下样品孔。然后将梳子旋转180度，加载引导件的凹槽（在垂直电泳凝胶的情况下）或L形延伸部（在水平电泳凝胶的情况下）与样品阱对准，以提供容易的导向在将样品装载到井中时，样品传送仪器的通路。

10. 发明授权

US5389785A ION filter apparatus and method of production thereof 失效
标题翻译： ION过滤装置及其制造方法
公开(公告)号：US5389785A
公开(公告)日：1995-02-14
申请号：US54523
申请日：1993-04-28
申请人： Urs Steiner , Nigel P. Gore , Helmut Rother
发明人： Urs Steiner , Nigel P. Gore , Helmut Rother
IPC分类号： G01N27/62 , H01J9/14 , H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/068 , H01J49/4255
摘要： The invention relates to an ion filter and a method for the production of the ion filter. The ion filter comprises a plurality of elongated solid, rod assemblies. Typically, four rod assemblies, corresponding to four rod electrodes, are utilized. Each rod assembly has a curved rod surface, and at least two abutment surfaces. In one embodiment, the rod is hyperbolic in curvature. These surfaces are formed with one profiled grinding tool simultaneously in such a manner and angle of contact from a processing direction such that no undercuts are formed from this processing direction. The abutment surfaces are shaped such that one abutment surface of one rod assembly can be aligned with another abutment surface of another rod assembly when the rod surfaces are directed toward a longitudinal axis located in the interior of the ion filter. The rod assemblies are electrically insulated from each other with an insulating piece adhesively bonded to each rod assembly.
摘要翻译：本发明涉及离子过滤器和用于生产离子过滤器的方法。离子过滤器包括多个细长的固体棒组件。通常，使用对应于四个杆电极的四个杆组件。每个杆组件具有弯曲的杆表面和至少两个邻接表面。在一个实施例中，杆是弯曲的双曲线。这些表面由一个成型研磨工具同时以这样的方式和从加工方向接触的角度形成，使得从该加工方向不会形成底切。邻接表面被成形为使得当杆表面指向位于离子过滤器内部的纵向轴线时，一个杆组件的一个邻接表面可以与另一个杆组件的另一个邻接表面对准。杆组件彼此电绝缘，绝缘片粘合到每个杆组件上。

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