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11. 发明授权

US07101646B2 Developing method and apparatus 失效
标题翻译：开发方法和装置
公开(公告)号：US07101646B2
公开(公告)日：2006-09-05
申请号：US11229534
申请日：2005-09-20
申请人： Kiyohisa Tateyama , Masafumi Nomura , Taketora Shinogi
发明人： Kiyohisa Tateyama , Masafumi Nomura , Taketora Shinogi
IPC分类号： G03F7/30
CPC分类号： G03D3/065 , G03D3/06 , G03F7/30 , G03F7/3071 , H01L21/6715 , H01L21/67253
摘要： In this developing method and apparatus, a concentration measuring unit 222 picks part of developing fluid in a blending tank 186 to measure the resist concentration by an absorption photometry and feeds the detected resist concentration to a control unit 240. The control unit 240 controls respective valves 210, 212, 216 of a TMAH concentrate solution 200, a solvent pipe 204 and a drain pipe 208 in a manner that the developing fluid in the blending tank 186 has a TMAH concentration corresponding to a measured resist-concentration value to accomplish a constant developing rate, performing component control of the developing fluid. The developing fluid transferred from the blending tank 186 to a supply tank 188 is fed to a developer nozzle DN in a developing section 126 through a developer pipe 224 owing to the drive of a pump 228. Accordingly, even if the developing fluid is reused in the developing process in multiple times, it is possible to make sure of the uniformity in development.
摘要翻译：在该显影方法和装置中，浓度测量单元222拾取混合罐186中的显影液的一部分，通过吸收测光法测量抗蚀剂浓度，并将检测到的抗蚀剂浓度供给到控制单元240。控制单元240以这样的方式控制TMAH浓缩液200，溶剂管204和排水管208的各个阀210,212,216，使得混合罐186中的显影流体具有对应于测量的抗蚀剂层的TMAH浓度，浓度值以实现恒定的显影速率，进行显影液的成分控制。通过泵228的驱动，从混合罐186向供给罐188输送的显影液通过显影剂管道224被供给到显影部分126中的显影剂喷嘴DN。因此，即使显影液在显影过程中重复使用多次，也可以确保显影的均匀性。

12. 发明申请

US20060105428A1 Alkaline protease 有权
标题翻译：碱性蛋白酶
公开(公告)号：US20060105428A1
公开(公告)日：2006-05-18
申请号：US11318576
申请日：2005-12-28
申请人： Tsuyoshi Sato , Mitsuyoshi Okuda , Yasushi Takimura , Nobuyuki Sumitomo , Masafumi Nomura , Tohru Kobayashi
发明人： Tsuyoshi Sato , Mitsuyoshi Okuda , Yasushi Takimura , Nobuyuki Sumitomo , Masafumi Nomura , Tohru Kobayashi
IPC分类号： C12P21/06 , C12N9/64 , C07H21/04 , C12N15/74 , C12N1/21
CPC分类号： C07H21/04 , C12N9/54
摘要： The present invention relates to genes expressing an alkaline protease having a prepro sequence, vectors containing the same, and transformants containing said vector. The present invention also relates to a method for producing an alkaline protease.
摘要翻译：本发明涉及表达具有前原序列的碱性蛋白酶，含有其的载体和含有该载体的转化体的基因。本发明还涉及碱性蛋白酶的制造方法。

13. 发明授权

US06759228B2 Alkaline protease 有权
标题翻译：碱性蛋白酶
公开(公告)号：US06759228B2
公开(公告)日：2004-07-06
申请号：US09920954
申请日：2001-08-03
申请人： Mikio Takaiwa , Mitsuyoshi Okuda , Katsuhisa Saeki , Hiromi Kubota , Jun Hitomi , Yasushi Kageyama , Shitsuw Shikata , Masafumi Nomura
发明人： Mikio Takaiwa , Mitsuyoshi Okuda , Katsuhisa Saeki , Hiromi Kubota , Jun Hitomi , Yasushi Kageyama , Shitsuw Shikata , Masafumi Nomura
IPC分类号： C12N952
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C11D3/38618
摘要： An alkaline protease having the following properties; a gene encoding the same; a microorganism producing the same; and washing compositions containing the same; (i) acting over a broad pH value range of 4 to 13 and achieving, at pH 6 to 12, 80% or more the activity at the optimum pH value; (ii) when treated at 40° C. for 30 minutes, being stable over a pH value range of 6 to 11; (iii) having an isoelectric point of about 8.9 to 9.1; and (iv) having casein digesting activity that is not inhibited by oleic acid. The alkaline protease of the present invention is highly stable to various surface active agents and fatty acids, and exhibits high stability to oxidizing agents, and is therefore useful as an enzyme to be used in detergents for automatic dishwashers and laundry detergents, both containing bleaching components.
摘要翻译：具有以下特性的碱性蛋白酶; 编码该基因的基因; 生产该微生物的微生物; 和含有该组合物的洗涤组合物; （i）在4至13的广泛pH值范围内起作用，并且在最佳pH值下达到pH6至12,80％或更高的活性; （ii）当在40℃下处理30分钟时，在6至11的pH值范围内是稳定的; （iii）具有约8.9至9.1的等电点; 和（iv）具有不被油酸抑制的酪蛋白消化活性。本发明的碱性蛋白酶对各种表面活性剂和脂肪酸高度稳定，对氧化剂表现出高稳定性，因此可用作自动洗碗机和洗衣洗涤剂的洗涤剂中的酶，两者均含有漂白组分。

14. 发明授权

US06730702B1 Therapeutic agents for inflammatory diseases of intestine 有权
标题翻译：肠道炎症性疾病的治疗剂
公开(公告)号：US06730702B1
公开(公告)日：2004-05-04
申请号：US10129361
申请日：2002-05-03
申请人： Toru Kono , Masafumi Nomura
发明人： Toru Kono , Masafumi Nomura
IPC分类号： A61K3119
CPC分类号： A61K31/192
摘要： The present invention provides a novel agent for prophylaxis or treatment of inflammatory bowel diseases for oral administration or intra-intestinal infusion, which comprises as an active ingredient a compound of the formula (I): or a pharmaceutically acceptable salt thereof; a use of said active ingredient in preparation of an agent for prophylaxis or treatment of inflammatory bowel diseases; and a method for prophylaxis or treatment of inflammatory bowel diseases.
摘要翻译：本发明提供了用于预防或治疗口服或肠内输注的炎性肠病的新型药剂，其包含作为活性成分的式（I）化合物或其药学上可接受的盐; 所述活性成分在制备用于预防或治疗炎症性肠病的药剂中的用途; 以及预防或治疗炎症性肠病的方法。

15. 发明授权

US06372704B2 Detergent composition 有权
标题翻译：洗涤剂组成
公开(公告)号：US06372704B2
公开(公告)日：2002-04-16
申请号：US09734006
申请日：2000-12-12
申请人： Shitsuw Shikata , Masafumi Nomura , Toshihiro Oki , Hitoshi Tanimoto , Tsutomu Tokumoto , Nobuyuki Ogura
发明人： Shitsuw Shikata , Masafumi Nomura , Toshihiro Oki , Hitoshi Tanimoto , Tsutomu Tokumoto , Nobuyuki Ogura
IPC分类号： C11D300
CPC分类号： C11D3/0084 , C11D3/046 , C11D3/386
摘要： The present invention provides a detergent composition which is excellent in enzyme stability and exhibits excellent detergency particularly to protein-related dirt of socks and other items even under laundering conditions at a lower temperature. That is, the present invention provides a detergent composition comprising specific proportions of (a) an anionic surfactant, (b) a chlorine scavenger, (c) a protease whose &agr;-keratin-hydrolyzing activity at 10° C. is not less than 0.09×10−3 &mgr;g/mPU·min and (d) a protease whose &agr;-keratin-hydrolyzing activity at 10° C. is less than 0.09×10−3 &mgr;g/mPU·min.
摘要翻译：本发明提供了一种洗涤剂组合物，即使在较低温度下的洗涤条件下，酶稳定性优异，特别是与蛋白质相关的袜子和其它物品的污垢也具有优异的洗涤性。也就是说，本发明提供了包含特定比例的（a）阴离子表面活性剂，（b）氯清除剂，（c）在10℃下的α-角蛋白水解活性不小于0.09的蛋白酶的洗涤剂组合物 x10-3mug / mPU.min，（d）10℃下α-角蛋白水解活性低于0.09×10-3mug / mPU.min的蛋白酶。

16. 发明授权

US06306455B1 Substrate processing method 失效
标题翻译：基板加工方法
公开(公告)号：US06306455B1
公开(公告)日：2001-10-23
申请号：US09141721
申请日：1998-08-27
申请人： Hideyuki Takamori , Masafumi Nomura , Tsutae Omori
发明人： Hideyuki Takamori , Masafumi Nomura , Tsutae Omori
IPC分类号： B05D312
CPC分类号： H01L21/67248 , B05C11/08 , B05D1/005 , H01L21/6838
摘要： A method of processing a substrate for forming a coating film on a substrate comprising the steps of (a) mounting a substrate on a temperature controlling means which is capable of having a heat influence on the substrate, and controlling temperature of the substrate by the temperature controlling means, (b) controlling temperature of a coating solution to be supplied to the substrate, (c) controlling temperature of a contact member in contact with the substrate when the substrate is transported and held, (d) detecting temperature of an atmosphere of a process space for applying the coating solution to the substrate, (e) setting a desired temperature on the basis of temperature/film-thickness data previously obtained by forming the coating film on the substrate, (f) controlling a temperature controlling operation of at least step (c) on the basis of the desired temperature set in the step (e) and the temperature detected in the step (d), and (g) applying the coating solution to the substrate.
摘要翻译：一种处理在基板上形成涂膜的基板的方法，包括以下步骤：（a）将基板安装在能够对基板产生热影响的温度控制装置上，并将基板的温度控制在温度控制装置，（b）控制供给到基板的涂布液的温度，（c）控制基板被输送和保持时与基板接触的接触部件的温度，（d）检测温度，用于将涂布溶液涂布到基板上的处理空间，（e）基于通过在基板上形成涂膜而获得的温度/膜厚度数据设定所需温度，（f）控制在基板上的温度控制操作基于步骤（e）中设定的所需温度和步骤（d）中检测到的温度，最小步骤（c），和（g）将涂布溶液施加到副策划

17. 发明授权

US08454995B2 Peroral tablet for bowel cleansing 失效
标题翻译：口服片剂肠道清洁
公开(公告)号：US08454995B2
公开(公告)日：2013-06-04
申请号：US13392605
申请日：2010-08-27
申请人： Masafumi Nomura , Tetsuyuki Nishiyama , Mari Ichikawa , Kyoko Fukaya
发明人： Masafumi Nomura , Tetsuyuki Nishiyama , Mari Ichikawa , Kyoko Fukaya
IPC分类号： A61K9/20
CPC分类号： A61K33/42 , A61K9/2054 , A61K31/717 , A61K45/06 , A61K2300/00
摘要： To provide a peroral tablet for bowel cleansing which leaves no remains in the intestinal tract after bowel cleansing, which exhibits a dissolution property equivalent to that of conventional sodium phosphate-containing tablets including crystalline cellulose, and which is a small-size agent readily taken by a subject.The peroral tablet for bowel cleansing containing the following ingredients (A) and (B): (A) 80 to 95 mass % of sodium phosphate, and (B) (B1) 7 to 11 mass % of hydroxypropyl cellulose which has such a particle size that ≧99% of the particles thereof pass through a mesh having an opening of 350 μm and whose 2-mass % aqueous solution has a viscosity of 2.0 to 10.0 mPa.s, (B2) 5 to 13 mass % of hydroxypropyl cellulose which has such a particle size that ≧99% of the particles thereof pass through a mesh having an opening of 150 μm and whose 2-mass % aqueous solution has a viscosity of 3.0 to 5.9 mPa.s, or (B3) 7 to 11 mass % of hydroxypropyl cellulose which has such a particle size that ≧99% of the particles thereof pass through a mesh having an opening of 150 μm and whose 2-mass % aqueous solution has a viscosity of 6.0 to 4,000 mPa.s, and having a water-insoluble ingredient content of 5 mass % or less.
摘要翻译：为了提供肠道清洁的口服片剂，其肠清洗后没有残留在肠道中，其表现出与包含结晶纤维素的常规含磷酸钠片剂相当的溶解性能，并且其是容易被课程。含有以下成分（A）和（B）的肠溶清洁口服片剂：（A）80〜95质量％的磷酸钠，（B）（B1）7〜11质量％的具有这样的粒子的羟丙基纤维素大于99％的颗粒通过开口为350μm的网，其2质量％的水溶液的粘度为2.0〜10.0mPa·s，（B2）为5〜13质量％的羟丙基纤维素其粒径> 99％的颗粒通过开口为150μm的网，其2质量％的水溶液的粘度为3.0〜5.9mPa.s，或（B3）7〜其粒径为99％以上的羟丙基纤维素的质量为11质量％，通过开口为150μm的网，其2质量％的水溶液的粘度为6.0〜4000mPa.s，并且具有5质量％以下的水不溶成分含量。

18. 发明授权

US07368273B2 Alkaline protease 有权
标题翻译：碱性蛋白酶
公开(公告)号：US07368273B2
公开(公告)日：2008-05-06
申请号：US10385662
申请日：2003-03-12
申请人： Mitsuyoshi Okuda , Tsuyoshi Sato , Kazuhiro Saito , Nobuyuki Sumitomo , Yoshifumi Izawa , Katsuhisa Saeki , Tohru Kobayashi , Masafumi Nomura
发明人： Mitsuyoshi Okuda , Tsuyoshi Sato , Kazuhiro Saito , Nobuyuki Sumitomo , Yoshifumi Izawa , Katsuhisa Saeki , Tohru Kobayashi , Masafumi Nomura
IPC分类号： C12N9/48 , C11D3/386
CPC分类号： C11D3/386 , C12N9/54 , C12Y304/21062
摘要： An alkaline protease wherein an amino acid residue at (a) position 65, (b) position 101, (c) position 163, (d) position 17-0, (e) position 171, (f) position 273, (g) position 320, (h) position 359 or (i) position 387 of SEQ. ID NO: 2 or at a position corresponding thereto has been selected from the following amino acid residues: position (a): proline, position (b): asparagine, position (e): histidine, aspartic acid, phenylalanine, lysine, asparagine, seine, isoleucine, leucine, glutamine, threonine and valine, position (d): valine and leucine, position (e): alanine, glutamic acid, glycine and threonine, position (K): isoleucine, glycine and threonine, position (g): phenylalanine, valine, threonine, leucine, isoleucine and glycine, position (h): seine, leucine, valine, isoleucine and glutamine, position (i): alanine, lysine, glutamine, glutamic acid, arginine and histidine. A method to an alkaline protease having activity even in the presence of a highly concentrated fatty acid, and exhibiting excellent detergency for the removal of a complex stain containing protein, sebum and the like, and therefore useful as an ingredient in a detergent.
摘要翻译：（a）位置65，（b）位置101，（c）位置163，（d）位置17-0，（e）位置171，（f）位置273，（g）位置320，（h）位置359或（i）SEQ ID NO：位置（a）：脯氨酸，位置（b）：天冬酰胺，位置（e）：组氨酸，天冬氨酸，苯丙氨酸，赖氨酸，天冬酰胺，（e）：丙氨酸，谷氨酸，甘氨酸和苏氨酸，位置（K）：异亮氨酸，甘氨酸和苏氨酸，位置（g）：缬氨酸和亮氨酸，（i）：丙氨酸，赖氨酸，谷氨酰胺，谷氨酸，精氨酸和组氨酸，位置（h）：ine碱，亮氨酸，缬氨酸，异亮氨酸和谷氨酰胺。一种碱性蛋白酶的方法，即使在高度浓缩的脂肪酸的存在下也具有活性，并且对于去除含有蛋白质，皮脂等的复合污渍具有优异的去污力，因此可用作洗涤剂中的成分。

19. 发明授权

US07182531B2 Developing method and apparatus 失效
标题翻译：开发方法和装置
公开(公告)号：US07182531B2
公开(公告)日：2007-02-27
申请号：US11476574
申请日：2006-06-29
申请人： Kiyohisa Tateyama , Masafumi Nomura , Taketora Shinogi
发明人： Kiyohisa Tateyama , Masafumi Nomura , Taketora Shinogi
IPC分类号： G03D5/00
CPC分类号： G03D3/065 , G03D3/06 , G03F7/30 , G03F7/3071 , H01L21/6715 , H01L21/67253
摘要： In this developing method and apparatus, a concentration measuring unit 222 picks part of developing fluid in a blending tank 186 to measure the resist concentration by an absorption photometry and feeds the detected resist concentration to a control unit 240. The control unit 240 controls respective valves 210, 212, 216 of a TMAH concentrate solution 200, a solvent pipe 204 and a drain pipe 208 in a manner that the developing fluid in the blending tank 186 has a TMAH concentration corresponding to a measured resist-concentration value to accomplish a constant developing rate, performing component control of the developing fluid. The developing fluid transferred from the blending tank 186 to a supply tank 188 is fed to a developer nozzle DN in a developing section 126 through a developer pipe 224 owing to the drive of a pump 228. Accordingly, even if the developing fluid is reused in the developing process in multiple times, it is possible to make sure of the uniformity in development.
摘要翻译：在该显影方法和装置中，浓度测量单元222拾取混合罐186中的显影液的一部分，通过吸收测光法测量抗蚀剂浓度，并将检测到的抗蚀剂浓度输送到控制单元240.控制单元240控制各个阀 210,212,216的TMAH浓缩液200，溶剂管204和排水管208，使得混合罐186中的显影液具有对应于测量的抗蚀剂浓度值的TMAH浓度，以实现恒定显影速率，执行显影液的成分控制。从混合罐186输送到供给罐188的显影液由于泵228的驱动而通过显影管224被供给到显影部126中的显影剂喷嘴DN。因此，即使显影液再利用发展过程多次，有可能确保发展的一致性。

20. 发明申请

US20060246384A1 Developing method and apparatus 失效
标题翻译：开发方法和装置
公开(公告)号：US20060246384A1
公开(公告)日：2006-11-02
申请号：US11476574
申请日：2006-06-29
申请人： Kiyohisa Tateyama , Masafumi Nomura , Taketora Shinogi
发明人： Kiyohisa Tateyama , Masafumi Nomura , Taketora Shinogi
IPC分类号： G03C1/005
CPC分类号： G03D3/065 , G03D3/06 , G03F7/30 , G03F7/3071 , H01L21/6715 , H01L21/67253
摘要： In this developing method and apparatus, a concentration measuring unit 222 picks part of developing fluid in a blending tank 186 to measure the resist concentration by an absorption photometry and feeds the detected resist concentration to a control unit 240. The control unit 240 controls respective valves 210, 212, 216 of a TMAH concentrate solution 200, a solvent pipe 204 and a drain pipe 208 in a manner that the developing fluid in the blending tank 186 has a TMAH concentration corresponding to a measured resist-concentration value to accomplish a constant developing rate, performing component control of the developing fluid. The developing fluid transferred from the blending tank 186 to a supply tank 188 is fed to a developer nozzle DN in a developing section 126 through a developer pipe 224 owing to the drive of a pump 228. Accordingly, even if the developing fluid is reused in the developing process in multiple times, it is possible to make sure of the uniformity in development.
摘要翻译：在该显影方法和装置中，浓度测量单元222拾取混合罐186中的显影液的一部分，通过吸收测光法测量抗蚀剂浓度，并将检测到的抗蚀剂浓度输送到控制单元240.控制单元240控制各个阀 210,212,216的TMAH浓缩液200，溶剂管204和排水管208，使得混合罐186中的显影液具有对应于测量的抗蚀剂浓度值的TMAH浓度，以实现恒定显影速率，执行显影液的成分控制。从混合罐186输送到供给罐188的显影液由于泵228的驱动而通过显影管224被供给到显影部126中的显影剂喷嘴DN。因此，即使显影液再利用发展过程多次，有可能确保发展的一致性。

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