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11. 发明授权

US06643544B1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US06643544B1
公开(公告)日：2003-11-04
申请号：US09958602
申请日：2001-10-12
申请人： Hirotoshi Adachi , Kazuya Katagai , Naruhito Higo
发明人： Hirotoshi Adachi , Kazuya Katagai , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： The present invention provides an iontophoresis device and an energization method whereby a prostaglandin can be effectively and continuously administered via a skin or mucosa. The iontophoresis device comprises the first electrode structure (31); the second electrode structure (32); and a power supply (33) electrically connected between the first and the second electrode structures (31), (32). At least one of the first and the second electrode structures contains a prostaglandin and also stabilizing means for inhibiting hydrolysis of the prostaglandin during storage. The power supply (33) is equipped with constant current supplying means and, when both electrode structures contain a prostaglandin, also polarity inverting means. Output current from the power supply may allow the prostaglandin to be delivered to a skin or mucosa.
摘要翻译：本发明提供了一种离子电渗疗法装置和通电方法，其中前列腺素可通过皮肤或粘膜有效且连续地施用。离子电渗装置包括第一电极结构（31）; 第二电极结构（32）; 和电连接在第一和第二电极结构（31），（32）之间的电源（33）。第一和第二电极结构中的至少一个包含前列腺素以及用于在储存期间抑制前列腺素水解的稳定手段。电源（33）配备有恒流供给装置，并且当两个电极结构都包含前列腺素时，还具有极性反转装置。来自电源的输出电流可允许将前列腺素输送至皮肤或粘膜。

12. 发明申请

US20120095386A9 COMPOSITION AND DEVICE STRUCTURE FOR IONTOPHORESIS 失效
标题翻译：组合物和器件结构用于IOPOPHORESIS
公开(公告)号：US20120095386A9
公开(公告)日：2012-04-19
申请号：US12895934
申请日：2010-10-01
申请人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
发明人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
IPC分类号： A61N1/30 , A61P9/06 , A61K31/495 , A61P25/04 , A61K31/4468 , A61K31/167
CPC分类号： A61N1/0448 , A61K9/0009 , A61K9/0014 , A61K47/32 , A61N1/0444
摘要： Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
摘要翻译：用于离子电渗的装置结构100提供电极101和导电层102.导电层102含有活性成分D和碱性水溶胀甲基丙烯酸酯共聚物P1和/或酸性水溶胀甲基丙烯酸酯共聚物P2。将电极101和导电层102放置在背衬103的中空部分中，并且电极端子104通过背衬103连接到电极101.粘合层105设置在背衬103周围，并且在使用该装置时将衬垫106放置以覆盖背衬103的中空部分。

13. 发明申请

US20090130127A1 Adjuvant or Pharmaceutical Preparation for Transdermal or Transmucousal Administration 审中-公开
标题翻译：辅助剂或透皮或透粘膜给药的药物制剂
公开(公告)号：US20090130127A1
公开(公告)日：2009-05-21
申请号：US11997413
申请日：2006-07-31
申请人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
IPC分类号： A61K39/39 , A61K31/201 , A61K31/341 , A61K31/045 , A61K31/23
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034 , Y02A50/401
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译：一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状 R 1和R 2独立地表示碳原子数1〜16的烷基侧链。

14. 发明授权

US08155738B2 Composition and device structure for iontophoresis 失效
标题翻译：离子电渗法的组成和器件结构
公开(公告)号：US08155738B2
公开(公告)日：2012-04-10
申请号：US12895934
申请日：2010-10-01
申请人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
发明人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
IPC分类号： A61N1/30 , A61K9/70 , A61K9/22 , A61F13/00 , A61M35/00
CPC分类号： A61N1/0448 , A61K9/0009 , A61K9/0014 , A61K47/32 , A61N1/0444
摘要： Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
摘要翻译：用于离子电渗的装置结构100提供电极101和导电层102.导电层102含有活性成分D和碱性水溶胀甲基丙烯酸酯共聚物P1和/或酸性水溶胀甲基丙烯酸酯共聚物P2。将电极101和导电层102放置在背衬103的中空部分中，并且电极端子104通过背衬103连接到电极101.粘合层105设置在背衬103周围，并且在使用该装置时将衬垫106放置以覆盖背衬103的中空部分。

15. 发明授权

US07914813B2 Interface for transdermal drug administration device 有权
标题翻译：透皮给药装置的界面
公开(公告)号：US07914813B2
公开(公告)日：2011-03-29
申请号：US10588168
申请日：2005-02-02
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61F13/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.
摘要翻译：旨在提供一种透皮给药装置的界面，其能够从多个突起通过皮肤几乎均匀且有利地供应药物。用于透皮给药装置的该界面具有平板8.平板8包括能够刺穿皮肤的多个二维布置的锥形或棱锥形突起6和能够递送分别布置的药物的多个开口7 与预测对应。开口7分别设置在其对应的突起6附近。平板8可以由金属或陶瓷制成。开口数与突出数之比可以为1：1〜1：2。

16. 发明申请

US20090285877A1 Percutaneous absorption preparation containing palonosetron 审中-公开
标题翻译：含帕洛诺司琼的经皮吸收制剂
公开(公告)号：US20090285877A1
公开(公告)日：2009-11-19
申请号：US12453566
申请日：2009-05-14
申请人： Takashi Yasukochi , Yukihisa Naka , Tsuyoshi Endo , Hirotoshi Adachi
发明人： Takashi Yasukochi , Yukihisa Naka , Tsuyoshi Endo , Hirotoshi Adachi
IPC分类号： A61K9/70 , A61K31/473
CPC分类号： A61K31/473 , A61K9/7053 , A61K9/7061 , A61K9/7076
摘要： There is provided a percutaneous absorption preparation that has a simple laminated structure and a long shelf life, while maintaining excellent percutaneous absorption for palonosetron. The percutaneous absorption preparation comprises a support and a drug-containing pressure-sensitive adhesive layer formed on at least one side of the support, wherein the drug-containing pressure-sensitive adhesive layer comprises, as essential constituent components, an adhesive base, palonosetron or a pharmaceutically acceptable acid addition salt thereof, and at least one type of fatty alcohol selected from the group consisting of C6-12 straight-chain saturated alcohols, C10-22 straight-chain unsaturated alcohols, C10-22 branched alcohols and C10-15 cyclic alcohols, and the constituent components other than palonosetron or its pharmaceutically acceptable acid addition salt are carboxyl group-free components.
摘要翻译：提供了具有简单的层压结构和长的保存期限的经皮吸收制剂，同时保持帕洛诺司琼的优异的经皮吸收。经皮吸收制剂包括在载体的至少一侧上形成的载体和含药物的压敏粘合剂层，其中药物压敏粘合剂层包含作为必要组分的组分的粘合剂基质，帕洛诺司琼或其药学上可接受的酸加成盐和至少一种选自C 6-12直链饱和醇，C10-22直链不饱和醇，C10-22支链醇和C10-15环状脂肪醇的脂肪醇醇，除了帕洛诺司琼或其药学上可接受的酸加成盐以外的组成成分是无羧基组分。

17. 发明申请

US20050177092A1 Apparatus and assembly for administering antimicrobial agent 审中-公开
标题翻译：用于施用抗微生物剂的装置和组装
公开(公告)号：US20050177092A1
公开(公告)日：2005-08-11
申请号：US10512442
申请日：2002-04-25
申请人： Hirotoshi Adachi , Naruhito Higo , Shuji Sato , Aarti Naik , Yogeshvar Kalia , Richard Guy
发明人： Hirotoshi Adachi , Naruhito Higo , Shuji Sato , Aarti Naik , Yogeshvar Kalia , Richard Guy
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A device and assembly for administering antimicrobial for killing resident microorganisms on human skin and thereby effectively preventing infections caused by the microorganisms, are provided. The device for administering antimicrobial of the invention uses iontophoresis, and it comprises: a donor electrode (100) containing an antimicrobial; a reference electrode (110) provided as a counter electrode of the donor electrode; and a power unit (120) for applying current between the donor electrode and the reference electrode in such a manner as to allow the total amount of current applied to be 1 to 30 mA·min/cm2. The area on the skin to which the donor electrode (100) is applied is suitably 1 to 100 cm2. Thus, the catheter or injection needle insertion site on human skin is disinfected.
摘要翻译：提供了一种用于施用抗微生物剂以杀死人皮肤上的驻留微生物并因此有效防止由微生物引起的感染的装置和组件。用于施用本发明的抗微生物剂的装置使用离子电渗疗法，并且其包括：含有抗微生物剂的供体电极（100）设置为供体电极的对电极的参考电极（110）; 以及用于以允许施加的电流总量为1至30mA.min / cm 2的方式在施主电极和参考电极之间施加电流的功率单元（120）。施加施主电极（100）的皮肤上的面积适当地为1〜100cm 2。因此，人体皮肤上的导管或注射针插入部位被消毒。

18. 发明授权

US5908400A Device structure for iontophoresis 失效
标题翻译：离子电渗法的装置结构
公开(公告)号：US5908400A
公开(公告)日：1999-06-01
申请号：US878852
申请日：1997-06-20
申请人： Naruhito Higo , Hirotoshi Adachi , Tatsuya Meno
发明人： Naruhito Higo , Hirotoshi Adachi , Tatsuya Meno
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/325 , A61N1/0448
摘要： An iontophoretic device structure of the dissolution-on-use type is provided, wherein an ionized drug is transdermally or transmucosally administered into a living body. The device structure comprises (a) a non-polarizable electrode, (b) a hydrophilic, polymeric gel layer containing an ion exchange resin which is able to specifically inhibit the movement of ions dissolved out from the electrode while in use, and (c) a drug layer containing a drug in a dry condition in a drug retaining membrane, wherein when said device is in use, said drug layer is brought into contact with said hydrophilic, polymeric gel layer so that said drug in the dry condition is dissolved. A humectant may be contained in the hydrophilic, polymeric gel layer and/or the drug layer.
摘要翻译：提供了使用溶解型的离子电渗疗法器件结构，其中电离药物经皮或经粘膜施用于生物体。该装置结构包括（a）不可极化电极，（b）含有离子交换树脂的亲水性聚合物凝胶层，其能够在使用时特异性地抑制从电极溶出的离子的移动，以及（c）在药物保持膜中含有处于干燥状态的药物的药物层，其中当使用所述装置时，使所述药物层与所述亲水性聚合物凝胶层接触，使得干燥条件下的所述药物溶解。保湿剂可以包含在亲水性聚合物凝胶层和/或药物层中。

19. 发明授权

US08858962B2 Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration 有权
标题翻译：用于透皮或经粘膜给药的佐剂或药物制剂
公开(公告)号：US08858962B2
公开(公告)日：2014-10-14
申请号：US13367679
申请日：2012-02-07
申请人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
IPC分类号： A61K9/00 , A61K39/39 , A61K47/26 , A61K39/00 , A61K47/34 , A61K47/10 , A61K47/12
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034 , Y02A50/401
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译：一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状 R 1和R 2独立地表示碳原子数1〜16的烷基侧链。

20. 发明授权

US07937141B1 Device for iontophoresis 有权
标题翻译：离子电渗疗法装置
公开(公告)号：US07937141B1
公开(公告)日：2011-05-03
申请号：US09958113
申请日：2000-04-06
申请人： Kazutaka Inoue , Hirotoshi Adachi
发明人： Kazutaka Inoue , Hirotoshi Adachi
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A device for iontophoresis that reduces irritation at the beginning of energization and efficiently supplies an amount of current required for drug administration in a predetermined length of time, is provided. With the device for iontophoresis, the oscillation frequency and duty cycle of a transistor 15 are adjusted at the beginning of energization, thereby controlling a back electromotive force developed across a coil 13 to gradually increase the output voltage. The microcomputer 12 controls the transistor 15 so as to receive signals from an output voltage detecting circuit that is formed of resistors 23 and 24 and an output current detecting circuit that is formed of resistors 25 and 26 and a capacitor 27, preventing an increasing of the output voltage when the detected output current reaches a limiting value, and preventing an increasing of the output current when the detected output voltage reaches a limiting value.
摘要翻译：提供一种用于离子电渗疗法的装置，其在通电开始时减少刺激，并且在预定时间长度内有效地提供药物施用所需的电流量。利用离子电渗法的装置，在通电开始时调整晶体管15的振荡频率和占空比，由此控制在线圈13上产生的反电动势，逐渐增加输出电压。微型计算机12控制晶体管15以接收来自由电阻器23和24形成的输出电压检测电路的信号和由电阻器25和26以及电容器27形成的输出电流检测电路，从而防止当检测到的输出电流达到极限值时，输出电压，并且当检测到的输出电压达到极限值时防止输出电流的增加。

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