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1. 发明申请

US20120156258A1 Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration 有权
标题翻译：用于透皮或经粘膜给药的佐剂或药物制剂
公开(公告)号：US20120156258A1
公开(公告)日：2012-06-21
申请号：US13367679
申请日：2012-02-07
申请人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
IPC分类号： A61K9/00 , A61M37/00 , A61N1/30 , A61K39/39 , A61P37/04
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034 , Y02A50/401
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译：一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状，R 1和R 2独立地表示碳原子数1〜16的烷基侧链。

2. 发明申请

US20090130127A1 Adjuvant or Pharmaceutical Preparation for Transdermal or Transmucousal Administration 审中-公开
标题翻译：辅助剂或透皮或透粘膜给药的药物制剂
公开(公告)号：US20090130127A1
公开(公告)日：2009-05-21
申请号：US11997413
申请日：2006-07-31
申请人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
IPC分类号： A61K39/39 , A61K31/201 , A61K31/341 , A61K31/045 , A61K31/23
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034 , Y02A50/401
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译：一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状 R 1和R 2独立地表示碳原子数1〜16的烷基侧链。

3. 发明授权

US08858962B2 Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration 有权
标题翻译：用于透皮或经粘膜给药的佐剂或药物制剂
公开(公告)号：US08858962B2
公开(公告)日：2014-10-14
申请号：US13367679
申请日：2012-02-07
申请人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
IPC分类号： A61K9/00 , A61K39/39 , A61K47/26 , A61K39/00 , A61K47/34 , A61K47/10 , A61K47/12
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034 , Y02A50/401
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译：一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状 R 1和R 2独立地表示碳原子数1〜16的烷基侧链。

4. 发明申请

US20100030100A1 Microneedle Device For Diagnosis Of Allergy 审中-公开
标题翻译：用于诊断过敏的微针装置
公开(公告)号：US20100030100A1
公开(公告)日：2010-02-04
申请号：US12525818
申请日：2008-02-05
申请人： Seiji Tokumoto , Toshiyuki Matsudo , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Toshiyuki Matsudo , Tetsuji Kuwahara
IPC分类号： A61B5/00
CPC分类号： A61B10/0035 , A61M37/0015 , A61M2037/0046
摘要： There is provided an inexpensive microneedle device for diagnosis of an allergy, enabling one to perform a clear skin test with simple operation for a short period of time in the diagnosis of allergies. The microneedle device (1) comprises: a microneedle substrate (2), microneedles (3) formed on the substrate at a density of 100 to 10000 needles per 1 cm2, being capable of piercing the skin 50 μm to 500 μm deep, and allergen-holding means (4) formed on the microneedles, holding at least one allergen. The microneedles (3) can be prepared by the use of a non-metallic synthetic or natural resin material.
摘要翻译：提供了用于诊断过敏的便宜的微针装置，使得能够在过敏症的诊断中在短时间内进行简单的操作进行清晰的皮肤试验。微针装置（1）包括：微针基底（2），以100至10000针/ cm 2的密度形成在基底上的微针（3），能够将皮肤刺穿50毫米至500毫米深，变应原 - 保持装置（4），形成在微针上，保持至少一种变应原。微针（3）可以通过使用非金属合成或天然树脂材料制备。

5. 发明申请

US20090099502A1 Microneedle Device And Transdermal Administration Device Provided With Microneedles 审中-公开
标题翻译：微针装置和带有微针的透皮管理装置
公开(公告)号：US20090099502A1
公开(公告)日：2009-04-16
申请号：US12296002
申请日：2007-04-06
申请人： Seiji Tokumoto , Toshiyuki Matsudo , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Toshiyuki Matsudo , Tetsuji Kuwahara
IPC分类号： A61M5/32 , B05D3/00 , A61N1/30 , A61N7/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0023
摘要： The present invention provides a microneedle device having a coating, which is effective even with a low molecular weight active compound and can sustain the effect of the drug for a long period of time, and a transdermal drug administration apparatus with microneedles. The microneedle device (5) has, on a microneedle substrate (8), a plurality of microneedles (6) that can pierce the skin, wherein the surface of the microneedles (6) and/or the microneedle substrate (8) is partly or entirely coated in fixed state with a coating carrier containing polyvinyl alcohol. The polyvinyl alcohol preferably has a hydrolysis degree of 94.5 mol % or more. Furthermore, the coating carrier can contain a drug.
摘要翻译：本发明提供一种具有涂层的微针装置，其即使使用低分子量活性化合物也是有效的，并且可以长期维持药物的效果，并且具有微针的透皮药物给药装置。微针装置（5）在微针基板（8）上具有可刺穿皮肤的多个微针（6），其中微针（6）和/或微针基板（8）的表面部分或部分完全用固定状态涂覆含有聚乙烯醇的涂层载体。聚乙烯醇的水解度优选为94.5摩尔％以上。此外，涂布载体可以含有药物。

6. 发明申请

US20110112509A1 MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVICE 有权
标题翻译： MICRONEEDLE DEVICE，以及通过使用MICRONEEDLE装置来提高流感疫苗的效率的方法
公开(公告)号：US20110112509A1
公开(公告)日：2011-05-12
申请号：US13001995
申请日：2009-05-22
申请人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
发明人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
IPC分类号： A61M5/00
CPC分类号： A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
摘要翻译：本发明提供使用能够增强流感疫苗的免疫原性的微针装置增强免疫原性的方法。根据使用本发明的微针装置的增强免疫原性的方法，将具有由聚乳酸制成的微针的微针装置涂敷于A型菌株（H1N1），A型菌株（H3N2）和A型菌株作为活性成分的B菌株与皮肤直接接触，以便经皮施用上述流感疫苗。在经皮给药之后，将月桂醇施用于已经与微针装置直接接触的皮肤部位。

7. 外观设计

USD634017S1 Combined medical patch and package 有权
标题翻译：组合医疗补丁和包装
公开(公告)号：USD634017S1
公开(公告)日：2011-03-08
申请号：US29356307
申请日：2010-02-23
申请人： Seiji Tokumoto , Tetsuji Kuwahara , Toshiyuki Matsudo
设计人： Seiji Tokumoto , Tetsuji Kuwahara , Toshiyuki Matsudo

8. 发明申请

US20100221314A1 Microneedle Device 审中-公开
标题翻译：微针装置
公开(公告)号：US20100221314A1
公开(公告)日：2010-09-02
申请号：US12738123
申请日：2008-10-15
申请人： Toshiyuki Matsudo , Tetsuji Kuwahara , Seiji Tokumoto
发明人： Toshiyuki Matsudo , Tetsuji Kuwahara , Seiji Tokumoto
IPC分类号： A61K9/70 , A61K38/00 , A61K39/00 , A61P37/04
CPC分类号： A61K9/0021 , A61M37/0015
摘要： A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided.A microneedle device (1) includes a plurality of microneedles (3) on a microneedle substrate (2), which are capable of piercing the skin. A portion of or entire surface of the microneedles (3) and/or the microneedle substrate (2) has a coating including a coating carrier in a solid state. The coating carrier includes a high molecular weight pharmaceutical compound and polysaccharides compatible with the high molecular weight pharmaceutical compound. Herein, as the polysaccharide, for example, pullulan or hydroxypropylcellulose can be used.
摘要翻译：提供了一种具有基本上均匀地包含高分子量药物化合物的涂层的微针装置。微针装置（1）在微针基板（2）上包括能够刺穿皮肤的多个微针（3）。微针（3）和/或微针衬底（2）的一部分或整个表面具有包括固体状态的涂层载体的涂层。涂层载体包括高分子量药物化合物和与高分子量药物化合物相容的多糖。这里，作为多糖，可以使用例如支链淀粉或羟丙基纤维素。

9. 发明申请

US20090030365A1 Transdermal Drug Administration Apparatus Having Microneedles 有权
标题翻译：具有微针的透皮药物管理装置
公开(公告)号：US20090030365A1
公开(公告)日：2009-01-29
申请号：US12278483
申请日：2007-02-07
申请人： Seiji Tokumoto , Toshiyuki Matsudo , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Toshiyuki Matsudo , Tetsuji Kuwahara
IPC分类号： A61N1/30 , A61M5/32 , A61N7/00 , A61L31/08
CPC分类号： A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61N1/306
摘要： It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).
摘要翻译：旨在提供具有微针的透皮给药装置，其能够通过简单的方法穿透皮肤给药生物活性物质（药物）并允许生物活性物质的快速吸收。本发明的装置包括微针装置（50），其包括具有能够刺穿皮肤的多个微针（51）的微针基底（53），设置在其上的吸收体（11），所述吸收体（11）包括能吸收的材料液体和设置在吸收剂（11）上的溶解溶液储存器（18），溶解液储存器（18）含有用于溶解药物的溶解溶液（16）并能够破坏隔膜（20）溶液储存器（18）和吸收剂（11）。将包含干药物的涂层设置在微针（51）和/或微针基片（53）上。

10. 发明授权

US09028463B2 Microneedle device, and method for enhancing the efficacy of influenza vaccine by using microneedle device 有权
标题翻译：微针装置以及通过使用微针装置增强流感疫苗的功效的方法
公开(公告)号：US09028463B2
公开(公告)日：2015-05-12
申请号：US13001995
申请日：2009-05-22
申请人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
发明人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
IPC分类号： A61M31/00 , A61K39/145 , A61B17/20 , A61M37/00 , A61K39/00
CPC分类号： A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
摘要翻译：本发明提供使用能够增强流感疫苗的免疫原性的微针装置增强免疫原性的方法。根据使用本发明的微针装置的增强免疫原性的方法，将具有由聚乳酸制成的微针的微针装置涂敷于A型菌株（H1N1），A型菌株（H3N2）和A型菌株作为活性成分的B菌株与皮肤直接接触，以便经皮施用上述流感疫苗。在经皮给药之后，将月桂醇施用于已经与微针装置直接接触的皮肤部位。

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