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1. 发明授权

US08275454B2 Iontophoresis device activated in use 有权
标题翻译：离子渗透装置在使用中激活
公开(公告)号：US08275454B2
公开(公告)日：2012-09-25
申请号：US10584159
申请日：2004-12-27
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force. The protruding portion 17 has a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm 20. A liner 19 is removably attached on the undersurface of both the absorber 11 and the adhesive layer 12.
摘要翻译：提供在使用中活化的离子电渗疗装置，其能够以取决于药物使用量的量的量供给溶解液。在使用中所激活的该离子电渗疗装置包括：由含有干燥药物10并能够吸收液体的材料形成的吸收体11; 围绕吸收体11设置的壁材13，在其下面具有粘合剂层12; 设置在吸收体11和壁材13上的支撑体15，在其中央部具有开口14; 设置在支撑体15的下表面上的电极25; 设置在支撑件15上的隔膜20; 以及设置在隔膜20上的溶解液储存器18，保持用于将药物溶解在隔膜20与其本身之间的溶解液，并具有用于通过按压力破坏隔膜20的突出部17。突出部17例如具有直线状的顶端部，并且被配置成允许其与隔膜20接触或接近隔膜20.衬套19可拆卸地附接在吸收体11和吸收体11的下表面上粘合剂层12。

2. 发明申请

US20110152743A1 IONTOPHORESIS DEVICE ACTIVATED IN USE 有权
标题翻译：使用激活的IOPOPHORESIS设备
公开(公告)号：US20110152743A1
公开(公告)日：2011-06-23
申请号：US10584159
申请日：2004-12-27
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force. The protruding portion 17 has a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm 20. A liner 19 is removably attached on the undersurface of both the absorber 11 and the adhesive layer 12.
摘要翻译：提供在使用中活化的离子电渗疗装置，其能够以取决于药物使用量的量的量供给溶解液。在使用中所激活的该离子电渗疗装置包括：由含有干燥药物10并能够吸收液体的材料形成的吸收体11; 围绕吸收体11设置的壁材13，在其下面具有粘合剂层12; 设置在吸收体11和壁材13上的支撑体15，在其中央部具有开口14; 设置在支撑体15的下表面上的电极25; 设置在支撑件15上的隔膜20; 以及设置在隔膜20上的溶解液储存器18，保持用于将药物溶解在隔膜20与其本身之间的溶解液，并具有用于通过按压力破坏隔膜20的突出部17。突出部17例如具有直线状的顶端部，并且被配置成允许其与隔膜20接触或接近隔膜20.衬套19可拆卸地附接在吸收体11和吸收体11的下表面上粘合剂层12。

3. 发明申请

US20090318845A1 Iontophoresis Device and Method for Producing Same 审中-公开
标题翻译：离子渗透装置及其制造方法
公开(公告)号：US20090318845A1
公开(公告)日：2009-12-24
申请号：US12087054
申请日：2006-12-25
申请人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
发明人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer (2) formed on a base (1), a drug-loaded member (3) arranged on the electrode-layer-forming side of the electrode film, and a dissolution liquid-storing container (5) arranged on the non-electrode-layer-forming side of the electrode film, wherein the electrode film is provided with a dissolution liquid passing hole (9), a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode film via an aluminum lid member (7) which covers the dissolution liquid passing hole (9), and the aluminum lid member (7) is arranged within the flange outer diameter of the dissolution liquid-storing container.
摘要翻译：为了提供容易生产的批量生产型离子电渗疗法装置，其具有溶解液储存容器与离子电渗电极结合的结构，溶解液和药物可以通过简单的操作混合，并且没有泄漏的风险的电力。该装置包括具有形成在基底（1）上的电极层（2）和布置在电极膜的电极层形成侧的药物负载构件（3）的电极膜和溶解液储存容器（5），设置在电极膜的非电极层形成侧，其中电极膜设置有溶解液通过孔（9），溶解液储存容器（5）的凸缘（5a）通过覆盖溶解液通过孔（9）的铝盖构件（7）与电极膜接合，铝盖构件（7）配置在溶解液储存容器的凸缘外径内。

4. 发明申请

US20090221952A1 Device for Transdermal Preparation 审中-公开
标题翻译：透皮制剂装置
公开(公告)号：US20090221952A1
公开(公告)日：2009-09-03
申请号：US12087055
申请日：2006-12-25
申请人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
发明人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Saori Takahashi , Tatsuya Ogawa
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： To provide an easily producible mass-production type transdermal drug device having a structure that a dissolution liquid and a drug can be mixed by simple operations. The device comprises an electrode holder (1) having an electrode layer (1b) formed on a substrate (1a), a drug-loaded member (2) provided on a surface of the electrode holder (1) for forming the electrode layer (1b), and a dissolution liquid-storing container (5) provided on a surface of the electrode holder (1) for not forming the electrode layer (1b), wherein a dissolution liquid passing hole (8) is formed in the electrode holder (1), a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode holder (1) via a lid material (6) covering the dissolution liquid passing hole (8), the dissolution liquid-storing container (5) has a protrusion (5b) opposing the dissolution liquid passing hole (8), and the protrusion (5b) has a recessed surface at the tip.
摘要翻译：提供一种易于生产的批量生产型透皮药物装置，其具有可以通过简单的操作混合溶解液体和药物的结构。该装置包括具有形成在基板（1a）上的电极层（1b）的电极保持器（1），设置在用于形成电极层（1b）的电极保持器（1）的表面上的药物负载部件）和设置在不形成电极层（1b）的电极保持件（1）的表面上的溶解液储存容器（5），其中在电极保持器（1）中形成溶解液通孔（8）），溶解液储存容器（5）的凸缘（5a）通过覆盖溶解液通过孔（8）的盖材料（6），溶解液储存容器（ 5）具有与溶解液通过孔（8）相对的突起（5b），突起（5b）在尖端具有凹陷表面。

5. 发明授权

US06597947B1 Iontophoresis device 有权
标题翻译：离子渗透装置
公开(公告)号：US06597947B1
公开(公告)日：2003-07-22
申请号：US09958599
申请日：2001-10-12
申请人： Kazutaka Inoue , Hirotoshi Adachi , Hiroyuki Maeda , Naruhito Higo
发明人： Kazutaka Inoue , Hirotoshi Adachi , Hiroyuki Maeda , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： The present invention provides an iontophoresis device allowing effective and continuous absorption for a long period. The iontophoresis device comprises the first electrode structure (100a) and the second electrode structure (110a) each having a hydrophilic conductive layer (102a, 112a) containing active ingredient and an electrode member (101a, 111a), and a power supply (120a) having polarity inverting means for switching over a current direction between the two electrode structures, wherein at least one of the first and the second electrode structures contains chloride ions and before administration, a chloride-ion content (P mg) is within a range satisfying the following equation: 1.0×(I×T×0.022)≦P wherein T represents a polarity inverting time (min) until polarity is inverted after energization in a certain direction and I represents an average current (mA).
摘要翻译：本发明提供一种允许长时间有效且持续吸收的离子电渗装置。离子电渗装置包括：第一电极结构（100a）和第二电极结构（110a），每个第一电极结构具有含有活性成分的亲水性导电层（102a，112a）和电极部件（101a，111a）;以及电源（120a）具有用于切换两个电极结构之间的电流方向的极性反转装置，其中第一和第二电极结构中的至少一个包含氯离子并且在给药之前，氯离子含量（P mg）在满足以下等式：其中T表示在一定方向通电之后极性反转的极性反转时间（min），I表示平均电流（mA）。

6. 发明申请

US20120156258A1 Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration 有权
标题翻译：用于透皮或经粘膜给药的佐剂或药物制剂
公开(公告)号：US20120156258A1
公开(公告)日：2012-06-21
申请号：US13367679
申请日：2012-02-07
申请人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
发明人： Seiji Tokumoto , Hirotoshi Adachi , Tetsuji Kuwahara
IPC分类号： A61K9/00 , A61M37/00 , A61N1/30 , A61K39/39 , A61P37/04
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034 , Y02A50/401
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译：一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状，R 1和R 2独立地表示碳原子数1〜16的烷基侧链。

7. 发明申请

US20110021972A1 Composition and Device Structure For Iontophoresis 失效
标题翻译：离子电渗法的组成和器件结构
公开(公告)号：US20110021972A1
公开(公告)日：2011-01-27
申请号：US12895934
申请日：2010-10-01
申请人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
发明人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
IPC分类号： A61N1/30 , A61K31/4468 , A61K31/167 , A61K31/495 , A61P25/04 , A61P9/06
CPC分类号： A61N1/0448 , A61K9/0009 , A61K9/0014 , A61K47/32 , A61N1/0444
摘要： Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
摘要翻译：用于离子电渗的装置结构100提供电极101和导电层102.导电层102含有活性成分D和碱性水溶胀甲基丙烯酸酯共聚物P1和/或酸性水溶胀甲基丙烯酸酯共聚物P2。将电极101和导电层102放置在背衬103的中空部分中，并且电极端子104通过背衬103连接到电极101.粘合层105设置在背衬103周围，并且在使用该装置时将衬垫106放置以覆盖背衬103的中空部分。

8. 发明申请

US20100022942A1 DEVICE FOR PERCUTANEOUS ABSORPTION PREPARATION 有权
标题翻译：用于经皮吸收制备的装置
公开(公告)号：US20100022942A1
公开(公告)日：2010-01-28
申请号：US12441842
申请日：2007-08-31
申请人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Tatsuya Ogawa , Hitoshi Otomo
发明人： Seiji Tokumoto , Hirotoshi Adachi , Yasushi Fuchita , Tatsuya Ogawa , Hitoshi Otomo
IPC分类号： A61N1/30 , A61M35/00
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member (1) and an electrode layer (2) and having a dissolution liquid passage hole (9), a drug impregnation member (3) mounted on the electrode layer (2) side of the electrode film, and a dissolution liquid storage container (5) bonded to the base member (1) side of the electrode film via a lid member (7) covering the solution passage hole (9). The dissolution liquid storage container (5) comprises a bottom and a sidewall. A protrusion (5b) which faces the dissolution liquid passage hole (9) is provided at the center of the bottom, and the sidewall is provided with a vertically folded part (5c).
摘要翻译：本发明提供了一种用于经皮吸收制剂的装置，其具有能够独立于力水平显示良好的溶液迁移的溶液储存容器。用于经皮吸收制剂的装置包括：电极膜，包括基底部件（1）和电极层（2），并具有溶解液体通过孔（9）;药物浸渍部件（3），安装在电极层）侧，以及通过覆盖所述溶液通孔（9）的盖部件（7）与所述电极膜的基材（1）侧接合的溶解液收容容器（5）。溶解液储存容器（5）包括底部和侧壁。在底部的中心设有面向溶解液通路孔（9）的突起（5b），侧壁设有垂直折叠部（5c）。

9. 发明申请

US20070255195A1 Iontophoresis device 审中-公开
标题翻译：离子渗透装置
公开(公告)号：US20070255195A1
公开(公告)日：2007-11-01
申请号：US11659908
申请日：2005-08-11
申请人： Hirotoshi Adachi
发明人： Hirotoshi Adachi
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044 , A61N1/0444 , A61N1/30 , A61N1/325
摘要： An iontophoresis device which allows excellent transdermal absorption of an anionically chargeable physiologically active substance is provided. The iontophoresis device comprises a cathode (25) and an interface (31) or (32) composed of a cationically chargeable membrane, wherein an anionically chargeable physiologically active substance (drug) (10) is placed between the cathode (25) and the interface (31) or in the interface (32). A wall member (13) with an adhesive layer (12) in the bottom is placed around an absorbent (11), and a support (15) having an opening (14) in the center is placed on the absorbent (11) and the wall member (13). When the device is used, the dissolution liquid for the drug is supplied to the absorbent (11) through the opening (14). The absorbent (11) and the interface (31) or (32) become wet with the dissolution liquid and the drug (10) is activated uniformly.
摘要翻译：提供了允许对阴离子可带电的生理活性物质进行极好的透皮吸收的离子电渗疗法装置。离子电渗装置包括阴极（25）和由可阳离子电荷的膜构成的界面（31）或（32），其中阴极可带电的生理活性物质（药物）（10）被放置在阴极（25）和界面（31）或接口（32）中。在吸收体11的周围放置有在底部具有粘合剂层12的壁部件13，在吸收体11上设有具有中央部的开口部14的支承体15，壁构件（13）。当使用该装置时，用于药物的溶解液通过开口（14）供给到吸收剂（11）。吸收剂（11）和界面（31）或（32）变得被溶解液弄湿，药物（10）被均匀地活化。

10. 发明申请

US20070123837A1 Interface for transdermal drug administration device 有权
标题翻译：透皮给药装置的界面
公开(公告)号：US20070123837A1
公开(公告)日：2007-05-31
申请号：US10588168
申请日：2005-02-02
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.
摘要翻译：旨在提供一种透皮给药装置的界面，其能够从多个突起通过皮肤几乎均匀且有利地供应药物。用于透皮给药装置的该界面具有平板8。平板8包括能够刺穿皮肤的多个二维布置的锥形或棱锥形突起6和能够输送药物的多个开口7，该开口分别与突起相对应地布置。开口7分别设置在其对应的突起6附近。平板8可以由金属或陶瓷制成。开口数与突出数之比可以为1：1〜1：2。

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