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1. 发明申请

US20070123837A1 Interface for transdermal drug administration device 有权
标题翻译：透皮给药装置的界面
公开(公告)号：US20070123837A1
公开(公告)日：2007-05-31
申请号：US10588168
申请日：2005-02-02
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.
摘要翻译：旨在提供一种透皮给药装置的界面，其能够从多个突起通过皮肤几乎均匀且有利地供应药物。用于透皮给药装置的该界面具有平板8。平板8包括能够刺穿皮肤的多个二维布置的锥形或棱锥形突起6和能够输送药物的多个开口7，该开口分别与突起相对应地布置。开口7分别设置在其对应的突起6附近。平板8可以由金属或陶瓷制成。开口数与突出数之比可以为1：1〜1：2。

2. 发明授权

US08275454B2 Iontophoresis device activated in use 有权
标题翻译：离子渗透装置在使用中激活
公开(公告)号：US08275454B2
公开(公告)日：2012-09-25
申请号：US10584159
申请日：2004-12-27
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force. The protruding portion 17 has a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm 20. A liner 19 is removably attached on the undersurface of both the absorber 11 and the adhesive layer 12.
摘要翻译：提供在使用中活化的离子电渗疗装置，其能够以取决于药物使用量的量的量供给溶解液。在使用中所激活的该离子电渗疗装置包括：由含有干燥药物10并能够吸收液体的材料形成的吸收体11; 围绕吸收体11设置的壁材13，在其下面具有粘合剂层12; 设置在吸收体11和壁材13上的支撑体15，在其中央部具有开口14; 设置在支撑体15的下表面上的电极25; 设置在支撑件15上的隔膜20; 以及设置在隔膜20上的溶解液储存器18，保持用于将药物溶解在隔膜20与其本身之间的溶解液，并具有用于通过按压力破坏隔膜20的突出部17。突出部17例如具有直线状的顶端部，并且被配置成允许其与隔膜20接触或接近隔膜20.衬套19可拆卸地附接在吸收体11和吸收体11的下表面上粘合剂层12。

3. 发明申请

US20110152743A1 IONTOPHORESIS DEVICE ACTIVATED IN USE 有权
标题翻译：使用激活的IOPOPHORESIS设备
公开(公告)号：US20110152743A1
公开(公告)日：2011-06-23
申请号：US10584159
申请日：2004-12-27
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force. The protruding portion 17 has a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm 20. A liner 19 is removably attached on the undersurface of both the absorber 11 and the adhesive layer 12.
摘要翻译：提供在使用中活化的离子电渗疗装置，其能够以取决于药物使用量的量的量供给溶解液。在使用中所激活的该离子电渗疗装置包括：由含有干燥药物10并能够吸收液体的材料形成的吸收体11; 围绕吸收体11设置的壁材13，在其下面具有粘合剂层12; 设置在吸收体11和壁材13上的支撑体15，在其中央部具有开口14; 设置在支撑体15的下表面上的电极25; 设置在支撑件15上的隔膜20; 以及设置在隔膜20上的溶解液储存器18，保持用于将药物溶解在隔膜20与其本身之间的溶解液，并具有用于通过按压力破坏隔膜20的突出部17。突出部17例如具有直线状的顶端部，并且被配置成允许其与隔膜20接触或接近隔膜20.衬套19可拆卸地附接在吸收体11和吸收体11的下表面上粘合剂层12。

4. 发明授权

US07914813B2 Interface for transdermal drug administration device 有权
标题翻译：透皮给药装置的界面
公开(公告)号：US07914813B2
公开(公告)日：2011-03-29
申请号：US10588168
申请日：2005-02-02
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61F13/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.
摘要翻译：旨在提供一种透皮给药装置的界面，其能够从多个突起通过皮肤几乎均匀且有利地供应药物。用于透皮给药装置的该界面具有平板8.平板8包括能够刺穿皮肤的多个二维布置的锥形或棱锥形突起6和能够递送分别布置的药物的多个开口7 与预测对应。开口7分别设置在其对应的突起6附近。平板8可以由金属或陶瓷制成。开口数与突出数之比可以为1：1〜1：2。

5. 发明申请

US20070264316A1 Patch Activated In Use 审中-公开
标题翻译：补丁激活使用
公开(公告)号：US20070264316A1
公开(公告)日：2007-11-15
申请号：US10584172
申请日：2004-12-27
申请人： Hirotoshi Adachi , Naruhito Higo , Seiji Tokumoto
发明人： Hirotoshi Adachi , Naruhito Higo , Seiji Tokumoto
IPC分类号： A61F13/02
CPC分类号： A61K9/703 , A61F13/0203 , A61K9/7084
摘要： Provided a patch activated in use capable of uniformly activating a drug by supplying a solution when used. The patch activated in use comprises an absorber 11 containing a dry drug 10 and formed of a material capable of absorbing a liquid, a wall material 13 arranged around the absorber 11 and having an adhesive layer 12 on the lower surface thereof, a support 15 arranged on the absorber 11 and the wall material 13 and having an opening 14 at the center, a diaphragm 20 arranged on the support 15, and a dissolution liquid reservoir 18 arranged on the diaphragm 20, holding a dissolution liquid dissolving the drug in a space with the diaphragm 20 and having a protruding portion 17 which breaks the diaphragm 20 by pressure. The protruding portion 17 has a liner top end portion and arranged in contact or in the proximity with the diaphragm 20. A liner 19 is detachably provided on the lower surface of the absorber 11 and adhesive layer 12.
摘要翻译：提供使用时能够通过在使用时提供溶液来均匀地活化药物的活化片。在使用中活化的贴片包括含有干药10并由能够吸收液体的材料形成的吸收体11，围绕吸收体11排列并且在其下表面上具有粘合层12的壁材13，在吸收器11和壁材料13上，中心具有开口14，设置在支撑体15上的隔膜20和布置在隔膜20上的溶解液储存器18，将溶解药物的溶解液保持在空间中，隔膜20具有突出部分17，其通过压力破坏隔膜20。突出部分17具有衬里顶端部分并且与隔膜20接触或邻近设置。衬垫19可拆卸地设置在吸收体11和粘合剂层12的下表面上。

6. 发明申请

US20070250018A1 Transdermal Drug Administration System with Microneedles 审中-公开
标题翻译：透皮药物管理系统与微针
公开(公告)号：US20070250018A1
公开(公告)日：2007-10-25
申请号：US11659894
申请日：2005-08-11
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A transdermal drug administration system with microneedles which can perforate the skin (stratum corneum) by a simple operation at the time of transdermal administration of a physiologically active substance (drug) is provided. The present transdermal drug administration system with microneedles comprises microneedle device (50) having a plurality of microneedles (51) which can perforate the skin and a plurality of solution passages (52); absorbent (11) which is disposed on microneedle device (50), comprising dried drug (10) and a material which can absorb liquid; and dissolution liquid reservoir (18) which is disposed on absorbent (11) and stores dissolution liquid (16) for dissolving drug (10) and in which a diaphragm (20) provided between absorbent (11) can be broken by pressing. Dissolution liquid reservoir (18) is pressed to break diaphragm (20), and at the same time, the microneedle (51) perforates the skin (stratum corneum), and drug (10) dissolved in dissolution liquid (16) is transmitted through microneedle device (50) to the skin.
摘要翻译：提供了一种透皮给药系统，其具有通过在经皮给药生理活性物质（药物）时通过简单操作穿透皮肤（角质层）的微针。本发明的具有微针的透皮药物给药系统包括具有能使皮肤穿孔的多个微针（51）和多个溶液通道（52）的微针装置（50）。吸收剂（11），其设置在微针装置（50）上，包括干燥药物（10）和能够吸收液体的材料; 和溶解液储存器（18），其设置在吸收剂（11）上并储存用于溶解药物（10）的溶解液体（16），并且其中设置在吸收剂（11）之间的隔膜（20）可以通过压制而破裂。溶解液体储存器（18）被按压以打破隔膜（20），同时微针（51）穿透皮肤（角质层），溶解在溶解液体（16）中的药物（10）通过微针装置（50）到皮肤。

7. 发明申请

US20050085860A1 Transdermal/transmucosal preparations for electroporation 审中-公开
标题翻译：用于电穿孔的透皮/透粘膜制剂
公开(公告)号：US20050085860A1
公开(公告)日：2005-04-21
申请号：US10501946
申请日：2003-01-20
申请人： Kenji Mori , Seiji Tokumoto , Naruhito Higo , Shuji Sato , Kenji Sugibayashi
发明人： Kenji Mori , Seiji Tokumoto , Naruhito Higo , Shuji Sato , Kenji Sugibayashi
IPC分类号： A61K9/70 , A61K31/05 , A61K31/155 , A61K31/192 , A61K31/196 , A61K31/375 , A61K47/36 , A61N1/30 , A61P25/04 , A61P39/06 , A61P43/00
CPC分类号： A61N1/30
摘要： A preparation for transdermal or transmucosal administration for electroporation is provided that enables efficient administration of a compound to be administered such as a drug. The preparation for transdermal or transmucosal administration for electroporation includes a drug reservoir (11) having dispersed therein a compound to be administered (physiologically active substance), such as a drug, in a base of a solid or semisolid form, a backing (12) retaining the drug reservoir, and a pair of electrodes for electroporation (13) provided on the drug reservoir (11). An adhesive layer (14) is provided on a flange portion of the backing (12). An insulating layer (15) is provided on at least a section of the electrodes for electroporation (13) contacting an application site other than a section on the drug reservoir (11).
摘要翻译：提供了用于电穿孔的经皮或经粘膜给药的制剂，其能够有效施用待给药的化合物例如药物。透皮或经粘膜给药用于电穿孔的制剂包括其中分散有固体或半固体形式的基质中的待给药化合物（生理活性物质）如药物的药物储存器（11），背衬（12）保持药物储存器和设置在药物储存器（11）上的一对用于电穿孔的电极（13）。粘合剂层（14）设置在背衬（12）的凸缘部分上。绝缘层（15）设置在用于电穿孔（13）的电极的至少一部分上，接触除了药物储存器（11）上的部分之外的施用部位。

8. 发明申请

US20050271725A1 Adhesive gel composition for iontophoresis preparation and process for producing the same 审中-公开
标题翻译：用于离子电渗疗法制备的粘合剂凝胶组合物及其制备方法
公开(公告)号：US20050271725A1
公开(公告)日：2005-12-08
申请号：US10525531
申请日：2003-08-30
申请人： Mitsuru Kuribayashi , Shuichi Ikeda , Seiji Tokumoto , Kenji Mori , Naruhito Higo
发明人： Mitsuru Kuribayashi , Shuichi Ikeda , Seiji Tokumoto , Kenji Mori , Naruhito Higo
IPC分类号： A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/16 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61N1/04 , A61N1/30 , A61P5/44 , A61K9/14
CPC分类号： A61N1/0428 , A61K9/0009 , A61K9/0014 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/16 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61N1/0444 , A61N1/0496
摘要： The present invention provides an adhesive gel composition for iontophoretic formulations which is useful for the application through the skin or the mucosa, which excels in all of drug absorption, drug stability, gel shape retention and gel adhesion, which is easy to prepare and fill at the time of production, and which can be produced at low costs and a method for producing the same. The adhesive gel composition for iontophoretic formulations is produced by mixing an ionic synthetic polymer(s), a nonionic synthetic polymer(s), a naturally-occurring polymer(s), a polyhydric alcohol(s), a crosslinking agent(s) and a drug(s). In the production of the adhesive gel composition for iontophoretic formulations, oxygen dissolved in the gel is positively removed by carrying out replacement with nitrogen and/or vacuum kneading at the time of the ingredients are mixed and kneaded.
摘要翻译：本发明提供了一种用于离子电渗疗法制剂的粘合性凝胶组合物，其可用于通过皮肤或粘膜的应用，其在药物吸收，药物稳定性，凝胶形状保留和凝胶粘附方面均优异，易于制备和填充生产时间，可以以低成本制造的方法及其制造方法。用于离子电渗疗法制剂的粘合凝胶组合物通过将离子合成聚合物，非离子合成聚合物，天然存在的聚合物，多元醇，交联剂和一种药物。在用于离子电渗疗法制剂的粘合剂凝胶组合物的制备中，通过在混合和捏合成分时，用氮气和/或真空捏合进行置换，可以有效地去除溶解在凝胶中的氧气。

9. 发明申请

US20050169976A1 Insulin administration apparatus 审中-公开
标题翻译：胰岛素给药装置
公开(公告)号：US20050169976A1
公开(公告)日：2005-08-04
申请号：US10510694
申请日：2003-03-28
申请人： Kenji Mori , Naruhito Higo , Seiji Tokumoto , Shuji Sato , Kenji Sugibayashi
发明人： Kenji Mori , Naruhito Higo , Seiji Tokumoto , Shuji Sato , Kenji Sugibayashi
IPC分类号： A61K9/08 , A61K9/10 , A61K38/28 , A61K47/32 , A61K47/36 , A61M1/36 , A61N1/30 , A61N1/32 , A61P3/10
CPC分类号： A61N1/0416 , A61K38/28 , A61N1/0424 , A61N1/0432 , A61N1/044 , A61N1/30 , A61N1/327
摘要： The present invention provides an insulin-administering device enabling the effective administration of insulin via a percutaneous or submucous administration route. The present device is used to percutaneously or transmucosally administer an insulin lispro represented by the structural formula indicated below, or a pharmaceutically acceptable salt thereof, using iontophoresis and electroporation.
摘要翻译：本发明提供了能够通过经皮或粘膜下给药途径有效施用胰岛素的胰岛素给药装置。本发明的装置用于使用离子电渗疗法和电穿孔来经皮或经粘膜内施用由下述结构式表示的赖脯胰岛素或其药学上可接受的盐。

10. 发明授权

US06597947B1 Iontophoresis device 有权
标题翻译：离子渗透装置
公开(公告)号：US06597947B1
公开(公告)日：2003-07-22
申请号：US09958599
申请日：2001-10-12
申请人： Kazutaka Inoue , Hirotoshi Adachi , Hiroyuki Maeda , Naruhito Higo
发明人： Kazutaka Inoue , Hirotoshi Adachi , Hiroyuki Maeda , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： The present invention provides an iontophoresis device allowing effective and continuous absorption for a long period. The iontophoresis device comprises the first electrode structure (100a) and the second electrode structure (110a) each having a hydrophilic conductive layer (102a, 112a) containing active ingredient and an electrode member (101a, 111a), and a power supply (120a) having polarity inverting means for switching over a current direction between the two electrode structures, wherein at least one of the first and the second electrode structures contains chloride ions and before administration, a chloride-ion content (P mg) is within a range satisfying the following equation: 1.0×(I×T×0.022)≦P wherein T represents a polarity inverting time (min) until polarity is inverted after energization in a certain direction and I represents an average current (mA).
摘要翻译：本发明提供一种允许长时间有效且持续吸收的离子电渗装置。离子电渗装置包括：第一电极结构（100a）和第二电极结构（110a），每个第一电极结构具有含有活性成分的亲水性导电层（102a，112a）和电极部件（101a，111a）;以及电源（120a）具有用于切换两个电极结构之间的电流方向的极性反转装置，其中第一和第二电极结构中的至少一个包含氯离子并且在给药之前，氯离子含量（P mg）在满足以下等式：其中T表示在一定方向通电之后极性反转的极性反转时间（min），I表示平均电流（mA）。

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