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1. 发明授权

US5908400A Device structure for iontophoresis 失效
标题翻译：离子电渗法的装置结构
公开(公告)号：US5908400A
公开(公告)日：1999-06-01
申请号：US878852
申请日：1997-06-20
申请人： Naruhito Higo , Hirotoshi Adachi , Tatsuya Meno
发明人： Naruhito Higo , Hirotoshi Adachi , Tatsuya Meno
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/325 , A61N1/0448
摘要： An iontophoretic device structure of the dissolution-on-use type is provided, wherein an ionized drug is transdermally or transmucosally administered into a living body. The device structure comprises (a) a non-polarizable electrode, (b) a hydrophilic, polymeric gel layer containing an ion exchange resin which is able to specifically inhibit the movement of ions dissolved out from the electrode while in use, and (c) a drug layer containing a drug in a dry condition in a drug retaining membrane, wherein when said device is in use, said drug layer is brought into contact with said hydrophilic, polymeric gel layer so that said drug in the dry condition is dissolved. A humectant may be contained in the hydrophilic, polymeric gel layer and/or the drug layer.
摘要翻译：提供了使用溶解型的离子电渗疗法器件结构，其中电离药物经皮或经粘膜施用于生物体。该装置结构包括（a）不可极化电极，（b）含有离子交换树脂的亲水性聚合物凝胶层，其能够在使用时特异性地抑制从电极溶出的离子的移动，以及（c）在药物保持膜中含有处于干燥状态的药物的药物层，其中当使用所述装置时，使所述药物层与所述亲水性聚合物凝胶层接触，使得干燥条件下的所述药物溶解。保湿剂可以包含在亲水性聚合物凝胶层和/或药物层中。

2. 发明申请

US20120095386A9 COMPOSITION AND DEVICE STRUCTURE FOR IONTOPHORESIS 失效
标题翻译：组合物和器件结构用于IOPOPHORESIS
公开(公告)号：US20120095386A9
公开(公告)日：2012-04-19
申请号：US12895934
申请日：2010-10-01
申请人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
发明人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
IPC分类号： A61N1/30 , A61P9/06 , A61K31/495 , A61P25/04 , A61K31/4468 , A61K31/167
CPC分类号： A61N1/0448 , A61K9/0009 , A61K9/0014 , A61K47/32 , A61N1/0444
摘要： Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
摘要翻译：用于离子电渗的装置结构100提供电极101和导电层102.导电层102含有活性成分D和碱性水溶胀甲基丙烯酸酯共聚物P1和/或酸性水溶胀甲基丙烯酸酯共聚物P2。将电极101和导电层102放置在背衬103的中空部分中，并且电极端子104通过背衬103连接到电极101.粘合层105设置在背衬103周围，并且在使用该装置时将衬垫106放置以覆盖背衬103的中空部分。

3. 发明申请

US20110021972A1 Composition and Device Structure For Iontophoresis 失效
标题翻译：离子电渗法的组成和器件结构
公开(公告)号：US20110021972A1
公开(公告)日：2011-01-27
申请号：US12895934
申请日：2010-10-01
申请人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
发明人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
IPC分类号： A61N1/30 , A61K31/4468 , A61K31/167 , A61K31/495 , A61P25/04 , A61P9/06
CPC分类号： A61N1/0448 , A61K9/0009 , A61K9/0014 , A61K47/32 , A61N1/0444
摘要： Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
摘要翻译：用于离子电渗的装置结构100提供电极101和导电层102.导电层102含有活性成分D和碱性水溶胀甲基丙烯酸酯共聚物P1和/或酸性水溶胀甲基丙烯酸酯共聚物P2。将电极101和导电层102放置在背衬103的中空部分中，并且电极端子104通过背衬103连接到电极101.粘合层105设置在背衬103周围，并且在使用该装置时将衬垫106放置以覆盖背衬103的中空部分。

4. 发明申请

US20070123837A1 Interface for transdermal drug administration device 有权
标题翻译：透皮给药装置的界面
公开(公告)号：US20070123837A1
公开(公告)日：2007-05-31
申请号：US10588168
申请日：2005-02-02
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.
摘要翻译：旨在提供一种透皮给药装置的界面，其能够从多个突起通过皮肤几乎均匀且有利地供应药物。用于透皮给药装置的该界面具有平板8。平板8包括能够刺穿皮肤的多个二维布置的锥形或棱锥形突起6和能够输送药物的多个开口7，该开口分别与突起相对应地布置。开口7分别设置在其对应的突起6附近。平板8可以由金属或陶瓷制成。开口数与突出数之比可以为1：1〜1：2。

5. 发明授权

US06643544B1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US06643544B1
公开(公告)日：2003-11-04
申请号：US09958602
申请日：2001-10-12
申请人： Hirotoshi Adachi , Kazuya Katagai , Naruhito Higo
发明人： Hirotoshi Adachi , Kazuya Katagai , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： The present invention provides an iontophoresis device and an energization method whereby a prostaglandin can be effectively and continuously administered via a skin or mucosa. The iontophoresis device comprises the first electrode structure (31); the second electrode structure (32); and a power supply (33) electrically connected between the first and the second electrode structures (31), (32). At least one of the first and the second electrode structures contains a prostaglandin and also stabilizing means for inhibiting hydrolysis of the prostaglandin during storage. The power supply (33) is equipped with constant current supplying means and, when both electrode structures contain a prostaglandin, also polarity inverting means. Output current from the power supply may allow the prostaglandin to be delivered to a skin or mucosa.
摘要翻译：本发明提供了一种离子电渗疗法装置和通电方法，其中前列腺素可通过皮肤或粘膜有效且连续地施用。离子电渗装置包括第一电极结构（31）; 第二电极结构（32）; 和电连接在第一和第二电极结构（31），（32）之间的电源（33）。第一和第二电极结构中的至少一个包含前列腺素以及用于在储存期间抑制前列腺素水解的稳定手段。电源（33）配备有恒流供给装置，并且当两个电极结构都包含前列腺素时，还具有极性反转装置。来自电源的输出电流可允许将前列腺素输送至皮肤或粘膜。

6. 发明授权

US08275454B2 Iontophoresis device activated in use 有权
标题翻译：离子渗透装置在使用中激活
公开(公告)号：US08275454B2
公开(公告)日：2012-09-25
申请号：US10584159
申请日：2004-12-27
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force. The protruding portion 17 has a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm 20. A liner 19 is removably attached on the undersurface of both the absorber 11 and the adhesive layer 12.
摘要翻译：提供在使用中活化的离子电渗疗装置，其能够以取决于药物使用量的量的量供给溶解液。在使用中所激活的该离子电渗疗装置包括：由含有干燥药物10并能够吸收液体的材料形成的吸收体11; 围绕吸收体11设置的壁材13，在其下面具有粘合剂层12; 设置在吸收体11和壁材13上的支撑体15，在其中央部具有开口14; 设置在支撑体15的下表面上的电极25; 设置在支撑件15上的隔膜20; 以及设置在隔膜20上的溶解液储存器18，保持用于将药物溶解在隔膜20与其本身之间的溶解液，并具有用于通过按压力破坏隔膜20的突出部17。突出部17例如具有直线状的顶端部，并且被配置成允许其与隔膜20接触或接近隔膜20.衬套19可拆卸地附接在吸收体11和吸收体11的下表面上粘合剂层12。

7. 发明申请

US20110152743A1 IONTOPHORESIS DEVICE ACTIVATED IN USE 有权
标题翻译：使用激活的IOPOPHORESIS设备
公开(公告)号：US20110152743A1
公开(公告)日：2011-06-23
申请号：US10584159
申请日：2004-12-27
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force. The protruding portion 17 has a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm 20. A liner 19 is removably attached on the undersurface of both the absorber 11 and the adhesive layer 12.
摘要翻译：提供在使用中活化的离子电渗疗装置，其能够以取决于药物使用量的量的量供给溶解液。在使用中所激活的该离子电渗疗装置包括：由含有干燥药物10并能够吸收液体的材料形成的吸收体11; 围绕吸收体11设置的壁材13，在其下面具有粘合剂层12; 设置在吸收体11和壁材13上的支撑体15，在其中央部具有开口14; 设置在支撑体15的下表面上的电极25; 设置在支撑件15上的隔膜20; 以及设置在隔膜20上的溶解液储存器18，保持用于将药物溶解在隔膜20与其本身之间的溶解液，并具有用于通过按压力破坏隔膜20的突出部17。突出部17例如具有直线状的顶端部，并且被配置成允许其与隔膜20接触或接近隔膜20.衬套19可拆卸地附接在吸收体11和吸收体11的下表面上粘合剂层12。

8. 发明授权

US06597947B1 Iontophoresis device 有权
标题翻译：离子渗透装置
公开(公告)号：US06597947B1
公开(公告)日：2003-07-22
申请号：US09958599
申请日：2001-10-12
申请人： Kazutaka Inoue , Hirotoshi Adachi , Hiroyuki Maeda , Naruhito Higo
发明人： Kazutaka Inoue , Hirotoshi Adachi , Hiroyuki Maeda , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： The present invention provides an iontophoresis device allowing effective and continuous absorption for a long period. The iontophoresis device comprises the first electrode structure (100a) and the second electrode structure (110a) each having a hydrophilic conductive layer (102a, 112a) containing active ingredient and an electrode member (101a, 111a), and a power supply (120a) having polarity inverting means for switching over a current direction between the two electrode structures, wherein at least one of the first and the second electrode structures contains chloride ions and before administration, a chloride-ion content (P mg) is within a range satisfying the following equation: 1.0×(I×T×0.022)≦P wherein T represents a polarity inverting time (min) until polarity is inverted after energization in a certain direction and I represents an average current (mA).
摘要翻译：本发明提供一种允许长时间有效且持续吸收的离子电渗装置。离子电渗装置包括：第一电极结构（100a）和第二电极结构（110a），每个第一电极结构具有含有活性成分的亲水性导电层（102a，112a）和电极部件（101a，111a）;以及电源（120a）具有用于切换两个电极结构之间的电流方向的极性反转装置，其中第一和第二电极结构中的至少一个包含氯离子并且在给药之前，氯离子含量（P mg）在满足以下等式：其中T表示在一定方向通电之后极性反转的极性反转时间（min），I表示平均电流（mA）。

9. 发明授权

US08155738B2 Composition and device structure for iontophoresis 失效
标题翻译：离子电渗法的组成和器件结构
公开(公告)号：US08155738B2
公开(公告)日：2012-04-10
申请号：US12895934
申请日：2010-10-01
申请人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
发明人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
IPC分类号： A61N1/30 , A61K9/70 , A61K9/22 , A61F13/00 , A61M35/00
CPC分类号： A61N1/0448 , A61K9/0009 , A61K9/0014 , A61K47/32 , A61N1/0444
摘要： Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
摘要翻译：用于离子电渗的装置结构100提供电极101和导电层102.导电层102含有活性成分D和碱性水溶胀甲基丙烯酸酯共聚物P1和/或酸性水溶胀甲基丙烯酸酯共聚物P2。将电极101和导电层102放置在背衬103的中空部分中，并且电极端子104通过背衬103连接到电极101.粘合层105设置在背衬103周围，并且在使用该装置时将衬垫106放置以覆盖背衬103的中空部分。

10. 发明授权

US07914813B2 Interface for transdermal drug administration device 有权
标题翻译：透皮给药装置的界面
公开(公告)号：US07914813B2
公开(公告)日：2011-03-29
申请号：US10588168
申请日：2005-02-02
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61F13/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.
摘要翻译：旨在提供一种透皮给药装置的界面，其能够从多个突起通过皮肤几乎均匀且有利地供应药物。用于透皮给药装置的该界面具有平板8.平板8包括能够刺穿皮肤的多个二维布置的锥形或棱锥形突起6和能够递送分别布置的药物的多个开口7 与预测对应。开口7分别设置在其对应的突起6附近。平板8可以由金属或陶瓷制成。开口数与突出数之比可以为1：1〜1：2。

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