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131. 发明授权

US06887432B2 Cuvette arrays 有权
标题翻译：比色杯阵列
公开(公告)号：US06887432B2
公开(公告)日：2005-05-03
申请号：US10077363
申请日：2002-02-15
申请人： Manfred Kansy , Hansjörg Tschirky , Werner Schneider , Heinrich Büttgen , Tilo Callenbach , Karl Mazenauer
发明人： Manfred Kansy , Hansjörg Tschirky , Werner Schneider , Heinrich Büttgen , Tilo Callenbach , Karl Mazenauer
IPC分类号： G01N1/10 , B01L3/00 , G01N21/03 , G01N35/00 , G01N35/02
CPC分类号： B01L3/50855 , B01L3/50255 , B01L2200/025 , B01L2200/028 , B01L2300/0829 , G01N2021/0321 , G01N2021/0357
摘要： An integrally built, linear array of cuvettes is made of a plastic material. Every cuvette of the array has the same shape and dimensions. Neighboring cuvettes are connected to each other by a single web. Each of the single webs has a curved shape and each cuvette has means forming integral part thereof and serving for accurately positioning the cuvette into an opening of a cuvette holder and means for removably connecting the cuvette to the cuvette holder. Each cuvette has an upper chamber and a lower chamber having a common symmetry axis passing through the centers of both chambers. Each of the upper and lower chambers has a substantially cylindrical shape. The cross-section of the upper chamber at the central part thereof is larger than the cross-section of the lower chamber. The lower chamber has an open lower end. The upper chamber has an open top end and an annular bottom wall having a central circular opening which connects the upper chamber with the lower chamber. The inner surface of the bottom wall of the upper chamber (17) is part of a conical surface the cross-section of which forms an angle of about 80 degrees with the symmetry axis, so that there is an abrupt change of cross-section between the upper chamber and the lower chamber. A two-dimensional array of cuvettes comprises a plurality of linear cuvette arrays inserted into a cuvette holder having a matrix array of cuvette receiving openings. A system of two-dimensional cuvette arrays is built by stacking two or more of such two-dimensional arrays of cuvettes. Foil shaped layers serving, e.g. as a filter, are adapted to be attached to each cuvette to cover at least one opening thereof.
摘要翻译：整体建造的线性排列的比色杯由塑料材料制成。阵列的每个比色杯具有相同的形状和尺寸。相邻的比色皿通过单个网络彼此连接。每个单个腹板具有弯曲的形状，并且每个比色皿具有形成其整体部分的装置，并且用于将比色皿精确地定位到比色杯保持器的开口中，以及用于将比色皿可移除地连接到比色杯保持器的装置。每个比色杯具有通过两个腔室的中心的共同对称轴的上部腔室和下部腔室。上下腔室中的每一个具有基本上圆柱形的形状。上室的中心部分的横截面大于下室的横截面。下室具有开放的下端。上部腔室具有敞开的顶端和具有连接上部腔室和下部腔室的中心圆形开口的环形底壁。上腔室（17）的底壁的内表面是圆锥形表面的一部分，其横截面与对称轴线形成大约80度的角度，使得横截面之间存在突然变化上室和下室。二维比色皿阵列包括插入具有矩阵阵列的比色皿容纳开口的比色皿支架的多个线性比色杯阵列。通过堆叠两个或更多个这样的二维比色皿阵列来构建二维比色皿阵列的系统。箔形层，例如。作为过滤器，适于附接到每个比色皿以覆盖其至少一个开口。

132. 发明申请

US20050042149A1 Nanoscale chemical synthesis 审中-公开
标题翻译：纳米级化学合成
公开(公告)号：US20050042149A1
公开(公告)日：2005-02-24
申请号：US10953592
申请日：2004-09-29
申请人： Allen Bard
发明人： Allen Bard
IPC分类号： B01J19/00 , B01L3/00 , B01L9/00 , G01N1/28 , G01N30/60 , G01N30/88 , G01N35/00
CPC分类号： G01N1/28 , B01J19/0093 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2300/0809 , B01L2300/0896 , B82Y30/00 , G01N30/6034 , G01N30/6091 , G01N30/6095 , G01N2030/8881 , G01N2035/00326
摘要： A modular reactor system and method for synthesizing nanoscale quantities of chemical compounds characterized by a continuous flow reactor under high pressure having uniform temperature throughout the reaction mixture. The apparatus includes a number of generic components such as pumps, flow channels, manifolds, flow restrictors, valves and at least one modular reactor, as small as one nanoliter in volume, where larger quantities can be produced by either using larger nanoscale sized units or adding parallel and serially disposed nanoscale reactor units.
摘要翻译：一种用于合成纳米级量化学化合物的模块化反应器系统和方法，其特征在于在整个反应混合物中具有均匀温度的高压连续流动反应器。该设备包括许多通用部件，例如泵，流动通道，歧管，限流器，阀和至少一个体积小至一纳升的模块式反应器，其中可以通过使用较大的纳米尺寸的单元或添加平行和串联设置的纳米级反应器单元。

133. 发明申请

US20040228771A1 Reconfigurable modular microfluidic system and method of fabrication 有权
标题翻译：可重构模块化微流体系统及其制造方法
公开(公告)号：US20040228771A1
公开(公告)日：2004-11-18
申请号：US10807051
申请日：2004-03-23
申请人： Kionix, Inc.
发明人： Peng Zhou , Lincoln Young
IPC分类号： B01L003/00
CPC分类号： B01L3/502715 , B01J2219/0081 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/043 , B01L2300/0816 , B01L2300/0829 , B01L2300/0861 , B01L2300/0874 , G01N30/6082 , G01N30/6095 , Y10T29/49 , Y10T29/49002 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , G01N30/74 , G01N30/6047 , G01N2030/8881
摘要： A reconfigurable modular microfluidic system, providing a microfluidic breadboard platform for the formation of fluidic network and fluidic sealing upon a system assembly. Modular microfluidic elements or nullchipsnull are arranged on a precisely machined alignment base to form a fluidic network, with fluid connections provided directly from chip-to-chip at overlapping corners. Fluidic access to external devices is possible at every fluid connection and through special ingress/egress chips. By maintaining a largely planar layout, optical access is provided for detecting or visualization for every chip. The assembly may be covered by a perforated cover plate.
摘要翻译：可重构模块化微流体系统，提供用于在系统组件上形成流体网络和流体密封的微流体面包板平台。模块化微流体元件或“芯片”被布置在精确加工的对准基底上以形成流体网络，其中在重叠的角落处直接从芯片到芯片提供流体连接。在每个流体连接和特殊的入口/出口芯片处都可以对外部设备进行流体访问。通过维持大体平面的布局，提供了光学访问，用于每个芯片的检测或可视化。组件可以被穿孔盖板覆盖。

134. 发明授权

US06674525B2 Split focusing cytometer 有权
标题翻译：分离聚焦细胞仪
公开(公告)号：US06674525B2
公开(公告)日：2004-01-06
申请号：US10114790
申请日：2002-04-03
申请人： Ronald Bardell , Bernhard H. Weigl , C. Frederick Battrell
发明人： Ronald Bardell , Bernhard H. Weigl , C. Frederick Battrell
IPC分类号： G01N110
CPC分类号： G01N15/05 , A61M1/14 , A61M2206/11 , B01D21/0012 , B01D21/283 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L2200/027 , B01L2200/028 , B01L2200/0636 , B01L2200/0647 , B01L2200/0668 , B01L2300/0829 , B01L2300/0861 , B01L2300/0874 , B01L2300/0883 , B01L2400/0406 , B01L2400/0436 , B01L2400/0457 , B01L2400/0487 , B01L2400/084 , F16K7/17 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K99/0059 , F16K2099/008 , F16K2099/0084 , G01N15/0255 , G01N15/1456 , G01N2001/4016 , G01N2001/4061 , G01N2001/4094 , G01N2015/0288 , G01N2015/1411 , G01N2015/1413 , G01N2015/144 , G01N2015/1486 , G01N2035/00247 , Y10T436/25375 , Y10T436/2575
摘要： A microcytometer which combines lysing and cytometry into a unified system that achieves blood lysis and white blood cell count in a single device. The device focuses the white cells into a thin ribbon which is then focused into a single stream for analysis.
摘要翻译：将细胞裂解和细胞计数结合成统一的系统的微细胞计数仪，其在单个装置中实现血液溶解和白细胞计数。该设备将白细胞聚焦成薄带，然后将其聚焦成单个流进行分析。

135. 发明授权

US5603351A Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device 失效
标题翻译：用于抑制组合化学装置流体中交叉污染的方法和系统
公开(公告)号：US5603351A
公开(公告)日：1997-02-18
申请号：US483331
申请日：1995-06-07
申请人： Satyam C. Cherukuri , Robert R. Demers , Zhong H. Fan , Aaron W. Levine , Sterling E. McBride , Peter J. Zanzucchi
发明人： Satyam C. Cherukuri , Robert R. Demers , Zhong H. Fan , Aaron W. Levine , Sterling E. McBride , Peter J. Zanzucchi
IPC分类号： B01F5/06 , B01J4/02 , B01J19/00 , B01L3/00 , B01L9/00 , C40B40/06 , C40B60/14 , F04B19/00 , H02N11/00 , F17D1/14 , C25B15/08 , F17D1/20
CPC分类号： B01L3/502738 , B01F15/0264 , B01J19/0046 , B01J19/0093 , B01J4/02 , B01L3/5025 , B01L3/50273 , F04B19/006 , H02N11/006 , B01F13/0059 , B01F5/0601 , B01J2219/00317 , B01J2219/00353 , B01J2219/00358 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01J2219/0068 , B01J2219/0072 , B01J2219/00722 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/00891 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0415 , B01L2400/0487 , B01L9/527 , C40B40/06 , C40B60/14 , Y10S366/03 , Y10T137/87249 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： A system and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which serves to interface and perform electro-optic measurements of material in the reaction cells of the device array. The device array incorporates a modular configuration with three distinct layers or plates. The device array comprises a top feedthru plate, a center distribution plate and a bottom cell plate. The three plates are stacked vertically and coupled together to form a liquid-tight seal. Reservoirs, microchannels and reactions cells are controllably etched onto the plates using traditional semiconductor fabrication techniques. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate. The center distribution plate comprises a plurality of micron sized reservoirs, microchannels, reservoir feeds, cell feeds and overflow feeds for the distribution of reagent fluids to the reaction cells located in the bottom cell plate. The detachable bottom cell plate serves as a microlaboratory tray of reaction cells. Once the proper reagents or other materials are introduced into the reaction cells, the bottom cell plate is decoupled from the device array and removed for incubation or analysis.
摘要翻译：一种用于并行地实现多个组合过程的系统和方法，包括具有微米级贮存器的微电子和流体阵列（器件阵列），连接微通道和蚀刻到衬底中的反应池。设备阵列由站来支持，该站用于对设备阵列的反应单元中的材料进行接口和电光测量。器件阵列包含具有三个不同层或板的模块化配置。装置阵列包括顶部进料板，中心分配板和底部单元板。三个板垂直堆叠并且联接在一起以形成液密密封。使用传统的半导体制造技术将储存器，微通道和反应池可控地蚀刻到板上。顶部进料板用作装置阵列的盖，并且包含选择性地定位在位于中心分布板中的储存器上方的孔。中心分配板包括多个微米尺寸的储存器，微通道，储存器进料，细胞进料和用于将试剂流体分配到位于底部单元板中的反应池的溢流进料。可拆卸的底部细胞板用作反应池的微实验托盘。一旦将适当的试剂或其他材料引入反应池中，底部细胞板与装置阵列分离并去除以进行孵育或分析。

136. 发明授权

US5519635A Apparatus for chemical analysis with detachable analytical units 失效
标题翻译：具有可拆卸分析单元的化学分析装置
公开(公告)号：US5519635A
公开(公告)日：1996-05-21
申请号：US301028
申请日：1994-09-06
申请人： Ryo Miyake , Masaharu Ishii , Hideo Enoki , Isao Yamazaki , Kazumichi Imai , Tadafumi Kuroishi , Yu-ming Hsueh
发明人： Ryo Miyake , Masaharu Ishii , Hideo Enoki , Isao Yamazaki , Kazumichi Imai , Tadafumi Kuroishi , Yu-ming Hsueh
IPC分类号： G01N1/00 , B01L3/00 , B01L9/00 , G01N30/02 , G01N30/34 , G01N30/60 , G01N30/86 , G01N30/88 , G01N35/00 , G01N35/08 , G01N37/00 , G01N35/10
CPC分类号： B01F13/0059 , B01F5/0475 , B01F5/0485 , B01L3/502715 , B01L9/527 , G01N30/88 , G01N35/085 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L3/0268 , B01L3/502753 , G01N2030/027 , G01N2030/8881 , G01N2035/00326 , G01N30/60 , G01N30/6095 , Y10T436/11 , Y10T436/25375 , Y10T436/2575
摘要： In order to provide an apparatus for chemical analysis capable of eliminating time consuming changing connections of flow paths and analytical elements, and of operating for analysis without any special knowledge, the apparatus for chemical analysis comprises a main body of analytical apparatus provided with sampling device for sucking sample, liquid controller for transferring the sucked sample and reagents, and detector for measuring the sample, and analytical unit provided with a liquid connector and a signal connector for connecting to the main body of analytical apparatus, and memory storing at least analytical method, and analysis of the sample is performed by attaching and fixing the analytical unit to said main body of analytical apparatus, transferring at least analytical method stored in the memory to the main body of analytical apparatus, and analyzing the sample in accordance the said analytical method.
摘要翻译：为了提供一种用于化学分析的设备，其能够消除流路和分析元件的耗时变化的连接以及在没有任何特殊知识的情况下进行分析的操作，所述用于化学分析的装置包括分析装置的主体，其具有采样装置吸取样品，用于转移吸取的样品和试剂的液体控制器和用于测量样品的检测器;以及分析单元，其具有连接到分析装置的主体的液体连接器和信号连接器，以及至少存储至少分析方法的存储器，通过将分析单元附着并固定在分析装置的主体上，至少将存储在存储器中的分析方法转移到分析装置的主体，并根据所述分析方法分析样品来进行样品的分析。

137. 发明授权

US4814144A Centrifugal analyzer rotor unit and insert elements 失效
标题翻译：离心分析仪转子单元和插入元件
公开(公告)号：US4814144A
公开(公告)日：1989-03-21
申请号：US559521
申请日：1983-12-08
申请人： Hermann Edelmann , Anton Pasch , Sigmar Klose , Hans-Peter Haar , Karlheinz Mann
发明人： Hermann Edelmann , Anton Pasch , Sigmar Klose , Hans-Peter Haar , Karlheinz Mann
IPC分类号： G01N33/48 , B01F5/06 , B01F13/00 , B04B5/04 , G01N21/07 , G01N35/00 , G01N37/00
CPC分类号： B01L3/5027 , B01F15/0233 , B01F5/0641 , B01F5/0682 , B01F5/0694 , B04B5/0407 , G01N21/07 , B01F13/0059 , B01L2200/028 , B01L2200/16 , B01L2300/021 , B01L2300/0806 , B01L2400/0409
摘要： A rotor unit for a centrifugal analyzer comprises a rotatably-driven circular rotor base; and a rotor head comprising a plurality of insert elements each having at least one chamber sample for the reception of a sample liquid, at least one measuring chamber radially outwardly from the associated sample chamber for the measurement of characteristic parameters for the detection of components of the sample, at least one liquid channel connecting the sample chamber with the measuring chamber and each insert element is releasably mounted on the rotor base at any one of a plurality of different selectable angular positions wherein the insert element is positionally stable when the rotor base is rotating.
摘要翻译：用于离心分析器的转子单元包括可旋转驱动的圆形转子基座; 以及转子头，其包括多个插入元件，每个插入元件具有至少一个用于接收样品液体的室样品，至少一个从相关联的样品室径向向外的测量室，用于测量用于检测样品的组分的特征参数样品，将样品室与测量室连接的至少一个液体通道和每个插入元件可以以多个不同的可选角度位置中的任何一个可释放地安装在转子基座上，其中当转子基座旋转时，插入元件位置稳定。

138. 发明授权

US4589551A Container for handling, transportation and storage of microscope slides 失效
标题翻译：用于处理，运输和储存显微镜载玻片的容器
公开(公告)号：US4589551A
公开(公告)日：1986-05-20
申请号：US636319
申请日：1984-07-31
申请人： Keith Hellon
发明人： Keith Hellon
IPC分类号： B01L9/00 , G02B21/34 , B65D85/48 , B65D1/36
CPC分类号： B01L9/52 , G02B21/34 , B01L2200/028 , B01L2300/043 , B01L2300/0822
摘要： A container for handling, transportation and storage of microscope slides includes a plurality of individual microscope slide-receiving compartments. Each compartment includes a plurality of rounded protuberances extending upwardly in each individual compartment for contacting a lower surface of the microscope slide to space the microscope slide upwardly from an inner surface of the compartments and a plurality of rounded protuberances extending downwardly from one or more cover members to restrain vertical slide movement while maintaining longitudinal and lateral spacing of the microscope slides. The container includes one or more plastic cover members having a generally planar surface overlying the plurality of microscope slides when the cover is in a closed position including a plurality of downwardly extending rounded protuberances within each of the slide-receiving compartments for vertical restraint of each microscope slide with minimum contact against the specimen-receiving face of each slide. The container covers are secured to the container by elongated, flexible hinge material to enable the cover member to be rotated or articulated from the closed position to an open, stackable position disposed adjacent an outer, lower surface of the container. Each cover member includes a plurality of alignment posts received within indentations within a ledge surface of partition walls forming the container compartments to maintain the cover members in a fixed position.
摘要翻译：用于处理，运输和储存显微镜载玻片的容器包括多个单独的显微镜载玻片容纳室。每个隔室包括多个圆形突起，每个圆形突起在每个单独的隔室中向上延伸，用于接触显微镜载玻片的下表面，以将显微镜载玻片从隔室的内表面向上空间，以及从一个或多个盖构件向下延伸的多个圆形突起以保持垂直滑动运动，同时保持显微镜载玻片的纵向和横向间距。容器包括一个或多个塑料盖构件，当盖处于关闭位置时，其具有覆盖多个显微镜载玻片的大致平面的表面，该闭合位置包括在每个滑动容纳隔室内的多个向下延伸的圆形突起，用于每个显微镜的垂直约束以与每张幻灯片的样本接收面最少接触的方式滑动。容器盖通过细长的柔性铰链材料固定到容器上，以使得盖构件能够从关闭位置旋转或铰接到邻近容器的外部下表面设置的打开的可堆叠位置。每个盖构件包括多个对准柱，其接收在形成容器隔室的分隔壁的凸缘表面内的凹陷内，以将盖构件保持在固定位置。

139. 发明申请

US20190217304A1 VARIABLE SPACING RACK 审中-公开
公开(公告)号：US20190217304A1
公开(公告)日：2019-07-18
申请号：US16327263
申请日：2017-08-21
申请人： BIOCONTROL SYSTEMS, INC.
发明人： Joseph Berry
IPC分类号： B01L9/06 , B01L7/00
CPC分类号： B01L9/06 , B01L7/52 , B01L2200/022 , B01L2200/028 , B01L2300/0829
摘要： A variable spacing PCR amp tube rack can include a plurality of rotors and a plurality of carriages engaged with the rotors so that rotation of the rotors causes translation of the carriages with respect to one another. The rack can include a blade assembly that allows an operator to separate sets of coupled PCR amp tubes from one another. The rack can be designed to accommodate 0.1 ml PCR amp tubes and adjust their spacing from 4.5 mm to 9.0 mm.

140. 发明申请

US20190210020A1 HIGH DENSITY NANOFLUIDICS 审中-公开
公开(公告)号：US20190210020A1
公开(公告)日：2019-07-11
申请号：US16238873
申请日：2019-01-03
申请人： Genturi, Inc.
发明人： Jeff KROGMEIER , Hardeep SINGH , Robert DUBROW , Laurent MENARD , Andrew GOLDEN , Samrudhi SHARMA
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/028 , B01L2200/12 , B01L2300/0848 , B01L2300/0858 , B01L2300/0877 , B01L2300/0896 , B01L2300/123 , B01L2400/0415
摘要： Nanofluidic chips are described herein that are configured for high-volume manufacturing and maintaining sample integrity in multiplexed devices comprising: at least two devices, wherein each device comprises at least one sample inlet and at least one nanochannel; and a detection region, wherein the at least two devices pass through the detection region and wherein the at least two devices are fluidically distinct from the inlet through the detection region, and wherein actuation energy can be applied independently to at least two devices.

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