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91. 发明授权

US07978326B2 DNA sequencing system 有权
标题翻译： DNA测序系统
公开(公告)号：US07978326B2
公开(公告)日：2011-07-12
申请号：US12630683
申请日：2009-12-03
申请人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura, legal representative
发明人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

92. 发明申请

US20110159549A1 Temperature control for light-emitting diode stabilization 审中-公开
标题翻译：温度控制用于发光二极管稳定
公开(公告)号：US20110159549A1
公开(公告)日：2011-06-30
申请号：US12895848
申请日：2010-09-30
申请人： Mark F. Oldham , Vinod L. Mirchandani
发明人： Mark F. Oldham , Vinod L. Mirchandani
IPC分类号： C12P19/34 , H01J7/24
CPC分类号： G01N21/64 , F21K9/00 , F21K9/64 , F21V29/54 , F21V29/677 , F21V29/74 , F21Y2115/10 , G01J3/0286 , G01J3/10 , G01N21/645 , G01N21/6452 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2201/0638 , G01N2201/1211 , G05D23/1919 , G05D23/20
摘要： A system is provided that includes a light-emitting diode (LED); a temperature sensor in thermal contact with the LED and capable of measuring an operating temperature and generating an operating temperature signal; and a temperature regulating system capable of receiving the operating temperature signal and regulating the operating temperature based on the operating temperature signal. A method for stabilizing the temperature of an LED is provided. A method is provided that includes providing a system comprising an LED, a reaction region, and a sample in the reaction region; generating excitation beams with the LED; directing excitation beams to the sample; detecting an optical property of the sample to obtain detection data; measuring the- operating temperature of the light emitting diode; and adjusting the detection data of an excitation beam characteristic shift related to the operating temperature, when the LED is operated at the operating temperature to generate the excitation beams.
摘要翻译：提供一种包括发光二极管（LED）的系统; 与LED热接触的温度传感器，能够测量工作温度并产生工作温度信号; 以及能够基于工作温度信号接收工作温度信号和调节工作温度的温度调节系统。提供了一种用于稳定LED的温度的方法。提供了一种方法，其包括在反应区域中提供包括LED，反应区域和样品的系统; 用LED产生激励光束; 将激发光束引导到样品; 检测样品的光学特性以获得检测数据; 测量发光二极管的工作温度; 并且当LED在工作温度下操作以产生激发光束时，调整与工作温度相关的激发光束特性偏移的检测数据。

93. 发明授权

US07955864B2 Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other 有权
标题翻译：使与第二流体接触的第一流体的离散体积彼此不混溶的装置和方法
公开(公告)号：US07955864B2
公开(公告)日：2011-06-07
申请号：US11508044
申请日：2006-08-22
申请人： David M. Cox , Willy Wiyatno , Mark F. Oldham , James C. Nurse , Douglas P. Greiner , Sam L. Woo , Richard T. Reel , Dennis A. Lehto , Linda G. Lee , Janusz B. Wojtowicz
发明人： David M. Cox , Willy Wiyatno , Mark F. Oldham , James C. Nurse , Douglas P. Greiner , Sam L. Woo , Richard T. Reel , Dennis A. Lehto , Linda G. Lee , Janusz B. Wojtowicz
IPC分类号： G01N1/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.
摘要翻译：在本申请中描述的各种实施例涉及用于在管道内产生与第二流体不混溶的一种或多种流体的离散体积的装置，系统和方法。离散体积可用于涉及小体积的生物化学或分子生物学过程，例如微升体积，纳升级体积或更小体积。该系统可以包括一种装置，该装置包括至少一个导管，其操作地连接到一个或多个泵，用于提供通过与离散体积的流体不混溶的流体彼此分离的离散体积，例如水不混溶流体 - 油分离体积。

94. 发明授权

US07871810B2 Multiaxis focusing mechanism for microarray analysis 有权
标题翻译：用于微阵列分析的多轴聚焦机制
公开(公告)号：US07871810B2
公开(公告)日：2011-01-18
申请号：US10980886
申请日：2004-11-03
申请人： Scott R. Warren , Louis B. Hoff , Mark F. Oldham
发明人： Scott R. Warren , Louis B. Hoff , Mark F. Oldham
IPC分类号： C12M1/00 , G01N15/06 , G01N21/47
CPC分类号： G06K9/00127 , G06K9/32
摘要： Systems and methods for positioning a multi-featured biological array relative to a signal acquisition device. Detection of the array's positional deviation may be achieved by a calibration beam reflected from the array surface and detected by a position sensitive detector (PSD). The PSD-measured positional deviation can be transformed and used in a control loop to correct for positional variations of the array. The calibration beam and PSD may also be used to detect the array or feature boundaries, thereby allowing lateral centering or positioning of the array relative to the signal acquisition device.
摘要翻译：用于相对于信号采集装置定位多功能生物阵列的系统和方法。通过从阵列表面反射并由位置敏感检测器（PSD）检测的校准光束可以实现阵列位置偏差的检测。可以将PSD测量的位置偏差变换并用于控制回路中以校正阵列的位置变化。校准光束和PSD也可用于检测阵列或特征边界，从而允许阵列相对于信号采集装置的侧向对中或定位。

95. 发明申请

US20100261158A1 Method and System for Multiplex Genetic Analysis 有权
标题翻译：多重遗传分析方法与系统
公开(公告)号：US20100261158A1
公开(公告)日：2010-10-14
申请号：US11423403
申请日：2006-06-09
申请人： Eric S. Nordman , Mark F. Oldham , Timothy Woudenberg
发明人： Eric S. Nordman , Mark F. Oldham , Timothy Woudenberg
IPC分类号： C12Q1/68 , C12M1/34 , C40B60/14 , C40B60/00 , C02F1/461
CPC分类号： C12Q1/6874 , C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N21/6486 , G01N2021/6441 , C12Q2563/107
摘要： The present disclosure provides apparatus, systems and method for detecting separately and substantially simultaneously light emissions from a plurality of localized light-emitting analytes. A system according to exemplary embodiments of the present disclosure comprises a sample holder having structures formed thereon for spatially separating and constraining a plurality of light-emitting analytes each having a single nucleic acid molecule or a single nucleic acid polymerizing enzyme, a light source configured to illuminate the sample holder, an optical assembly configured to collect and detect separately and substantially simultaneously light emissions associated with the plurality of light emitting analytes. The system may further include a computer system configured to analyze the light emissions to determine the structures or properties of a target nucleic acid molecule associated with each analyte.
摘要翻译：本公开提供了用于单独和基本同时地检测来自多个局部发光分析物的光发射的装置，系统和方法。根据本公开的示例性实施例的系统包括具有形成在其上的结构的样本保持器，用于空间分离和约束各自具有单个核酸分子或单个核酸聚合酶的多个发光分析物，光源被配置为照亮样品架，光学组件被配置成分别收集和检测与多个发光分析物相关联的基本上同时的发光。该系统还可以包括被配置为分析光发射以确定与每个分析物相关联的靶核酸分子的结构或性质的计算机系统。

96. 发明申请

US20100216143A1 Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength 审中-公开
标题翻译：通过激发波长区分多个荧光信号的装置和方法
公开(公告)号：US20100216143A1
公开(公告)日：2010-08-26
申请号：US12642009
申请日：2009-12-18
申请人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
发明人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
IPC分类号： C12Q1/68 , G01J1/58
摘要： An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.
摘要翻译：提供一种用于通过激发波长区分多个可检测信号的装置和方法。该装置可以包括可以例如在一个井中的样品保留区域中的样品发射相应的激发光波长或波长范围的光源。样品可以包含两种或更多种可检测的标记，例如荧光染料，其中当荧光染料在靶组分存在下被激发时，其能够产生增加的可检测的发射。可检测标记物可以具有与其它可检测标记物的范围重叠的激发波长范围和/或发射波长范围。可以设置检测器，用于检测在至少一个其他标记的重叠波长范围内从第一标记发射的发射波长或波长范围。

97. 发明申请

US20100193672A1 Optical Camera Alignment 有权
标题翻译：光学相机对准
公开(公告)号：US20100193672A1
公开(公告)日：2010-08-05
申请号：US12534802
申请日：2009-08-03
申请人： Barry J. Blasenheim , H. Pin Kao , Mark F. Oldham
发明人： Barry J. Blasenheim , H. Pin Kao , Mark F. Oldham
IPC分类号： G01N21/63
CPC分类号： G01N21/253 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L7/52 , B01L9/50 , B01L9/523 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/0099 , G01N35/028 , G01N35/1002 , G01N35/1074 , G01N2035/00287 , G01N2035/00366 , G01N2035/0405 , G01N2035/0425 , G01N2035/1039
摘要： A camera alignment system that can enable alignment in at least one of three planes and about an axis of at least one of the planes. An alignment mount can mate to a camera and lens. The alignment mount can comprise a mechanism to adjust the camera relative to the lens to that an image plane of the camera aligns with an image plane of the lens in a predetermined orientation. One predetermined orientation can be that the image plane of the camera being parallel to the image plane of the lens.
摘要翻译：一种相机对准系统，其能够实现三个平面中的至少一个和至少一个平面的轴线的对准。对准安装座可与摄像机和镜头配合使用。对准安装座可以包括一个机构，用于相机相对于镜头调整到照相机的图像平面与预定取向的透镜的图像平面对准。一个预定方向可以是相机的图像平面平行于透镜的图像平面。

98. 发明申请

US20090305909A1 Method and System for Multiplex Genetic Analysis 审中-公开
标题翻译：多重遗传分析方法与系统
公开(公告)号：US20090305909A1
公开(公告)日：2009-12-10
申请号：US12482815
申请日：2009-06-11
申请人： Eric S. Nordman , Mark F. Oldham , Timothy Woudenberg
发明人： Eric S. Nordman , Mark F. Oldham , Timothy Woudenberg
IPC分类号： C40B50/18 , C40B50/14
CPC分类号： C12Q1/6874 , C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N21/6486 , G01N2021/6441 , C12Q2563/107
摘要： A method for selectively immobilizing a molecule of interest on a substrate is disclosed. A substrate having a first surface component and a second surface component is provided. The first and second surface components have different surface characteristics. The molecule of interest is selectively coupled to the first surface component based upon a difference between the surface characteristics of the first surface component and the surface characteristics of the second surface component.
摘要翻译：公开了一种用于选择性地将感兴趣的分子固定在基底上的方法。提供了具有第一表面部件和第二表面部件的基板。第一和第二表面部件具有不同的表面特性。基于第一表面成分的表面特性和第二表面成分的表面特性之间的差异，感兴趣的分子选择性地耦合到第一表面成分。

99. 发明授权

US07570443B2 Optical camera alignment 有权
标题翻译：光学相机对准
公开(公告)号：US07570443B2
公开(公告)日：2009-08-04
申请号：US11086275
申请日：2005-03-22
申请人： Barry J. Blasenheim , H. Pin Kao , Mark F. Oldham
发明人： Barry J. Blasenheim , H. Pin Kao , Mark F. Oldham
IPC分类号： G02B7/02
CPC分类号： G01N21/253 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L7/52 , B01L9/50 , B01L9/523 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/0099 , G01N35/028 , G01N35/1002 , G01N35/1074 , G01N2035/00287 , G01N2035/00366 , G01N2035/0405 , G01N2035/0425 , G01N2035/1039
摘要： A camera alignment system that can enable alignment in at least one of three planes and about an axis of at least one of the planes. An alignment mount can mate to a camera and lens. The alignment mount can comprise a mechanism to adjust the camera relative to the lens to that an image plane of the camera aligns with an image plane of the lens in a predetermined orientation. One predetermined orientation can be that the image plane of the camera being parallel to the image plane of the lens.
摘要翻译：一种相机对准系统，其能够实现三个平面中的至少一个和至少一个平面的轴线的对准。对准安装座可与摄像机和镜头配合使用。对准安装座可以包括一个机构，用于相机相对于镜头调整到照相机的图像平面与预定取向的透镜的图像平面对准。一个预定方向可以是相机的图像平面平行于透镜的图像平面。

100. 发明申请

US20090140128A1 Methods, systems and apparatus for light concentrating mechanisms 审中-公开
标题翻译：光浓缩机制的方法，系统和装置
公开(公告)号：US20090140128A1
公开(公告)日：2009-06-04
申请号：US12284109
申请日：2008-09-18
申请人： Mark F. Oldham , Eric S. Nordman , Charles R. Connell , Sun Hongye , Steven M. Blair , Christina E. Inman
发明人： Mark F. Oldham , Eric S. Nordman , Charles R. Connell , Sun Hongye , Steven M. Blair , Christina E. Inman
IPC分类号： G12B21/06
CPC分类号： G01N21/648 , G01N2021/6432
摘要： An embodiment relates generally to resonant structure. The resonant structure includes a substrate and a nano-bowtie antenna deposited over the substrate. The resonant structure also includes an enclosure deposited over the substrate and surrounding the nano-bowtie antenna, where the enclosure is configured to raise an enhancement level in the nano-bowtie antenna.
摘要翻译：实施例一般涉及谐振结构。谐振结构包括沉积在衬底上的衬底和纳米蝴蝶结天线。谐振结构还包括沉积在衬底上并围绕纳米天线的外壳，其中外壳被配置为提高纳米天线的增强水平。

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