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91. 发明申请

US20070078146A1 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US20070078146A1
公开(公告)日：2007-04-05
申请号：US10840734
申请日：2004-05-05
申请人： Ashok Naraian , Michael Clare , Paul Collins , Joyce Crich , Rajesh Devraj , Daniel Flynn , Lifeng Geng , Matthew Graneto , Cathleen Hanau , Gunnar Hanson , Susan Hartmann , Michael Hepperle , He Huang , Ish Khanna , Francis Koszyk , Shuyuan Liao , Suzanne Metz , Win Naing , Richard Partis , Thao Perry , Shashidhar Rao , Shaun Selness , Michael South , Michael Stealey , John Talley , Michael Vazquez , John Walker , Richard Weier , Xiangdong Xu , Syaulan Yang , Yi Yu
发明人： Ashok Naraian , Michael Clare , Paul Collins , Joyce Crich , Rajesh Devraj , Daniel Flynn , Lifeng Geng , Matthew Graneto , Cathleen Hanau , Gunnar Hanson , Susan Hartmann , Michael Hepperle , He Huang , Ish Khanna , Francis Koszyk , Shuyuan Liao , Suzanne Metz , Win Naing , Richard Partis , Thao Perry , Shashidhar Rao , Shaun Selness , Michael South , Michael Stealey , John Talley , Michael Vazquez , John Walker , Richard Weier , Xiangdong Xu , Syaulan Yang , Yi Yu
IPC分类号： A61K31/506 , A61K31/4439 , C07D43/02
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D473/00 , C07D487/04 , C07D491/10 , C07D495/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶药物障碍。特别感兴趣的化合物由式IA定义，其中R 1，R 2，R 3和R 4是如说明书中所述。

92. 发明申请

US20060211694A1 Diaryl substituted pyridinones 失效
标题翻译：二芳基取代的吡啶酮
公开(公告)号：US20060211694A1
公开(公告)日：2006-09-21
申请号：US11226556
申请日：2005-09-14
申请人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
发明人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
IPC分类号： A61K31/53 , A61K31/506 , A61K31/498 , A61K31/497 , A61K31/501 , A61K31/4439 , A61K31/4747 , A61K31/4709 , A61K31/4412
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， >和R 5＆gt;在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

94. 发明授权

US07067540B2 Substituted pyridinones 有权
标题翻译：取代的吡啶酮
公开(公告)号：US07067540B2
公开(公告)日：2006-06-27
申请号：US10367987
申请日：2003-02-14
申请人： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
发明人： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
IPC分类号： A61K31/44 , C07D213/02 , C07D401/02
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， >和R 5＆gt;在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

95. 发明授权

US07037507B2 T helper cell epitopes 失效
标题翻译： T辅助细胞表位
公开(公告)号：US07037507B2
公开(公告)日：2006-05-02
申请号：US10935155
申请日：2004-09-08
申请人： David Charles Jackson , Souravi Ghosh , John Walker
发明人： David Charles Jackson , Souravi Ghosh , John Walker
IPC分类号： A61K39/175
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/57 , C07K2319/00 , C12N2760/18422
摘要： The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of SSKTQTHTQQDRPPQPS (SEQ ID NO: 1); QPSTELEETRTSRARHS (SEQ ID NO: 2); QSLRTSLEQSNKAIEEI (SEQ ID NO: 18); and DESSCVFVSESAICSQN (SEQ ID NO: 23).
摘要翻译：本发明提供了用于诱导包含这些表位中的至少一个的免疫应答的T辅助细胞表位和组合物。表位包含在选自SSKTQTHTQQDRPPQPS（SEQ ID NO：1）的肽序列中; QPSTELEETRTSRARHS（SEQ ID NO：2）; QSLRTSLEQSNKAIEEI（SEQ ID NO：18）; 和DESSCVFVSESAICSQN（SEQ ID NO：23）。

96. 发明申请

US20050273203A1 Accurate blending module and method 有权
标题翻译：精确的混合模块和方法
公开(公告)号：US20050273203A1
公开(公告)日：2005-12-08
申请号：US11125640
申请日：2005-05-09
申请人： Louis Bellafiore , James Sanderson , John Walker
发明人： Louis Bellafiore , James Sanderson , John Walker
IPC分类号： G05B21/00 , G05D21/02
CPC分类号： G05D21/02
摘要： An accurate blending module for adjusting the pH of solutions containing therapeutic proteins includes a recirculation loop that receives the therapeutic protein solution via a feed pump and an acid solution via an adjusting pump. The recirculation loop includes a recirculation pump and a pH sensor that detects the pH of the solution in the recirculation loop. A controller communicates with the pH sensor and the adjusting pump. The adjusting pump adds acid to the recirculation loop based on the pH readings taken by the pH sensor. The recirculation pump recirculates the therapeutic protein solution and acid in the recirculation loop so that it is mixed. As a result, the pH of the therapeutic protein solution is precisely controlled and adjusted in a non-destructive fashion.
摘要翻译：用于调节含有治疗性蛋白质的溶液的pH的精确混合模块包括通过经由调节泵的进料泵和酸溶液接收治疗性蛋白质溶液的再循环回路。再循环回路包括再循环泵和pH传感器，其检测再循环回路中的溶液的pH。控制器与pH传感器和调节泵通信。调节泵根据pH传感器采集的pH读数，向再循环回路添加酸。再循环泵将治疗性蛋白质溶液和酸循环到再循环回路中，使其混合。结果，治疗性蛋白质溶液的pH被非破坏性地精确地控制和调节。

97. 发明申请

US20050176775A1 Substituted pyridinones 审中-公开
标题翻译：取代的吡啶酮
公开(公告)号：US20050176775A1
公开(公告)日：2005-08-11
申请号：US10918826
申请日：2004-08-13
申请人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marrufo , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
发明人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marrufo , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
IPC分类号： A61K20060101 , A61K31/4412 , A61K31/4415 , A61K31/4439 , A61P29/00 , C07D211/86 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/84 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04 , C07D41/02
CPC分类号： C07D213/69 , C04B35/632 , C07D213/64 , C07D213/70 , C07D213/73 , C07D213/80 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04
摘要： Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式I的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， SUB＆gt;和R 5＆gt;在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

98. 发明申请

US20050164402A1 Sample presentation device 审中-公开
标题翻译：样品展示装置
公开(公告)号：US20050164402A1
公开(公告)日：2005-07-28
申请号：US11036707
申请日：2005-01-13
申请人： Christopher Belisle , John Walker , Sarah Ngola , Douglas Greiner , Mark Levy , Xiaoxia Zhao , Irene Chen , Mark Stolowitz , Donald Paquin
发明人： Christopher Belisle , John Walker , Sarah Ngola , Douglas Greiner , Mark Levy , Xiaoxia Zhao , Irene Chen , Mark Stolowitz , Donald Paquin
IPC分类号： B01L3/00 , C23C26/00 , C23C30/00 , G01N1/00
CPC分类号： B01L3/5085 , B01L3/502707 , B01L3/502792 , B01L3/5088 , B01L2200/12 , B01L2300/087 , B01L2300/089 , B82Y15/00 , B82Y30/00 , C23C26/00 , C23C30/00 , Y10T436/24 , Y10T436/25
摘要： The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.
摘要翻译：本发明涉及可用于执行分析测量的样本呈现装置。这些装置已被配置成能够实现液体处理的各个方面，例如：保留，储存，运输，集中，定位和转移。此外，这些设备可以增强分析物的检测和表征。本发明的样品展示装置由具有不同润湿性的多个区域的一个或多个基材组成。公开了使用本发明的样品呈现装置分析样品的方法，以及制备样品显示装置的方法。

99. 发明申请

US20050154913A1 Method and apparatus for handling user identities under single sign-on services 有权
标题翻译：在单点登录服务下处理用户身份的方法和装置
公开(公告)号：US20050154913A1
公开(公告)日：2005-07-14
申请号：US10504954
申请日：2003-02-28
申请人： Luis Barriga , Avelina Pardo-Blazquez , John Walker , Jesus-Angel de Gregorio
发明人： Luis Barriga , Avelina Pardo-Blazquez , John Walker , Jesus-Angel de Gregorio
IPC分类号： H04L9/32 , G06F1/00 , G06F15/00 , G06F21/00 , G06F21/20 , H04L9/00 , H04L29/06 , H04L29/08 , H04W12/06
CPC分类号： H04L63/0815 , G06F21/33 , G06F21/41 , G06F2221/2115 , H04L63/0884 , H04L67/04 , H04L67/1002 , H04L67/16 , H04W12/06
摘要： An apparatus and method for providing Single Sign-On services to a user when accessing a selected Service Provider from a plurality of Service Providers. An Authentication Provider authenticates the user at with a user-identity, provides the user with a token as proof of the authentication, and assigns a temporary alias-identity to the user for use when the user accesses the selected Service Provider. The Authentication Provider and the selected Service Provider link the assigned alias-identity and the user-identity to identify the user at respective sites. The user accesses the selected Service Provider by presenting the token along with a local user-identity valid for the selected Service Provider. When the user attempts a subsequent access at the selected Service Provider, the user is identified by the shared alias-identity, if the user allowed permanent linking. If the user did not allow permanent linking, the process is repeated for each subsequent access.
摘要翻译：一种用于在从多个服务提供商访问所选服务提供商时向用户提供单点登录服务的装置和方法。认证提供者以用户身份认证用户，向用户提供令牌作为认证的证明，并且向用户分配临时别名身份以供用户访问所选择的服务提供商时使用。认证提供者和所选择的服务提供商链接所分配的别名身份和用户身份以识别相应站点处的用户。用户通过呈现令牌以及对所选服务提供商有效的本地用户身份来访问所选择的服务提供商。当用户尝试在所选服务提供商处的后续访问时，如果用户允许永久链接，则该用户被共享的别名标识。如果用户不允许永久链接，则对每个后续访问重复该过程。

100. 发明申请

US20050093560A1 New methodology to measure many more transistors on the same test area 有权
标题翻译：在同一测试区域测量更多晶体管的新方法
公开(公告)号：US20050093560A1
公开(公告)日：2005-05-05
申请号：US10696320
申请日：2003-10-29
申请人： Franklin Duan , Minxuan Liu , John Walker , Nabil Mansour , Carl Monzel
发明人： Franklin Duan , Minxuan Liu , John Walker , Nabil Mansour , Carl Monzel
IPC分类号： G01R31/28 , G01R31/02
CPC分类号： G01R31/2884
摘要： A test methodology which provides that test structures, such as transistors, are arranged in a plurality of rows. A logic circuit controls which row is to be measured. An incrementer receives a triggering signal and functions as an address adder. Each time the triggering signal rises from 0 to 1, the output of the incrementer increases by 1. The output of the incrementer serves as the address input into a decoder. The decoder is connected to the rows of test structures. Preferably, each test structure contains a control circuit which is controlled by this signal (i.e., the output of the decoder). If the test structures are transistors, bias to each of the transistors can be applied separately with a common gate, source and well, and measurement can be done with a separate drain node.
摘要翻译：提供诸如晶体管的测试结构的测试方法被布置成多行。逻辑电路控制要测量哪一行。增量器接收触发信号并用作地址加法器。每当触发信号从0上升到1时，增量器的输出增加1.加法器的输出作为输入到解码器的地址。解码器连接到测试结构的行。优选地，每个测试结构包含由该信号（即解码器的输出）控制的控制电路。如果测试结构是晶体管，则可以使用公共栅极，源极和阱单独施加对每个晶体管的偏置，并且可以使用单独的漏极节点进行测量。

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