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1. 发明授权

US08686185B2 Manufacturing method of 2-hydroxy-5-phenylalkylaminobenzoic acid derivatives and their salts 有权
标题翻译： 2-羟基-5-苯基烷基氨基苯甲酸衍生物及其盐的制备方法
公开(公告)号：US08686185B2
公开(公告)日：2014-04-01
申请号：US12742217
申请日：2008-10-30
申请人： Byoung Joo Gwag , Jae Young Cho , Young Ae Lee , Cheng Qiling , Yulian Wu , Li Xing
发明人： Byoung Joo Gwag , Jae Young Cho , Young Ae Lee , Cheng Qiling , Yulian Wu , Li Xing
IPC分类号： C07C229/64
CPC分类号： C07C227/18 , C07C229/64
摘要： The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylamino benzoic acid derivatives represented by specific Chemical formulas or their salts, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino]benzoic acid or its salt.
摘要翻译：本发明提供了用于大规模生产由特定化学式表示的2-羟基-5-（取代的）苯基烷基氨基苯甲酸衍生物或其盐，特别是2-羟基-5- [2-（4-三氟甲基苯基）乙基氨基] 苯甲酸或其盐。

2. 外观设计

USD677546S1 Oscillating tool working attachment 有权
标题翻译：振动工具工作附件
公开(公告)号：USD677546S1
公开(公告)日：2013-03-12
申请号：US29396463
申请日：2011-06-30
申请人： Hongtao Zhou , Li Xing , Baijun Zhang
设计人： Hongtao Zhou , Li Xing , Baijun Zhang

3. 发明申请

US20110185581A1 COMPACT CIRCULAR SAW 审中-公开
标题翻译：紧凑圆锯
公开(公告)号：US20110185581A1
公开(公告)日：2011-08-04
申请号：US12835393
申请日：2010-07-13
申请人： Li Xing , Yibao Zhang , Feng Zhang
发明人： Li Xing , Yibao Zhang , Feng Zhang
IPC分类号： B23D45/16 , B25F5/02
CPC分类号： B23D45/16 , B25F5/02
摘要： A circular saw includes a housing, a motor having a rotating axis and a center of gravity on the rotating axis, a handle, a circular blade, a fixed guard, and a base plate having a width supporting the housing. The motor and the circular blade are parallel or coplanar with respect to each other and the circular saw does not extend beyond the width of the base plate in the width direction.
摘要翻译：圆锯包括壳体，具有旋转轴线的旋转轴线和重心在旋转轴上的电机，手柄，圆形刀片，固定护罩和具有支撑壳体的宽度的底板。马达和圆形刀片相对于彼此平行或共面，并且圆锯不延伸超过基板在宽度方向上的宽度。

4. 发明申请

US20100189648A1 INHIBITORS FOR DISRUPTING THE INTERACTION OF UBIQUITINATION RELATED ENZYMES AND USES THEREOF 审中-公开
标题翻译：抑制UBIQUITINATION相关酶的相互作用的抑制剂及其用途
公开(公告)号：US20100189648A1
公开(公告)日：2010-07-29
申请号：US12513154
申请日：2007-11-01
申请人： Lan Huang , Li Xing
发明人： Lan Huang , Li Xing
IPC分类号： A61K31/437 , C07D471/04 , C07D231/18 , A61K31/415 , C07D239/93 , A61K31/517 , C07D209/20 , A61K31/404 , A61K49/00 , A61P35/00 , G06G7/48 , C12N9/00
CPC分类号： A61K31/403 , A61K31/415 , A61K31/437 , A61K31/517 , C07D209/14 , C07D231/18 , C07D239/93 , C07D471/04
摘要： A hydrophobic binding pocket on ubiquitin-protein ligase E3 is described, and used in designing the inhibitors disrupting ubiquitin conjugating enzyme E2 and E3 interaction. Four types of inhibitors designed by using the binding pocket are provided, which can be used for cancer treatment.
摘要翻译：描述了泛素 - 蛋白质连接酶E3上的疏水结合口袋，并用于设计破坏泛素缀合酶E2和E3相互作用的抑制剂。提供通过使用结合口袋设计的四种类型的抑制剂，其可用于癌症治疗。

5. 发明授权

US07259266B2 Benzopyran compounds useful for treating inflammatory conditions 失效
标题翻译：可用于治疗炎性疾病的苯并吡喃化合物
公开(公告)号：US07259266B2
公开(公告)日：2007-08-21
申请号：US10801429
申请日：2004-03-16
申请人： Jeffry Carter , David Brown , Li Xing , Karl Aston , John Springer , Francis Koszyk , Steven Kramer , Renee Huff , Yi Yu , Bruce Hamper , Subo Laio , Angela Deprow , Teresa Fletcher , E. Ann Hallinan , James Kiefer , David Limburg , Lijuan Wang , Cindy Ludwig , John McCall , John Talley
发明人： Jeffry Carter , David Brown , Li Xing , Karl Aston , John Springer , Francis Koszyk , Steven Kramer , Renee Huff , Yi Yu , Bruce Hamper , Subo Laio , Angela Deprow , Teresa Fletcher , E. Ann Hallinan , James Kiefer , David Limburg , Lijuan Wang , Cindy Ludwig , John McCall , John Talley
IPC分类号： C07D311/04
CPC分类号： C07D311/58 , C07D311/64 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D417/04 , C07D417/06 , C07D493/04
摘要： The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.
摘要翻译：本发明涉及可用于治疗与环氧合酶-2介导的病症有关的病症的方法和化合物。特别感兴趣的化合物是苯并吡喃及其由式1定义的类似物，其中Z，X，R 1，R 2，R 3和R 3， ^{4如说明书中所述。}

6. 发明授权

US07014474B2 Electrical connection and component assembly for constitution of a hard disk drive 有权
标题翻译：用于构成硬盘驱动器的电气连接和部件组装
公开(公告)号：US07014474B2
公开(公告)日：2006-03-21
申请号：US11102272
申请日：2005-04-08
申请人： Li Xing Wu , Liu Jun Zhang
发明人： Li Xing Wu , Liu Jun Zhang
IPC分类号： H01R12/00
CPC分类号： G11B33/122 , G11B5/4806 , G11B5/4853 , G11B5/486 , H01R12/62 , H01R43/0256 , H05K3/365 , H05K2201/10234 , H05K2203/041
摘要： An electrical connection and a method of electrically coupling are disclosed. In one embodiment, a circuit substrate with a first set of circuitry has a bonding pad mounted to a surface of the circuit board. The bonding pad is electrically coupled to the first set of circuitry. A flexible circuit substrate with a second set of circuitry has a connecting pad mounted to a surface of the flexible circuit substrate facing the surface of the circuit board. The connecting pad is electrically coupled to the second set of circuitry. A ball of conductive material is mounted on the bonding pad. A clamping device presses the connecting pad to the ball of conductive material.
摘要翻译：公开了电气连接和电耦合的方法。在一个实施例中，具有第一组电路的电路基板具有安装到电路板表面的焊盘。接合焊盘电耦合到第一组电路。具有第二组电路的柔性电路基板具有安装到面向电路板表面的柔性电路基板的表面的连接焊盘。连接焊盘电耦合到第二组电路。导电材料球安装在焊盘上。夹紧装置将连接垫压到导电材料球上。

7. 发明授权

US07006921B1 Method for accurately estimating pKa of molecules using atom type definitions and partial least squares 失效
标题翻译：使用原子类型定义和偏最小二乘法准确估计分子的pKa的方法
公开(公告)号：US07006921B1
公开(公告)日：2006-02-28
申请号：US09626099
申请日：2000-07-26
申请人： Li Xing , Rober C. Glen
发明人： Li Xing , Rober C. Glen
IPC分类号： G06F19/00
CPC分类号： G06F19/704
摘要： A computer implemented software method enables the prediction of the pKa of an arbitrary molecule based upon a knowledge of the molecular structure of that molecule and a statistical analysis of the molecular structures of a group of molecules (training set) for which the pKa is known. Hierarchical atom connectivity trees are constructed for the training set and the various atoms types identified in each molecule are associated in a bit string for that molecule and also associated with the experimentally determined pKa for that molecule. PLS analysis of the training set data yields coefficients associated with each atom type represented in the bit strings. A hierarchical atom connectivity tree may then be constructed for the molecule of interest. The predicted pKa is determined by multiplying the number of occurrences of each atom type in the molecule of interest by the PLS coefficient determined for that atom type and summing the resulting multiplications.
摘要翻译：基于对该分子的分子结构的了解和一组分子的分子结构的统计分析（训练集合），计算机实现的软件方法能够预测任意分子的pK a a ），已知pK 。为训练集合构建分层原子连接性树，并且在每个分子中鉴定的各种原子类型与该分子的位串相关联，并且还与该分子的实验确定的pK 相关联。训练集数据的PLS分析产生与位串中表示的每个原子类型相关联的系数。然后可以为感兴趣的分子构建分层的原子连接性树。通过将感兴趣分子中每个原子类型的出现次数乘以为该原子类型确定的PLS系数并将所得到的乘法相加来确定预测的pK 。

8. 发明申请

US20050148627A1 Benzopyran compounds for use in the treatment and prevention of inflammation related conditions 审中-公开
标题翻译：苯并吡喃化合物用于治疗和预防炎症相关病症
公开(公告)号：US20050148627A1
公开(公告)日：2005-07-07
申请号：US10801446
申请日：2004-03-16
申请人： Jeffery Carter , David Brown , Li Xing , Karl Aston , John Springer , Francis Koszyk , Steven Kramer , Sofya Tsymbalov , Renee Huff , Yi Yu , Bruce Hamper , Subo Laio , Angela Deprow , Theresa Fletcher , E. Hallinan , James Kiefer , David Limburg , Lijuan Wang
发明人： Jeffery Carter , David Brown , Li Xing , Karl Aston , John Springer , Francis Koszyk , Steven Kramer , Sofya Tsymbalov , Renee Huff , Yi Yu , Bruce Hamper , Subo Laio , Angela Deprow , Theresa Fletcher , E. Hallinan , James Kiefer , David Limburg , Lijuan Wang
IPC分类号： A61K31/353 , A61K31/382 , A61K31/47 , A61P29/00 , C07D215/54 , C07D311/58 , C07D311/64 , C07D311/94 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D493/04
CPC分类号： C07D405/04 , C07D215/54 , C07D311/58 , C07D311/64 , C07D311/94 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D493/04
摘要： The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.
摘要翻译：本发明涉及可用于治疗与环氧合酶-2介导的病症有关的病症的方法和化合物。特别感兴趣的化合物是苯并吡喃及其由式1定义的类似物，其中Z，X，R 1，R 2，R 3和R 3， ^{4如说明书中所述。}

9. 发明授权

US08906862B2 Multiple antigen delivery system using hepatitis E virus-like particle 有权
标题翻译：使用戊型肝炎病毒样颗粒的多重抗原递送系统
公开(公告)号：US08906862B2
公开(公告)日：2014-12-09
申请号：US13220356
申请日：2011-08-29
申请人： R. Holland Cheng , Li Xing , Tatsuo Miyamura , Yasuhiro Yasutomi , Tian-Cheng Li , Naokazu Takeda
发明人： R. Holland Cheng , Li Xing , Tatsuo Miyamura , Yasuhiro Yasutomi , Tian-Cheng Li , Naokazu Takeda
IPC分类号： A61K38/16 , C07K14/005 , A61K39/29 , A61K39/21 , A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/29 , A61K2039/5258 , A61K2039/541 , A61K2039/542 , C07K14/005 , C07K2319/40 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2770/28123 , C12N2770/28134 , C12N2770/28142
摘要： This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.
摘要翻译：本发明提供了用于免疫保护系统的口腔/粘膜，双重模态激活的肽/核酸组合物。

10. 发明申请

US20120060665A1 GUIDING MECHANISM FOR AN ELECTRIC TOOL 有权
标题翻译：电动工具指导机制
公开(公告)号：US20120060665A1
公开(公告)日：2012-03-15
申请号：US13218016
申请日：2011-08-25
申请人： Li Xing , Wei Dai , Shaojun Wang
发明人： Li Xing , Wei Dai , Shaojun Wang
IPC分类号： B23D59/00
CPC分类号： B23D59/00 , B25H1/0078 , Y10T83/8763 , Y10T83/8878
摘要： A guiding mechanism for an electric tool includes at least two guiding elements at least one of which has a first end portion having at least one protruding portion extending outwards therefrom and the other of which has a second end portion having at least one groove therein which may be engaged with the protruding portion. The groove has a cut-out and the protruding portion has an elastic clamping portion which may be engaged with the cut-out.
摘要翻译：电动工具的引导机构包括至少两个引导元件，其中至少一个引导元件具有第一端部部分，该第一端部部分具有从其向外延伸的至少一个突出部分，另一个引导元件具有第二端部，其中至少一个凹槽与突出部分接合。凹槽具有切口，并且突出部分具有可与切口接合的弹性夹持部分。

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