专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07515994B2 Accurate blending module and method 有权
标题翻译：精确的混合模块和方法
公开(公告)号：US07515994B2
公开(公告)日：2009-04-07
申请号：US11125640
申请日：2005-05-09
申请人： Louis Bellafiore , James Sanderson , John Walker
发明人： Louis Bellafiore , James Sanderson , John Walker
IPC分类号： G05B21/00
CPC分类号： G05D21/02
摘要： An accurate blending module for adjusting the pH of solutions containing therapeutic proteins includes a recirculation loop that receives the therapeutic protein solution via a feed pump and an acid solution via an adjusting pump. The recirculation loop includes a recirculation pump and a pH sensor that detects the pH of the solution in the recirculation loop. A controller communicates with the pH sensor and the adjusting pump. The adjusting pump adds acid to the recirculation loop based on the pH readings taken by the pH sensor. The recirculation pump recirculates the therapeutic protein solution and acid in the recirculation loop so that it is mixed. As a result, the pH of the therapeutic protein solution is precisely controlled and adjusted in a non-destructive fashion.
摘要翻译：用于调节含有治疗性蛋白质的溶液的pH的精确混合模块包括通过经由调节泵的进料泵和酸溶液接收治疗性蛋白质溶液的再循环回路。再循环回路包括再循环泵和pH传感器，其检测再循环回路中的溶液的pH。控制器与pH传感器和调节泵通信。调节泵根据pH传感器采集的pH读数，向再循环回路添加酸。再循环泵将治疗性蛋白质溶液和酸循环到再循环回路中，使其混合。结果，治疗性蛋白质溶液的pH被非破坏性地精确地控制和调节。

2. 发明申请

US20050273203A1 Accurate blending module and method 有权
标题翻译：精确的混合模块和方法
公开(公告)号：US20050273203A1
公开(公告)日：2005-12-08
申请号：US11125640
申请日：2005-05-09
申请人： Louis Bellafiore , James Sanderson , John Walker
发明人： Louis Bellafiore , James Sanderson , John Walker
IPC分类号： G05B21/00 , G05D21/02
CPC分类号： G05D21/02
摘要： An accurate blending module for adjusting the pH of solutions containing therapeutic proteins includes a recirculation loop that receives the therapeutic protein solution via a feed pump and an acid solution via an adjusting pump. The recirculation loop includes a recirculation pump and a pH sensor that detects the pH of the solution in the recirculation loop. A controller communicates with the pH sensor and the adjusting pump. The adjusting pump adds acid to the recirculation loop based on the pH readings taken by the pH sensor. The recirculation pump recirculates the therapeutic protein solution and acid in the recirculation loop so that it is mixed. As a result, the pH of the therapeutic protein solution is precisely controlled and adjusted in a non-destructive fashion.
摘要翻译：用于调节含有治疗性蛋白质的溶液的pH的精确混合模块包括通过经由调节泵的进料泵和酸溶液接收治疗性蛋白质溶液的再循环回路。再循环回路包括再循环泵和pH传感器，其检测再循环回路中的溶液的pH。控制器与pH传感器和调节泵通信。调节泵根据pH传感器采集的pH读数，向再循环回路添加酸。再循环泵将治疗性蛋白质溶液和酸循环到再循环回路中，使其混合。结果，治疗性蛋白质溶液的pH被非破坏性地精确地控制和调节。

3. 发明申请

US20060280651A1 INDUSTRIAL BIOSYNTHESIZER SYSTEM AND METHOD 审中-公开
标题翻译：工业生物化学系统及方法
公开(公告)号：US20060280651A1
公开(公告)日：2006-12-14
申请号：US11379114
申请日：2006-04-18
申请人： Louis Bellafiore , John Walker , James Sanderson
发明人： Louis Bellafiore , John Walker , James Sanderson
IPC分类号： C40B30/04 , C40B50/02 , G01N21/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00398 , B01J2219/00423 , B01J2219/00477 , B01J2219/00479 , B01J2219/00481 , B01J2219/00497 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00648 , B01J2219/00689 , B01J2219/00698 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725
摘要： A synthesizer system for use as either a freestanding or facility integrated device and a method of use. The system includes an inlet manifold of diaphragm valves that receives at least two liquid feeds. The streams flow either to a blending module or directly to a delivery module. From there they are delivered to a reactor for the sequential creation of desired compounds. For flow through solid phase synthesis added capability for feed recirculation and effluent detection with feedback control is included.
摘要翻译：用作独立或设备集成设备和使用方法的合成器系统。该系统包括容纳至少两个液体进料的隔膜阀的入口歧管。这些流流到混合模块或直接流到传送模块。从那里它们被递送到反应器以顺序地制备所需化合物。对于通过固相合成的流动，包括用于进料再循环的添加能力和具有反馈控制的流出物检测。

4. 发明授权

US08271139B2 Multi-stage accurate blending system and method 有权
标题翻译：多级准确混合系统及方法
公开(公告)号：US08271139B2
公开(公告)日：2012-09-18
申请号：US12124644
申请日：2008-05-21
申请人： Louis Bellafiore , James Sanderson
发明人： Louis Bellafiore , James Sanderson
IPC分类号： G05B21/00
CPC分类号： G05D11/139 , B01F15/0408 , B01F15/0479 , G05D21/02
摘要： An accurate blending system for blending a feed liquid and first and second adjusting liquids includes a first feed means adapted to communicate with a supply of feed liquid, a second feed means adapted to communicate with a supply of the first adjusting liquid and a third feed means adapted to communicate with a supply of the second adjusting liquid. The first, second and third feed means may be pumps, valves or combinations thereof. A mixing device is in communication with the first, second and third feed means. First and second sensors are in communication with the mixing device. A controller communicates with the first and second sensors so that first and second characteristics of the solution in the mixing device can be detected. The controller also communicates with the first and second feed means so that delivery of first and second adjusting liquid to the mixing device can be controlled based upon the detected first and second characteristics of the solution in the mixing device.
摘要翻译：用于混合进料液体和第一和第二调节液体的精确混合系统包括适于与进料液体供应连通的第一进料装置，适于与第一调节液体的供应源连通的第二进料装置和第三进料装置适于与第二调节液体的供应物通信。第一，第二和第三进料装置可以是泵，阀或其组合。混合装置与第一，第二和第三进料装置连通。第一和第二传感器与混合装置连通。控制器与第一和第二传感器通信，从而可以检测混合装置中溶液的第一和第二特性。控制器还与第一和第二进料装置连通，从而可以基于检测到的混合装置中的溶液的第一和第二特性来控制向混合装置输送第一和第二调节液体。

5. 发明授权

US07072742B1 Accurate blending module and method 有权
标题翻译：精确的混合模块和方法
公开(公告)号：US07072742B1
公开(公告)日：2006-07-04
申请号：US10688391
申请日：2003-10-17
申请人： Louis Bellafiore , James Sanderson
发明人： Louis Bellafiore , James Sanderson
IPC分类号： G05B21/00
CPC分类号： G05D21/02
摘要： An accurate blending module for retrofitting existing laboratory or industrial systems or use as a standalone device and a method of use. The module includes a proportioning submodule that receives and merges at least two liquid feeds. The merged stream flows to a blending submodule. The resulting blended liquid stream flows through a detection submodule which detects a characteristic of the blended liquid stream. The detection submodule sends a corresponding signal to a controller. The controller adjusts the proportioning submodule based on the signal.
摘要翻译：用于改造现有实验室或工业系统或用作独立设备和使用方法的精确混合模块。该模块包括接收和合并至少两个液体进料的比例子模块。合并的流流到混合子模块。所得到的混合液流流过检测混合液体流的特性的检测子模块。检测子模块向控制器发送相应的信号。控制器根据信号调整比例子模块。

6. 发明申请

US20110259831A1 TRACKING REGULATOR SYSTEM AND METHOD FOR PROCESSING COLUMNS 审中-公开
标题翻译：跟踪调节器系统和处理柱的方法
公开(公告)号：US20110259831A1
公开(公告)日：2011-10-27
申请号：US12765498
申请日：2010-04-22
申请人： Michael Brandt , Mark Dunn , Louis Bellafiore
发明人： Michael Brandt , Mark Dunn , Louis Bellafiore
IPC分类号： G05D16/00 , B01D17/12
CPC分类号： G01N30/6021 , G01N30/56
摘要： A processing column system includes an inlet, an outlet, a piston head and a piston pressure chamber for providing a controlled bed pressure to the piston head and thus to a substrate and/or liquid bed positioned within the column. A tracking regulator is in fluid communication with a source of pressurized hydraulic fluid and the piston pressure chamber as well as the inlet to the column. The tracking regulator receives a pressure of a process fluid flow into the processing column. The tracking regulator has a hydraulic fluid drain port in fluid communication with the source of pressurized hydraulic fluid. The tracking regulator directs hydraulic fluid from the piston pressure chamber to the source of pressurized hydraulic fluid when the tracking regulator detects a drop in the pressure of the process fluid flow. The source of pressurized hydraulic fluid provides to the tracking regulator a pressure equal to a set bed pressure of the system plus a maximum anticipated process flow pressure. The tracking regulator directs additional hydraulic fluid from the source of pressurized hydraulic fluid to the piston pressure chamber of the processing column so that a pressure therein is greater than the set bed pressure when the tracking regulator detects an increase in the pressure of the process fluid flow.
摘要翻译：处理塔系统包括入口，出口，活塞头和活塞压力室，用于向活塞头提供受控床压力，从而提供位于柱内的基底和/或液床。跟踪调节器与加压液压流体源和活塞压力室以及塔的入口流体连通。跟踪调节器接收进入处理柱的工艺流体流的压力。跟踪调节器具有与加压液压流体源流体连通的液压流体排放口。当跟踪调节器检测到过程流体流的压力下降时，跟踪调节器将液压流体从活塞压力室引导到加压液压流体源。加压液压流体的源向跟踪调节器提供等于系统的设定床压力加上最大预期过程流压力的压力。跟踪调节器将额外的液压流体从加压液压流体源引导到处理塔的活塞压力室，使得当跟踪调节器检测到过程流体流的压力增加时，其中的压力大于设定的床压力。

7. 发明申请

US20110293753A1 Tocotrienol Compositions 审中-公开
标题翻译：生育三烯酚组合物
公开(公告)号：US20110293753A1
公开(公告)日：2011-12-01
申请号：US12790292
申请日：2010-05-28
申请人： Louis Bellafiore , James A. Radosevich , Ed Glicken
发明人： Louis Bellafiore , James A. Radosevich , Ed Glicken
IPC分类号： A61K36/889 , A61P29/00 , A61K36/9066 , A61P31/10 , A61P33/00 , A61P39/00 , A61P35/00 , A61P31/04
CPC分类号： A61K31/355 , A61K9/4875 , A61K31/375 , A61K36/16 , A61K36/38 , A61K36/41 , A61K36/53 , A61K36/81 , A61K36/886 , A61K45/06 , A61K2300/00
摘要： Compositional formulations are provided that comprise at least one tocotrienol or a derivative thereof, in combination with compounds derived from plant extracts. The compositions can be provided in a functionally acceptable carrier, or separately in a combined regimen. In some examples, the compositions can be effective for reducing, preventing or treating medical conditions including, for example, benign tissue growths, pre-cancerous lesions, cancer, inflammations, viral infections, bacterial infections, fungal infections, parasitic infections, impaired bodily function, or cell and tissue damage due to trauma, cell and/or tissue injury from stroke events, cell and/or tissue damage from ischemic events. The mechanism of action for cancer prevention and therapy includes telomerase and/or angiogenesis inhibition.
摘要翻译：提供包含至少一种生育三烯酚或其衍生物与来自植物提取物的化合物组合的组合物制剂。组合物可以在功能上可接受的载体中提供，或者以组合方案单独提供。在一些实例中，组合物可有效减少，预防或治疗医学病症，包括例如良性组织生长，癌前病变，癌症，炎症，病毒感染，细菌感染，真菌感染，寄生虫感染，身体功能受损，或由于来自中风事件的创伤，细胞和/或组织损伤，来自缺血事件的细胞和/或组织损伤引起的细胞和组织损伤。癌症预防和治疗的作用机制包括端粒酶和/或血管发生抑制。

8. 发明申请

US20090235508A1 HOIST-FREE CHROMATOGRAPHY COLUMN AND METHOD 审中-公开
标题翻译：无空白色谱柱和方法
公开(公告)号：US20090235508A1
公开(公告)日：2009-09-24
申请号：US12481405
申请日：2009-06-09
申请人： Louis Bellafiore
发明人： Louis Bellafiore
IPC分类号： B23P19/00
CPC分类号： G01N30/6021 , B01D15/20 , B01D15/22 , Y10T29/49815 , Y10T29/53
摘要： a chromatography column, or other type of processing column, including a column tube having a top end cap having an opening there through and an open bottom end. A bottom end cap covers and is removably attached to the open bottom end of the column tube and a piston is slidably positioned within the column tube. A rod is attached to the piston and passes through the top end cap opening. The length of the rod may be extended so that the piston may be lowered partially through the open bottom end of the column tube when the bottom end cap is removed. An arrangement for raising the piston includes a hydraulic pump that communicates with a portion of an interior of the column tube above the piston via a port formed in the top end cap.
摘要翻译：色谱柱或其他类型的处理柱，其包括具有顶端盖的顶管和其底部开口的柱管。底端盖覆盖并可移除地附接到柱管的开口底端，活塞可滑动地定位在柱管内。杆连接到活塞并穿过顶端盖开口。杆的长度可以延长，使得当底端盖被移除时，活塞可以部分地降低通过柱管的开口底端。用于升高活塞的装置包括液压泵，其通过形成在顶端盖中的端口与活塞上方的柱管内部的一部分连通。

9. 发明申请

US20060124525A1 Hoist-free chromatography column and method 审中-公开
标题翻译：无提升色谱柱及方法
公开(公告)号：US20060124525A1
公开(公告)日：2006-06-15
申请号：US11221018
申请日：2005-09-07
申请人： Louis Bellafiore
发明人： Louis Bellafiore
IPC分类号： B01D15/08
CPC分类号： G01N30/6021 , B01D15/20 , B01D15/22 , Y10T29/49815 , Y10T29/53
摘要： A chromatography column, or other type of processing column, including a column tube having a top end cap having an opening there through and an open bottom end. A bottom end cap covers and is removably attached to the open bottom end of the column tube and a piston is slidably positioned within the column tube. A rod is attached to the piston and passes through the top end cap opening. The length of the rod may be extended so that the piston may be lowered partially through the open bottom end of the column tube when the bottom end cap is removed. An arrangement for raising the piston includes a hydraulic pump that communicates with a portion of an interior of the column tube above the piston via a port formed in the top end cap.
摘要翻译：色谱柱或其它类型的处理柱，包括具有顶端盖的顶管和其底部开口的柱管。底端盖覆盖并可移除地附接到柱管的开口底端，活塞可滑动地定位在柱管内。杆连接到活塞并穿过顶端盖开口。杆的长度可以延长，使得当底端盖被移除时，活塞可以部分地降低通过柱管的开口底端。用于升高活塞的装置包括液压泵，其通过形成在顶端盖中的端口与活塞上方的柱管内部的一部分连通。

10. 发明授权

US06395915B1 Method for producing purified tocotrienols and tocopherols using liquid chromatography 有权
标题翻译：使用液相色谱法生产纯化的生育三烯酚和生育酚的方法
公开(公告)号：US06395915B1
公开(公告)日：2002-05-28
申请号：US09657718
申请日：2000-09-08
申请人： Louis Bellafiore , Kevin Henretta
发明人： Louis Bellafiore , Kevin Henretta
IPC分类号： C11B310
CPC分类号： C07D311/72
摘要： A method separating tocotrienols from tocopherols and the isomers thereof on a large-scale or commercially feasible basis. Separation is accomplished using reverse phase partition liquid chromatography. The chromatography column is prepared using a stationary phase comprising a hydrophobic or aromatic reverse phase chromatography media. The mobile phase consists of a solvent which is capable of solubilizing the crude stock, tocotrienols and tocopherols. The chromatography column containing the stationary and mobile phases is loaded with a crude feed stock and the tocotrienols, tocopherols and/or isomers thereof are eluted at a predetermined linear velocity.
摘要翻译：在大规模或商业上可行的基础上分离生育三烯酚与生育酚及其异构体的方法。使用反相分离液相色谱法进行分离。使用包含疏水或芳族反相色谱介质的固定相制备色谱柱。流动相由能够溶解原油，生育三烯酚和生育酚的溶剂组成。含有固定相和流动相的层析柱装载有原料原料，生长醇类，生育酚和/或异构体以预定的线速度洗脱。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式