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1. 发明授权

US5962849A Particle selection method and a time-of flight mass spectrometer 失效
标题翻译：粒子选择方法和飞行时间质谱仪
公开(公告)号：US5962849A
公开(公告)日：1999-10-05
申请号：US826311
申请日：1997-03-25
申请人： Naoaki Saito , Mitsumori Tanimoto , Kazuyoshi Koyama , Yasushi Iwata
发明人： Naoaki Saito , Mitsumori Tanimoto , Kazuyoshi Koyama , Yasushi Iwata
IPC分类号： G01N27/62 , H01J49/40 , G01D59/44 , H01J49/00
CPC分类号： H01J49/40
摘要： In the time-of-flight mass spectrometer, the mass spectrometer with high resolution is provided which defines the initial position and the initial velocity of the charged particles and selects only the stable charged particles to measure.First, all of the charged particles Pe are accelerated to one direction in a homogeneous or spatially uniform electric field during a common finite period of time, and then all of the charged particles Pe are accelerated to the opposite direction of the former in a homogeneous or spatially uniform electric field during a common finite period of time and given the same momentum in the opposite direction of the former. Two kind of particle selection method can be adopted. Only the charged particles Pe passing through a predetermined position at a predetermined time are selected by the selector. The charged particles Pe passing through the selector are defected by the first and second deflectors and then only the charged particles passing through a predetermined point of the slit are selected and reach the ion detector. Finally, the mass spectrum is obtained by measuring the time-of-flight of the particles using the ion detector.
摘要翻译：在飞行时间质谱仪中，提供了具有高分辨率的质谱仪，其定义了带电粒子的初始位置和初始速度，并且仅选择稳定的带电粒子进行测量。首先，在均匀或空间均匀的电场中，所有带电粒子Pe在均匀或空间均匀的电场中被加速到一个方向，然后所有带电粒子Pe被加速到前者的相反方向，在相同的有限时间段内空间均匀的电场，并给出与前者相反方向相同的动量。可采用两种粒子选择方法。选择器仅选择在预定时间内通过预定位置的带电粒子Pe。穿过选择器的带电粒子Pe被第一和第二偏转器缺陷，然后仅选择通过狭缝的预定点的带电粒子并到达离子检测器。最后，通过使用离子检测器测量颗粒的飞行时间来获得质谱。

2. 发明授权

US5559325A Method of automatically controlling the space charge in ion traps 失效
标题翻译：自动控制离子阱空间电荷的方法
公开(公告)号：US5559325A
公开(公告)日：1996-09-24
申请号：US286672
申请日：1994-08-05
申请人： Jochen Franzen
发明人： Jochen Franzen
IPC分类号： H01J49/42 , G01D59/44 , H01J49/00
CPC分类号： H01J49/4265
摘要： The invention relates to a method of automatically controlling the space charge in ion traps when they are used as a mass spectrometer. If ionization conditions remain the same, space charge is proportional to the measured concentration of a substance; if there are rapid changes in substance concentrations, as can be found in coupling with gas chromatography for example, the space charge must be controlled to obtain spectra of consistent quality. The invention is based on the possibility of performing rapid consecutive scans and consists in utilizing the integrated ion currents of consecutive spectra to forecast by calculation the value of the ion generation rate at the time of the ionization phase for the next scan. Calculation may be based on linear, quadratic or cubic extrapolation but also on assumptions regarding the function of change of the concentration, and an adaptation of the function parameters.
摘要翻译：本发明涉及一种当将离子阱用作质谱仪时自动控制离子阱的空间电荷的方法。如果电离条件保持不变，空间电荷与物质的测量浓度成比例; 如果物质浓度发生快速变化，例如在气相色谱偶联中可以发现，必须控制空间电荷以获得质量一致的光谱。本发明基于执行快速连续扫描的可能性，并且包括利用连续光谱的积分离子电流通过计算在下一次扫描的电离阶段时离子产生速率的值来预测。计算可以基于线性，二次或立方外推，也可以基于关于浓度变化函数的假设以及功能参数的适应。

3. 发明授权

US6051831A High-mass detector with high mass-resolution for time-of-flight mass spectrometers 失效
标题翻译：高质量检测器，具有高质量分辨率，用于飞行时间质谱仪
公开(公告)号：US6051831A
公开(公告)日：2000-04-18
申请号：US949374
申请日：1997-10-14
申请人： Claus Koster
发明人： Claus Koster
IPC分类号： H01J49/02 , H01J49/40 , G01D59/44 , H01J49/00
CPC分类号： H01J49/025 , H01J43/246
摘要： The invention relates to ion detectors for heavy ions with high mass resolution and high sensitivity usable in time-of-flight mass spectrometers. It relates to sensitive measuring methods for large masses in the range of about ten thousand to several hundred thousand atomic mass units. Specifically it relates to the conversion of large ions into smaller ions, which can then be detected with standard ion detectors for ions of smaller and average masses.The invention consists of a thin multichannel plate, such as is normally used for secondary-electron multiplication, used as a conversion device, in combination with a standard ion detector. However, in contrast to normal secondary-electron multiplier operation, it is operated at reversed polarity in order to produce large numbers of low-weight positive ions by a self-contained amplification process engaging secondary electrons accelerated in backward direction. This device and operating method leads to a reduction in signal width and offers high sensitivity for large ions.
摘要翻译：本发明涉及可用于飞行时间质谱仪中的高质量分辨率和高灵敏度的重离子离子检测器。它涉及大量在大约一万到几十万个原子质量单位范围内的敏感测量方法。具体地说，它涉及将大离子转化成较小的离子，然后可以用标准离子检测器检测较小和平均质量的离子。本发明结合标准离子检测器，由通常用于二次电子倍增的薄多孔板，用作转换装置。然而，与正常的二次电子倍增器操作相比，它以相反的极性操作，以便通过独立的放大过程产生大量的低重量的正离子，从而接合在向后加速的二次电子。该装置和操作方法导致信号宽度的减小，并为大离子提供高灵敏度。

4. 发明授权

US5900628A Method of processing mass spectrum 失效
标题翻译：加工质谱的方法
公开(公告)号：US5900628A
公开(公告)日：1999-05-04
申请号：US825894
申请日：1997-04-02
申请人： Morio Ishihara
发明人： Morio Ishihara
IPC分类号： G01N27/62 , H01J49/02 , H01J49/26 , G01D59/44 , H01J49/00
CPC分类号： H01J49/0036
摘要： There is disclosed a method of extracting information about the mass of a substance from a complex mass spectrum containing peaks arising from polyvalent ions. These polyvalent ions possess electric charges which are integral multiples of the elementary electric charge. Ions including these polyvalent ions are detected, and a mass spectrum is obtained. On the mass spectrum, ion intensity I is represented as a function of a variable x corresponding to mass-to-charge ratio. The mass spectrum, given by I(x), is transformed into a mass spectrum I(t) of a variable t, using the relation t=1/(x-H), where H is a unit mass of ions added to the polyvalent ions. Peaks appear on the mass spectrum I(t). Among these peaks, at least a given number of peaks appear at regular intervals. The spacing between these regularly spaced peaks is found.
摘要翻译：公开了从包含由多价离子引起的峰的复杂质谱中提取关于物质质量的信息的方法。这些多价离子具有作为基本电荷的整数倍的电荷。检测出包含这些多价离子的离子，得到质谱。在质谱上，离子强度I表示为对应于质荷比的变量x的函数。由I（x）给出的质谱使用关系式t = 1 /（xH）转换成变量t的质谱I（t），其中H是加到多价离子中的离子的单位质量。峰出现在质谱I（t）上。在这些峰中，至少给定数量的峰以规则的间隔出现。找到这些规则间隔的峰之间的间距。

5. 发明授权

US07569835B2 Gating grid and method of manufacture 失效
标题翻译：门格栅和制造方法
公开(公告)号：US07569835B2
公开(公告)日：2009-08-04
申请号：US11714691
申请日：2007-03-06
申请人： Brian G. Frederick , Lawrence J. LeGore , Rosemary Smith , Scott Collins , Robert H. Jackson, III
发明人： Brian G. Frederick , Lawrence J. LeGore , Rosemary Smith , Scott Collins , Robert H. Jackson, III
IPC分类号： H01J29/52 , H01J37/063 , G01D59/44 , H01J49/00
CPC分类号： H01J49/061 , Y10S438/927 , Y10S438/977 , Y10T29/49046 , Y10T29/49117
摘要： The present invention relates generally to grids for gating a stream of charged particles and methods for manufacturing the same. In one embodiment, the present invention relates to a Bradbury-Nielson gate having transmission line grid elements. In one embodiment is a feed structure for a gating grid where a drive source is coupled to a feeding transmission line with the same geometry as the chopper and continues with the same geometry to a termination transmission line. Also included is a method for fabricating a gate for charged particles which includes micromachining at least two gate elements from at least one wafer, wherein each gate element includes at least one grid element; metalizing the grid elements; and assembling the gate elements such that the grid elements of the gate elements are interleaved, thereby forming a Bradbury Nielson gate.
摘要翻译：本发明一般涉及用于选通带电粒子流的栅格及其制造方法。在一个实施例中，本发明涉及具有传输线网格元件的Bradbury-Nielson门。在一个实施例中是用于门控格栅的馈送结构，其中驱动源耦合到与斩波器具有相同几何形状的馈电传输线，并且以相同的几何形状连续地连接到终端传输线。还包括一种用于制造带电粒子的栅极的方法，其包括从至少一个晶片微加工至少两个栅极元件，其中每个栅极元件包括至少一个栅格元件; 金属化网格元素; 以及组装门元件，使得门元件的栅格元件交错，从而形成Bradbury Nielson门。

6. 发明授权

US5525799A Portable gas chromatograph-mass spectrometer 失效
标题翻译：便携式气相色谱 - 质谱仪
公开(公告)号：US5525799A
公开(公告)日：1996-06-11
申请号：US225111
申请日：1994-04-08
申请人： Brian D. Andresen , Joel D. Eckels , James F. Kimmons , David W. Myers
发明人： Brian D. Andresen , Joel D. Eckels , James F. Kimmons , David W. Myers
IPC分类号： G01N30/72 , G01N30/88 , H01J49/00 , G01D59/44
CPC分类号： H01J49/0022 , G01N2030/0095 , G01N30/7206 , G01N30/88
摘要： A gas chromatograph-mass spectrometer (GC-MS) for use as a field portable organic chemical analysis instrument. The GC-MS is designed to be contained in a standard size suitcase, weighs less than 70 pounds, and requires less than 600 watts of electrical power at peak power (all systems on). The GC-MS includes: a conduction heated, forced air cooled small bore capillary gas chromatograph, a small injector assembly, a self-contained ion/sorption pump vacuum system, a hydrogen supply, a dual computer system used to control the hardware and acquire spectrum data, and operational software used to control the pumping system and the gas chromatograph. This instrument incorporates a modified commercial quadrupole mass spectrometer to achieve the instrument sensitivity and mass resolution characteristic of laboratory bench top units.
摘要翻译：用作现场便携式有机化学分析仪器的气相色谱 - 质谱仪（GC-MS）。 GC-MS设计为包含在标准尺寸的手提箱中，重量小于70磅，峰值功率（所有系统）都需要少于600瓦的电力。 GC-MS包括：传导加热，强制空气冷却的小孔毛细管气相色谱仪，小型注射器组件，独立离子/吸附泵真空系统，氢气供应，用于控制硬件和获取的双计算机系统频谱数据和用于控制泵送系统和气相色谱仪的操作软件。该仪器采用改进的商业四极杆质谱仪，以实现实验室台式机组的仪器灵敏度和质量分辨率特性。

7. 发明授权

US5986258A Extended Bradbury-Nielson gate 失效
标题翻译：扩大布拉德伯里 - 尼尔森门
公开(公告)号：US5986258A
公开(公告)日：1999-11-16
申请号：US911639
申请日：1997-08-15
申请人： Melvin Park
发明人： Melvin Park
IPC分类号： H01J49/16 , H01J49/40 , G01D59/44 , H01J49/00
CPC分类号： H01J49/061 , H01J49/40
摘要： A method and apparatus for analyzing ions by determining times of flight include using a deflector to direct ions away from their otherwise intended or parallel course. Deflectors are used as gates, so that particular ions may be selected for deflection, while others are allowed to continue along their parallel or otherwise straight path, from the ion source, through a flight tube, and eventually, to a detector. According to the present invention, an extended Bradbury-Nielson gate, in the form of a series of plates, with equal but alternating opposite polarity potentials, is used as an ion deflector or gate.
摘要翻译：通过确定飞行时间来分析离子的方法和装置包括使用偏转器将离子远离其它预期或平行的过程。偏转器用作门，使得可以选择特定的离子进行偏转，而其他离子可以沿着它们的平行或其他直线路径从离子源，通过飞行管，并且最终到达检测器。根据本发明，使用具有相等但交替相反极性电位的一系列板形式的延伸的Bradbury-Nielson门作为离子导流板或栅极。

8. 发明授权

US5962851A Multipole ion guide for mass spectrometry 失效
公开(公告)号：US5962851A
公开(公告)日：1999-10-05
申请号：US794970
申请日：1997-02-05
申请人： Craig M. Whitehouse , Erol Gulcicek
发明人： Craig M. Whitehouse , Erol Gulcicek
IPC分类号： G01N27/62 , H01J49/04 , H01J49/16 , H01J49/26 , H01J49/40 , H01J49/42 , G01D59/44 , H01J49/00
CPC分类号： B01D59/44 , H01J49/0481 , H01J49/063
摘要： A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide a.sub.n and q.sub.n values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.

9. 发明授权

US5859433A Ion trap mass spectrometer with vacuum-external ion generation 失效
标题翻译：离子阱质谱仪，具有真空 - 外部离子产生
公开(公告)号：US5859433A
公开(公告)日：1999-01-12
申请号：US671854
申请日：1996-06-28
申请人： Jochen Franzen
发明人： Jochen Franzen
IPC分类号： H01J49/42 , G01D59/44 , H01J49/00
CPC分类号： H01J49/424 , H01J49/0404 , H01J49/24
摘要： The invention relates to an RF quadrupole ion trap mass spectrometer with ionization of the substance molecules outside the vacuum system.The invention consists of using only a single high-vacuum pump for generating the vacuum without any differential pump stages and generating the necessary pressure stages for operating the mass spectrometer by means of a sequence of openings with adjusted conductances. The necessarily very small inlet opening to the vacuum system is only able to transport very small quantities of ions of the analyzed substances in the gas stream. However, these quantities are adequate for operating the mass spectrometer because the ion trap used as mass spectrometer is capable of collecting and storing ions over relatively long periods of time.
摘要翻译：本发明涉及一种具有离子真空系统外的物质分子的RF四极离子阱质谱仪。本发明包括仅使用单个高真空泵来产生没有任何差分泵级的真空，并且通过具有调节的电导的一系列开口产生用于操作质谱仪的必要的压力级。到真空系统的必要非常小的入口仅能够在气流中输送非常少量的分析物质的离子。然而，这些量足以操作质谱仪，因为用作质谱仪的离子阱能够在相当长的时间内收集和存储离子。

10. 发明授权

US5793039A Mass spectrometer, skimmer cone assembly, skimmer cone and its manufacturing method 失效
标题翻译：质谱仪，撇渣锥组件，撇渣器及其制造方法
公开(公告)号：US5793039A
公开(公告)日：1998-08-11
申请号：US605572
申请日：1996-02-22
申请人： Konosuke Oishi , Masamichi Tsukada , Toyoharu Okumoto , Takashi Iino
发明人： Konosuke Oishi , Masamichi Tsukada , Toyoharu Okumoto , Takashi Iino
IPC分类号： G01N27/62 , G21K1/02 , H01J49/04 , H01J49/26 , G01D59/44 , H01J49/00
CPC分类号： H01J49/067
摘要： Disclosed is a structure comprising; (a) Plasma gas is supplied to torch tube 8 from inert pressure vessel 1. (b) Nebulizer 3 absorbs sample 4 to vaporize the sample as aerosol and to introduce it into plasma 5. (c) Plasma 5 touches sampling cone 10 having an opening at the apex and a conical surface, whereby an ion stream is extracted through the opening of the sampling cone whose pressure is reduced at the rear face thereof. (d) The extracted ion stream further touches skimmer cone 12 of the conical surface having a small hole at the apex, and is absorbed into vacuum chamber 13 where the pressure is further reduced at the rear face. (e) The ion stream is flowed into quadruple pole filter 18 to carry out the mass spectrometry analysis of the ion stream.
摘要翻译：公开了一种结构，包括：（a）将等离子体气体从惰性压力容器1供应给割炬管8.（b）雾化器3吸收样品4以使气溶胶蒸发，并将其引入等离子体5.（c）等离子体5接触采样锥10，在顶点处开口并具有锥形表面，由此通过其后面压力减小的取样锥体的开口提取离子流。（d）提取的离子流进一步接触顶点处具有小孔的圆锥形表面的撇渣器锥体12，并被吸收到真空室13中，在该真空室13中后面进一步减小压力。（e）离子流流入四极过滤器18，进行离子流的质谱分析。

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