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1. 发明授权

US5962849A Particle selection method and a time-of flight mass spectrometer 失效
标题翻译：粒子选择方法和飞行时间质谱仪
公开(公告)号：US5962849A
公开(公告)日：1999-10-05
申请号：US826311
申请日：1997-03-25
申请人： Naoaki Saito , Mitsumori Tanimoto , Kazuyoshi Koyama , Yasushi Iwata
发明人： Naoaki Saito , Mitsumori Tanimoto , Kazuyoshi Koyama , Yasushi Iwata
IPC分类号： G01N27/62 , H01J49/40 , G01D59/44 , H01J49/00
CPC分类号： H01J49/40
摘要： In the time-of-flight mass spectrometer, the mass spectrometer with high resolution is provided which defines the initial position and the initial velocity of the charged particles and selects only the stable charged particles to measure.First, all of the charged particles Pe are accelerated to one direction in a homogeneous or spatially uniform electric field during a common finite period of time, and then all of the charged particles Pe are accelerated to the opposite direction of the former in a homogeneous or spatially uniform electric field during a common finite period of time and given the same momentum in the opposite direction of the former. Two kind of particle selection method can be adopted. Only the charged particles Pe passing through a predetermined position at a predetermined time are selected by the selector. The charged particles Pe passing through the selector are defected by the first and second deflectors and then only the charged particles passing through a predetermined point of the slit are selected and reach the ion detector. Finally, the mass spectrum is obtained by measuring the time-of-flight of the particles using the ion detector.
摘要翻译：在飞行时间质谱仪中，提供了具有高分辨率的质谱仪，其定义了带电粒子的初始位置和初始速度，并且仅选择稳定的带电粒子进行测量。首先，在均匀或空间均匀的电场中，所有带电粒子Pe在均匀或空间均匀的电场中被加速到一个方向，然后所有带电粒子Pe被加速到前者的相反方向，在相同的有限时间段内空间均匀的电场，并给出与前者相反方向相同的动量。可采用两种粒子选择方法。选择器仅选择在预定时间内通过预定位置的带电粒子Pe。穿过选择器的带电粒子Pe被第一和第二偏转器缺陷，然后仅选择通过狭缝的预定点的带电粒子并到达离子检测器。最后，通过使用离子检测器测量颗粒的飞行时间来获得质谱。

2. 发明申请

US20080290269A1 Time-Of-Flight Mass Spectrometer 审中-公开
标题翻译：飞行时间质谱仪
公开(公告)号：US20080290269A1
公开(公告)日：2008-11-27
申请号：US11908758
申请日：2006-01-25
申请人： Naoaki Saito , Masataka Ohkubo , Kazuyoshi Koyama , Eisuke Miura
发明人： Naoaki Saito , Masataka Ohkubo , Kazuyoshi Koyama , Eisuke Miura
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A time-of-flight mass spectrometer comprising an accelerating portion that includes a repeller electrode and an extractor electrode, in which an inner surface on the extractor electrode side of the repeller electrode has a curved shape, the extractor electrode is a flat plate with a hole in the center or a plate structure including a mesh structure, and the accelerating portion converges a distribution of times of flight accompanying deviations in the acceleration start position of ions and also performs trajectory control by correcting a distribution of the introduction energy of ions. In accordance with the above-described structure, it is possible to realize both functions of a conventional accelerating portion and ion lens system with only an accelerating portion and it is possible to simplify and reduce the size of the time-of-flight mass spectrometer.
摘要翻译：一种飞行时间质谱仪，其特征在于，具有：包括排斥电极的加速部和所述排斥电极的所述提取电极侧的内表面具有弯曲形状的提取电极，所述提取电极为平板，中心的孔或包括网状结构的板结构，并且加速部收敛伴随离子的加速开始位置的偏差的飞行时间分布，并且还通过校正离子的引入能量的分布来进行轨迹控制。根据上述结构，可以实现仅加速部分的传统加速部分和离子透镜系统的功能，并且可以简化和减小飞行时间质谱仪的尺寸。

3. 发明授权

US06709833B2 Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate 失效
标题翻译：识别磷脂酰肌醇-3,4-二磷酸的单克隆抗体
公开(公告)号：US06709833B2
公开(公告)日：2004-03-23
申请号：US09518737
申请日：2000-03-03
申请人： Yasuhisa Fukui , Satoshi Nagata , Ryuichi Shirai , Naoaki Saito
发明人： Yasuhisa Fukui , Satoshi Nagata , Ryuichi Shirai , Naoaki Saito
IPC分类号： C07K1628
CPC分类号： C07K16/18 , G01N33/5308 , Y10S435/975
摘要： A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous for PI-3,4-P2-specific immunoassay. The gene in the variable regions of the monoclonal antibody has been identified, which enables producing recombinant antibodies.
摘要翻译：特异性识别磷脂酰肌醇-3,4-二磷酸（PI-3,4-P2）但不与结构相似的磷脂抗原交叉反应的新型单克隆抗体对PI-3,4-P2特异性免疫测定是有利的。已经鉴定了单克隆抗体可变区中的基因，其能够产生重组抗体。

4. 发明申请

US20050043514A1 Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate 审中-公开
标题翻译：识别磷脂酰肌醇-3,4-二磷酸的单克隆抗体
公开(公告)号：US20050043514A1
公开(公告)日：2005-02-24
申请号：US10723748
申请日：2003-11-25
申请人： Yasuhisa Fukui , Satoshi Nagata , Ryuichi Shirai , Naoaki Saito
发明人： Yasuhisa Fukui , Satoshi Nagata , Ryuichi Shirai , Naoaki Saito
IPC分类号： C12N15/02 , C07K16/18 , C07K16/44 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/577 , C07K16/00
CPC分类号： C07K16/18 , G01N33/5308 , Y10S435/975
摘要： A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous for PI-3,4-P2-specific immunoassay. The gene in the variable regions of the monoclonal antibody has been identified, which enables producing recombinant antibodies.
摘要翻译：特异性识别磷脂酰肌醇-3,4-二磷酸（PI-3,4-P2）但不与结构相似的磷脂抗原交叉反应的新型单克隆抗体对PI-3,4-P2特异性免疫测定是有利的。已经鉴定了单克隆抗体可变区中的基因，其能够产生重组抗体。

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