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1. 发明授权

US4851440A Leukotriene antagonists, processes for the preparation thereof, the use thereof for the treatment of diseases, and precursors 失效
标题翻译：白三烯拮抗剂，其制备方法，其用于治疗疾病的用途和前体
公开(公告)号：US4851440A
公开(公告)日：1989-07-25
申请号：US222975
申请日：1988-07-22
申请人： Gerhard Beck , Peter Below , Andreas Bergmann
发明人： Gerhard Beck , Peter Below , Andreas Bergmann
IPC分类号： A61K31/35 , A61K31/10 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/23 , A61K31/235 , A61K31/352 , A61K31/395 , A61K31/40 , A61K31/41 , A61K31/445 , A61K31/535 , A61P1/04 , A61P9/00 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C43/00 , C07C43/23 , C07C323/16 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/08 , C07D303/14 , C07D303/16 , C07D303/22 , C07D303/34 , C07D311/66 , C07D333/18 , C07D405/12 , C07D409/12 , C12N9/99
CPC分类号： C07D213/30 , A61K31/215 , C07C323/00 , C07D303/14 , C07D303/16 , C07D303/22 , C07D303/34 , C07D405/12
摘要： Leukotriene antagonists, processes for the preparation thereof, the use thereof for the treatment of diseases, and precursors.Compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and X have the indicated meanings, processes for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds are described. In addition, precursors for the preparation of compounds of the formula I are described.
摘要翻译：白三烯拮抗剂，其制备方法，其用于治疗疾病的用途和前体。其中R 1，R 2，R 3，R 4，R 5，R 6和X具有指定含义的式I化合物（I）的化合物，这些化合物的制备方法，其作为药物的用途，以及基于描述了这些化合物。此外，描述了制备式I化合物的前体。

2. 发明授权

US4898868A 3-demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and intermediates 失效
标题翻译： 3-脱甲基-4-氟代戊二酸衍生物，其制备方法，基于这些化合物的药物产品，其用途和中间体
公开(公告)号：US4898868A
公开(公告)日：1990-02-06
申请号：US216752
申请日：1988-07-08
申请人： Andreas Bergmann , Wilhelm Bartmann , Gerhard Beck , Hans-Hermann Lau
发明人： Andreas Bergmann , Wilhelm Bartmann , Gerhard Beck , Hans-Hermann Lau
IPC分类号： C07D213/30 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/40 , A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61P3/06 , A61P9/10 , C07C45/68 , C07C47/55 , C07C51/00 , C07C51/09 , C07C59/00 , C07C59/125 , C07C59/68 , C07C59/72 , C07C59/90 , C07C67/00 , C07C313/00 , C07C323/52 , C07C333/04 , C07D309/10 , C07D309/30 , C07D405/06 , C07D405/10 , C07D407/12 , C07D409/06 , C07D409/12 , C07D493/04 , C07D493/14 , C07F7/18 , C07H15/18
CPC分类号： C07D405/06 , C07C323/00 , C07C45/68 , C07C47/55 , C07C59/68 , C07C59/72 , C07D309/10 , C07D309/30 , C07D409/06 , C07F7/1856
摘要： 3-Demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and intermediates3-Demethyl-4-fluoromevalonic acid derivatives of the formula I, and the corresponding dihydroxy carboxylic acid derivatives of the formula II ##STR1## in which R, X and Y have the stated meanings, processes for the preparation of these compounds, the use thereof as medicaments, and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I and formula II are described.
摘要翻译： 3-脱甲基-4-氟代戊二酸衍生物，其制备方法，基于这些化合物的药物产品，其用途和中间体式I的3-去甲基-4-氟代甲基戊酸衍生物和相应的二羟基羧酸其中R，X和Y具有所述含义的式II“IMAGE”衍生物，这些化合物的制备方法，其作为药物的用途以及药物产品。此外，描述了用于制备式I和式II化合物的新中间体。

3. 发明申请

US20110155950A1 PROCESS FOR THE PREPARATION OF 4-BROMOPHENYL DERIVATIVES 审中-公开
标题翻译：制备4-溴苯衍生物的方法
公开(公告)号：US20110155950A1
公开(公告)日：2011-06-30
申请号：US13056692
申请日：2009-07-30
申请人： Andreas Lindenmaier , Martin Vogt , Gerhard Beck , Achim Bührer
发明人： Andreas Lindenmaier , Martin Vogt , Gerhard Beck , Achim Bührer
IPC分类号： C09K3/00
CPC分类号： C07C41/22 , Y02P20/582 , C07C43/225
摘要： Disclosed is a process for the preparation of a mixture of 4-bromophenyl derivatives (compound of formula (2)) and 2,4-dibromophenyl derivatives (compound of formula (3)) comprising the steps of [1] reacting in a two-phase (liquid-liquid) system a bromide containing source with a phenyl derivative (formula (1)) in the presence of an excess of an oxidizing agent, an acid, and optionally a catalyst selected from vanadium pentoxide and ammonium heptamolybdate forming 4-bromo- (compound of formula (2)) and 2,4-dibromo derivatives (compound of formula (3)) and as intermediate product the 2-bromo derivative (compound of formula (4)) which reacts in step [2] to the 2,4-dibromo derivative (formula (3)) according to the following reaction scheme 2 wherein R1 is hydroxy; C1-C5alkoxy; or —NR2R3; and R2 and R3 independently from each other are hydrogen; or C1-C5alkyl.
摘要翻译：公开了一种制备4-溴苯基衍生物（式（2）化合物）和2,4-二溴苯基衍生物（式（3）化合物）的混合物的方法，包括以下步骤：[1] 相（液 - 液）体系含有苯基衍生物（式（1））的溴化物源在过量的氧化剂，酸和任选的催化剂存在下，选自五氧化二钒和七钼酸铵，形成4-溴 - （式（2）的化合物）和2,4-二溴衍生物（式（3）的化合物），作为在步骤[2]中反应的2-溴衍生物（式（4）的化合物）作为中间产物，与 2,4-二溴衍生物（式（3）），其中R 1是羟基; C1-C5烷氧基; 或-NR2R3; R2和R3彼此独立地为氢; 或C 1 -C 5烷基。

4. 发明授权

US4970313A Optically active 3-demethylmevalonic acid derivatives, and intermediates 失效
标题翻译：光学活性3-脱甲基甲基戊酸衍生物和中间体
公开(公告)号：US4970313A
公开(公告)日：1990-11-13
申请号：US280762
申请日：1988-12-06
申请人： Gunther Wess , Kurt Kesseler , Ekkehard Baader , Gerhard Beck
发明人： Gunther Wess , Kurt Kesseler , Ekkehard Baader , Gerhard Beck
IPC分类号： C07D213/55 , C07B31/00 , C07B53/00 , C07C51/00 , C07C51/09 , C07C51/367 , C07C59/01 , C07C59/125 , C07C59/42 , C07C59/58 , C07C67/00 , C07C69/63 , C07D309/30 , C07D319/06 , C07D405/06
CPC分类号： C07D405/06 , C07D319/06 , Y02P20/55
摘要： A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## (.beta.-hydroxy lactones) in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.
摘要翻译：一种制备光学活性3-脱甲基戊醛酸衍生物的方法和中间体制备式I的光学活性3-脱甲基戊醛酸衍生物的方法（3,5-二羟基羧酸衍生物）或其中R，R 1和Y具有指定含义的式II II（β-羟基内酯）。本发明还涉及式XII的醛，其中M表示指定的保护基。本发明的3-脱甲基甲基戊酸衍生物可用于降低宿主的胆固醇水平。

5. 发明授权

US4855323A Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases 失效
标题翻译：白三烯拮抗剂，其制备方法及其用于治疗疾病的用途
公开(公告)号：US4855323A
公开(公告)日：1989-08-08
申请号：US223129
申请日：1988-07-22
申请人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hiristo Anagnostopulos
发明人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hiristo Anagnostopulos
IPC分类号： A61K31/38 , A61K31/085 , A61K31/10 , A61K31/12 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/381 , A61K31/395 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/00 , C07C43/178 , C07C43/20 , C07C43/235 , C07C43/263 , C07C45/00 , C07C47/52 , C07C49/84 , C07C51/00 , C07C59/125 , C07C65/21 , C07C67/00 , C07C69/007 , C07C69/025 , C07C69/675 , C07C69/92 , C07C201/00 , C07C235/06 , C07C235/16 , C07C239/00 , C07C239/14 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/16 , C07C323/19 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/18 , C07D317/36 , C07D333/16
CPC分类号： C07D317/36 , A61K31/10 , A61K31/215 , C07C323/00
摘要： Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.
摘要翻译：白细胞三烯拮抗剂，其制备方法及其用于治疗其中R1，R2，R3，R4，R5和X具有指定含义的疾病的用途，其制备方法化合物，其作为药物的用途，以及基于这些化合物的药物。

6. 发明授权

US4700311A System for optimizing process parameters in photoactive semiconductor manufacturing in-situ 失效
标题翻译：光源半导体制造原位工艺参数优化系统
公开(公告)号：US4700311A
公开(公告)日：1987-10-13
申请号：US694932
申请日：1985-01-25
申请人： Helmut Tributsch , Gerhard Beck , Marinus Kunst , Udo Kuppers , Hans-Joachim Lewerenz , Jochen Lilie , Andre Werner
发明人： Helmut Tributsch , Gerhard Beck , Marinus Kunst , Udo Kuppers , Hans-Joachim Lewerenz , Jochen Lilie , Andre Werner
IPC分类号： H01L21/66 , H01L21/205 , H01L31/04 , H01L31/20 , C30B25/16 , H01L31/18
CPC分类号： H01L31/202 , Y02E10/50 , Y02P70/521 , Y10S136/29
摘要： Materials and systems substantially having photoactive properties are produced with a high quality output and without time losses in the fabrication process. To determine the quality of the photoactive material in situ, conductivity is induced in the material by exciting charge carriers through irradiation, and an electromagnetic field influenced thereby is measured, with the result of the measurement being evaluated by a computer with a corresponding control of actuating members such as valves and controllers. Optimum process parameters are thus found and used for the process.
摘要翻译：基本上具有光敏性质的材料和系统在制造过程中以高质量的输出产生并且没有时间损失。为了在原位确定光活性材料的质量，通过照射激发载流子，在材料中诱发电导率，并且测量受影响的电磁场，其结果是通过计算机进行评估，计算机具有相应的致动控制会员如阀门和控制器。因此找到最佳工艺参数并用于该过程。

7. 发明授权

US4098815A Novel analogues of prostanoic acids not occurring in nature 失效
标题翻译：没有发生在自然中的先天性的新型模拟物
公开(公告)号：US4098815A
公开(公告)日：1978-07-04
申请号：US751951
申请日：1976-12-17
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07C45/56 , C07C45/66 , C07C405/00 , C07C177/00
CPC分类号： C07C405/00 , C07C45/567 , C07C45/66 , Y10S514/826
摘要： The present invention relates to novel not naturally occurring analogues of prostanoic acids of the formula ##STR1## as well as a process for their preparation. The compounds of the invention have valuable pharmacological properties similar to those of the natural prostaglandins and therefore can be used as medicaments.

8. 发明授权

US06794526B2 Process for the preparation of manganese complexes of salen compounds 失效
标题翻译：制备salen化合物锰络合物的方法
公开(公告)号：US06794526B2
公开(公告)日：2004-09-21
申请号：US10312999
申请日：2003-01-02
申请人： Gerhard Beck , Claus Korhummel , Hanspeter Baier , Frank Bachmann , Cornelia Makowka , Reiner Linde , Bernd Kirrmann
发明人： Gerhard Beck , Claus Korhummel , Hanspeter Baier , Frank Bachmann , Cornelia Makowka , Reiner Linde , Bernd Kirrmann
IPC分类号： C07F1300
CPC分类号： C07F13/005
摘要： A process for the preparation of manganese complexes of salen compounds which comprises carrying out the reaction of a salen compound with a manganese compound in DMF is described. In a preferred embodiment, the salen compound itself is synthesised likewise in DMF and reacted without intermediate isolation to form the manganese complex.
摘要翻译：描述了一种制备萨伦化合物锰络合物的方法，其包括在DMF中进行萨伦化合物与锰化合物的反应。在一个优选的实施方案中，萨伦化合物本身同样地在DMF中合成并在不经中间分离反应形成锰络合物的情况下反应。

9. 发明授权

US5294724A 4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters and a process for their preparation 失效
标题翻译： 4-羟基四氢吡喃-2-酮和相应的二羟基羧酸衍生物，盐和酯及其制备方法
公开(公告)号：US5294724A
公开(公告)日：1994-03-15
申请号：US578240
申请日：1990-09-06
申请人： Heiner Jendralla , Gunther Wess , Kurt Kesseler , Gerhard Beck
发明人： Heiner Jendralla , Gunther Wess , Kurt Kesseler , Gerhard Beck
IPC分类号： C07D319/06 , A61K31/35 , A61K31/357 , A61K31/365 , A61K31/366 , A61P3/06 , A61P9/10 , A61P43/00 , C07C1/24 , C07C17/12 , C07C17/26 , C07C39/08 , C07C43/23 , C07C45/46 , C07C46/04 , C07C50/24 , C07C69/712 , C07C323/20 , C07C331/10 , C07D309/30 , C07C69/612 , C07C321/04 , C07C321/26
CPC分类号： C07C17/12 , C07C1/24 , C07C17/263 , C07C17/2632 , C07C323/20 , C07C331/10 , C07C45/46 , C07C46/04 , C07C50/24 , C07C69/712 , C07D309/30 , C07C2101/02
摘要： 4-Hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceuticals, and pharmaceutical preparations and precursors.Compounds of the formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings indicated, and also their pharmacologically tolerable salts with bases and their pharmacologically tolerable esters, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. In addition, compounds of the formula III ##STR3## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and Y have the meanings indicated are described.
摘要翻译： 4-羟基四氢吡喃-2-酮和相应的二羟基羧酸衍生物，盐和酯，其制备方法，它们作为药物的用途，以及药物制剂和前体。其中X，Y，R 1，R 2，R 3，R 4和R 5具有所示含义的式I化合物（*化学结构*）I和相应的式II（* CHEMICAL STRUCTURE *）II的开链二羟基羧酸，以及它们与碱的药理学上可耐受的盐及其药理学上可耐受的酯，这些化合物的制备方法，它们作为药物和药物制剂的用途。另外，描述了其中R 1，R 2，R 3，R 4，R 5，X和Y具有所述含义的式III化合物（*化学结构*）III。

10. 发明授权

US5209832A Process for the preparation of metal complex dyes 失效
标题翻译：制备金属复合染料的方法
公开(公告)号：US5209832A
公开(公告)日：1993-05-11
申请号：US805428
申请日：1991-12-11
申请人： Wilhelm Schmidt , Gerhard Beck
发明人： Wilhelm Schmidt , Gerhard Beck
IPC分类号： C09B45/01 , C09B45/08 , C09B45/10 , C09B45/12 , C09B45/20 , C09B55/00
CPC分类号： C09B45/01 , C09B45/20
摘要： The invention relates to a process for the preparation of a metal complex dye under production conditions, which comprises reacting at least one dye with a metal donor, adding said metal donor or said dye discontinuously before the end point of the metallizing is reached, and determining the end of the metallizing voltametrically.The process makes it possible to prepare metal complex dyes in good yield and purity.
摘要翻译：本发明涉及在生产条件下制备金属络合物染料的方法，该方法包括使至少一种染料与金属供体反应，在达到金属化终点之前不连续地加入所述金属供体或所述染料，并确定金属化电压的结束。该方法使得可以以良好的产率和纯度制备金属络合染料。

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