会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • PROCESS FOR THE PREPARATION OF 4-BROMOPHENYL DERIVATIVES
    • 制备4-溴苯衍生物的方法
    • US20110155950A1
    • 2011-06-30
    • US13056692
    • 2009-07-30
    • Andreas LindenmaierMartin VogtGerhard BeckAchim Bührer
    • Andreas LindenmaierMartin VogtGerhard BeckAchim Bührer
    • C09K3/00
    • C07C41/22Y02P20/582C07C43/225
    • Disclosed is a process for the preparation of a mixture of 4-bromophenyl derivatives (compound of formula (2)) and 2,4-dibromophenyl derivatives (compound of formula (3)) comprising the steps of [1] reacting in a two-phase (liquid-liquid) system a bromide containing source with a phenyl derivative (formula (1)) in the presence of an excess of an oxidizing agent, an acid, and optionally a catalyst selected from vanadium pentoxide and ammonium heptamolybdate forming 4-bromo- (compound of formula (2)) and 2,4-dibromo derivatives (compound of formula (3)) and as intermediate product the 2-bromo derivative (compound of formula (4)) which reacts in step [2] to the 2,4-dibromo derivative (formula (3)) according to the following reaction scheme 2 wherein R1 is hydroxy; C1-C5alkoxy; or —NR2R3; and R2 and R3 independently from each other are hydrogen; or C1-C5alkyl.
    • 公开了一种制备4-溴苯基衍生物(式(2)化合物)和2,4-二溴苯基衍生物(式(3)化合物)的混合物的方法,包括以下步骤:[1] 相(液 - 液)体系含有苯基衍生物(式(1))的溴化物源在过量的氧化剂,酸和任选的催化剂存在下,选自五氧化二钒和七钼酸铵,形成4-溴 - (式(2)的化合物)和2,4-二溴衍生物(式(3)的化合物),作为在步骤[2]中反应的2-溴衍生物(式(4)的化合物)作为中间产物,与 2,4-二溴衍生物(式(3)),其中R 1是羟基; C1-C5烷氧基; 或-NR2R3; R2和R3彼此独立地为氢; 或C 1 -C 5烷基。