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    • 8. 发明专利
    • Tocopherol derivative, ascorbic acid derivative and skin preparation for external use comprising surfactant having lipopeptide structure
    • 化妆品衍生物,抗坏血酸衍生物和皮肤制剂,用于包含具有脂蛋白结构的表面活性剂的外用
    • JP2005336171A
    • 2005-12-08
    • JP2005128105
    • 2005-04-26
    • Showa Denko Kk昭和電工株式会社
    • KATO EIKOTSUZUKI SATOSHIOGATA EIJI
    • A61K8/00A61K8/02A61K8/06A61K8/30A61K8/49A61K8/64A61K8/67A61Q19/00A61K7/48A61K7/00
    • PROBLEM TO BE SOLVED: To provide a skin preparation for external use (including cosmetics) which simultaneously comprises at least a tocopherol glycine ester and an ascorbic acid compound and is enhanced in stability with time. SOLUTION: The skin preparation for external use comprises (A) a tocopherol glycine ester, (B) an ascorbic acid-2-phosphoric acid ester and a specific amount of (C) an anionic surfactant having a lipopeptide structure. The skin preparation for external use (including cosmetics) exhibits enhanced stability of the tocopherol glycine ester and is prevented from discoloration (including turbidity) of the preparation and/or generation of precipitation with the lapse of time though it simultaneously contains the tocopherol glycine ester and the ascorbic acid compound to effectively exhibit efficacy and effects thereof over a long period of time. COPYRIGHT: (C)2006,JPO&NCIPI
    • 要解决的问题:提供同时包含至少一种生育酚甘氨酸酯和抗坏血酸化合物的外用皮肤制剂(包括化妆品),并且随时间稳定性提高。 < P>解决方案:外用皮肤制剂包含(A)生育酚甘氨酸酯,(B)抗坏血酸-2-磷酸酯和特定量的(C)具有脂肽结构的阴离子表面活性剂。 外用皮肤制剂(包括化妆品)表现出增强的生育酚甘氨酸酯的稳定性,并且随着时间的推移防止了制剂的变色(包括浊度)和/或沉淀的产生,尽管它同时含有生育酚甘氨酸酯和 所述抗坏血酸化合物在长时间内有效地显示其功效和效果。 版权所有(C)2006,JPO&NCIPI