发明专利
JP2005350445A Hydrated lamellar phase or liposome which contains fatty monoamine or cationic polymer which promotes intracellular penetration, and cosmetic or pharmaceutical composition containing the same, and method for screening such substance
有权
基本信息:
- 专利标题： Hydrated lamellar phase or liposome which contains fatty monoamine or cationic polymer which promotes intracellular penetration, and cosmetic or pharmaceutical composition containing the same, and method for screening such substance
- 专利标题（中）：含有促进细胞内渗透的脂肪单胺或阳离子聚合物的水杨酸钠或脂质体，以及含有它们的化妆品或药物组合物以及用于筛选这些物质的方法
- 申请号：JP2004370552 申请日：2004-12-22
- 公开(公告)号：JP2005350445A 公开(公告)日：2005-12-22
- 发明人： ANDRE VALERIE , BONNET ISABELLE , PERRIER ERIC
- 申请人： Coletica , コレティカColetica
- 专利权人： Coletica,コレティカColetica
- 当前专利权人： Coletica,コレティカＣｏｌｅｔｉｃａ
- 优先权： FR0405640 2004-05-25
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K8/00 ; A61K8/02 ; A61K8/04 ; A61K8/14 ; A61K8/30 ; A61K8/35 ; A61K8/37 ; A61K8/40 ; A61K8/41 ; A61K8/44 ; A61K8/49 ; A61K8/55 ; A61K8/58 ; A61K8/64 ; A61K8/65 ; A61K8/72 ; A61K8/73 ; A61K8/81 ; A61K8/84 ; A61K8/96 ; A61K8/98 ; A61K9/127 ; A61K9/20 ; A61K47/14 ; A61K47/16 ; A61K47/18 ; A61K47/24 ; A61K47/28 ; A61K47/34 ; A61K47/36 ; A61K47/38 ; A61K47/42 ; A61K47/44 ; A61K49/12 ; A61P3/02 ; A61P3/04 ; A61P17/16 ; A61P39/06 ; A61Q1/00 ; A61Q1/04 ; A61Q1/06 ; A61Q1/10 ; A61Q5/00 ; A61Q5/06 ; A61Q5/10 ; A61Q19/00 ; A61Q19/02 ; A61Q19/04 ; A61Q19/08 ; B01J13/16 ; C12N15/00 ; C12Q1/02 ; G01N21/78 ; G01N33/15 ; A61K7/00 ; A61K7/025 ; A61K7/032 ; A61K7/06 ; A61K7/13 ; A61K7/48
摘要：
PROBLEM TO BE SOLVED: To provide a hydrated lamellar phase or a liposome which promotes intracellular penetration; to obtain a cosmetic or pharmaceutical composition containing the hydrated lamellar phase or the liposome; and to provide a method for screening such substance. SOLUTION: The hydrated lamellar phase or liposome contains either a polyethylenimine, or a substance which stimulates the intracellular penetration and selected from the group consisting of a fatty monoamine of a 10-18C carbon-containing chain length and a cationic polymer, optionally at least one fluorescent compound which is essentially inert with respect to the intracellular penetration, which enables this penetration to be visualised. The cosmetic composition and the pharmaceutical composition use the hydrated lamellar phase or liposome. A substance held in the hydrated lamellar phase or in the liposome, or a substance potentially having the ability for stimulating the intercellular penetration of an active ingredient is screened by detecting the intercellular penetration of at least the fluorescent compound by measuring the intercellular fluorescence by using the hydrated lamellar phase or the liposome. COPYRIGHT: (C)2006,JPO&NCIPI
摘要（中）：
要解决的问题：提供促进细胞内渗透的水合层状相或脂质体; 以获得含有水合层状相或脂质体的化妆品或药物组合物; 并提供筛选该物质的方法。 溶液：水合层状相或脂质体含有聚乙烯亚胺或刺激细胞内渗透并选自含10-18C含碳链长度的脂肪单胺和阳离子聚合物的物质，任选地 至少一种荧光化合物，其相对于细胞内渗透基本上是惰性的，这使得能够使该渗透成为可视化的。 化妆品组合物和药物组合物使用水合层状相或脂质体。 保持在水合层状相或脂质体中的物质或潜在地具有刺激活性成分的细胞间渗透能力的物质通过使用以下方法检测至少荧光化合物的细胞间渗透来测定细胞间荧光： 水合层状相或脂质体。 版权所有（C）2006，JPO＆NCIPI
公开/授权文献:
- JP4950419B2 公开/授权日：2012-06-13