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1. 发明专利

JP2009051741A Nfat signal inhibitor and nfat signal inhibition method 审中-公开
标题翻译： NFAT信号抑制剂和NFAT信号抑制方法
公开(公告)号：JP2009051741A
公开(公告)日：2009-03-12
申请号：JP2007217134
申请日：2007-08-23
申请人： Kao Corp , National Inst Of Medicinal Materials , ナショナル・インスティテュート・オブ・メディシナル・マテリアルズNational Institute of Medicinal Materials , 花王株式会社
发明人： NAGASAWA AZUMI , MORIWAKI SHIGERU , NISHIZAWA YOSHINORI , NGUYEN HU ZON , BUI CHI BAN , RI GUE GA , GO BAN TORAI , FAN BAN TAIN , NGUYEN KIM BICHI
IPC分类号： A61K36/18 , A61K8/97 , A61K36/28 , A61K36/53 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/10 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/06 , A61P19/08 , A61P25/00 , A61P29/00 , A61P31/00 , A61P31/06 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61Q7/00 , A61Q19/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a new nuclear factor of activated T cells (NFAT) signal inhibitor which can inhibit NFAT signal.
SOLUTION: This NFAT signal inhibitor comprises at least one selected from the group consisting of at least plant selected from Dolichandrone spthacea, Cocculus orbiculatus, and Siegesbeckia orientalis L., the extract of the plant, and an ingredient contained in the extract, as an active ingredient. The NFAT signal inhibitor of the present invention can be applied to various fields such as external preparations, pharmaceutical compositions, cosmetics and foods.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供可抑制NFAT信号的活化T细胞（NFAT）信号抑制剂的新核因子。解决方案：该NFAT信号抑制剂包括至少一种选自至少一种选自杜立丹酮，，藜，Coc and L.，植物提取物，以及提取物中所含的成分的植物，作为活性成分。本发明的NFAT信号抑制剂可以应用于外用制剂，药物组合物，化妆品，食品等各种领域。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2005343887A Elastase inhibitor 审中-公开
标题翻译：弹性抑制剂
公开(公告)号：JP2005343887A
公开(公告)日：2005-12-15
申请号：JP2005126684
申请日：2005-04-25
申请人： Kao Corp , 花王株式会社
发明人： MORIWAKI SHIGERU , MORIZAKI NAOKO , HALL CHRISTINE
IPC分类号： A61K8/00 , A61K8/64 , A61K8/65 , A61K8/72 , A61K8/96 , A61K38/01 , A61K38/16 , A61Q5/00 , A61Q7/02 , A61Q9/02 , A61Q9/04 , A61Q15/00 , A61Q19/00 , A61Q19/08 , A61K7/155 , A61K7/00 , A61K7/48
CPC分类号： A61Q9/02 , A61K8/645 , A61K38/011 , A61K38/012 , A61K38/018 , A61K2800/782 , A61Q7/02 , A61Q15/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceuticals or a cosmetic exerting body hair growth inhibitory effect and skin aging preventive effects such as amelioration of skin resilience and skin firmness and wrinkles. SOLUTION: An elastase inhibitor is provided, comprising a protein hydrolyzate (except soybean and almond protein hydrolyzates) as active ingredient. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供药物或化妆品发挥身体毛发生长抑制作用和皮肤老化预防效果，例如改善皮肤弹性和皮肤紧致性和皱纹。解决方案：提供弹性蛋白酶抑制剂，其包含蛋白质水解产物（大豆和杏仁蛋白水解物除外）作为活性成分。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2003048845A Water-soluble essence of ginger 有权
标题翻译： GINGER的水可溶性
公开(公告)号：JP2003048845A
公开(公告)日：2003-02-21
申请号：JP2001236854
申请日：2001-08-03
申请人： Kao Corp , 花王株式会社
发明人： SHIBUYA YUSUKE , MORIWAKI SHIGERU , TSUJI NAOKO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/9068 , A61P17/00 , A61Q5/00 , A61Q7/02 , A61Q9/04 , A61Q19/00 , A61K35/78 , A61K7/00 , A61K7/155 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/97 , A61K36/9068 , A61K2800/75 , A61Q7/02
摘要： PROBLEM TO BE SOLVED: To provide a water-soluble essence of ginger hardly irritating the skin because of containing no zingerols, and useful as a hair-controlling agent and an external preparation having high safety because of having excellent activities for inhibiting the growth of the hair. SOLUTION: This water-soluble essence of the ginger is the essence obtained by extracting the ginger with water or a hydrated alcohol, and substantially free from the zingerols. The hair-controlling agent and the external preparation contains the essence.
摘要翻译：要解决的问题：为了提供姜的水溶性精华，因为不含姜酸酯，几乎不刺激皮肤，并且由于具有优异的抑制生长的活性，因此可用作具有高安全性的头发控制剂和外用制剂头发。解决方案：姜的这种水溶性香精是通过用水或水合醇提取生姜，基本上不含姜饼而获得的精华。护发剂和外用制剂含有精华。

4. 发明专利

JP2010001227A Hair-growing agent, nfat signal inhibitor and calcineurin inhibitor 审中-公开
标题翻译：发胶剂，NFAT信号抑制剂和CALCINEURIN抑制剂
公开(公告)号：JP2010001227A
公开(公告)日：2010-01-07
申请号：JP2008159242
申请日：2008-06-18
申请人： Kao Corp , National Inst Of Medicinal Materials , ナショナル・インスティテュート・オブ・メディシナル・マテリアルズNational Institute of Medicinal Materials , 花王株式会社
发明人： NAGASAWA AZUMI , MORIWAKI SHIGERU , NISHIZAWA YOSHINORI , NGUYEN HU ZON , BUI CHI BAN , RI GUE GA , GO BAN TORAI , FAN BAN TAIN , NGUYEN KIM BICHI
IPC分类号： A61K8/97 , A61K36/899 , A61P9/04 , A61P17/06 , A61P17/14 , A61P19/08 , A61P25/18 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , A61Q7/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a new hair-growing agent, an NFAT signal inhibitor and a calcineurin inhibitor, an NFAT signal inhibiting method, and a calcineurin activity-inhibiting agent. SOLUTION: The hair-growing agent, the NFAT signal inhibitor and the calcineurin inhibitor each contains at least one selected from the group consisting of a lemon grass plant and the extract of the plant as an active ingredient. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供新的毛发生长剂，NFAT信号抑制剂和钙调磷酸酶抑制剂，NFAT信号抑制法和钙调神经磷酸酶抑制剂。解决方案：毛发生长剂，NFAT信号抑制剂和钙调神经磷酸酶抑制剂各自含有选自柠檬草植物和植物提取物中的至少一种作为活性成分。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2004267095A Bedsore model animal 审中-公开
标题翻译： BEDSORE模型动物
公开(公告)号：JP2004267095A
公开(公告)日：2004-09-30
申请号：JP2003062033
申请日：2003-03-07
申请人： Kao Corp , 花王株式会社
发明人： SOGA HAJIME , OUCHI ATSUSHI , MORIWAKI SHIGERU
IPC分类号： A01K67/027
摘要： PROBLEM TO BE SOLVED: To easily provide an experimental model animal capable of reproducing a bedsore-like skin necrotic condition.
SOLUTION: A method for creating a bedsore model animal comprises picking up the skin of an experimental mammal, nipping the skin in between two hard and flat plates, fixing both sides thereof with clips and then carrying out a press treatment under a pressure of 0.015-15 MPa for 3-24 h.
COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：为了容易地提供能够再现褥疮样皮肤坏死状况的实验模型动物。解决方案：用于产生褥疮模型动物的方法包括拾取实验哺乳动物的皮肤，将皮肤夹在两个硬和平板之间，用夹子固定两侧，然后在压力下进行压力处理 0.015-15MPa 3-24小时。版权所有（C）2004，JPO＆NCIPI

6. 发明专利

JPH11279040A Composition for external use for skin 失效
标题翻译：用于皮肤外用的组合物
公开(公告)号：JPH11279040A
公开(公告)日：1999-10-12
申请号：JP8141898
申请日：1998-03-27
申请人： Kao Corp , 花王株式会社
发明人： SUZUKI YASUTO , TSUJI NAOKO , MORIWAKI SHIGERU , NISHIZAWA YOSHINORI
IPC分类号： C07D207/16 , A61K8/00 , A61K8/02 , A61K8/30 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61K8/58 , A61K8/97 , A61K31/185 , A61K31/195 , A61K31/22 , A61K31/27 , A61K31/40 , A61K31/66 , A61P17/00 , A61Q5/00 , A61Q7/00 , A61Q9/04 , A61Q19/00 , A61Q19/08 , A61K7/48 , A61K7/00 , A61K7/06
CPC分类号： A61K8/97 , A61K8/44 , A61K8/442 , A61K8/55 , A61Q7/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To obtain a composition for external use for skin that can manifest the effect of skin aging prevention or improvement such as inhibition of occurrence of skin wrinkles and the inhibitory action of skin hair growth.
SOLUTION: This composition for external use contains, as an active ingredient, a compound represented by formula I [X is COOR
2 (R
2 is H, an alkyl), a group of formula (R
3 and R
4 are each H, an alkyl, aralkyl), a group of formula III (R
5 is H, an alkyl or the like; R
6 is an aralkyl), SO
3 H; Y is N(R
1 ') (R
1 ' is H, a lower alkyl), O, CH
2 ; Z is CON (R
7 )R
8 or COOR
9 (R
7 , R
8 , and R
9 are each H, an alkyl) or the like; R
1 is H, an alkyl, an aralkyl or the like] or its salts. The compound of formula I is, for example, N-i-butoxy-L-leucineamide. The compound of the formula is preferably formulated in an amount of 0.0001-40 wt.% to the whole composition. The compound of formula I can be readily synthesized.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：获得能够表现皮肤老化防止或改善的效果的皮肤外用组合物，例如抑制皮肤皱纹的发生和皮肤毛发生长的抑制作用。解决方案：该外用组合物含有由式I表示的化合物[X为COOR 2（R 2为H，烷基）），式（R 3和R 式（4）各自为H，烷基，芳烷基），式III的基团（R 5为H，烷基等; R 6为芳烷基），SO 3 H; Y是N（R'）（R 1'是H，低级烷基），O，CH 2; Z是CON（R 7）R 8或COOR 9（R 7，R 8和R 9各自为H，烷基）等; R 1是H，烷基，芳烷基等]或其盐。式I的化合物是例如N-异丁氧基-L-亮氨酸酰胺。配方的化合物优选配制成对整个组合物为0.0001-40重量％的量。式I化合物可以容易地合成。

7. 发明专利

JP2007332159A External preparation for skin 有权
标题翻译：外用皮肤制剂
公开(公告)号：JP2007332159A
公开(公告)日：2007-12-27
申请号：JP2007219867
申请日：2007-08-27
申请人： Kao Corp , 花王株式会社
发明人： SUZUKI YASUTO , WATANABE MIKAKO , OHASHI YUKIHIRO , MORIWAKI SHIGERU , TSUJI NAOKO
IPC分类号： A61K8/44 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide an external preparation for skin, which has preventing or improving effects to the aging skin such as wrinkles and also has a suppression effect to hair growth.
SOLUTION: The external preparation for skin comprises a malonic acid amide derivative represented by formula (1), or a salt thereof, (wherein R
1 and R
2 are H, an alkyl, an alkenyl or an aralkyl; R
3 is H, an alkyl or an alkenyl, or may form a heterocycle with R
4 and a vicinal nitrogen atom; R
4 is H, an alkyl, an alkenyl or an aralkyl, or may form a heterocycle with R
3 and a vicinal nitrogen atom; R
5 is hydroxy, an alkoxy, an alkenyloxy or an amino acid residue; and n is 0, 1, 3, 4 or 5). The compound of this invention has excellent preventing and improving effects to the aging skin and also has a suppression effect to hair growth.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为皮肤提供外用制剂，其对皱纹等老化皮肤具有预防或改善作用，并且还具有抑制毛发生长的作用。皮肤外用剂包含由式（1）表示的丙二酸酰胺衍生物或其盐，其中R 1 和R 2 H，烷基，烯基或芳烷基; R 3是H，烷基或链烯基，或可以与R SP 4和邻位氮原子形成杂环; R 4是H，烷基，烯基或芳烷基，或者可以与R 3 SP 3和邻位氮原子形成杂环; R SP 5 >是羟基，烷氧基，烯氧基或氨基酸残基; n是0,1,3,4或5）。本发明的化合物对皮肤老化具有优异的防止和改善的效果，并且还具有抑制毛发生长的作用。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2005343872A Aromatase activator 审中-公开
标题翻译： AROMATASE激活器
公开(公告)号：JP2005343872A
公开(公告)日：2005-12-15
申请号：JP2004168996
申请日：2004-06-07
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , MORIWAKI SHIGERU , OUCHI ATSUSHI , KUSUOKU HIROSHI
IPC分类号： A61K8/96 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/42 , A61K36/48 , A61K36/53 , A61K36/75 , A61K36/81 , A61K36/896 , A61K36/899 , A61P3/06 , A61P5/30 , A61P9/10 , A61P15/12 , A61P19/08 , A61P19/10 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/12 , A61P43/00 , A61K35/78 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a medicine or a cosmetic that is highly safe and useful for preventing, ameliorating or treating various symptoms caused by estrogen deficiency by promoting estrogen formation in the body. SOLUTION: The subject aromatase activator comprises one or more kinds selected from a plant selected from Hydrangea serrata, Arnica Montana Arnica, Foeniculum vulgare, Curcuma longa, Corydalis turtschaninovii, Isodon japonicus, Scutellaria baicalensis, Curcuma zedoaria, Catalpa ovata, Citrus aurantium, Sasa Veitchii, Schizonepeta tenuifolia, Cassia obatusifolia, Magnolia obovata, Evodia rutaecarpa, Bupleurum falcatum, Asarum sieboldii, Zanthoxylum piperitum, Elettaria cardamomum, Malva sylvestris, Cnidium officinale, Angelica acutiloba, Lycopersicon esculentum, Glehnia littoralis, Atractylodes japonica, Luffa cylindrica, Carthamus tinctorius, Typha latifolia, Lilium candidum, Gentiana scabra and rosin, their extracts, oryza oil, hydrolyzed wheat essence, shea butter and rice fermented essence. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：通过促进体内雌激素形成，获得高度安全和有效的药物或化妆品，用于预防，改善或治疗由雌激素缺乏引起的各种症状。解决方案：本发明的芳香酶活化剂包括选自以下的植物中的一种或多种：选自绣球绣球，山金车花，茯苓，姜黄，紫草，紫草，黄芩，枸杞，枸杞，，Sasa Veitchii，Schizonepeta tenuifolia，Cassia obatusifolia，Magnolia obovata，Evodia rutaecarpa，Bupleurum falcatum，Asarum sieboldii，Zanthoxylum piperitum，Elettaria豆蔻，马鞭草，Cnidium officinale，当归，茄子，白花椒，百合，龙胆，松香，他们的提取物，oryza油，水解小麦精华，乳木果油和米发酵精华。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2005206609A Preventive for skin aging 审中-公开
标题翻译：预防皮肤老化
公开(公告)号：JP2005206609A
公开(公告)日：2005-08-04
申请号：JP2005110561
申请日：2005-04-07
申请人： Kao Corp , 花王株式会社
发明人： TSUJI NAOKO , MORIWAKI SHIGERU , IMOKAWA GENJI , SUZUKI YASUTO , NISHIZAWA YOSHINORI
IPC分类号： A61K8/00 , A61K8/30 , A61K8/46 , A61K8/49 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61K7/48 , A61K7/00 , A61K7/035
摘要： PROBLEM TO BE SOLVED: To provide medicines or cosmetics capable of preventing and improving symptoms caused by skin aging typified by wrinkles.
SOLUTION: The preventive for skin aging comprises a mercaptopropionamide derivative of formula (1) [wherein, R
1 is H or an acyl; R
2 is H or a (substituted) hydrocarbon; R
3 is H, a (substituted) hydrocarbon, a (substituted) heterocyclic or an acyl; and n is 1-20] or a salt thereof.
COPYRIGHT: (C)2005,JPO&NCIPI

10. 发明专利

JP2013060460A Nfat signal inhibitor and nfat signal-inhibiting method 审中-公开
标题翻译： NFAT信号抑制剂和NFAT信号抑制方法
公开(公告)号：JP2013060460A
公开(公告)日：2013-04-04
申请号：JP2012274686
申请日：2012-12-17
申请人： Kao Corp , 花王株式会社
发明人： NAGASAWA AZUMI , MORIWAKI SHIGERU
IPC分类号： A61K36/23 , A61K8/97 , A61K36/28 , A61P17/00 , A61P17/06 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , C12N9/16 , C12N9/99 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a new NFAT signal inhibitor capable of inhibiting an NFAT signal.SOLUTION: The NFAT signal inhibitor includes at least one selected from the group consisting of at least one plant selected from plant species listed in plant name columns of Table 1, the extract of the plant, and an ingredient contained in the extract, as an active ingredient. The NFAT signal inhibitor can be applied to various fields such as external preparations, pharmaceutical compositions, cosmetics and foods.

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