专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JPH0291100A PROTEIN INHIBITING HUMAN PHOSPHOLIPASE A2 失效
公开(公告)号：JPH0291100A
公开(公告)日：1990-03-30
申请号：JP24255688
申请日：1988-09-29
申请人： TEIJIN LTD
发明人： IMAIZUMI ATSUSHI , SUWA YORIMASA , OKADA MASAHIRO , SUZUKI YOJI , KUDO ICHIRO , INOUE KEIZO
IPC分类号： C12P21/00 , A61K38/55 , A61P29/00 , C12P21/06
摘要： NEW MATERIAL:A protein having inhibiting activity against phlogogenic phospholipase A2 obtained by enzyme treatment of human complement C3. USE:Anti-inflammatory drug with a slight adverse effect or remedy of systemic lupus erythematosus, chronic rheumatism or bronchial asthma, etc. PREPARATION:For instance, 0.5 M NaCl is added to human C3 and heated at 37 deg.C for several min, then immobilized enzyme in which trypsin is immobilized to agarose is added and reacted for 10min with shaking, thus the immobilized enzyme is precipitated by centrifuge and supernatant is collected, then applied to high-performance liquid chromatography and eluted with tris buffer solution, thus a protein having inhibiting activity against phospholipase A2 derived from synovial fluid of human chronic rheumatism patient.

2. 发明专利

JPH0123447B2 失效
公开(公告)号：JPH0123447B2
公开(公告)日：1989-05-02
申请号：JP10377782
申请日：1982-06-18
申请人： TEIJIN LTD
发明人： ONO SHOJI , SUZUKI YOJI , IMAIZUMI ATSUSHI
IPC分类号： A61K39/02 , A61K35/74 , A61K38/04 , A61K39/10

3. 发明专利

JPS6222064A METHOD FOR MEASURING VIII-TH FACTOR CLOTTING ACTIVE ANTIGEN 失效
公开(公告)号：JPS6222064A
公开(公告)日：1987-01-30
申请号：JP16106085
申请日：1985-07-23
申请人： TEIJIN LTD
发明人： MASUDA KENICHI , HOSODA KENJI , SUZUKI YOJI , SUZUKI HIDEAKI
IPC分类号： G01N33/53 , A61K39/00 , C12Q1/00 , G01N33/543 , G01N33/577
摘要： PURPOSE:To easily and quickly and economically make specific measurement of FVIII:CAg by using two monoclonal antibodies which recognize different antigen sites without reacting with serum components to measure the VIII-th factor clotting active antigen. CONSTITUTION:The FVIII:CAg is specifically measured by acting the 2nd anti- FVIII:CAg subjected to enzyme labeling, radioactive material labeling or fluorescent labeling to the FVIII:CAg conjugated with the solid phase antibody obtd. by bringing the 1st anti-FVIII:CAg monoclonal a antibody fixed to the solid phase into contact with a specimen of the human plasma, bodily fluid or soln. contg. the FVIII:CAg, etc. The antibody to be used may be an IgG antibody, intact antibody or antibody fragment such as F(ab')2 or Fab'. This method is simpler and more economical than a measuring method in which the IgG prepd. from a hemophilia A patient or anti-VIII:CAg polyclonal antibody is used.

4. 发明专利

JPS6144470B2 失效
公开(公告)号：JPS6144470B2
公开(公告)日：1986-10-02
申请号：JP24454683
申请日：1983-12-27
申请人： TEIJIN LTD
发明人： SUZUKI YOJI , IMAIZUMI ATSUSHI , YAMAGUCHI HISAO , KANEZAKI MASAHARU , ONO SHOJI
IPC分类号： C12N1/38 , C12N1/20 , C12R1/01

5. 发明专利

JPS6139951B2 失效
公开(公告)号：JPS6139951B2
公开(公告)日：1986-09-06
申请号：JP11537176
申请日：1976-09-28
申请人： TEIJIN LTD
发明人： ONO SHOJI , SUGYAMA TAKASHI , KAWAKAMI YOSHIKO , ICHIKAWA YATARO , SUZUKI YOJI , OOMORI HITOSHI , AZUMA AKIKO
IPC分类号： C07D499/68 , A61K31/43 , A61P31/04 , C07D499/64

6. 发明专利

JPS5176485A Koseibushitsuno seizoho 失效
标题翻译： KOSEIBUSHITSUNO SEIZOHO
公开(公告)号：JPS5176485A
公开(公告)日：1976-07-02
申请号：JP14826474
申请日：1974-12-26
申请人： Teijin Ltd
发明人： SUZUKI YOJI , MISAWA FUMIO , SAWADA SHUZO , MATSUBARA SADAKAZU
IPC分类号： C12P19/48 , C07H15/22 , C07H15/234 , C12R1/66 , C12R1/74 , C12R1/845 , C12R1/865

7. 发明专利

JPS6351389A CEPHALOSPORIN DERIVATIVE, PRODUCTION THEREOF AND COMPOSITION HAVING ANTIMICROBIAL ACTIVITY 失效
公开(公告)号：JPS6351389A
公开(公告)日：1988-03-04
申请号：JP19565786
申请日：1986-08-22
申请人： TEIJIN LTD
发明人： HARADA TOSHIAKI , IMAI HIROSHI , YOSHISATO AKINOBU , ICHIKAWA YATARO , SUZUKI YOJI
IPC分类号： C07D501/46 , A61K31/545 , A61K31/546 , A61P31/04
摘要： NEW MATERIAL:A compound expressed by formula I [R is H or protecting group; R is (substituted)phenyl; R is 5--6-membered ring hetero aromatic cation capable of containing O, S and N hetero atom in a ring and condensing with other ring]. EXAMPLE:(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-phenoxyiminoacetamido ]-3-pyri diniummethyl-3-cephem-4-carboxylate. USE:An antimicrobial agent against Gram-positive and Gram-negative bacteria. PREPARATION:A cephalosporin compound (salt) expressed by formula III (R is H or protecting group; Q is acyloxy, carbamoyloxy or halogen; p is 0 or 1) is reacted with a compound (salt) expressed by the formula R ' (R ' is base corresponding to R ) and, as necessary, followed by deprotecting, salt forming, esterification and reductive reaction.

8. 发明专利

JPS6219595A CEPHALOSPORIN DERIVATIVE, PRODUCTION THEREOF AND ANTIBACTERIAL AGENT COMPRISING SAME AS ACTIVE INGREDIENT 失效
公开(公告)号：JPS6219595A
公开(公告)日：1987-01-28
申请号：JP15688685
申请日：1985-07-18
申请人： TEIJIN LTD
发明人： YOSHISATO AKINOBU , HARADA TOSHIAKI , IMAI YUSHI , ICHIKAWA YATARO , SUZUKI YOJI , SUMOTO KUNIHIRO , MIYANO SEIJI
IPC分类号： C07D519/06 , A61K31/545 , A61P31/04 , C07D487/08 , C07D501/46 , C07D519/00
摘要： NEW MATERIAL:A compound shown by the formula I [R is (protected) amino; R is H, (substituted)lower alkyl, (substituted)cycloalkyl or (substituted)hetero cyclic; R -R are H or alkyl] its salt or its ester. EXAMPLE:(6R, 7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoace-tamido]-3-(1- azabicyclo[3,3,1]non-1-io)methyl-3-cephem-4-carboxylate. USE:An antibacterial agent against Gram-positive and negative bacteria. PREPARATION:A cephalosporin compound (salt) shown by the formula II (R is H or protecting group; Q is acyloxy, carbamoyloxy or halogen; P is 0 or 1) is reacted with a compound (salt) shown by the formula III, optionally deprotected, subjected to salt formation and esterified and/or reduced.

9. 发明专利

JPS59181222A Production of infection protective antigen ha fraction for bordetella pertussis 失效
$Production of infection protective antigen ha fraction for bordetella pertussis$
标题翻译：生产BORDETELLA PERTUSSIS的感染保护性抗原HA区
公开(公告)号：JPS59181222A
公开(公告)日：1984-10-15
申请号：JP5468083
申请日：1983-03-30
申请人： Chemo Sero Therapeut Res Inst , Teijin Ltd
发明人： GINNAGA AKIHIRO , KOBA HIROSHI , SAKUMA SHIN , KITAGAWA HISASHI , YAMADA AKIRA , SUZUKI YOJI
IPC分类号： A61K39/095 , A61K38/36 , A61K39/10 , C12N1/20
摘要： PURPOSE: To obtain the titled fraction in large amounts, by controlling temperature and amount of dissolved oxygen at specific values in cultivating Bordetella pertussis in a culture medium containing cyclodextrin, etc. under defoaming conditions.
CONSTITUTION: Bordetella pertussis is inoculated into a liquid culture medium containing 0.001W5g/l cyclodextrin or a derivative thereof, e.g. methylated α- cyclodextrin, and the cultivation with aeration is carried out with agitation at 20W37°C cultivation temperature while keeping the amount of dissolved oxygen at 0.7W6.0ppm in the culture medium and defoaming, e.g. by mechanical defoaming means or addition of chemical defoaming agent to collect the aimed infection protective antigen HA fraction in the logarithmic growth phase or bacterial growth stage of stationary phase. The above-mentioned liquid culture medium is preferably Stainer-Scholte culture medium, particularly preferably an improved culture medium prepared by adjusting 0.1W20g/l casamino acid, 0.01W1g/l ascorbic acid and 0.1W5g/l glutathione in the Stainer-Scholte culture medium as a basic culture medium.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：在消泡条件下，在含有环糊精等的培养基中，通过控制培养百日盛博氏杆菌中的特定值的温度和溶解氧量来获得大量的标题。组成：将百日咳博德特氏菌接种到含有0.001-5g / l环糊精或其衍生物的液体培养基中，甲基化α-环糊精，并且在20-37℃培养温度下搅拌进行通气培养，同时将培养基中溶解氧的量保持在0.7-6.0ppm，并且消泡，例如，通过机械消泡手段或添加化学消泡剂来收集目标感染保护性抗原HA级分在固定相的对数生长期或细菌生长期。上述液体培养基优选为Stainer-Scholte培养基，特别优选通过在Stainer-Scholte培养基中调节0.1-20g / l酪蛋白氨基酸，0.01-1g / l抗坏血酸和0.1-5g / l谷胱甘肽而制备的改良培养基， Scholte培养基作为基础培养基。

10. 发明专利

JPS5112941A 失效
公开(公告)号：JPS5112941A
公开(公告)日：1976-01-31
申请号：JP8210974
申请日：1974-07-19
申请人： TEIJIN LTD
发明人： SUZUKI YOJI , SHIMA YOSHUKI , KAWAUCHI TSUYOSHI , KATO TOSHUKI , MISAWA FUMIO , OKIMOTO MASAYUKI , SAITO NAOHISA , MATSUBARA SADAKAZU
IPC分类号： C12N9/10 , C12P19/18

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式