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2. 发明专利

JP2514297B2 失效
公开(公告)号：JP2514297B2
公开(公告)日：1996-07-10
申请号：JP25660792
申请日：1992-09-25
申请人： TEIJIN LTD
发明人： MORINAGA TSUTAE , MIURA KINICHIRO , SHIMOTOONO KUNITADA , IKEGAMI MASATO , ICHIKAWA YATARO
IPC分类号： C12N15/09 , C12N1/21 , C12N15/00 , C12R1/19 , C12R1/92

4. 发明专利

JPH0549272B2 失效
公开(公告)号：JPH0549272B2
公开(公告)日：1993-07-23
申请号：JP17948690
申请日：1990-07-09
申请人： TEIJIN LTD
发明人： MORINAGA TSUTAE , MIURA KINICHIRO , SHIMOTOONO KUNITADA , IKEGAMI MASATO , ICHIKAWA YATARO
IPC分类号： C12N1/21 , C12N15/09 , C12N15/83 , C12R1/19

5. 发明专利

JPH0441782B2 失效
公开(公告)号：JPH0441782B2
公开(公告)日：1992-07-09
申请号：JP8610184
申请日：1984-05-01
申请人： TEIJIN LTD
发明人： WASHIMI YOSHIHIKO , KOIKE YUKYA , ICHIKAWA YATARO , YOSHIDA NOBUHIKO , AOKI NOBUO
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07K14/81 , C07K16/38 , G01N33/573 , G01N33/577

6. 发明专利

JPH03259099A DETECTION OF HEPATITIS C VIRUS AND RELATING NUCLEIC ACID AND OLIGO-DNA SET FOR PRIMER 失效
公开(公告)号：JPH03259099A
公开(公告)日：1991-11-19
申请号：JP5664290
申请日：1990-03-09
申请人： TEIJIN LTD
发明人： MORINAGA TSUTAE , CHAYAMA KAZUAKI , KUMADA HIROMITSU , ICHIKAWA YATARO
IPC分类号： G01N33/576 , C12N15/09 , C12Q1/68 , C12Q1/70 , C12R1/92
摘要： PURPOSE:To enable the detection of the subject material in high sensitivity by amplifying a specific DNA and coloring with a color-developing agent or by hybridizing with a labeled and amplified nucleic acid. CONSTITUTION:A nucleic acid prepared from serum or liver tissue made to react with a template-dependent DNA polymerase (e.g. Taq DNA polymerase) to obtain a synthetic cDNA (A). Separately, an oligo-DNA set (B) for amplification primer of hepatitis C virus and its relating nucleic acid is prepared by selecting each one DNA from the DNA group 1 of formula I and the DNA group 2 of formula II. The component A is amplified with the component B and the obtained DNA is separated by agarose gel electrophoresis to obtain amplified DNA (C). The component C is stained with ethidium bromide, etc., and irradiated with ultraviolet radiation to effect the color development and detect the hepatitis C virus and its relating nucleic acid. As necessary, the component C is hybridized with hepatitis C virus labeled with biotin, etc., and the desired nucleic acid is detected.

8. 发明专利

JPH03127800A TUMOR NECROSIS FACTOR ACTIVITY INHIBITOR 失效
公开(公告)号：JPH03127800A
公开(公告)日：1991-05-30
申请号：JP26488789
申请日：1989-10-13
申请人： TEIJIN LTD
发明人： SUZUKI JUN , YONE KENJI , ICHIKAWA YATARO
IPC分类号： G01N33/50 , A61K38/00 , A61P29/00 , C07K1/20 , C07K14/00 , G01N33/53
摘要： NEW MATERIAL:The title inhibitor having the following characteristics: (1) obtainable by purification of urine; (2) inhibiting the cytocidal effect of tumor necrosis factor on L929 cells; (3) molecular weight: 30000+ or -5000 (gel permeation technique); (4) isoelectric point: PI=5.7+ or -1.0; (5) effecting deactivation when treated with protease; (6) stable under heat treatment at 56 deg.C for 60min. USE:Therapeutic agents and diagnostics for the diseases in which tumor necrosis factors such as for membranoproliferative glomerulonephritis are involved. PREPARATION:For example, the urine of patients with membranoproliferative glomerulonephritis is put to ultrafiltration to concentrate the fraction with a molecular weight of >=10000, and a phosphoric acid buffer is added to the resulting concentrate followed by being put to column chromatography to collect a fraction with tumor necrosis factor activity inhibitory ability, which is then subjected to anion exchange column chromatography, and the adsorbate is eluted through NaCl concentration gradient, thus obtaining the objective tumor necrosis factor activity inhibitor.

9. 发明专利

JPH03112952A NOVEL PHENOL DERIVATIVE 失效
公开(公告)号：JPH03112952A
公开(公告)日：1991-05-14
申请号：JP24927089
申请日：1989-09-27
申请人： TEIJIN LTD
发明人： AZUMA SHIZUO , HIRAMATSU TOSHIYUKI , ICHIKAWA YATARO
IPC分类号： C07D207/16 , A01N37/18 , C07C235/12 , C07C323/59
摘要： NEW MATERIAL:The phenol derivative of formula I [R , R and R are H or is H, lower alkyl. phenyl, benzyl, -CH2CH2SCH3, CH2OH, group of formula II, -CH2SH, -CH2COOCH3, group of formula III, group of formula IV or together with R form -CH2CH2CH2- or group of formula V; n is 0, 1 or 2 (n=0 corresponds to a bond)]. EXAMPLE:The compound of formula VI. USE:Useful as a synthetic intermediate for phenoxy-aliphatic carboxylic acid derivative having excellent herbicidal activity against narrow-leaved weeds. PREPARATION:The compound of formula I is produced e.g. according to the reaction formula.

10. 发明专利

JPH031959B2 失效
公开(公告)号：JPH031959B2
公开(公告)日：1991-01-11
申请号：JP25418684
申请日：1984-12-03
申请人： TEIJIN LTD
发明人： WAKABAYASHI KENJI , WASHIMI YOSHIHIKO , ICHIKAWA YATARO , MIMURO ATSUSHI , AOKI NOBUO
IPC分类号： G01N33/577 , A61K39/395 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/435 , C07K16/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91

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