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1. 发明专利

JPS6144470B2 失效
公开(公告)号：JPS6144470B2
公开(公告)日：1986-10-02
申请号：JP24454683
申请日：1983-12-27
申请人： TEIJIN LTD
发明人： SUZUKI YOJI , IMAIZUMI ATSUSHI , YAMAGUCHI HISAO , KANEZAKI MASAHARU , ONO SHOJI
IPC分类号： C12N1/38 , C12N1/20 , C12R1/01

2. 发明专利

JPS5963183A Cultivation and medium for microorganism belonging to bordetella 失效
标题翻译：微生物的培养和培养与BORDETELLA相关
公开(公告)号：JPS5963183A
公开(公告)日：1984-04-10
申请号：JP17326282
申请日：1982-10-04
申请人： Teijin Ltd
发明人： SUZUKI YOUJI , IMAIZUMI ATSUSHI , KANEZAKI MASAHARU , ONO SHIYOUJI , YAMAGUCHI HISAO
IPC分类号： C12N1/20 , A61K39/095 , A61K39/10 , C12P21/00 , C12R1/01
摘要： PURPOSE: To obtain a biologically active substance effective for medical treatment from a culture efficiently and advantageously, by cultivating a microorganism belonging to the genus Bordetella in a medium containing cassamino acid, ascorbic acid, and glutathione.
CONSTITUTION: A microorganism such as Bordetella pertussis, Bordella bronchiseptica, etc., belonging to the genus Bordella is cultivated in a medium containing 0.1W20g/l casamino acid, 0.01W1g/l ascorbic acid, and 0.1W5g/l glutathine. Consequently, a microorganism such as Bordetella, etc. is cultivated efficiently, pathogenic bacteria such as Bordetella pertussis, etc. are detected quickly and securely to give data useful for clinical diagnosis. A physiologically active substances such as vaccine of whooping cough, active substance or enriching insulin secretion, etc. accumulated in the culture are separaed and purified from the culture, to give a vaccine for preventing whooping cough, a physiologically active substance useful for remedying diabetes, etc. efficiently.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在含有卡氨酸，抗坏血酸和谷胱甘肽的培养基中培养属于博德特氏菌属的微生物，有效和有利地从培养物中获得有效治疗的生物活性物质。构成：将含有0.1-20g / l酪蛋白氨基酸，0.01-1g / l抗坏血酸和0.1-5g / l谷胱甘肽的培养基培养在属于博德氏菌属的百日咳博德特氏菌，博德氏菌属博莱氏菌属等微生物。因此，能够高效地培养博德特氏菌等微生物，快速，安全地检测病原菌如百日咳博德特氏菌等，为临床诊断提供数据。从培养物中积聚的培养物中积聚的百日咳疫苗，活性物质或富集胰岛素分泌物等生理活性物质分离和纯化，得到用于预防百日咳的疫苗，用于治疗糖尿病的生理活性物质，等等。

3. 发明专利

JPS6255075A CULTIVATION OF MICROORGANISM BELONGING TO BORDETELLA GENUS AND MEDIUM THEREFOR 失效
公开(公告)号：JPS6255075A
公开(公告)日：1987-03-10
申请号：JP10488886
申请日：1986-05-09
申请人： TEIJIN LTD
发明人： SUZUKI YOJI , IMAIZUMI ATSUSHI , KANEZAKI MASAHARU , ONO SHOJI , YAMAGUCHI HISAO
IPC分类号： C12N1/38 , A61K39/10 , C12N1/20 , C12Q1/04 , C12R1/01
摘要： PURPOSE:To enable the stable and efficient culture of a microbial strain belonging to Bordetella genus, by using a medium containing specific amounts of casamino acid, ascorbic acid, etc. CONSTITUTION:A microbial strain belonging to Bordetella genus such as Bordetella pertussis, Bordetella bronchiseptica, etc., is detected and/or cultured by using a medium obtained by adding 0.1-20g/l of casamino acid, 0.01-1g/l of ascorbic acid, 0.1g/l of glutathione and 0.001-5g/l of cyclodextrin or its derivative to conventional medium such as SS medium, SSA medium, etc.

4. 发明专利

JPS6028277B2 失效
公开(公告)号：JPS6028277B2
公开(公告)日：1985-07-03
申请号：JP17326282
申请日：1982-10-04
申请人： TEIJIN LTD
发明人： SUZUKI YOJI , IMAIZUMI ATSUSHI , KANEZAKI MASAHARU , ONO SHOJI , YAMAGUCHI HISAO
IPC分类号： C12N1/20 , A61K39/095 , A61K39/10 , C12P21/00 , C12R1/01

5. 发明专利

JPS5867182A CULTURE AND CULTURE MEDIUM 失效
公开(公告)号：JPS5867182A
公开(公告)日：1983-04-21
申请号：JP16347781
申请日：1981-10-15
申请人： TEIJIN LTD
发明人： SUZUKI YOUJI , IMAIZUMI ATSUSHI , YAMAGUCHI HISAO , KANEZAKI MASAHARU , ONO SHIYOUJI
IPC分类号： C12N1/38 , C12Q1/04
摘要： PURPOSE:A culture medium containing cyclodextrin or its derivative is used to culture a microorganism in Bordetella stably in high efficiency. CONSTITUTION:Cyclodextrin, or its derivative, preferably etherified cyclodextrin, particularly methyldextrin such as hexakis(2,6-O-dimethyl)-alpha-cyclodextrin is added by 1-5,000g/ml to a conventional liquid culture medium, solid medium, SS medium or a medium solidified by adding a small amount of agar to the SS medium and a microorganism in Bordetella such as Bordetella pertussis or Bordetella bronchiseptica is cultured therein.

6. 发明专利

JPS60155127A PREPARATION OF BIOLOGICALLY ACTIVE SUBSTANCE 失效
公开(公告)号：JPS60155127A
公开(公告)日：1985-08-15
申请号：JP25910384
申请日：1984-12-10
申请人： TEIJIN LTD
发明人： SUZUKI YOUJI , IMAIZUMI ATSUSHI , KANEZAKI MASAHARU , ONO SHIYOUJI , YAMAGUCHI HISAO
IPC分类号： A61K39/095 , A61K35/74 , A61K39/10
摘要： PURPOSE:To obtain advantageously a biologically active substance such as remedy for diabetes, mold vaccine, etc., by cultivating a bacterium belonging to the genus Bordetella in a specific madium containing Casamino acid, ascorbic acid, and gluthathione stably and efficiently. CONSTITUTION:A bacterium such as Bordetella pertussis, Bordetella parapertussis, etc.) belonging to the genus Bordetella is cultivated in a medium containing 0.1-20/l Casamino acid, 0.01-1g/l ascorbic acid, and 0.1-5g/l gluthathione, and a biologically active substance is collected from the culture. Well-known Stainer.Scholte medium, SSA medium, etc. are preferable as the medium. Advantageously, 0.001-5g/l cyclodextrin or its derivative besides the components is added to the medium. A mold is stably and efficiently grown, to obtain advantageously an active substance such as insulin secretion enhancing active substance, LPF-HA, etc. of vaccine component of Bordetella pertussis, etc.

7. 发明专利

JPS59175439A Preparation of fibrous hemagglutinin 失效
标题翻译： FIBROUS HEMAGGLUTININ的制备
公开(公告)号：JPS59175439A
公开(公告)日：1984-10-04
申请号：JP4726883
申请日：1983-03-23
申请人： Chemo Sero Therapeut Res Inst , Teijin Ltd
发明人： SUZUKI YOUJI , IMAIZUMI ATSUSHI , KANEZAKI MASAHARU , ONO SHIYOUJI , GINEI AKIHIRO
IPC分类号： A61K39/095 , A61K38/36 , A61K39/10 , C12N1/20
摘要： PURPOSE: To prepare the titled hemagglutinin, in high efficiency, by culturing Bordetella pertussis in a medium containing specific amounts of casamino acid, ascorbic acid and glutathione, and separating from the cultured product.
CONSTITUTION: Bordetella pertussis is cultured in a medium (e.g. SS medium, SSB medium, SSA medium, etc.) containing 0.1W20g/l of casamino acid (hydrolyzed product of casein with an acid), 0.01W1g/l of ascorbic acid (vitamin C), 0.1W5g/l of glutathione (a kind of peptide existing in yeast, animal lever, muscle, etc.), and 0.001W5g/l of cyclodextrin or its derivative, at 30W38°C for 10W100hr. The objective fibrous hemagglutinin (F-HA) is separated from the resultant cultured product. F-HA has participation in the initial defence to the infection with Bordetella pertussis.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在含有特定量的酪蛋白氨基酸，抗坏血酸和谷胱甘肽的培养基中培养百日咳百日咳杆菌，并从培养产物中分离，以高效制备标题血凝素。构成：百日咳博德特氏菌在含有0.1-20g / l酪蛋白氨基酸（酪蛋白与酸的水解产物）的培养基（例如SS培养基，SSB培养基，SSA培养基等）中培养，0.01-1g / l抗坏血酸（维生素C），0.1-5g / l谷胱甘肽（酵母中存在的一种肽，动物杠杆，肌肉等）和0.001-5g / l环糊精或其衍生物，在30-38℃下 10-100hr。从所得培养产物中分离出目的纤维血凝素（F-HA）。 F-HA参与了百日咳博德特氏菌感染的初步防御。

8. 发明专利

JPS5953833B2 失效
公开(公告)号：JPS5953833B2
公开(公告)日：1984-12-27
申请号：JP16347781
申请日：1981-10-15
申请人： TEIJIN LTD
发明人： SUZUKI YOJI , IMAIZUMI ATSUSHI , YAMAGUCHI HISAO , KANEZAKI MASAHARU , ONO SHOJI
IPC分类号： C12N1/38 , C12Q1/04

9. 发明专利

JPS59187778A Culture medium for cultivating microorganism 失效
标题翻译：培养微生物培养基
公开(公告)号：JPS59187778A
公开(公告)日：1984-10-24
申请号：JP24454683
申请日：1983-12-27
申请人： Teijin Ltd
发明人： SUZUKI YOUJI , IMAIZUMI ATSUSHI , YAMAGUCHI HISAO , KANEZAKI MASAHARU , ONO SHIYOUJI
IPC分类号： C12N1/38 , C12N1/20 , C12R1/01
摘要： PURPOSE: To make a culture medium suitable for cultivating microorganisms belonging to the genus Bordetella, by incorporating a cyclodextrin or a derivative in a culture medium.
CONSTITUTION: Microorganisms belonging to the genus Bordetella are Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica, etc., and particularly Bordetella pertussis I phase bacteria tend to cause phase change and are not easily and stably cultivated. A culture medium for cultivating the I phase bacteria of the Bordetella pertussis contains 10W5,000 micrograms/ml cyclodextrin or a derivative thereof therein. Other components in the culture medium are broth or peptone, etc. well known in the past, and the culture medium is a liquid or solid culture medium containing agar or gelatin, etc. Aminocyclodextrin, acetylcyclodextrin, or methylcyclodextrin, etc. may be used as the cyclodextrin derivative.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在培养基中加入环糊精或衍生物，制备适合培养属于博德特氏菌属的微生物的培养基。构成：属于博德特氏菌属的微生物是百日咳博德特氏菌，百日咳博德特氏菌和支气管炎博德特氏菌等，特别是百日咳杆菌I型细菌倾向于引起相变，不容易稳定地培养。用于培养百日盛博列氏菌的I期细菌的培养基含有10-5,000微克/ ml环糊精或其衍生物。培养基中的其它组分是过去熟知的肉汤或蛋白胨等，培养基是含有琼脂或明胶等的液体或固体培养基。氨基环糊精，乙酰基环糊精或甲基环糊精等可用作环糊精衍生物。

10. 发明专利

JPS5918989B2 JPS5918989B2 - 失效
公开(公告)号：JPS5918989B2
公开(公告)日：1984-05-01
申请号：JP16347881
申请日：1981-10-15
申请人： Teijin Ltd
发明人： SUZUKI YOJI , IMAIZUMI ATSUSHI , YAMAGUCHI HISAO , KANEZAKI MASAHARU , ONO SHOJI
IPC分类号： C12P1/04 , C12N1/20 , C12N1/38 , C12R1/01

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