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1. 发明专利

JP2009082106A Polypeptide derived from helicobacter cinaedi and use thereof 审中-公开
标题翻译：来自HELICOBACTER CINAEDI的多肽和其使用
公开(公告)号：JP2009082106A
公开(公告)日：2009-04-23
申请号：JP2007258917
申请日：2007-10-02
申请人： Chemo Sero Therapeut Res Inst , Kumamoto Univ , 国立大学法人熊本大学 , 財団法人化学及血清療法研究所
发明人： AKAIKE TAKAAKI , SASAKI YUTAKA , MASAKI TAKAYUKI
IPC分类号： C12N15/09 , C07K14/205 , C07K16/12 , C12P21/08 , G01N33/569
摘要： PROBLEM TO BE SOLVED: To provide a recombinant polypeptide (molecular weight of 30 kD) derived from Helicobacter cinaedi (H. cinaedi) and a serologically diagnostic method for H. cinaedi-infected patients using the same. SOLUTION: Disclosed is a serologically diagnostic method comprising as a solid antigen a polypeptide having a specific amino acid sequence, the peptide characterized by (1) enabling to bind to the serum of H. cinaedi-infected patients and (2) having an amino acid sequence in which one or several amino acids are deleted, added and substituted, and a peptide comprising one part of the polypeptide. The method comprises an antigen-antibody method using any polypeptides or peptides of the peptide which can bind to the serum of H. cinaedi-infected patients. The serologically diagnostic method may be selected from the group consisting of ELISA method, Western blotting method and dot blotting method. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供由幽门螺杆菌（H.cinaedi）得到的重组多肽（分子量30kD）和使用其的中枢性感染患者的血清学诊断方法。解决方案：公开了一种血清学诊断方法，其包含作为固体抗原的具有特定氨基酸序列的多肽，所述肽的特征在于（1）能够结合中毒素感染患者的血清和（2）具有其中一个或几个氨基酸被缺失，添加和取代的氨基酸序列和包含一部分多肽的肽。该方法包括使用可以结合中毒素感染患者的血清的肽的任何多肽或肽的抗原 - 抗体方法。血清学诊断方法可以选自ELISA法，Western印迹法和斑点印迹法。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2008224562A System, method and program for inspecting foreign substance 审中-公开
标题翻译：用于检查外部物质的系统，方法和程序
公开(公告)号：JP2008224562A
公开(公告)日：2008-09-25
申请号：JP2007066013
申请日：2007-03-15
申请人： Chemo Sero Therapeut Res Inst , Kumamoto Univ , 国立大学法人熊本大学 , 財団法人化学及血清療法研究所
发明人： MUNAKATA MIZUE , WAKAMATSU KAZUYA , YOSHIKAWA HIROYUKI , OBA HIDEKI , TAKAHASHI KAZUHIRO , ISHIHARA YOSHIMITSU
IPC分类号： G01N21/90 , G01N21/88
摘要： PROBLEM TO BE SOLVED: To improve the correctness for determining the existence of a foreign substance when the foreign substance is inspected by using image data processing.
SOLUTION: The image data having a plurality of pixels arrayed in a plurality of columns in the longitudinal direction and a plurality of rows in the lateral direction is generated based on information on an image obtained by imaging an object 10 to be inspected. An average value or an accumulation value of intensity values of the pixels in the generated image data is calculated in at least one column or row in the longitudinal or lateral direction. A difference between the average values or the accumulation values in two adjacent columns or rows is calculated as a differential value of the average value or the accumulation value in each column or row. It determines whether each differential value is within a predetermined threshold. The existence of the foreign substance is determined based on the number of the differential values outside the threshold.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：通过使用图像数据处理来提高检查异物的异物的确定的正确性。解决方案：基于关于通过对待检查对象10进行成像而获得的图像的信息，生成具有沿纵向排列在多个列中的多个像素和横向方向上的多个行的图像数据。生成的图像数据中的像素的强度值的平均值或累加值在纵向或横向方向上至少一列或多列计算。将两个相邻列或行中的平均值或累积值之间的差值计算为每列或每列的平均值或累加值的微分值。它确定每个差分值是否在预定阈值内。基于阈值之外的差分值的数量来确定异物的存在。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2008061622A Method for grasping morbidity of patient treated with hematopoietic stem cell implantation 有权
标题翻译：用HEMATOPOIETIC干细胞植入术治疗患者的莫尔比值的方法
公开(公告)号：JP2008061622A
公开(公告)日：2008-03-21
申请号：JP2006245381
申请日：2006-09-11
申请人： Chemo Sero Therapeut Res Inst , Mitsubishi Kagaku Iatron Inc , 株式会社三菱化学ヤトロン , 財団法人化学及血清療法研究所
发明人： IGAMI HISASHI , ONO TOMOKO , FURUSAKI FUMIO , YONEYAMA AKIKO , IKEDA CHIAKI
IPC分类号： C12Q1/37 , G01N33/573
摘要： PROBLEM TO BE SOLVED: To provide a method for grasping the morbidity of a patient who has been treated with and/or to be treated with a hematopoietic stem cell transplantation, and to provide a kit for grasping the same. SOLUTION: This method for grasping the morbidity of the patient analyzes the amount and/or enzyme activity of the nicking enzyme (ADAMTS13) of von Willebrand factor (vWF) (preferably further the amount of the vWF), and the kit for grasping the same contains an antibody or its fragments capable of binding specifically with the ADAMTS13. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于掌握已用造血干细胞移植治疗和/或待造血干细胞移植治疗的患者的发病率的方法，并提供用于抓取该病毒的试剂盒。解决方案：用于掌握患者发病率的方法分析血管性血友病因子（vWF）的切口酶（ADAMTS13）的量和/或酶活性（优选进一步的vWF的量），以及用于掌握其中含有能够与ADAMTS13特异性结合的抗体或其片段。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2008005836A The humanized anti-human osteopontin antibody 有权
标题翻译：人类抗人类骨质疏松抗体
公开(公告)号：JP2008005836A
公开(公告)日：2008-01-17
申请号：JP2007144162
申请日：2007-05-30
申请人： Astellas Pharma Inc , Chemo Sero Therapeut Res Inst , アステラス製薬株式会社 , 財団法人化学及血清療法研究所
发明人： YAMAMOTO NOBUYA , SAKAI FUMIHIKO , HIGUCHI HIROFUMI , TORIKAI MASAHARU , NAKAJIMA TOSHIHIRO
IPC分类号： C12N15/09 , A61K39/00 , A61P19/02 , A61P29/00 , A61P37/08 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , G01N33/53
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： PROBLEM TO BE SOLVED: To provide a humanized anti-human osteopontin(a kind of glycoprotein involved in cell adhesion) antibody rich in bone, which is superior to conventional anti-human osteopontin antibodies in terms of activity (antigen-binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, hypoxic conditions or denaturants, and the like). SOLUTION: The humanized anti-human osteopontin antibody is such as to contain heavy chain-variable and light chain-variable domains each comprising a specific amino acid sequence, wherein a heavy chain-stationary domain constitutes human Igγ1 and a light chain-stationary domain constitutes human Igκ. A method for producing the antibody is also provided. Further, curative agents for rheumatoid arthritis and the like each containing the antibody are provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种富含骨的人源化抗人骨桥蛋白（一种参与细胞粘附的糖蛋白），其活性方面优于常规的抗人骨桥蛋白抗体（抗原结合活性，白细胞迁移抑制活性等）和/或稳定性（耐热，缺氧条件或变性剂等）。解决方案：人源化抗人骨桥蛋白抗体包含各自包含特异性氨基酸序列的重链可变和轻链可变结构域，其中重链 - 固定结构域构成人Igγ1和轻链 - 固定结构域构成人Igκ。还提供了生产抗体的方法。此外，提供了各自含有抗体的类风湿性关节炎等的治疗剂。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2007297279A Modification of group i mite allergen 审中-公开
标题翻译： I组MITE过敏症的修改
公开(公告)号：JP2007297279A
公开(公告)日：2007-11-15
申请号：JP2004192972
申请日：2004-06-30
申请人： Chemo Sero Therapeut Res Inst , Toshiro Takai , 財団法人化学及血清療法研究所 , 敏朗高井
发明人： TAKAI TOSHIRO
IPC分类号： C07K14/435 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/645
CPC分类号： C07K14/43531 , A61K39/0003
摘要： PROBLEM TO BE SOLVED: To provide a modification of group I mite allergen that has replaced an amino acid at a catalytic center. SOLUTION: The modification of group I mite allergen has replaced an amino acid residue at a catalytic center by a gene recombination technique and has the following characteristics (1)-(4): (1) It has not protease activities. (2) It does not induce production of an IgE antibody. (3) It does not induce production of a Th2 type cytokine. (4) It induces production of an antigen-specific IgG antibody. A yeast producing the modification and a method for producing the modification are also provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供在催化中心取代氨基酸的I组螨变应原的改进。解决方案：通过基因重组技术，I型螨变应原的修饰取代了催化中心的氨基酸残基，具有以下特征（1） - （4）：（1）它没有蛋白酶活性。（2）不诱导产生IgE抗体。（3）不诱导产生Th2型细胞因子。（4）诱导产生抗原特异性IgG抗体。还提供了产生该修饰的酵母和一种生产该修饰的方法。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2007181455A TRANSGENIC FOWL COMPRISING PROTEIN DERIVED FROM EXTRANEOUS GENE AND CONTAINING Gla RESIDUE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：包含从外来基因衍生的蛋白质和含有Gla残留的蛋白质的转基因方法及其生产方法
公开(公告)号：JP2007181455A
公开(公告)日：2007-07-19
申请号：JP2006332520
申请日：2006-12-08
申请人： Chemo Sero Therapeut Res Inst , Kaneka Corp , 株式会社カネカ , 財団法人化学及血清療法研究所
发明人： NAKAISHI TOMOYUKI , SHINDO TAKUYA , KAMINAKA KAZUYOSHI
IPC分类号： A01K67/027 , C07K14/745 , C12N15/09 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide a new method for producing a protein containing a Gla residue. SOLUTION: A transgenic fowl is obtained by a method for infecting the heart or blood vessel formed in an embryo of a fowl in the initial stage of embryo development with a retrovirus vector containing an extraneous gene by micro-injection and hatching the embryo. Thereby, the protein containing the Gla residue is produced. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供一种生产含有Gla残基的蛋白质的新方法。解决方案：通过在胚胎发育的初始阶段感染在家禽胚胎中形成的心脏或血管的方法获得转基因家禽，其中包含通过微量注射和孵化胚胎的含有外来基因的逆转录病毒载体。由此，生成含有Gla残基的蛋白质。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2007089578A Transgenic avian which has foreign gene containing sequence encoding feline-derived protein and method for production thereof 有权
标题翻译：具有包含序列编码来源的蛋白质的外源基因的转基因生物及其生产方法
公开(公告)号：JP2007089578A
公开(公告)日：2007-04-12
申请号：JP2006234259
申请日：2006-08-30
申请人： Chemo Sero Therapeut Res Inst , Kaneka Corp , 株式会社カネカ , 財団法人化学及血清療法研究所
发明人： NAKAISHI TOMOYUKI , SHINDO TAKUYA , ANAMI TOMOKO
IPC分类号： A01K67/027 , A61K38/00 , A61K38/22 , A61K47/34 , A61K47/48 , A61P5/00 , A61P7/06 , C07K14/505 , C12N15/09 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide a transgenic avian which has a foreign gene containing sequence encoding feline-derived protein and method for production thereof. SOLUTION: The invention relates to the transgenic avian produced by infecting the heart or a blood vessel formed in the initial stage of development of the embryo of an avian with a replication-deficient retrovirus having the foreign gene therein by means of microinjection and incubating the embryo. The feline-derived protein can be produced by using the transgenic avian. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供一种转基因禽类，其具有含有编码猫科动物蛋白质的序列的外源基因及其生产方法。解决方案：本发明涉及通过感染在具有外源基因的复制缺陷型逆转录病毒的禽类的胚胎的初始发育阶段中形成的心脏或血管的转基因禽类，其通过显微注射和孵化胚胎。猫科动物蛋白质可以通过使用转基因禽类产生。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2007037421A Gene set for predicting the presence or absence of colon cancer lymph node metastasis 审中-公开
标题翻译：基因组预测结肠癌淋巴结转移的存在或不存在
公开(公告)号：JP2007037421A
公开(公告)日：2007-02-15
申请号：JP2005222995
申请日：2005-08-01
申请人： Chemo Sero Therapeut Res Inst , Dna Chip Research Inc , Osaka Univ , Shionogi & Co Ltd , 国立大学法人大阪大学 , 塩野義製薬株式会社 , 株式会社Dnaチップ研究所 , 財団法人化学及血清療法研究所
发明人： TAKEMASA ICHIRO , TAZAKI TAKENOBU , SONODA HIKARI , MATSUBARA KENICHI , HIGUCHI HIROFUMI
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting the presence or absence of colon cancer lymph node metastasis, and to provide a gene set which can be used for the method. SOLUTION: The method for selecting the gene set comprises the following processes (1) to (4). (1) The process for selecting gene groups capable of classifying the presence or absence of lymph node metastasis in right rates of classification of ≥75%, gene expression information in the colon cancer primary lesion tissue of a patient whose lymph node metastasis presence or absence has been clarified by histopathological judgment, (2) a process for selecting a common gene commonly selected by any analysis method from the gene group selected by the analysis method used in (1), (3) a process for indicating the classification of the presence or absence of the lymph node metastasis from a combination of two or more optional genes and selecting a combination of genes exhibiting interactions, and (4) a process for selecting a variable in a logistic regression model responding to the presence or absence of the lymph node metastasis with a combination of the common gene and the gene as an explanatory variable. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供预测结肠癌淋巴结转移的存在或不存在的方法，并提供可用于该方法的基因组。解决方案：选择基因组的方法包括以下方法（1）至（4）。（1）选择能够分类淋巴结转移的基因组的正确率分类≥75％的基因组的过程，淋巴结转移存在或不存在的患者的结肠癌原发性损伤组织中的基因表达信息已经通过组织病理学判断得到澄清，（2）通过任何分析方法从通过（1），（3）中使用的分析方法选择的基因组中选择的共同基因的选择方法，或不存在来自两个或多个任选基因的组合的淋巴结转移，并且选择表现出相互作用的基因的组合，以及（4）在对应于淋巴结的存在或不存在的逻辑回归模型中选择变量的过程具有共同基因和基因组合的转移作为解释变量。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2005206508A Inhibitory antibody against malignant tumor cell growth 审中-公开
标题翻译：抑制恶性肿瘤细胞生长的抗体
公开(公告)号：JP2005206508A
公开(公告)日：2005-08-04
申请号：JP2004013807
申请日：2004-01-22
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： NAKATAKE HIROSHI , NOZAKI CHIKAHIDE
IPC分类号： C12N15/02 , A61K39/395 , A61P35/00 , C07K16/28 , C12N5/10 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To obtain a new therapeutic agent against malignant tumor that has effectiveness and is excellently safe. SOLUTION: The antibody exhibits no affinity for an endothelial cell through combination with an endothelial cell-specific protein C receptor and controls malignant tumor cell growth in vivo by specific combination with a malignant tumor cell. COPYRIGHT: (C)2005,JPO&NCIPI

10. 发明专利

JP2004231617A Therapeutic agent for rheumatoid arthritis 审中-公开
标题翻译：治疗风湿性关节炎的治疗药物
公开(公告)号：JP2004231617A
公开(公告)日：2004-08-19
申请号：JP2003025051
申请日：2003-01-31
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： SASAKI TAKUMI , NOZAKI CHIKAHIDE
IPC分类号： A61K38/00 , A61K38/55 , A61P19/02 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To obtain a new therapeutic agent for chronic rheumatoid arthritis and juvenile rheumatoid arthritis.
SOLUTION: This therapeutic agent comprises a highly purified antithrombin III as a main active ingredient, and as necessary, a suitable stabilizer such as gelatin, a salt, sugar or an amino acid, and a vehicle are added thereto.
COPYRIGHT: (C)2004,JPO&NCIPI

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