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1. 发明专利

JP2007093597A Novel stress biomarker and applications thereof 有权
标题翻译：新型应力生物标记及其应用
公开(公告)号：JP2007093597A
公开(公告)日：2007-04-12
申请号：JP2006240039
申请日：2006-09-05
申请人： Prima Meat Packers Ltd , プリマハム株式会社
发明人： AKIMOTO MASANOBU , NAMIOKA MAKOTO , ARIHARA KEIZO , TOMITA KOHEI , ISHIKAWA SHINICHI , ITO MAKOTO , NAKAYAMA TSUTOMU , OHASHI NORIO , KATO AYAKO
IPC分类号： G01N27/447
摘要： PROBLEM TO BE SOLVED: To provide a screening method of stress-inhibiting substance or stress-enhancing substance, a stress determination method, or a stress diagnostic kit that utilizes a novel stress biomarker. SOLUTION: The serum of a rat loaded with stress by 10-hour submersion constraint is tested by two-dimensional electrophoresis. Electrophoretic images of two-dimensional electrophoresis before and after stress loading are compared, and protein, such as creatine kinase isozyme (CK-MM) detected as four kinds of spots which appear at pH 6.0-7.0 and molecular weight 40-55 kD after stress loading, is used as a marker. The stomach is immediately extracted after blood collection, the area of ulcerated part is measured, and the ratio of the area of the ulcerated part to that of the stomach as a whole is taken as the ulcer index (%). The ulcer index of stress-related gastric ulcer by the submersion constraint test was about 20%. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供应激抑制物质或应激增强物质的筛选方法，应力测定方法或利用新型应激生物标志物的应激诊断试剂盒。解决方案：通过二维电泳测试通过10小时浸没约束负载压力的大鼠血清。比较应激负荷前后二维电泳的电泳图像，肌酸激酶同功酶（CK-MM）等蛋白质检测出4种斑点，出现在pH 6.0-7.0，应激后分子量40〜55 kD 加载，用作标记。采集后立即抽出胃，测定溃疡部位的面积，将溃疡部位与胃部整体面积的比例作为溃疡指数（％）。通过淹没约束试验，应激相关胃溃疡溃疡指数约为20％。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2007045794A Antifatigue peptide derived from edible meat protein 有权
标题翻译：从食用蛋白质衍生的抗生素肽
公开(公告)号：JP2007045794A
公开(公告)日：2007-02-22
申请号：JP2005234407
申请日：2005-08-12
申请人： Kitasato Gakuen , Prima Meat Packers Ltd , プリマハム株式会社 , 学校法人北里学園
发明人： ARIHARA KEIZO , TOMITA KOHEI , ISHIKAWA SHINICHI , ITO MAKOTO , AKIMOTO MASANOBU , SAMEJIMA TAKASHI
IPC分类号： A61K38/00 , A23L1/305 , A61K36/06 , A61P3/00 , C07K5/103 , C07K5/113
摘要： PROBLEM TO BE SOLVED: To provide an antifatigue agent effective for preventing fatigue and recovering from the fatigue and safe, and to provide a functional food. SOLUTION: This antifatigue agent contains a peptide-containing fraction which is given by treating a suspension of actomyosin existing in muscle (skeletal muscle) of an animal in a large amount with a protease, such as papain, and then removing insoluble matter therefrom, wherein the peptide-containing fraction is found to have high antifatigue activity and Asp-Leu-Tyr-Ala, Ser-Leu-Tyr-Ala, and Val-Trp of which the each is a peptide having the antifatigue activity are purified/identified from the peptide-containing fraction having the high antifatigue activity. Further, the peptides having an antifatigue effect are obtained by being purified from a decomposition product of the actomyosin or chemically synthesized based on information about sequences thereof. Furthermore, the food having the antifatigue effect is obtained by adding the peptides having the antifatigue effect to a food. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效预防疲劳和疲劳恢复的抗疲劳剂，并提供功能性食品。解决方案：该抗疲劳剂含有含肽部分，其通过用诸如木瓜蛋白酶的蛋白酶大量处理存在于动物肌肉（骨骼肌）的肌动蛋白的悬浮液，然后除去不溶物发现其中含有肽的级分具有高的抗疲劳活性，并且其中各自为具有抗疲劳活性的肽的Asp-Leu-Tyr-Ala，Ser-Leu-Tyr-Ala和Val-Trp被纯化/ 从具有高抗疲劳活性的含肽级分鉴定。此外，通过从肌动球蛋白的分解产物纯化或基于其序列的信息化学合成获得具有抗疲劳作用的肽。此外，具有抗疲劳效果的食品通过将具有抗疲劳作用的肽加入到食物中而获得。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2007228875A Anti-fatigue peptide derived from meat protein 审中-公开
标题翻译：从蛋白质衍生的抗疲劳肽
公开(公告)号：JP2007228875A
公开(公告)日：2007-09-13
申请号：JP2006054352
申请日：2006-03-01
申请人： Prima Meat Packers Ltd , プリマハム株式会社
发明人： NAMIOKA MAKOTO , AKIMOTO MASANOBU , ARIHARA KEIZO , TOMITA KOHEI , ISHIKAWA SHINICHI , ITO MAKOTO
IPC分类号： A23L1/30 , A23J3/04 , A23J3/34 , A23L2/52
摘要： PROBLEM TO BE SOLVED: To provide an anti-fatigue agent or a functional food safe and effective for fatigue prevention or fatigue relief. SOLUTION: The functional food having anti-fatigue effect is obtained by adding enzyme decomposed substance having the anti-fatigue effect based on finding that the enzyme decomposed substance produced by treating animal muscle (skeletal muscle) with endo-form protease and/or exo-form protease has high anti-fatigue activity. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供安全有效的抗疲劳剂或功能性食品，用于疲劳预防或减轻疲劳。解决方案：具有抗疲劳作用的功能性食品通过加入具有抗疲劳作用的酶分解物质，基于发现通过用内部形式的蛋白酶和/或内部蛋白酶处理动物肌肉（骨骼肌）产生的酶分解物质，或外切蛋白酶具有高抗疲劳活性。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2006347937A HYPOTENSIVE PEPTIDE DERIVED FROM PROTEIN OF MEAT OF DOMESTIC ANIMAL 审中-公开
公开(公告)号：JP2006347937A
公开(公告)日：2006-12-28
申请号：JP2005175085
申请日：2005-06-15
申请人： PRIMA MEAT PACKERS LTD
发明人： ARIHARA KEIZO , ISHIKAWA SHINICHI , ITO MAKOTO , AKIMOTO MASANOBU , NAKAJIMA YASUYOSHI , KANAI SATOSHI
IPC分类号： C07K7/06 , A23L1/305 , A23L33/17 , A23L33/18 , A61K35/34 , A61K38/00 , A61K38/01 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/17 , A61P9/04 , A61P9/12 , A61P43/00 , C07K5/08 , C12N9/99 , C12P21/06
摘要： PROBLEM TO BE SOLVED: To provide new peptides given from edible meat which is situated in an important position among foods and having hypotensive action or angiotensin I converting enzyme inhibiting activity, and to provide a pharmaceutical composition containing the peptides as an active ingredient. SOLUTION: A peptide composition containing a pentapeptide having a structure of Ile-Arg-Val-Val-Glu and tripepides having structures of Val-Trp-Ile, Val-Gly-Arg, and Ile-Lys-Ile is obtained by hydrolyzing a protein of the edible meat, or myosin or actin of which the each is an important protein of the edible meat by action of a protease, such as Amano S (trade name). The peptides have the angiotensin I converting enzyme inhibiting activity and the hypotensive action, so as to be used as an angiotensin I converting enzyme inhibitor. Further, the peptides are highly safe and applied to a food for preventing hypertension and ameliorating a symptom thereof. COPYRIGHT: (C)2007,JPO&INPIT

5. 发明专利

JP2003102427A PHYSIOLOGICALLY FUNCTIONAL FOOD MATERIAL OR FOOD AND DRINK HAVING STRESS STOMACH ULCER PREVENTING FUNCTION 审中-公开
公开(公告)号：JP2003102427A
公开(公告)日：2003-04-08
申请号：JP2001297715
申请日：2001-09-27
申请人： PRIMA MEAT PACKERS LTD
发明人： ARIHARA KEIZO , NAKAJIMA YASUYOSHI , ISHIKAWA SHINICHI , ITO MAKOTO , AKIMOTO MASANOBU , KANAI SATOSHI , YAMANAKA HIROYUKI , SAMEJIMA TAKASHI , MOTONO KAZUO
IPC分类号： A23L2/38 , A23L1/30 , A23L1/305 , A23L2/52 , A23L13/00 , A23L1/31
摘要： PROBLEM TO BE SOLVED: To provide a physiologically functional food material originating from meat, preventing a stress ulcer. SOLUTION: This invention obtains a composition of a proteolytic treatment of crushed and/or milled meat by subjecting to a lactic fermentation by adding a sugar, a lactobacillus and if necessary water to the crushed and/or milled meat after removing fats and connective tissues as possible or in crushing and/or milling meat or subjecting to a proteolytic treatment by adding endo-form protease and/or exo-form protease and then heating to deactivate the protease after carrying out the a proteolytic treatment. This composition having stress ulcer preventing function is used as food material, physiologically functional food material, food and drink having the physiological function by adding to foods.

6. 发明专利

JPH0974995A LACTOBACILLUS ORIGINATED FROM INTESTINAL TRACT AND UNHEATED EDIBLE MEAT PRODUCT PRODUCED BY USING THE LACTOBACILLUS 失效
公开(公告)号：JPH0974995A
公开(公告)日：1997-03-25
申请号：JP25933495
申请日：1995-09-12
申请人： PRIMA MEAT PACKERS LTD
发明人： ARIHARA KEIZO , YAMANAKA HIROYUKI , AKIMOTO MASANOBU , KANAI SATOSHI , SAMEJIMA TAKASHI , MIKI TAMEO , ITO MAKOTO , KONDO HIROSHI
IPC分类号： C12N1/20 , A23B4/02 , A23B4/12 , A23B4/22 , A23L13/00 , C12R1/225 , C12R1/23 , C12R1/245 , A23L1/31
摘要： PROBLEM TO BE SOLVED: To obtain an unheated edible meat product effective for expelling pathogenic bacteria from intestinal tracts and controlling the intestinal functions and having excellent safety, taste and flavor by adding a specific lactobacillus originated from intestinal tract to an edible meat raw material and fermenting the material. SOLUTION: An unheated edible meat product is produced by fermenting an edible meat raw material in the presence of a lactobacillus originated from intestinal tracts, growing at a nitrite concentration of >=100ppm and a salt concentration of >=2% or growing at a nitrite concentration of >=200ppm at a culture temperature of

7. 发明专利

JP2001233898A ANTIHYPERTENSIVE PEPTIDE DERIVED FROM MEAT PROTEIN 失效
公开(公告)号：JP2001233898A
公开(公告)日：2001-08-28
申请号：JP2000048143
申请日：2000-02-24
申请人： PRIMA MEAT PACKERS LTD
发明人： ARIHARA KEIZO , NAKAJIMA YASUYOSHI , ITO MAKOTO , AKIMOTO MASANOBU , SAMEJIMA TAKASHI , MOTONO KAZUO
IPC分类号： A23L1/305 , A23L33/10 , A23L33/17 , A23L33/18 , A61K35/34 , A61K38/00 , A61K38/17 , A61P9/12 , A61P43/00 , C07K5/083 , C07K5/093 , C07K5/097 , C07K7/06 , C12N9/99 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide new peptides having antihypertensive action or angiotensin I-converting enzyme-inhibiting activity obtained from meat ranked as important food, and to provide a pharmacological composition comprising at least one of the peptides as an active component. SOLUTION: A peptide composition comprising pentapeptides having respective structures of Met-Asn-Pro-Pro-Lys and Ile-Thr-Thr-Asn-Pro is obtained by hydrolyzing meat protein or myosin of a principal meat protein by the action of a protease such thermolysin or protease K. These two pentapeptides and respective tripeptides having partial amino acid sequences Met-Asn-Pro and Pro-Pro-Lys of one of the pentapeptides have both of angiotensin I-converting enzyme-inhibiting activity and antihypertensive action. These peptides are highly safe and can be applied to food for prophylaxis of hypertension and amelioration of its symptom.

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