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1. 发明专利

JP2001278792A ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENT, MEDICINAL COMPOSITION, QUASI DRUG, COSMETIC MATERIAL, FOOD AND ANIMAL FEED CONTAINING THE SAME 失效
公开(公告)号：JP2001278792A
公开(公告)日：2001-10-10
申请号：JP2000088283
申请日：2000-03-28
申请人： KIKKOMAN CORP
发明人： UCHIDA RIICHIRO , KONDO KAZUNARI , SUZUKI TAKASHI , TOYODA MASATAKE , TOKUTAKE SHOICHI
IPC分类号： A61K8/49 , A61K8/96 , A61K8/97 , A61K8/9789 , A61K31/765 , A61K36/18 , A61K36/87 , A61K131/00 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q19/00 , A23K1/16 , A23L1/30 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a more effective anti-allergic and antiinflammatory agent by utilizing a highly safe proanthocyanidin. SOLUTION: This anti-allergic and anti-inflammatory agent is provided by using proanthocyanidin having >=3,000, desirably >=3,000 and

2. 发明专利

JP2001019675A HYDROXYAZEPANE DERIVATIVE AND ITS SALT 失效
公开(公告)号：JP2001019675A
公开(公告)日：2001-01-23
申请号：JP19299299
申请日：1999-07-07
申请人： KIKKOMAN CORP
发明人： KASAI KOICHI , OKADA KIYOSHI , SAITO SHINOBU , TOKUTAKE SHOICHI , TOBE KOUICHIROU
IPC分类号： C07D223/08 , A61K31/00 , A61K31/55 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61P3/00 , A61P3/10 , A61P31/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/02 , C07H17/02
摘要： PROBLEM TO BE SOLVED: To obtain a new compound having an excellent glucosidase inhibitory activity, useful as a therapeutic agent for diabetes by making the compound include a polyhydroxyazepane (7-membered amine). SOLUTION: This compound is shown by the formula [R1 to R4 are each H, a (substituted) alkyl or the like] such as (3S,4R, 5R,6R)-hexahydro-4- methyloxy-3,5,6-trihydroxy-1H-azepine. The compound of the formula is obtained by reacting pyranose with p-toluenesulfonyl chloride of 1-3 times as much as the molar amount of the compound in a solvent (e.g. pyridine, etc.), at -10 to 15 deg.C for about 4-48 hours to give a 6-O-arylsulfonyl pyranose and reacting the 6-O-arylsulfonylpyranose with sodium azide of 2-50 times as much as the substance in a polar solvent (e.g. water, etc.), at 50-100 deg.C for about 2-12 hours to give 6-azido-6-deoxypyranose and reducing 6-azido-6-deoxypyranose with ammonium formate in the presence of palladium-carbon at 10-100 deg.C for 3-50 hours.

3. 发明专利

JP2001002648A N-SUBSTITUTED AZEPAN DERIVATIVE AND SALT THEREOF 失效
公开(公告)号：JP2001002648A
公开(公告)日：2001-01-09
申请号：JP17037199
申请日：1999-06-17
申请人： KIKKOMAN CORP
发明人： KASAI KOICHI , OKADA KIYOSHI , SAITO SHINOBU , TOKUTAKE SHOICHI , TOBE KOUICHIROU
IPC分类号： C07D223/08 , A61K31/55 , A61K31/7042 , A61K31/7052 , A61P3/10 , C07H19/04
摘要： PROBLEM TO BE SOLVED: To obtain a new compound having significant glycosidase-inhibiting activities, capable of manifesting high possibilities corresponding to having properties such as immunoregulation activities, metastasis-controlling activities of malignant tumor cells, capable of reducing the absorbing rate of a glucose or the like, and useful for a therapeutic agent of diabetic. SOLUTION: This new compound is the one of the formula [R is a (substituted) alkyl or a monosaccharide residue], e.g. (3R,4R,5R,6S)-hexahydro-1- N-(2-hydroxyethyl)-3,4,5,6-tetrahydroxy-1H-azepine. The compound of the formula is obtained by aryl-sulfonylating a primary hydroxy group at 6-position of pyranose, optionally introducing protective groups to the free hydroxy groups remaining in the pyranose, reacting the produced compound with sodium azide, dissolving the compound obtained by reducing the resultant product in a polar solvent, adding 1-10 molar times of an alkyl halide and optionally a base to the obtained solution, and reacting the resultant mixture usually at 10-100 deg.C for 1-24 hr.

4. 发明专利

JPH1180148A PRODUCTION OF PROANTHOCYANIDIN 失效
公开(公告)号：JPH1180148A
公开(公告)日：1999-03-26
申请号：JP25143797
申请日：1997-09-02
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , ARIGA TOSHIAKI , HOSOYAMA HIROSHI
IPC分类号： C07D311/62 , C08G65/34 , C09K15/34
摘要： PROBLEM TO BE SOLVED: To improve the efficiency and purity in the extraction of proanthocyanidin from grape seeds, and their pomace. SOLUTION: The proanthocyanidin is extracted from grape seeds or their pomace by heating and refluxing their mixture with water miscible solvent or a mixture of water soluble solvent and water. The extracting efficiency and purity of the proanthocyanidin are improved by a preliminary deaeration of the water miscible solvents or the mixture of water miscible solvent and water.

5. 发明专利

JPH07289280A PRODUCTION OF NONREDUCING TERMINAL 6-AZIDO-MALTOPENTAOSE 失效
公开(公告)号：JPH07289280A
公开(公告)日：1995-11-07
申请号：JP8142194
申请日：1994-04-20
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , YAMATSUGU NOBUYUKI , OGUMA TETSUYA
IPC分类号： C12P19/26
摘要： PURPOSE:To efficiently. obtain the subject compound useful for a substrate, etc., for measuring the activities of an alpha-amylase by enzymolyzing a 6-azido- cyclodextrin in the presence of glucose and then reacting the resultant compound with a converting enzyme and a saccharifying enzyme in the presence of maltose. CONSTITUTION:This method for producing a nonreducing terminal 6-azido- maltopentaose expressed by formula III is to react a 6-azido-cyclodextrin expressed by formula I [(n) is 5 or 6] with a cyclodextrinase having functions to cleave the cyclodextrin and produce a maltooligosaccharide in accordance with the glucose polymerization degree of the cyclodextrin and the higher substrate specificity in the hydrolytic rate or affinity for the cyclodextrin than those of polysaccharides or a straight-chain oligosaccharide having the same polymerization degree as that of the cyclodextrin in the presence of glucose, produce the 6-azido-maltooligosaccharide expressed by formula II [(m) is 3-6 when (n) is 5 and 3-7 when (n) is 6], subsequently react the resultant azido- maltooligosaccharide with a cyclodextrin glucanotransferase and exo type saccharifying enzymes.

6. 发明专利

JPH07163395A METHOD FOR FRACTIONALLY DETERMINING ALPHA-AMYLASE ISOZYME ACTIVITY 失效
公开(公告)号：JPH07163395A
公开(公告)日：1995-06-27
申请号：JP9721494
申请日：1994-05-11
申请人： KIKKOMAN CORP , DAIICHI PURE CHEMICALS CO LTD
发明人： UCHIDA RIICHIRO , TOKUTAKE SHOICHI , YAMATSUGU NOBUYUKI , MOTOYAMA YOSHINORI , HOSOI KENJI
IPC分类号： C12N9/99 , C12Q1/00 , C12Q1/34 , C12Q1/40
摘要： PURPOSE:To carry out differential diagnosis by a simple operation in high accuracy by fractionally determining alpha-amylase isozyme activity from a measured value of a specific alpha-amylase activity. CONSTITUTION:alpha-Amylase isozyme activity is fractionally determined from a measured value of alpha-amylase activity obtained by reacting a substrate for measuring an alpha-amylase activity such as maltooligosaccharide with a specimen and a measured value of an alpha-amylase activity obtained by reacting the same substrate and specimen in the presence of an inhibitor such as 6 - deoxymaltooligosaccharide of the formula having different inhibition coefficients to two kinds of alpha-amylase isozymes.

7. 发明专利

JPH0672884A ALPHA-AMYLASE INHIBITOR AND MEDICINE USING THE SAME 失效
公开(公告)号：JPH0672884A
公开(公告)日：1994-03-15
申请号：JP12577693
申请日：1993-05-27
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , UCHIDA RIICHIRO , YAMATSUGU NOBUYUKI
IPC分类号： A61K31/70 , A61K31/702 , A61K31/715 , A61P3/04 , A61P3/08 , A61P3/10 , A61P43/00 , C07H3/06 , C12N9/99
摘要： PURPOSE:To obtain the subject medicine useful for preventing and treating super blood sugar disease such as corpulence and diabetes, free from side effects, showing strongly inhibitory action on alpha-amylase, especially alpha-amylase of pancreatic juice, comprising a specific deoxymaltooligosaccharide. CONSTITUTION:The objective medicine comprises a 6-deoxymaltooligosaccharide of the formula ((n) is 1-5). 6 -deoxy-D-maltotriose, 6 -deoxy-D-maltotetrose and 6 -deoxy-D-maltopentaose have high activity and are preferable as the compound of the formula. The compound of the formula, for example, is obtained by treating mono-6-deoxycyclodextrin with cyclodextrinase, simultaneously with an exo type saccharifying enzyme and purifying by active carbon column chromatography. A dose is preferably 0.5-10g calculated as the active ingredient of the medicine per adult daily.

8. 发明专利

JPH04229196A FRACTIONAL DETERMINATION OF ALPHA-AMYLASE ISOZYME ACTIVITY 失效
公开(公告)号：JPH04229196A
公开(公告)日：1992-08-18
申请号：JP41525390
申请日：1990-12-27
申请人： KIKKOMAN CORP , DAIICHI PURE CHEMICALS CO LTD , SEISHIN SEIYAKU KK
发明人： TOKUTAKE SHOICHI , YAMATSUGU NOBUYUKI , KOTANI KAZUO , SAITO KAZUNORI , TOBE KOUICHIROU
IPC分类号： C12Q1/40
摘要： PURPOSE:To easily perform the fractional determination of the subject activity in high accuracy by reacting a specific substrate and a conjugate enzyme to an alpha-amylase isozyme active substance in a specimen. CONSTITUTION:The substrates to be used in the subject process are composed of the 1st substrate consisting of a 6-deoxymalto-oligosaccharide derivative of formula (R is H, aromatic chromophore or residue of monosaccharide other than glucose; n is 2-6) and the 2nd substrate consisting of a substrate for the determination of alpha-amylase activity and having a reaction rate ratio to two kinds of alpha-amylase isozyme different from the reaction rate ratio to the 1st substrate. The 1st and the 2nd substrates are made to react with a specimen in the presence of a conjugate enzyme and the alpha-amylase isozyme activity is fractionally determined from the determination result of each alpha-amylase activity.

9. 发明专利

JPS6442497A INDOPHENYL-BETA-MALTOOLIGOSIDE DERIVATIVE, PRODUCTION THEREOF AND USE AS REAGENT FOR MEASURING ALPHA-AMYLASE ACTIVITY 失效
公开(公告)号：JPS6442497A
公开(公告)日：1989-02-14
申请号：JP19831987
申请日：1987-08-10
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , YAMATSUGU NOBUYUKI , KASAI KOICHI , TOBE KOUICHIROU
IPC分类号： C07H15/203 , A61K38/46 , A61P31/12 , A61P35/00 , C08B37/00 , C12Q1/40 , C12Q1/48
摘要： NEW MATERIAL:A compound shown by formula I (R is H or acyl; n is 1-6; A is group shown by formula II (X1-X6 are H, halogen, nitro, cyano, azide, acyl, sulfonic acid, nitroso, sulfonyl, allyl or alkyl; X3 and X4 are and X5 and X6 may be bonded to form condensed aromatic ring)]. EXAMPLE:Phenolindo-3'-chlorophenyl-beta-maltopentaoside. USE:A reagent for measuring alpha-amylase. PREPARATION:A 4-aminophenyl-beta-maltooligoside derivative [e.g. hexadecaa cetyl-(2-chloro-4-aminophenyl)-beta-maltopentaoside] shown by formula III is reacted with a quinone derivative (e.g. p-benzoquinone) shown by formula IV.

10. 发明专利

JP2006282612A Agent for prevention or treatment of cerebral infarction and functional food 审中-公开
标题翻译：用于预防或治疗谷类动物和功能食物的药剂
公开(公告)号：JP2006282612A
公开(公告)日：2006-10-19
申请号：JP2005106312
申请日：2005-04-01
申请人： Kikkoman Corp , Univ Of Tokyo , キッコーマン株式会社 , 国立大学法人東京大学
发明人： HISATSUNE TATSUHIRO , ITO HIDEYOSHI , TOKUTAKE SHOICHI , KATAYAMA HIROSHI
IPC分类号： A61K31/765 , A23L1/30 , A61K31/352 , A61P7/02
摘要： PROBLEM TO BE SOLVED: To provide an agent for the prevention or treatment of cerebral infarction and a food, drink or medicine containing the agent. SOLUTION: The invention provides (1) an agent for the prevention or treatment cerebral infarction containing a polymeric proantocyanidin of hexamer or higher macromer as an active component, (2) a food, drink or medicine containing the agent described in the item (1), and (3) a food or drink containing a polymeric proantocyanidin of hexamer or higher macromer and labeled that the food should be used for the prevention or treatment of cerebral infarction. The polymeric proanthocyanidin of hexamer or higher macromer has excellent prevention or treatment effect on cerebral infarction compared with low-molecular fraction of the compound and is useful for food industry and medical use. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供预防或治疗脑梗死的药剂和含有该药剂的食品，饮料或药物。解决方案：本发明提供（1）预防或治疗脑梗塞的药剂，其含有作为活性成分的六聚体或更高级大分子单体的聚合物原花青素，（2）含有该物质中描述的药剂的食品，饮料或药物（1）和（3）含有六聚体或更高级大分子单体的聚合物原花青素的食品或饮料，并标示该食物应用于预防或治疗脑梗死。六聚体或更高级大分子单体的聚合原花青素与化合物的低分子量比较，对脑梗死具有优异的预防或治疗作用，可用于食品工业和医疗用途。版权所有（C）2007，JPO＆INPIT

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