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1. 发明专利

JP2006282612A Agent for prevention or treatment of cerebral infarction and functional food 审中-公开
标题翻译：用于预防或治疗谷类动物和功能食物的药剂
公开(公告)号：JP2006282612A
公开(公告)日：2006-10-19
申请号：JP2005106312
申请日：2005-04-01
申请人： Kikkoman Corp , Univ Of Tokyo , キッコーマン株式会社 , 国立大学法人東京大学
发明人： HISATSUNE TATSUHIRO , ITO HIDEYOSHI , TOKUTAKE SHOICHI , KATAYAMA HIROSHI
IPC分类号： A61K31/765 , A23L1/30 , A61K31/352 , A61P7/02
摘要： PROBLEM TO BE SOLVED: To provide an agent for the prevention or treatment of cerebral infarction and a food, drink or medicine containing the agent. SOLUTION: The invention provides (1) an agent for the prevention or treatment cerebral infarction containing a polymeric proantocyanidin of hexamer or higher macromer as an active component, (2) a food, drink or medicine containing the agent described in the item (1), and (3) a food or drink containing a polymeric proantocyanidin of hexamer or higher macromer and labeled that the food should be used for the prevention or treatment of cerebral infarction. The polymeric proanthocyanidin of hexamer or higher macromer has excellent prevention or treatment effect on cerebral infarction compared with low-molecular fraction of the compound and is useful for food industry and medical use. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供预防或治疗脑梗死的药剂和含有该药剂的食品，饮料或药物。解决方案：本发明提供（1）预防或治疗脑梗塞的药剂，其含有作为活性成分的六聚体或更高级大分子单体的聚合物原花青素，（2）含有该物质中描述的药剂的食品，饮料或药物（1）和（3）含有六聚体或更高级大分子单体的聚合物原花青素的食品或饮料，并标示该食物应用于预防或治疗脑梗死。六聚体或更高级大分子单体的聚合原花青素与化合物的低分子量比较，对脑梗死具有优异的预防或治疗作用，可用于食品工业和医疗用途。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2006182706A Agent for increasing adiponectin amount in blood 审中-公开
标题翻译：增加血液中ADIPONECTIN量的药剂
公开(公告)号：JP2006182706A
公开(公告)日：2006-07-13
申请号：JP2004378550
申请日：2004-12-28
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： TOKUTAKE SHOICHI , UCHIDA RIICHIRO
IPC分类号： A61K31/353 , A23L1/30 , A61K36/18 , A61P3/00 , A61P3/10 , A61P9/10 , A61P43/00 , C07D311/62
摘要： PROBLEM TO BE SOLVED: To provide a new agent for increasing adiponectin amount in blood and a preventing or improving agent for arteriosclerosis, diabetic and metabolic syndrome, to provide foods and drinks, medicines, cosmetics or the like containing these agents. SOLUTION: The agent for increasing adiponectin amount in blood, containing proanthocyanidin as an active ingredient is provided. The preventing or improving agent for arteriosclerosis or diabetic caused by hyposecretion of adiponectin is provided. The preventing or improving agent for metabolic syndrome is provided. And foods, medicines and cosmetics containing the same are also provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于增加血液中的脂连蛋白量和用于动脉硬化，糖尿病和代谢综合征的预防或改善剂的新药，以提供含有这些药剂的食品和饮料，药物，化妆品等。提供了含有原花色素作为活性成分的用于增加血液中脂联素量的药剂。提供由脂联素分泌低分子量引起的动脉硬化或糖尿病的预防或改善剂。提供了代谢综合征的预防或改善剂。还提供含有该食品，药品和化妆品的食品。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2005314316A Anti-sars coronavirus agent 审中-公开
标题翻译：抗SARS CORONAVIRUS代理
公开(公告)号：JP2005314316A
公开(公告)日：2005-11-10
申请号：JP2004135462
申请日：2004-04-30
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： TOKUTAKE SHOICHI , KATAYAMA HIROSHI , YOSHINAKA YOSHIYUKI , YAMAMOTO NAOKI
IPC分类号： A23L1/30 , A61K8/00 , A61K8/49 , A61K8/97 , A61K31/352 , A61K31/353 , A61K36/18 , A61P31/14 , A61Q17/00 , C07D311/62 , A61K7/00 , A61K7/40 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a new anti-SARS colonavirus agent and an agent for the prevention or treatment of SARS colonavirus infection diseases. SOLUTION: This invention provides (1) the new anti-SARS colonavirus agent containing proanthocyanidin, catechin or a grape extract as an active component, (2) the agent for the prevention or treatment of SARS colonavirus infection diseases containing proanthocyanidin, catechin or the grape extract as an active component, (3) a food, drink, medicine or cosmetic containing the above anti-SARS colonavirus agent or the agent for the prevention or treatment of SARS colonavirus infection diseases and (4) a food or drink containing proanthocyanidin, catechin or the grape extract as an active component and labeled to be used for the prevention or amelioration of SARS colonavirus infection diseases. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：获得一种新的抗SARS杆状病毒药物和用于预防或治疗SARS结肠镜病毒感染疾病的药剂。解决方案：本发明提供（1）含有原花色素，儿茶素或葡萄提取物作为活性成分的新型抗SARS杆状病毒剂，（2）预防或治疗含有原花色素，儿茶素的SARS结肠镜病毒感染疾病的药剂或葡萄提取物作为活性成分，（3）含有上述抗SARS杆状病毒剂的食品，饮料，药物或化妆品或用于预防或治疗SARS结肠镜病毒感染疾病的药剂，以及（4）含有原花青素，儿茶素或葡萄提取物作为活性组分，并标记用于预防或改善SARS结肠镜病毒感染疾病。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2004238289A Thrombogenic inhibitor and functional food 审中-公开
标题翻译：致癌抑制剂和功能性食品
公开(公告)号：JP2004238289A
公开(公告)日：2004-08-26
申请号：JP2003026010
申请日：2003-02-03
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： YAMAMOTO JUNICHIRO , YAMASHITA TSUTOMU , SANO ATSUSHI , TOKUTAKE SHOICHI
IPC分类号： A23L1/30 , A61K31/353 , A61K36/00 , A61K36/06 , A61K36/18 , A61P7/02 , A61K35/72 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a thrombogenic inhibitor or a platelet aggregation inhibitor and a functional food usable for prophylaxis of diseases caused by thrombosis. SOLUTION: The thrombogenic inhibitor or platelet aggregation inhibitor comprises proanthocyanidin and the functional food comprises the drug. Proanthocyanidin derived from grape seeds are preferably used as the proanthocyanidin. A pharmaceutical preparation and the functional food can be used for treatment or prophylaxis of diseases associated with circulatory failure or vascular occlusion due to thrombosis, e.g. cerebrovascular diseases such as cerebral infarction, cerebrovascular dementia or transient cerebral ischemic attack, ischemic heart diseases such as myocardial infarction or angina pectoris or peripheral diseases such as chronic artery occlusion, intermittent claudication, numbness of limbs, hypacusia or pain. Furthermore, the pharmaceutical preparation and functional food can be used for the treatment or prophylaxis of diseases regarded as being associated with the circulatory failure due to the thrombosis as one cause such as so-called senility. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：待解决的问题：获得可用于预防血栓形成疾病的血栓形成抑制剂或血小板聚集抑制剂和功能性食品。解决方案：血栓形成抑制剂或血小板聚集抑制剂包括原花青素，功能性食品包括药物。来自葡萄籽的原花色素优选用作原花色素。药物制剂和功能性食品可用于治疗或预防与血栓形成引起的循环衰竭或血管闭塞相关的疾病，例如血液病。脑血管疾病如脑梗死，脑血管性痴呆或短暂性脑缺血发作，缺血性心脏病如心肌梗塞或心绞痛或周围疾病如慢性动脉闭塞，间歇性跛行，肢体麻木，腹痛或疼痛。此外，药物制剂和功能性食品可用于治疗或预防由于血栓形成而被认为与循环衰竭相关的疾病作为所谓衰老的原因之一。版权所有（C）2004，JPO＆NCIPI

5. 发明专利

JP2004016013A Composition for preventing fading of fish meat and method for preventing fading 审中-公开
公开(公告)号：JP2004016013A
公开(公告)日：2004-01-22
申请号：JP2002171586
申请日：2002-06-12
申请人： Kikkoman Corp , Nakajima Suisan Bio & Techno Kk , Taisho Technos Co Ltd , キッコーマン株式会社 , 中島水産バイオアンドテクノ株式会社 , 株式会社タイショーテクノス
发明人： KOJIMA SHINICHI , UENO KOICHI , OGURO TAKASHI , TOKUTAKE SHOICHI
IPC分类号： A23B4/08
摘要： PROBLEM TO BE SOLVED: To provide a composition for preventing fading of fish meat preventing deterioration of quality by the fading of the fish meat and an unheated processed product thereof in the early stage and to provide a method for preventing the fading.
SOLUTION: The composition for preventing the fading of the fish meat comprises (1) ascorbic acids, (2) proanthocyanidin and (3) one or more salts selected from the group consisting of sodium hydrogencarbonate, trisodium citrate, sodium acetate, sodium DL-malate, sodium carbonate and potassium carbonate. The composition is contained in the fish meat or unheated processed product thereof.
COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2005124517A Antithrombotic food and beverage 审中-公开
标题翻译：抗生素食品和饮料
公开(公告)号：JP2005124517A
公开(公告)日：2005-05-19
申请号：JP2003365414
申请日：2003-10-27
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： YAMAKOSHI JUN , SATO TAKUYA , UCHIDA RIICHIRO , TOKUTAKE SHOICHI , SAITO MINORU , KIKUCHI MAMORU , YODA TAKASHI , ABE KATSUSATO
IPC分类号： C12G3/12 , A23L1/30 , A61K36/899 , A61P7/02 , A61P9/10 , C12F3/10 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide foods and beverages exhibiting antithrombotic effect in antithrombotic foods and beverages effectively utilizing distillation residue which is a waste product for production of Shochu (Japanese distilled spirit). SOLUTION: The antithrombotic food and beverage comprise a distillation residue, obtained as a by-product of Shochu produced by a conventional method by using barley, rye, naked barley, adlay, etc., as a raw material, in which the majority of the residue is treated as an industrial waste, particularly a distillation residue of Shochu using barley as a raw material as an active ingredient. The antithrombotic food and beverage are obtained by adding the distillation residue to various kinds of foods and beverages. The distillation residue is formed in powder, tablet, capsule, etc., to provide a health food or the distillation residue is added to various kinds of beverages, e.g. an alcoholic beverage such as Shochu or a fruit-containing beverage, isotonic beverage, etc. to provide the antithrombotic food and beverage. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供在抗血栓形成食品和饮料中显示抗血栓形成作用的食品和饮料，有效地利用作为生产烧酒（日本蒸馏酒）的废弃产物的蒸馏残渣。解决方案：抗血栓形成的食品和饮料包含蒸馏残渣，作为通过使用大麦，黑麦，裸大麦，adlay等作为原料以常规方法生产的Shochu的副产物获得，其中大部分残留物作为工业废物处理，特别是使用大麦作为原料作为活性成分的Shochu的蒸馏残渣。通过将蒸馏残渣加入到各种食品和饮料中来获得抗血栓形成的食物和饮料。蒸馏残留物以粉末，片剂，胶囊等形成，以提供保健食品，或将蒸馏残余物加入到各种饮料中。诸如烧酒或含果实饮料的酒精饮料，等渗饮料等，以提供抗血栓形式的食物和饮料。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2004035510A Composition for prophylaxis or treatment of diabetes mellitus or its complication 有权
公开(公告)号：JP2004035510A
公开(公告)日：2004-02-05
申请号：JP2002197542
申请日：2002-07-05
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： TOMINAGA YOKO , TSUKAWAKI MIWAKO , WATANABE MAKI , TOMISAKA KAZUE , WAKAYAMA TADAAKI , SANO ATSUSHI , TOKUTAKE SHOICHI , GUYUEN VAN CHUEN
IPC分类号： A23L2/52 , A23L1/30 , A61K31/01 , A61K31/353 , A61K36/18 , A61K36/81 , A61P3/10 , A61P27/12 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a composition for prophylaxis or treatment of diabetes mellitus or its complication, having safety and larger effect, a composition for prophylaxis or treatment of cataract, and a composition for suppressing increase in blood glucose levels. SOLUTION: (1) The composition for prophylaxis or treatment of diabetes mellitus or its complication comprises lycopene and proanthocyanin as active ingredients. (2) The composition for prophylaxis or treatment of cataract comprises lycopene and proanthocyanin as active ingredients. (3) The composition for suppressing increase in the blood glucose levels comprises lycopene and proanthocyanin as active ingredients. In the item (1), (2) and/or (3), the lycopene is derived from tomato. In the item (1), (2) and/or (3), the proanthocyanin is an extract of seeds or skin of a grape. COPYRIGHT: (C)2004,JPO

8. 发明专利

JP2001278792A ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENT, MEDICINAL COMPOSITION, QUASI DRUG, COSMETIC MATERIAL, FOOD AND ANIMAL FEED CONTAINING THE SAME 失效
公开(公告)号：JP2001278792A
公开(公告)日：2001-10-10
申请号：JP2000088283
申请日：2000-03-28
申请人： KIKKOMAN CORP
发明人： UCHIDA RIICHIRO , KONDO KAZUNARI , SUZUKI TAKASHI , TOYODA MASATAKE , TOKUTAKE SHOICHI
IPC分类号： A61K8/49 , A61K8/96 , A61K8/97 , A61K8/9789 , A61K31/765 , A61K36/18 , A61K36/87 , A61K131/00 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q19/00 , A23K1/16 , A23L1/30 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a more effective anti-allergic and antiinflammatory agent by utilizing a highly safe proanthocyanidin. SOLUTION: This anti-allergic and anti-inflammatory agent is provided by using proanthocyanidin having >=3,000, desirably >=3,000 and

9. 发明专利

JP2001019675A HYDROXYAZEPANE DERIVATIVE AND ITS SALT 失效
公开(公告)号：JP2001019675A
公开(公告)日：2001-01-23
申请号：JP19299299
申请日：1999-07-07
申请人： KIKKOMAN CORP
发明人： KASAI KOICHI , OKADA KIYOSHI , SAITO SHINOBU , TOKUTAKE SHOICHI , TOBE KOUICHIROU
IPC分类号： C07D223/08 , A61K31/00 , A61K31/55 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61P3/00 , A61P3/10 , A61P31/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/02 , C07H17/02
摘要： PROBLEM TO BE SOLVED: To obtain a new compound having an excellent glucosidase inhibitory activity, useful as a therapeutic agent for diabetes by making the compound include a polyhydroxyazepane (7-membered amine). SOLUTION: This compound is shown by the formula [R1 to R4 are each H, a (substituted) alkyl or the like] such as (3S,4R, 5R,6R)-hexahydro-4- methyloxy-3,5,6-trihydroxy-1H-azepine. The compound of the formula is obtained by reacting pyranose with p-toluenesulfonyl chloride of 1-3 times as much as the molar amount of the compound in a solvent (e.g. pyridine, etc.), at -10 to 15 deg.C for about 4-48 hours to give a 6-O-arylsulfonyl pyranose and reacting the 6-O-arylsulfonylpyranose with sodium azide of 2-50 times as much as the substance in a polar solvent (e.g. water, etc.), at 50-100 deg.C for about 2-12 hours to give 6-azido-6-deoxypyranose and reducing 6-azido-6-deoxypyranose with ammonium formate in the presence of palladium-carbon at 10-100 deg.C for 3-50 hours.

10. 发明专利

JP2001002648A N-SUBSTITUTED AZEPAN DERIVATIVE AND SALT THEREOF 失效
公开(公告)号：JP2001002648A
公开(公告)日：2001-01-09
申请号：JP17037199
申请日：1999-06-17
申请人： KIKKOMAN CORP
发明人： KASAI KOICHI , OKADA KIYOSHI , SAITO SHINOBU , TOKUTAKE SHOICHI , TOBE KOUICHIROU
IPC分类号： C07D223/08 , A61K31/55 , A61K31/7042 , A61K31/7052 , A61P3/10 , C07H19/04
摘要： PROBLEM TO BE SOLVED: To obtain a new compound having significant glycosidase-inhibiting activities, capable of manifesting high possibilities corresponding to having properties such as immunoregulation activities, metastasis-controlling activities of malignant tumor cells, capable of reducing the absorbing rate of a glucose or the like, and useful for a therapeutic agent of diabetic. SOLUTION: This new compound is the one of the formula [R is a (substituted) alkyl or a monosaccharide residue], e.g. (3R,4R,5R,6S)-hexahydro-1- N-(2-hydroxyethyl)-3,4,5,6-tetrahydroxy-1H-azepine. The compound of the formula is obtained by aryl-sulfonylating a primary hydroxy group at 6-position of pyranose, optionally introducing protective groups to the free hydroxy groups remaining in the pyranose, reacting the produced compound with sodium azide, dissolving the compound obtained by reducing the resultant product in a polar solvent, adding 1-10 molar times of an alkyl halide and optionally a base to the obtained solution, and reacting the resultant mixture usually at 10-100 deg.C for 1-24 hr.

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