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1. 发明专利

JPH0541636B2 失效
公开(公告)号：JPH0541636B2
公开(公告)日：1993-06-24
申请号：JP998691
申请日：1991-01-04
申请人： SEISHIN SEIYAKU KK , DAIICHI KAGAKU YAKUHIN KK
发明人： TOBE KOICHIRO , MAKI AKEMICHI
IPC分类号： C07H15/203 , C12Q1/40

2. 发明专利

JPH04305594A BETA-(2-CHLORO-4-NITROPHENYL)-MALTOPENTAOSIDE 失效
公开(公告)号：JPH04305594A
公开(公告)日：1992-10-28
申请号：JP998691
申请日：1991-01-04
申请人： SEISHIN SEIYAKU KK , DAIICHI PURE CHEMICALS CO LTD
发明人： TOBE KOICHIRO , MAKI AKEMICHI
IPC分类号： C07H15/203 , C12Q1/40
摘要： PURPOSE:To obtain the title new maltopentaoside providing excellent measured results as a reagent for measuring amylase in humors, having a specific melting point and an absorption maximum of ultraviolet light absorption spectrum, containing 2-chloro-4-nitrophenyl group. CONSTITUTION:Maltopentaose shown by formula I is acylated with an organic acid anhydride (e.g. acetic anhydride) shown by the formula (RCO)2O (R is alkyl) to give a heptaacylmaltopentaose, which is halogenated with titanium petrachloride in chloroform while stirring under reflux to give a hexadecaacylmaltopentaosyl halide shown by formula II (X is halogen). Then this compound is reacted with 2-chloro-4-nitrophenol in benzene in the presence of a base and deprotected to give beta-(2-chloro-4-nitrophenyl)-maltopentoside shown by formula III having 198-201 deg.C melting point and an absorption maximum approximately at 259nm in ultraviolet light absorption spectrum.

3. 发明专利

JPH03172197A REAGENT FOR MEASURING ALPHA-AMYLASE ACTIVITY AND METHOD FOR MEASURING ALPHA-AMYLASE ACTIVITY 失效
公开(公告)号：JPH03172197A
公开(公告)日：1991-07-25
申请号：JP30904289
申请日：1989-11-30
申请人： DAIICHI PURE CHEMICALS CO LTD , KIKKOMAN CORP , SEISHIN SEIYAKU KK
发明人： SAITO KAZUNORI , KUROSAWA KAORU , TOKUTAKE SHOICHI , OGUMA TETSUYA , TOBE KOUICHIROU , SHIMIZU TOSHIYUKI
IPC分类号： C12Q1/40
摘要： PURPOSE:To measure the title activity for diagnosing pancreatitis in a short time by adding a maltooligoside derivative, in which non-reductive end is protected and a substance capable of optically detecting is bound to a reductive end, and a conjugated enzyme to a sample and optically measuring an isolated substance. CONSTITUTION:A maltooligoside derivative (e.g. 2-chloro-4-nitrophenyl=4 ,6 -O- benzilidene-beta-D-maltopentaoxide) in which a non-reductive end is modified with a protective group and substance capable of detecting by alpha- or beta-glucoside bond is bound to a reductive end and beta-amylase used as one of conjugated enzyme ingredients are added to alpha-amylase-containing sample to carry out enzymatic reaction and an isolated optically detectable substance (e.g. 2-chloro-4- nitrophenol) is determined to measure alpha-amylase.

4. 发明专利

JPS6035354B2 失效
公开(公告)号：JPS6035354B2
公开(公告)日：1985-08-14
申请号：JP1861975
申请日：1975-02-14
申请人： DAIICHI SEIYAKU KK , SEISHIN SEIYAKU KK
发明人： NAGASE OSAMU , NAKAGAWA ATSUSHI , SUZUKI SUSUMU
IPC分类号： C07H19/20 , C07H19/213

5. 发明专利

JPS57125349A Method and device for quantitative analysis of saccharide by liquid chromatograph 失效
标题翻译：通过液相色谱定量分析方法和装置
公开(公告)号：JPS57125349A
公开(公告)日：1982-08-04
申请号：JP1021081
申请日：1981-01-28
申请人： Seishin Seiyaku Kk
发明人： FUNADA KAZUE , IRIKURA YOSHIAKI , OZAWA YOSHINORI
IPC分类号： G01N30/88 , G01N30/74
CPC分类号： G01N30/74
摘要： PURPOSE:To stably perform quantitative analysis with high accuracy by a method wherein a solution containing saccharides is separated through a separating column of liquid chromatograph and hydrolized under heating while continously adding an acid or alkali solution thereto, and then colorimetry is effected by continuously adding reducing sugar coloring reagent to the solution hydrolized. CONSTITUTION:A given quantity of a solution 10 containing saccharides such as non-reducing saccharides, oligosaccharides or polysaccharides is sampled by a sampler 3 and eluting liquid 1 is sent to the sampler by a quantitative pump 2. The saccharide solution within the sampler 3 is fed to a separating column 4 of liquid chromatograph and separated with the eluting solution 1 fed thereto subsequently, so that the eluted solution enters a mixing portion 5. Meanwhile, a saccharide hydrolizing reagent (acid or alkali solution) is sent to the mixing portion 5 from a bottle 22 by a quantitative pump 20 in such a manner that its pulsatory current is reduced through a resistance coil 40. Then, the mixed solution is fed to a heating reaction tube 6 and hydrolized at temperature of 70-150 deg.C. Thereafter, the solution is fed to a mixing portion 7 to be mixed with reducing sugar coloring reagent and is reacted in a coloring reaction tube 8 at temperatur of 80-120 deg.C. The reacted solution is measured in a detecting section 9 by a spectrophotometer or colorimeter and the result is recorded on a recorder 38.
摘要翻译：目的：通过将含有糖的溶液通过液相色谱仪的分离柱分离并在加热下水解并在其中连续加入酸或碱溶液的方法，以高精度稳定进行定量分析，然后通过连续加入还原糖着色试剂溶液水解。构成：通过采样器3对给定量的含有糖类的溶液（如非还原性糖，寡糖或多糖）进行取样，并通过定量泵2将洗脱液1送入取样器。取样器3内的糖溶液为进料到液相色谱仪的分离柱4，并随后用洗脱液1分离，使洗脱溶液进入混合部分5.同时，将糖类水解试剂（酸或碱溶液）送入混合部分5 通过定量泵20从瓶22通过电阻线圈40使其脉动电流减小。然后，将混合溶液供给到加热反应管6中，并在70-150℃的温度下水解。然后，将该溶液送入混合部7，与还原糖着色试剂混合，在着色反应管8中在80-120℃的温度下反应。通过分光光度计或色度计在检测部分9中测量反应溶液，并将结果记录在记录器38上。

6. 发明专利

JPS55130916A MEDICINE FOR UEWFWNR PEWMRUEW SWLICWEY 失效
公开(公告)号：JPS55130916A
公开(公告)日：1980-10-11
申请号：JP3849179
申请日：1979-03-31
申请人： DAIICHI SEIYAKU CO , SEISHIN SEIYAKU KK
发明人： CHIMURA TETSUROU
IPC分类号： C07H19/213 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P13/02 , A61P15/00
摘要： PURPOSE:To provide a medicine for uregent premature delivery, having strong suppressing activity against the contraction of the uterus at the middle to latter stage of pregnancy, and containing N ,2'-O-dibutyryladenosine-3',5'-cyclic-phosphoric acid or its salt as an effective component. CONSTITUTION:The title medicine containing N ,2'-O-dibutyryladenosine-3',5'- cyclic phosphoric acid (DBC-AMP) or its alkali metal salt or alkaline earth metal salt, as an effective component. The DBC-AMP has strong suppressing activity against the abnormal contraction of the uterus at the middle to latter stage of pregnancy. Good result was obtained by the intravenous injection to a pregnant woman having potentiality for ungent premature delivery. The agent increases the c-AMP in the blood of a regnant woman, and exhibits no undesirable effects to the mother and the fetus.

7. 发明专利

JPS5239698A METHOD OF PRODUCING DIBUTYRYLADENOSINES 失效
公开(公告)号：JPS5239698A
公开(公告)日：1977-03-28
申请号：JP11611975
申请日：1975-09-26
申请人： DAIICHI SEIYAKU CO , SEISHIN SEIYAKU KK
发明人： HIRAYAMA TADAMITSU , NAKAGAWA ATSUSHI , KOTAKE SOUTAROU
IPC分类号： C07H19/213 , C07H19/20
摘要： PURPOSE:Title compounds useful as medicines and biochimical reagents are selectively prepared by reacting tertiary amine salts of salts of adenosine3',5'-cyclic phosphates with butyric acid anhydride in a specific solvent.

8. 发明专利

JPS5123294A NYOSANNO ANTEIKAHO 失效
公开(公告)号：JPS5123294A
公开(公告)日：1976-02-24
申请号：JP9428274
申请日：1974-08-19
申请人： SEISHIN SEIYAKU KK
发明人： MYAKE HISASHI , YOSHIDA FUMIHIKO
IPC分类号： G01N33/50 , C07D473/02 , C07D473/04 , C12Q1/62

9. 发明专利

JPH059196A NONREDUCING TERMINAL-MODIFIED MALTOOLIGOSACCHARIDE DERIVATIVE AND FRACTIONAL DETERMINATION OF ALPHA-AMYLASE ISOZYME ACTIVITY USING THE SAME 失效
公开(公告)号：JPH059196A
公开(公告)日：1993-01-19
申请号：JP18402891
申请日：1991-06-28
申请人： KIKKOMAN CORP , DAIICHI PURE CHEMICALS CO LTD , SEISHIN SEIYAKU KK
发明人： TOKUTAKE SHOICHI , UCHIDA RIICHIRO , KOTANI KAZUO , SAITO KAZUNORI , TOBE KOUICHIROU
IPC分类号： C07H3/06 , C07H15/203 , C07H15/26 , C12Q1/40
摘要： PURPOSE:To provide the subject new compound extremely useful as a substrate for the fractional determination of alpha-amylase isozyme in a specimen and enabling the fractional determination of (alpha-amylase isozyme with a simple process in high accuracy. CONSTITUTION:The nonreducing terminal-modified maltooligosaccharide of formula I ((n) is 2-6; R is H, aromatic chromophore, etc.; X is arylsulfonyl, arylimido, etc.; Y is H or hydrocarbon group), e.g. 2-chloro-4-nitrophenyl 6 -O-(t- butyldimethyl)silyl-beta--Dmaltopentaoside. The compound can be produced e.g. by reacting a D-maltooligoside of formula II with a carbonyl compound of formula III (R is H, methoxy, etc.; R is methoxy or ethoxy), subjecting the obtained compound of formula IV to dealkoxymethylidene reaction, converting the 6-hydroxyl group of the resultant partially acylated maltooligosaccharide derivative to trialkylsilyl group and deacylating the resultant compound of formula V (R is acyl; R and R are alkyl).

10. 发明专利

JPH051091A MALTOOLIGOSIDE DERIVATIVE, REAGENT FOR MEASURING ALPHA-AMYLASE ACTIVITY CONTAINING THE SAME AS ACTIVE INGREDIENT AND MEHTOD FOR MEASURING ALPHA-AMYLASE ACTIVITY USING THE SAME 失效
公开(公告)号：JPH051091A
公开(公告)日：1993-01-08
申请号：JP18047391
申请日：1991-06-26
申请人： KIKKOMAN CORP , DAIICHI PURE CHEMICALS CO LTD , SEISHIN SEIYAKU KK
发明人： TOKUTAKE SHOICHI , TOMIKURA TADASHI , KOTANI KAZUO , SAITO KAZUNORI , TOBE KOUICHIROU
IPC分类号： C07H3/06 , C07H11/00 , C07H15/203 , C07H15/26 , C07H17/02 , C07H17/075 , C12Q1/40
摘要： PURPOSE:To obtain a new maltooligoside derivative, useful as a reagent for measuring the alpha-amylase activity and capable of efficiently and accurately measuring the a-amylase activity. CONSTITUTION:A maltooligoside derivative expressed by formula I [(n) is 3-5; R is aromatic coloring group; X is =CHCH2N3 or =C=CH2; Y is H, hydrocarbon, etc.], e.g. 2-chloro-4-nitrophenyl-6 -azido-6 -deoxy-beta-D-maltopentaoxide. The aforementioned compound is obtained by reacting a D-maltooligoside expressed by formula II with a carbonyl compound expressed by formula III (R is H, methoxy, etc.; R is methoxy or ethoxy), providing a compound expressed by formula IV, then successively subjecting the resultant compound to acylation, removal of alkoxymethylidene group and alkylsulfonylation, subsequently iodinating and azidating the resultant product, affording an acylmaltooligoside derivative expressed by formula V(R is acyl; W is acyl, hydrocarbon, etc.) and then deacylating the aforementioned compound.

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