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1. 发明专利

JPH059196A NONREDUCING TERMINAL-MODIFIED MALTOOLIGOSACCHARIDE DERIVATIVE AND FRACTIONAL DETERMINATION OF ALPHA-AMYLASE ISOZYME ACTIVITY USING THE SAME 失效
公开(公告)号：JPH059196A
公开(公告)日：1993-01-19
申请号：JP18402891
申请日：1991-06-28
申请人： KIKKOMAN CORP , DAIICHI PURE CHEMICALS CO LTD , SEISHIN SEIYAKU KK
发明人： TOKUTAKE SHOICHI , UCHIDA RIICHIRO , KOTANI KAZUO , SAITO KAZUNORI , TOBE KOUICHIROU
IPC分类号： C07H3/06 , C07H15/203 , C07H15/26 , C12Q1/40
摘要： PURPOSE:To provide the subject new compound extremely useful as a substrate for the fractional determination of alpha-amylase isozyme in a specimen and enabling the fractional determination of (alpha-amylase isozyme with a simple process in high accuracy. CONSTITUTION:The nonreducing terminal-modified maltooligosaccharide of formula I ((n) is 2-6; R is H, aromatic chromophore, etc.; X is arylsulfonyl, arylimido, etc.; Y is H or hydrocarbon group), e.g. 2-chloro-4-nitrophenyl 6 -O-(t- butyldimethyl)silyl-beta--Dmaltopentaoside. The compound can be produced e.g. by reacting a D-maltooligoside of formula II with a carbonyl compound of formula III (R is H, methoxy, etc.; R is methoxy or ethoxy), subjecting the obtained compound of formula IV to dealkoxymethylidene reaction, converting the 6-hydroxyl group of the resultant partially acylated maltooligosaccharide derivative to trialkylsilyl group and deacylating the resultant compound of formula V (R is acyl; R and R are alkyl).

2. 发明专利

JPH07163395A METHOD FOR FRACTIONALLY DETERMINING ALPHA-AMYLASE ISOZYME ACTIVITY 失效
公开(公告)号：JPH07163395A
公开(公告)日：1995-06-27
申请号：JP9721494
申请日：1994-05-11
申请人： KIKKOMAN CORP , DAIICHI PURE CHEMICALS CO LTD
发明人： UCHIDA RIICHIRO , TOKUTAKE SHOICHI , YAMATSUGU NOBUYUKI , MOTOYAMA YOSHINORI , HOSOI KENJI
IPC分类号： C12N9/99 , C12Q1/00 , C12Q1/34 , C12Q1/40
摘要： PURPOSE:To carry out differential diagnosis by a simple operation in high accuracy by fractionally determining alpha-amylase isozyme activity from a measured value of a specific alpha-amylase activity. CONSTITUTION:alpha-Amylase isozyme activity is fractionally determined from a measured value of alpha-amylase activity obtained by reacting a substrate for measuring an alpha-amylase activity such as maltooligosaccharide with a specimen and a measured value of an alpha-amylase activity obtained by reacting the same substrate and specimen in the presence of an inhibitor such as 6 - deoxymaltooligosaccharide of the formula having different inhibition coefficients to two kinds of alpha-amylase isozymes.

3. 发明专利

JP2005124517A Antithrombotic food and beverage 审中-公开
标题翻译：抗生素食品和饮料
公开(公告)号：JP2005124517A
公开(公告)日：2005-05-19
申请号：JP2003365414
申请日：2003-10-27
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： YAMAKOSHI JUN , SATO TAKUYA , UCHIDA RIICHIRO , TOKUTAKE SHOICHI , SAITO MINORU , KIKUCHI MAMORU , YODA TAKASHI , ABE KATSUSATO
IPC分类号： C12G3/12 , A23L1/30 , A61K36/899 , A61P7/02 , A61P9/10 , C12F3/10 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide foods and beverages exhibiting antithrombotic effect in antithrombotic foods and beverages effectively utilizing distillation residue which is a waste product for production of Shochu (Japanese distilled spirit). SOLUTION: The antithrombotic food and beverage comprise a distillation residue, obtained as a by-product of Shochu produced by a conventional method by using barley, rye, naked barley, adlay, etc., as a raw material, in which the majority of the residue is treated as an industrial waste, particularly a distillation residue of Shochu using barley as a raw material as an active ingredient. The antithrombotic food and beverage are obtained by adding the distillation residue to various kinds of foods and beverages. The distillation residue is formed in powder, tablet, capsule, etc., to provide a health food or the distillation residue is added to various kinds of beverages, e.g. an alcoholic beverage such as Shochu or a fruit-containing beverage, isotonic beverage, etc. to provide the antithrombotic food and beverage. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供在抗血栓形成食品和饮料中显示抗血栓形成作用的食品和饮料，有效地利用作为生产烧酒（日本蒸馏酒）的废弃产物的蒸馏残渣。解决方案：抗血栓形成的食品和饮料包含蒸馏残渣，作为通过使用大麦，黑麦，裸大麦，adlay等作为原料以常规方法生产的Shochu的副产物获得，其中大部分残留物作为工业废物处理，特别是使用大麦作为原料作为活性成分的Shochu的蒸馏残渣。通过将蒸馏残渣加入到各种食品和饮料中来获得抗血栓形成的食物和饮料。蒸馏残留物以粉末，片剂，胶囊等形成，以提供保健食品，或将蒸馏残余物加入到各种饮料中。诸如烧酒或含果实饮料的酒精饮料，等渗饮料等，以提供抗血栓形式的食物和饮料。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2000239293A MALTOOLIGOSACCHARIDE DERIVATIVE AND ITS USE 失效
公开(公告)号：JP2000239293A
公开(公告)日：2000-09-05
申请号：JP4269599
申请日：1999-02-22
申请人： KIKKOMAN CORP
发明人： UCHIDA RIICHIRO , NASU AYAKO , IWAI YUKIHIKO , SOMEYA TAKAO , TOBE KOUICHIROU
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61P3/00 , A61P3/10 , A61P43/00 , C07H3/06 , C07H17/02
摘要： PROBLEM TO BE SOLVED: To obtain a new compound strongly inhibiting human α-amylase and therefore useful for prophylactic and/or therapy of such diseases as hyperglycemia, e.g. diabetes and diseases caused thereby. SOLUTION: This new compound is a compound of formula I (n is 0-3; X is H or a hydrophobic group), for example, (3R, 4R, 5R, 6S)-hexahydro-3,5,6- trihydroxy-1H-azepin-4-yl O-(6-deoxy-α-D-glucopyranosyl)-(1→4)-α-D- glucopyranoside. The compound of formula I is obtained, for example, by reacting a compound of formula II with p-toluenesulfonyl chloride in pyridine, and, as necessary, separating 61-tosyl, 63-modified maltooligosaccharide in a usual way, thereafter, obtaining 61-azide, 63-modified maltooligosaccharide by reacting the above-mentioned oligosaccharide with sodium azide in N,N- dimethylformamide, separating it in a usual way, and then reducing it in the presence of Pd-C by adding hydrogen gas thereto.

5. 发明专利

JP2000044589A MALTOOLIGOSACCHARIDE DERIVATIVE AND ITS USE 失效
公开(公告)号：JP2000044589A
公开(公告)日：2000-02-15
申请号：JP21922098
申请日：1998-08-03
申请人： KIKKOMAN CORP
发明人： UCHIDA RIICHIRO , NASU AYAKO , IWAI YUKIHIKO , SOMEYA TAKAO , TOBE KOUICHIROU
IPC分类号： C07H5/04 , A61K31/70 , A61K31/7008 , A61K31/7028 , A61K31/7042 , A61K31/7052 , A61P3/08 , A61P3/10 , A61P43/00 , C07H15/04 , C07H17/02 , C08B37/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound exhibiting excellent α-amylase inhibitory activity without any side effect such as diarrhea, and useful as a preventive/therapeutic agent by binding a specific polyhydroxy nitrogen-contg. compound to glucose with the reduced terminal. SOLUTION: This compound (hydrate or salt) is shown by formula I [A is a group of formula II (X is N3 or NH2; Y is CH2OH or COOH), formula III or formula IV; (n) is 1-6], e.g. O-α-D-glucopyranosyl-(1→4)-6-amino-6-deoxy-D- sorbitol. The illustrated compound is obtained by reducing 61-azido-61- deoxymaltose with sodium borohydride in an N,N-dimethylformamide solvent.

6. 发明专利

JPH09278789A MALTO-OLIGOSACCHARIDE DERIVATIVE, AND PRODUCTION AND USE OF THE SAME 失效
公开(公告)号：JPH09278789A
公开(公告)日：1997-10-28
申请号：JP11717596
申请日：1996-04-16
申请人： KIKKOMAN CORP
发明人： UCHIDA RIICHIRO , NASU AYAKO , MATSUURA KATSUKO , YAMAKOSHI JUN , KIKUCHI MAMORU , YAMATSUGU NOBUYUKI
IPC分类号： C07H17/02 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/715 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/10 , A61P27/02 , A61P43/00 , C08B37/00 , A61K31/73
摘要： PROBLEM TO BE SOLVED: To obtain the subject new derivative having a potent inhibiting activity against an α-amylase, without an adverse effect and used for the prevention and treatment of hyperglycemia such as diabetes mellitus by reducing 6-azido-6- deoxyglucose.glucose oligomer. SOLUTION: This new malto-oligosaccharide derivative expressed by formula I [(n) is an integer of 1-7] e.g.; hexakis [O-α-D-glucopyranosyl-(1→4)]-O-α-D- glucopyranosyl-(1→4)-hexahydro-1H-azepin-3R,4R,5R,6S-tetrol}, has a potent inhibiting activity against an α-amylase and with no adverse effect, and is useful for the prevention and treatment of hyperglycemia such as diabetes mellitus. The maltoligosaccharide derivative is obtained by reducing 6-azido-6- deoxyglucose. glucose oligomer expressed by formula II.

7. 发明专利

JP2014138617A Angiotensin-converting enzyme inhibitor peptide containing composition 审中-公开
标题翻译：抗氧化剂转化酶抑制剂含有组成成分的肽
公开(公告)号：JP2014138617A
公开(公告)日：2014-07-31
申请号：JP2014086171
申请日：2014-04-18
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： NAKAHARA TAKEHARU , UCHIDA RIICHIRO , AOTA HITOMI , SUGIMOTO KATSUTOSHI
IPC分类号： A23L1/305 , A61K38/55 , A61P9/12 , A61P43/00 , C07K5/072 , C07K5/083 , C12P21/06
摘要： PROBLEM TO BE SOLVED: To provide a composition containing an ACE inhibitor peptide which inhibits ACE effectively through intake of a small amount, has no possibility of side effects and allows hypertensive persons to ingest easily in daily life.SOLUTION: A composition containing an ACE inhibitor peptide contains a tripeptide Asp-Arg-Pro which is prepared by hydrolyzing a protein source with a solid koji culture and has an angiotensin-converting enzyme inhibiting activity in concentration of 47-154 μg/ml. Alternatively, a composition containing an ACE inhibitor peptide contains a tripeptide Gly-Val-Pro which is prepared by hydrolyzing a protein source with a solid koji culture in a concentration of 21-56 μg/ml.
摘要翻译：要解决的问题：为了提供含有ACE抑制剂肽的组合物，其通过少量摄取有效抑制ACE，不会有副作用，并且使得高血压人容易在日常生活中摄取。解决方案：含有ACE抑制剂的组合物肽含有通过用固体曲调培养物水解蛋白质源并且具有47-154μg/ ml浓度的血管紧张素转换酶抑制活性制备的三肽Asp-Arg-Pro。或者，含有ACE抑制剂肽的组合物含有三肽Gly-Val-Pro，其通过用浓度为21-56μg/ ml的固体曲调培养物水解蛋白质来制备。

8. 发明专利

JP2011115142A Liquid seasoning material improved in palatable taste 有权
标题翻译：在可口可乐的饮料中改进的液体食品
公开(公告)号：JP2011115142A
公开(公告)日：2011-06-16
申请号：JP2010002470
申请日：2010-01-08
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： TSUCHIYA KATSUNORI , JOKA MIKIO , UCHIDA RIICHIRO
IPC分类号： A23L27/00 , A23L27/50
摘要： PROBLEM TO BE SOLVED: To provide a soy sauce like seasoning material made as containing a low salt content, capable of giving a sufficient salty taste and thickness with punching effect although it has the low salt content, also sufficiently suppressing a different taste and having balanced tastes. SOLUTION: This liquid seasoning material effectively suppressed with the different taste of an ammonium ion having a salty taste-alternative action, also imparted with a salt taste-reinforced feeling and the thick feeling of palatable taste, and markedly improved with the preferable taste is obtained by incorporating 0.2 to 4.0% (w/v) ammonium ion to the soy sauce like seasoning material made as containing the low salt content and further optimizing the composition and content of a stevia sweetener. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种含有低盐含量的调味料的酱油，能够赋予足够的咸味和厚度，虽然其具有低的盐含量，但也充分抑制了不同的味道并具有平衡的口味。解决方案：这种液体调味料有效地抑制了具有咸味替代作用的铵离子的不同味道，同时赋予了盐味增强感和可口味的浓厚感，并且显着地改善了优选通过将0.2-4.0％（w / v）铵离子掺入到酱油中，如含有低盐含量的调味料，并进一步优化甜叶菊甜味剂的组成和含量而获得味道。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2002128663A ANTI-ALLERGIC AGENT CONTAINING SOYA SAPOGENOL B AS ACTIVE INGREDIENT 失效
公开(公告)号：JP2002128663A
公开(公告)日：2002-05-09
申请号：JP2000318735
申请日：2000-10-19
申请人： KIKKOMAN CORP
发明人： YAMAGUCHI HITOMI , OGAWA YOSHIHIRO , KANAMORI TOMOKO , YOSHIMURA MINEKA , SAITO MINORU , UCHIDA RIICHIRO
IPC分类号： A23G3/34 , A23G3/00 , A23L1/30 , A61K8/30 , A61K31/047 , A61P11/02 , A61P11/06 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q11/00 , C07C29/78 , C07C35/44 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a new anti-allergic agent, and a medicine, drink, food or cosmetic containing the same. SOLUTION: This anti-allergic medicine, drink, food or cosmetic, is characterized by containing soya sapogenol B (formula 1) or its derivative as an active ingredient, and the medicine, drink, food or the cosmetic is characterized by containing the anti-allergic agent.

10. 发明专利

JPH11335369A BLEACHING OF PROANTHOCYANIDIN EXTRACT 失效
公开(公告)号：JPH11335369A
公开(公告)日：1999-12-07
申请号：JP14406798
申请日：1998-05-26
申请人： KIKKOMAN CORP
发明人： UCHIDA RIICHIRO , SAITO SHINOBU , HOSOYAMA HIROSHI , ARIGA TOSHIAKI
IPC分类号： C07D311/40 , C07D311/62
摘要： PROBLEM TO BE SOLVED: To provide a bleaching method for obtaining high purity and pale colored proanthocyanidin extract conquering the demerit of the conventional proanthocyanidin extract from the plant body has. SOLUTION: The bleaching of the proanthocyanidin extract is carried out by extracting the extract including proanthocyanidin with an organic solvent including 0.1 to 9%(V/V) of water. The organic solvent including 0.1 to 9% (V/V) of water is one or more kinds of organic solvents selected from alkyl acetate, alcohols, ketones and acetonitriles or ethyl acetate.

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