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1. 发明公开

EP3999515A1 HALOGENIERTE TETRASILYLBORANATE 审中-实审转让
公开(公告)号：EP3999515A1
公开(公告)日：2022-05-25
申请号：EP20708060.7
申请日：2020-02-26
申请人： Wacker Chemie AG
发明人： FRITZ-LANGHALS, Elke , BOCHMANN, Sebastian , RUPPEL, Lars
IPC分类号： C07F5/02 , C07B39/00

2. 发明公开

EP3438077A1 PROCESS FOR DEOXYFLUORINATION OF PHENOLS 无效
公开(公告)号：EP3438077A1
公开(公告)日：2019-02-06
申请号：EP17184127.3
申请日：2017-07-31
申请人： Studiengesellschaft Kohle mbH , President and Fellows of Harvard College
发明人： RITTER, Tobias , NEUMANN, Constanze , BEYZAVI, Mohammad Hassan , STREBL-BANTILLO, Martin Georg , MANDAL, Debashis
IPC分类号： C07B39/00 , C07B59/00
摘要： The present invention refers to a process for transition-metal-assisted 18 F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for positron emission tomography (PET) imaging.

3. 发明授权

EP2266991B1 Process for producing thiazole derivative 有权转让
公开(公告)号：EP2266991B1
公开(公告)日：2018-07-11
申请号：EP10013476.6
申请日：2004-11-12
申请人： Daiichi Sankyo Company, Limited
发明人： Nagasawa, Hiroshi , Sato, Koji , Yagi, Tsutomu , Kitani, Yasuo
IPC分类号： C07D513/04 , C07B41/08 , C07B39/00 , C07B43/04
CPC分类号： C07D513/04
摘要： The present invention provides processes for producing a compound (5) based on the following reaction scheme. [F1]

4. 发明公开

EP3318547A1 PROCESS FOR THE CHLORINATION AND IODINATION OF COMPOUNDS USING N-HYDROXYPHTHALIMIDE 审中-公开
标题翻译：使用N-羟基邻苯二甲酰亚胺的化合物的氯化和碘化的方法
公开(公告)号：EP3318547A1
公开(公告)日：2018-05-09
申请号：EP17186879.7
申请日：2017-08-18
申请人： Justus-Liebig-Universität Gießen
发明人： Schreiner, Peter R. , Combe, Sascha H.
IPC分类号： C07C17/00 , C07C17/14 , C07C19/01 , C07C19/07 , C07C22/02 , C07C22/04 , C07C23/08 , C07C23/10 , C07C23/16 , C07C23/28 , C07C255/50 , C07C69/78 , C07C205/06 , C07C67/307 , C07C201/12 , C07B39/00 , C07C253/30
CPC分类号： C07C67/307 , C07B39/00 , C07C17/14 , C07C201/12 , C07C253/30 , C07C2602/08 , C07C2602/14 , C07C2602/18 , C07C69/76 , C07C22/04 , C07C23/08 , C07C23/10 , C07C23/16 , C07C22/08 , C07C25/02 , C07C255/50 , C07C205/11
摘要： The invention provides a process for the production of halogenated hydrocarbons comprising the usage of at least one halogenating agent which contains at least one halogen-atom per formular unit in combination with substituted or unsubstituted N- hydroxyphthalimide and a metal-containing salt-like compound or a carboxylic or sulfonic acid with or without solvent.
摘要翻译：本发明提供了一种生产卤代烃的方法，包括使用至少一种卤化剂，所述卤化剂每个单位单元含有至少一个卤素原子，与取代或未取代的N-羟基邻苯二甲酰亚胺和含金属的盐类化合物或有或没有溶剂的羧酸或磺酸。

5. 发明公开

EP3215476A1 METHOD FOR PREPARATION OF FLUORO, CHLORO AND FLUOROCHLORO ALKYLATED COMPOUNDS BY HOMOGENEOUS CATALYSIS 失效转让
标题翻译：均相催化制备氟，氯和氟代烷基化合物的方法
公开(公告)号：EP3215476A1
公开(公告)日：2017-09-13
申请号：EP15790551.4
申请日：2015-11-05
申请人： Lonza Ltd
发明人： TAESCHLER, Christoph , ZARAGOZA DOERWALD, Florencio , ELLINGER, Stefan , BELLER, Matthias , NEUMANN, Helfried , HE, Lin , NATTE, Kishore
IPC分类号： C07B39/00 , C07C17/275 , C07C22/08 , C07C41/30 , C07C43/225 , C07C45/69 , C07C49/80 , C07D207/325 , C07D207/333 , C07D209/10 , C07D333/12 , C07D473/08 , C07D473/10
CPC分类号： C07D473/10 , C07B39/00 , C07C17/272 , C07C17/275 , C07C22/08 , C07C41/30 , C07C43/225 , C07C45/68 , C07C45/69 , C07C49/80 , C07D207/325 , C07D207/33 , C07D207/333 , C07D209/10 , C07D333/12 , C07D473/08 , C07C49/84
摘要： The invention discloses a method for preparations of fluoro, chloro and fluorochloro alkylated compounds by homogeneous Pd catalyzed fluoro, chloro and fluorochloro alkylation with fluoro, chloro and fluorochloroalkyl halides in the presence of di(1-adamantyl)-adamantyl-n-butylphosphine and in the presence of 2,2,6,6-tetramethylpiperdine 1-oxyl.
摘要翻译：本发明公开了通过在二（1-金刚烷基） - 正丁基膦存在下和在存在二（1-金刚烷基） - 正丁基膦的情况下通过氟，氯和氟氯烷基卤化物的均相Pd催化的氟，氯和氟氯烷基化来制备氟，氯和氟氯烷基化的化合物的方法的2,2,6,6-四甲基哌啶1-氧基。

6. 发明公开

EP3212597A1 IMPROVED FLUORINATION PROCESS 审中-公开
标题翻译：改进的氟化过程
公开(公告)号：EP3212597A1
公开(公告)日：2017-09-06
申请号：EP15731300.8
申请日：2015-06-22
申请人： Sandoz AG
发明人： SCHÖNE, Olga , WILHELM, Thorsten , SPITZENSTÄTTER, Hans-Peter , JUEN, Julia
IPC分类号： C07B39/00 , C07H19/067 , C07H19/073
CPC分类号： C07H19/06 , C07H1/00 , C07H19/10
摘要： A process comprising (i) providing a mixture comprising a compound of formula (I) or isomers, stereoisomers, diastereomers, enantiomers or salts thereof; (ii)subjecting the mixture provided in (i) to fluorinating conditions in the presence of a fluorination agent selected from the group consisting of diethylamino (difluoro) sulfonium tetrafluoroborate and difluoro(morpholino) sulfonium tetrafluoroborate obtaining a mixture comprising a compound of formula (II) or isomers, stereoisomers diastereomers, enantiomers or salts thereof; (iii) optionally subjecting the mixture obtained in (ii) to deprotection conditions, obtaining a mixture comprising the compound of formula (III) or isomers, stereoisomers, diastereomers, enantiomers or salts thereof.
摘要翻译：（i）提供包含式（I）化合物或其异构体，立体异构体，非对映异构体，对映异构体或盐的混合物; （ii）使（i）中提供的混合物在选自二氟氨基（二氟）锍四氟硼酸盐和二氟（吗啉基）锍四氟硼酸盐的氟化剂存在下进行氟化条件，获得包含式（II））或其异构体，立体异构体非对映异构体，对映异构体或盐; （iii）任选使（ii）中获得的混合物经历脱保护条件，获得包含式（III）化合物或其异构体，立体异构体，非对映异构体，对映异构体或盐的混合物。

7. 发明授权

EP2763944B1 PROCESS FOR THE CHLORINATION OF A HYDROXYLATED ORGANIC COMPOUND 失效转让
标题翻译：方法氯化羟基化有机CONNECTION
公开(公告)号：EP2763944B1
公开(公告)日：2015-12-16
申请号：EP12755867.4
申请日：2012-09-06
申请人： Akzo Nobel Chemicals International B.V.
发明人： TEN KATE, Antoon, Jacob, Berend , KOOLAARD, André, Michiel , RENKEMA, Eilertdina, Henderika , DIRIX, Carolina, Anna, Maria, Christina , VERTOMMEN, Luc, Louis, Théophile
IPC分类号： C07B39/00 , C07D301/26 , C07C29/62 , C07C31/36
CPC分类号： C07C29/62 , C07B39/00 , C07D301/26 , C07C31/36

8. 发明授权

EP2123795B1 METHOD FOR PRODUCING IODIZING AGENT AND METHOD FOR PRODUCING AROMATIC IODINE COMPOUND 有权
标题翻译：用于生产制备芳族碘化合物A碘化AND METHOD
公开(公告)号：EP2123795B1
公开(公告)日：2015-05-06
申请号：EP08721602.4
申请日：2008-03-07
申请人： Japan Science and Technology Agency , Kyoto University , Nippoh Chemicals Co., Ltd
发明人： YOSHIDA, Junichi , SUGA, Seiji , KATAOKA, Kazuhide , MIDORIKAWA, Koji , HAGIWARA, Yuji
IPC分类号： C25B1/24 , C07B39/00 , C07C17/12 , C07C25/02 , C07C25/18 , C07C25/22 , C07C37/62 , C07C39/27 , C07C41/22 , C07C43/225 , C07C209/74 , C07C211/52 , C07C253/30 , C07C255/50
CPC分类号： C07C17/02 , C07B39/00 , C07C17/12 , C07C37/62 , C07C41/22 , C07C209/74 , C07C253/30 , C25B1/24 , C25B3/06 , C07C25/18 , C07C25/22 , C07C211/52 , C07C255/50 , C07C39/27 , C07C43/225

9. 发明授权

EP2547653B1 N-CARBOMETHOXY-N-METHOXY-(2-CHLOROMETHYL)-ANILINES, THEIR PREPARATION AND THEIR USE AS PRECURSORS FOR PREPARING 2-(PYRAZOL-3'-YLOXYMETHYLENE)-ANILIDES 有权
标题翻译：的N-甲酯基-N-甲氧基 - （2-氯甲基）苯胺，-aniliden它们的制备和作为前体用于制备2-（吡唑-3-“yloxymethylen）
公开(公告)号：EP2547653B1
公开(公告)日：2015-01-28
申请号：EP11709113.2
申请日：2011-03-17
申请人： BASF SE
发明人： DOCHNAHL, Maximilian , MÜLLER, Bernd
IPC分类号： C07C269/06 , C07D231/10 , C07B39/00 , C07C271/28 , C07D231/22
CPC分类号： C07C269/06 , C07C271/28 , C07D231/10 , C07D231/22

10. 发明公开

EP2763944A1 PROCESS FOR THE CHLORINATION OF A HYDROXYLATED ORGANIC COMPOUND 失效转让
标题翻译：方法氯化羟基化有机CONNECTION
公开(公告)号：EP2763944A1
公开(公告)日：2014-08-13
申请号：EP12755867.4
申请日：2012-09-06
申请人： Akzo Nobel Chemicals International B.V.
发明人： TEN KATE, Antoon, Jacob, Berend , KOOLAARD, André, Michiel , RENKEMA, Eilertdina, Henderika , DIRIX, Carolina, Anna, Maria, Christina , VERTOMMEN, Luc, Louis, Théophile
IPC分类号： C07B39/00 , C07D301/26 , C07C29/62 , C07C31/36
CPC分类号： C07C29/62 , C07B39/00 , C07D301/26 , C07C31/36
摘要： Process for the chlorination of an organic compound comprising at least one aliphatic hydroxyl group, said process comprising the steps of actively adding to said organic compound (i) hydrogen chloride and (ii) a HCl desolubilizer or a precursor thereof, and heating the resulting mixture at a reaction temperature in the range 20°-160°C, wherein said chlorination is performed in the presence of a catalyst selected from the group consisting of (a) ketones, (b) aldehydes, (c) carboxylic acids with 1-8 carbon atoms, (d) organic compounds comprising a β-diketone moiety or a β-keto aldehyde moiety, and (e) organic polymers comprising at least one carbonyl group, having a vapour pressure at the reaction temperature of less than 1 mbar, a weight average molecular weight M
w of 500 g/mole or more, and are soluble in the reaction mixture at the reaction temperature, and wherein the HCl desolubilizer is an alkali metal chloride salt, an alkaline earth metal chloride salt, or an acid.

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