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    • 4. 发明公开
    • PROCESS FOR PRODUCTION OF FLUOROCOMPOUNDS
    • VERFAHREN ZUR HERSTELLUNG VON FLUORVERBINDUNGEN
    • EP1903021A1
    • 2008-03-26
    • EP06729640.0
    • 2006-03-22
    • Tosoh F-Tech, Inc.
    • KONDO, NorihisaWATANABE, AkioKANEZAKI, HirokiKAWADA, Kosuke
    • C07C17/16C07C19/08C07C23/08C07C23/38C07C67/307C07C69/63C07C69/65C07D207/16
    • C07C67/307C07B39/00C07C17/16C07C2601/08C07C2603/74C07C19/08C07C23/38C07C23/08C07C69/65C07C69/63
    • The present invention provides a process for producing highly pure fluoro-compounds by making use of less costly and readily handleable N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products.
      Specifically the present invention provides a process for producing a fluoro-compound, comprising fluorinating an alcohol derivative represented by the following general formula (1):

              R 1 R 2 R 3 COH     (1)

      (wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group; and R 2 and R 3 are each independently a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group, wherein at least two of R 1 , R 2 and R 3 may together form part of a ring structure, either with or without a heteroatom) with N,N-diethyl-2-chloro-1,1,2-trifluoroethylamine to form a fluoro-compound represented by the following general formula (2):

              R 1 R 2 R 3 CF     (2)

      (wherein R 1 , R 2 and R 3 are as defined above), the process being characterized in that an alcohol derivative represented by the following general formula (3):

              R 4 OH     (3)

      (wherein R 4 represents a substituted or unsubstituted alkyl group or aryl group) is added to the reaction system.
    • 本发明提供了使用成本较低且易于处理的N-(2-氯-1,1,2-三氟乙基)二乙胺制备高纯度氟化合物的方法。 该方法几乎不产生或不产生氯化副产物。 具体地说,本发明提供一种氟化合物的制造方法,其特征在于,含氟化下述通式(1)表示的醇衍生物:ƒ€ƒ€ƒ€ƒ€ƒ€ƒR1 R 2 R 3 COH€ƒ€ƒ€ƒ(1)(其中R 1表示氢原子,取代或未取代的烷基,芳基,烷基羰基,烷氧基羰基,芳基羰基或芳氧基羰基; R 2和R 3各自独立地为取代或未取代的烷基,芳基,烷基羰基,烷氧基羰基,芳基羰基或芳氧基羰基,其中R 1,R 2和R 3中的至少两个可以一起形成环结构的一部分, 或不含杂原子)与N,N-二乙基-2-氯-1,1,2-三氟乙胺反应以形成由以下通式(2)表示的氟化合物:€ƒ€ƒ€ƒ€ƒ€ ƒ€ƒ€ƒR1 R 2 R 3 CF€ƒ€ƒ€ƒ(2)(其中R 1,R 2和R 3为 该方法的特征在于由以下通式(3)表示的醇衍生物:ƒ€ƒ€ƒ€ƒ€ƒ€ƒR4 OH€ƒ€ƒ€ƒ (3)(其中R 4表示取代或未取代的烷基或芳基)加入到反应体系中。
    • 6. 发明公开
    • EP0913380A4 -
    • EP0913380A4 - Google专利
    • EP0913380A4
    • 1999-05-19
    • EP97918365
    • 1997-05-02
    • C07C21/18C07C17/20C07C17/383C07C23/08
    • C07C23/08C07C17/206C07C17/208C07C17/383
    • In a process for preparing a fluorinated olefin having a carbon-carbon double bond, the carbon atoms of which have a fluorine atom, by reacting a halogenated olefin having at least one carbon-carbon double bond, a carbon atom or the carbon atoms of which bond have a chlorine atom or atoms bound thereto, and, in which the carbon atom or atoms with a single bond in the molecule have no halogen atom other than a fluorine atom, with an alkali metal fluoride, said reaction of the halogenated olefin with the alkali metal fluoride is conducted in the presence of an organic halogen-containing compound having a carbon-carbon single bond, a carbon or the carbons of which have at least one halogen atom other than fluorine atom.
    • 通过使碱金属氟化物与分子内具有至少一个碳 - 碳双键的卤代烯烃反应来制备具有与碳 - 碳双键的任一碳原子键合的氟原子的含氟烯烃的方法, 氯原子键合到其任一个碳原子上,并且其碳 - 碳单键的碳原子都不含有非氟卤素,其特征在于上述反应在有机卤化物存在下进行,所述有机卤化物具有至少一个 与碳 - 碳单键的任何碳原子键合的非氟卤素原子。