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1. 发明公开

EP4379368A1 SAMPLE SUPPORT UNIT, AND SAMPLE IONIZATION METHOD 审中-公开
公开(公告)号：EP4379368A1
公开(公告)日：2024-06-05
申请号：EP22910465.8
申请日：2022-09-02
申请人： Hamamatsu Photonics K.K.
发明人： IKEDA Takamasa , KOTANI Masahiro , OHMURA Takayuki
IPC分类号： G01N27/62 , H01J49/04 , H01J49/16
CPC分类号： G01N27/62 , H01J49/04 , H01J49/16
摘要： A sample support unit includes a substrate having a first surface and a second surface, and having a porous structure formed therein and opened to at least the first surface, and a frame removably attached to the substrate and retaining the substrate such that at least a part of the first surface is exposed. The frame has a fixing portion positioned outside the substrate when viewed in a direction perpendicular to the first surface, in the state of being attached to the substrate.

2. 发明公开

EP3401945A1 METHOD FOR LIQUID CHROMATOGRAPHIC MASS SPECTROMETRY AND LIQUID CHROMATOGRAPH MASS SPECTROMETER 审中-公开
公开(公告)号：EP3401945A1
公开(公告)日：2018-11-14
申请号：EP18170686.2
申请日：2018-05-03
申请人： Shimadzu Corporation
发明人： HIOKI, Yusaku
IPC分类号： H01J49/16 , H01J49/04
CPC分类号： G01N30/38 , G01N30/28 , G01N30/7233 , G01N30/84 , G01N33/6848 , G01N2030/027 , H01J49/0431 , H01J49/16 , H01J49/165
摘要： In an LC/MS analysis of a sample containing various compounds, additive supply pumps 164A and 164B in a post-column adding unit 16 draw and supply different kinds of additives A and B from containers 163A and 163B, respectively. The additives are mixed into an eluate through T-joints 162 and 161. A preferable combination of the additives is the combination of DMSO which produces the effect of gathering charge states and 2-propanol which produces the effect of promoting atomization or vaporization of droplets. By mixing the two additives into the eluate while mixing them at an appropriate flow-rate ratio according to a previously determined flow-rate program, the ionization efficiency can be nearly optimized for each compound during the process of generating ions by spraying electrically charged droplets of the eluate from an ESI spray 21. Consequently, the detection sensitivity becomes higher than conventional levels.

3. 发明公开

EP3265822A1 TISSUE ANALYSIS BY MASS SPECTROMETRY OR ION MOBILITY SPECTROMETRY 有权
标题翻译：用质谱或离子迁移谱法分析组织分析
公开(公告)号：EP3265822A1
公开(公告)日：2018-01-10
申请号：EP16710790.3
申请日：2016-03-07
申请人： Micromass UK Limited
发明人： PRINGLE, Steven Derek , KARANCSI, Tamás , JONES, Emrys , MORRIS, Michael Raymond , BALOG, Júlia , LANGRIDGE, James Ian , TAKÁTS, Zoltán , BOLT, Frances , GÖDÖRHÁZY, Lajos , SZALAY, Dániel , SIMON, Dániel , RICHARDSON, Keith
IPC分类号： G01N33/68 , H01J49/00 , A61B18/00
CPC分类号： H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
摘要： A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

4. 发明公开

EP3265821A1 LIQUID TRAP OR SEPARATOR FOR ELECTROSURGICAL APPLICATIONS 有权
标题翻译：用于电外科应用的液体分离器或分离器
公开(公告)号：EP3265821A1
公开(公告)日：2018-01-10
申请号：EP16710789.5
申请日：2016-03-07
申请人： Micromass UK Limited
发明人： KARANCSI, Tamás , GÖDÖRHÁZY, Lajos , SZALAY, Dániel , TAKÁTS, Zoltán , BALOG, Júlia , PRINGLE, Steven Derek , SIMON, Dániel
IPC分类号： G01N33/68 , A61B17/00 , G01N3/00 , G01N9/00 , H01J49/00 , A61B18/00 , G01N27/62 , G01N33/92
CPC分类号： H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
摘要： An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

5. 发明公开

EP3030895A1 BUBBLE REMOVAL FROM LIQUID FLOW INTO A MASS SPECTROMETER SOURCE 有权
标题翻译： EINE MUSENSPEKTROMETERQUELLE中的BLASENENTFERNUNG AUS EINEMFLÜSSIGKEITSSTROM
公开(公告)号：EP3030895A1
公开(公告)日：2016-06-15
申请号：EP14834194.4
申请日：2014-08-05
申请人： DH Technologies Development PTE. Ltd.
发明人： KOVARIK, Peter
IPC分类号： G01N27/62 , G01N1/28 , H01J49/04 , H01J49/26
CPC分类号： H01J49/0445 , B01D19/0042 , H01J49/0431 , H01J49/16
摘要： Methods and systems for delivering a liquid sample to an ion source are provided herein. In various aspects, the methods and systems can improve the stability of a flow of liquid sample delivered to an ion source. In accordance with various aspects, the methods and systems can remove bubbles (e.g., cavitation bubbles or otherwise) present in the liquid sample prior to its injection into an ionization chamber.
摘要翻译：本文提供了将液体样品输送到离子源的方法和系统。在各个方面，所述方法和系统可以提高输送到离子源的液体样品流的稳定性。根据各个方面，所述方法和系统可以在液体样品注入电离室之前去除存在于液体样品中的气泡（例如气蚀气泡或其它）。

6. 发明公开

EP2951569A1 SURFACE IONIZATION SOURCE 审中-公开
标题翻译：表面电离源
公开(公告)号：EP2951569A1
公开(公告)日：2015-12-09
申请号：EP14746256.8
申请日：2014-01-30
申请人： Smiths Detection Montreal Inc.
发明人： HENDRIKSE, Jan , ROMANOV, Vladimir
IPC分类号： G01N27/64 , H01J27/02 , H01J49/16 , H01J49/26
CPC分类号： H01J27/26 , G01N27/64 , H01J49/142 , H01J49/16 , H01J49/26
摘要： A surface ionization source comprises a tube having a first end, a second end, and an interior bore extending through the tube from the first end to the second end. The first end of the tube is configured to receive a flow of gas and the second end of the tube is configured to direct the flow of gas onto a surface configured to hold an analyte. A radioactive source is at least substantially disposed in the interior bore of the tube. The radioactive source is configured to form ions in the flow of gas as the flow of gas passes through the interior bore. The flow of gas containing the ions is directed onto the analyte to at least partially ionize the analyte.
摘要翻译：表面电离源包括具有第一端，第二端和从第一端到第二端延伸穿过管的内孔的管。管的第一端构造成接收气流，并且管的第二端构造成将气流引导到构造成保持分析物的表面上。放射源至少基本上设置在管的内孔中。放射源配置成在气体流通过内孔时在气体流中形成离子。含有离子的气体流被引导到分析物上以至少部分电离分析物。

7. 发明公开

EP2912678A1 PIEZO-ELECTRIC VIBRATION ON AN IN-SOURCE SURFACE IONIZATION STRUCTURE TO AID SECONDARY DROPLET REDUCTION 审中-公开
标题翻译：压电振荡器在源OBERFLÄCHENIONISIERUNGSSTRUKTUR减少二次熔滴
公开(公告)号：EP2912678A1
公开(公告)日：2015-09-02
申请号：EP12781142.0
申请日：2012-10-25
申请人： Micromass UK Limited
发明人： BAJIC, Stevan , DOUCE, David , JONES, Gordon
IPC分类号： H01J49/04 , H01J49/16
CPC分类号： H01J49/045 , H01J49/0031 , H01J49/0445 , H01J49/0454 , H01J49/061 , H01J49/16 , H01J49/161
摘要： An ion source is disclosed comprising a nebuliser and a target. The nebuliser is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target and to ionise analyte to form a plurality of analyte ions. The target is vibrated by a piezo-electric vibration device to reduce the size of resultant secondary droplets.

8. 发明公开

EP2040282A3 Micro sample heating probe and method of producing the same, and analyzer using the micro sample heating probe 有权
标题翻译： Mikroprobenheizsonde和用于采用所述Mikroprobenheizsonde它们的制备和分析装置的方法
公开(公告)号：EP2040282A3
公开(公告)日：2010-09-29
申请号：EP08015733.2
申请日：2008-09-05
申请人： Hitachi Ltd.
发明人： Horikoshi, Kazuhiko , Akamatsu, Naotoshi , Otani, Toshiaki
IPC分类号： H01J49/16 , H01J49/04
CPC分类号： H01J49/16 , H01J49/0459
摘要： An object of the present invention is to extract a micro foreign body of a few µm, which may cause a product defect of a device or the like, and to subject the foreign body to a mass analysis at a favorable S/N ratio without any contamination. A micro sample heating probe includes a sample holder made up of two members different in diameter, a supporting part, and a terminal part. The sample holder includes a heating mechanism only in a limited part, and just a region extremely close to the micro sample being an analysis target is heated locally. Therefore, even when a contaminated substance is attached to the probe, such substance is not heated, thereby preventing a noise from occurring, and enabling an analysis at a quite favorable S/N ratio.

9. 发明公开

EP1992005A2 A SAMPLING SYSTEM FOR USE WITH SURFACE IONIZATION SPECTROSCOPY 审中-公开
标题翻译：用于表面电离光谱的采样系统
公开(公告)号：EP1992005A2
公开(公告)日：2008-11-19
申请号：EP07757665.0
申请日：2007-02-28
申请人： Ionsense, Inc.
发明人： MUSSELMAN, Brian, D.
IPC分类号： H01J49/00
CPC分类号： H01J49/04 , G01N30/7293 , H01J49/0404 , H01J49/16
摘要： In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the device incorporates the source for ionization in combination with a jet separator to efficiently remove excess carrier gas while permitting ions to be more efficiently transferred into the vacuum chamber of the mass spectrometer. In an embodiment of the invention, improved collection of ions produced by the carrier gas containing metastable neutral excited-state species at greater distances from between the position of the analyte and the position of the mass spectrometer are enabled.
摘要翻译：在本发明的各种实施例中，装置允许通过含有亚稳态中性激发态物质的载气的作用产生的离子更有效地收集和传输到质谱仪中。在本发明的一个实施例中，该装置将离子源与射流分离器结合，以有效地去除多余的载气，同时允许离子更有效地传递到质谱仪的真空室中。在本发明的一个实施方式中，在分析物的位置和质谱仪的位置之间的距离更远的情况下，改善了由含有亚稳态中性激发态物质的载气产生的离子的收集。

10. 发明公开

EP1376652A3 A method and apparatus for acquiring information of a biochip 审中-公开
标题翻译：用于检测生物芯片的信息的方法和装置
公开(公告)号：EP1376652A3
公开(公告)日：2006-02-15
申请号：EP03014310.1
申请日：2003-06-25
申请人： CANON KABUSHIKI KAISHA
发明人： Okamoto, Tadashi , Takase, Hiromitsu , Hashimoto, Hiroyuki
IPC分类号： H01J49/40
CPC分类号： G01N23/2258 , H01J49/16 , H01J49/40
摘要： A measurement method is provided, which enables to obtain a two-dimensional image with better quantitative-ability by suppressing the influence of the charging-up, when the two-dimensional secondary ion image is obtained for a biological-related material fixed on a substrate having high resistivity by utilizing TOF-SIMS method in a certainly wide area. Two-dimensional image having considerably high positioning resolution-ability can be obtained by the procedure, in which the pulsed primary ion beam is irradiated at a spot, and the pulse-wise spot-applications of the primary ion beam and the simultaneous detection of the secondary ion generated from the irradiated primary ion beam are proceeded along with a discontinuous scanning pattern, and eventually the results of these secondary ion measurements results is reconstructed into a two-dimensional image in line with the aforementioned discontinuous scanning pattern.

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