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1. 发明授权

EP3729488B1 ION SOURCE 有权
公开(公告)号：EP3729488B1
公开(公告)日：2024-09-18
申请号：EP18839598.2
申请日：2018-12-21
IPC分类号： H01J49/04 , H01J49/14 , H01J27/20
CPC分类号： H01J27/20 , H01J49/049 , H01J49/145

2. 发明公开

EP3265822A1 TISSUE ANALYSIS BY MASS SPECTROMETRY OR ION MOBILITY SPECTROMETRY 有权
标题翻译：用质谱或离子迁移谱法分析组织分析
公开(公告)号：EP3265822A1
公开(公告)日：2018-01-10
申请号：EP16710790.3
申请日：2016-03-07
申请人： Micromass UK Limited
发明人： PRINGLE, Steven Derek , KARANCSI, Tamás , JONES, Emrys , MORRIS, Michael Raymond , BALOG, Júlia , LANGRIDGE, James Ian , TAKÁTS, Zoltán , BOLT, Frances , GÖDÖRHÁZY, Lajos , SZALAY, Dániel , SIMON, Dániel , RICHARDSON, Keith
IPC分类号： G01N33/68 , H01J49/00 , A61B18/00
CPC分类号： H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
摘要： A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

3. 发明公开

EP3265821A1 LIQUID TRAP OR SEPARATOR FOR ELECTROSURGICAL APPLICATIONS 有权
标题翻译：用于电外科应用的液体分离器或分离器
公开(公告)号：EP3265821A1
公开(公告)日：2018-01-10
申请号：EP16710789.5
申请日：2016-03-07
申请人： Micromass UK Limited
发明人： KARANCSI, Tamás , GÖDÖRHÁZY, Lajos , SZALAY, Dániel , TAKÁTS, Zoltán , BALOG, Júlia , PRINGLE, Steven Derek , SIMON, Dániel
IPC分类号： G01N33/68 , A61B17/00 , G01N3/00 , G01N9/00 , H01J49/00 , A61B18/00 , G01N27/62 , G01N33/92
CPC分类号： H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
摘要： An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

4. 发明公开

EP3062331A2 AMBIENT DESORPTION, IONIZATION, AND EXCITATION FOR SPECTROMETRY 有权
标题翻译： DESORPTION，IONISIERUNG UND ERREGUNG UNTER UMGEBUNGSBEDINGUNGENFÜRSPEKTROMETRIE
公开(公告)号：EP3062331A2
公开(公告)日：2016-08-31
申请号：EP16157116.1
申请日：2016-02-24
申请人： Agilent Technologies, Inc. (A Delaware Corporation)
发明人： Lopez-Avila, Viorica , Denning, Mark , Vahidpour, Mehrnoosh
IPC分类号： H01J49/04 , H01J27/20 , H01J49/14
CPC分类号： H01J49/102 , G01N21/714 , G01N30/95 , H01J27/16 , H01J49/0031 , H01J49/0409 , H01J49/049 , H01J49/105 , H01J49/161 , H05H1/46
摘要： An ion source (100; 400; 700; 1400) includes a plasma generator (104; 404; 1404) for supplying plasma at an ionization region proximate to a sample surface (120; 1120; 1220; 1320; 1420). The plasma generator applies energy that may be utilized for desorbing analytes from the sample surface as well as for generating plasma by which analytes are excited or ionized. Desorption and ionization/excitation may be controlled as individual modes. The ion source may be interfaced with an analytical instrument (118) such as an ion-based or optical-based spectrometer. A sample support (108; 708) may be provided, which may be capable of performing analytical separation.
摘要翻译：离子源（100; 400; 700; 1400）包括用于在靠近样品表面（120; 1120; 1220; 1320; 1420）的电离区域提供等离子体的等离子体发生器（104; 404; 1404）。等离子体发生器施加可用于从样品表面解吸分析物的能量，以及产生分析物被激发或电离的等离子体。解吸和电离/激发可以作为各种模式来控制。离子源可以与分析仪器（118）接口，例如基于离子或光学的光谱仪。可以提供可以进行分析分离的样品支架（108; 708）。

5. 发明授权

EP1118097B1 VORTEX GAS FLOW INTERFACE FOR ELECTROSPRAY MASS SPECTROMETRY 有权
标题翻译：气体回旋过渡件，电力喷雾质谱
公开(公告)号：EP1118097B1
公开(公告)日：2006-11-22
申请号：EP99954671.6
申请日：1999-09-27
申请人： Varian, Inc.
发明人： WELLS, Gregory, J. , TONG, Roger, C. , YEE, Peter, P.
IPC分类号： H01J49/04
CPC分类号： H01J49/165 , G01N30/7246 , G01N30/7266 , H01J49/049
摘要： An apparatus for efficiently removing a carrier liquid from charged liquid drops formed by electrospray ionization prior to introduction of the drops into a mass spectrometer (209). A central capillary tube (210) connects a region of the low pressure vacuum system containing the mass spectrometer (209) with a region at substantially atmospheric pressure, in which ion formation is produced by electrospray ionization. Heated, drying gas flows through a plurality of vortex forming channels (214) symmetrically disposed about the axis of the central capillary tube (210) which provides an entrance to the spectrometer (209). Gas exiting the vortex forming channels (214) enters tangentially to the inside of a vortex drying tube (222) with a small helix angle, causing the gas to swirl around the tube, forming a vortex. The vortex drying gas flows in a direction that is substantially transverse to the axis of the entrance capillary into the mass spectrometer (209). The vortex gas intersects the electrospray, separating undesired large drops from smaller drops by a vortex gas flow which imparts a centrifugal force to the drops. The largest drops are driven to the wall of the drying tube (222) and caused to fragment into smaller drops by evaporation and collision with the wall (222).

6. 发明公开

EP1118097A1 VORTEX GAS FLOW INTERFACE FOR ELECTROSPRAY MASS SPECTROMETRY 有权
标题翻译：气体回旋过渡件，电力喷雾质谱
公开(公告)号：EP1118097A1
公开(公告)日：2001-07-25
申请号：EP99954671.6
申请日：1999-09-27
申请人： Varian, Inc.
发明人： WELLS, Gregory, J. , TONG, Roger, C. , YEE, Peter, P.
IPC分类号： H01J49/04
CPC分类号： H01J49/165 , G01N30/7246 , G01N30/7266 , H01J49/049
摘要： An apparatus for efficiently removing a carrier liquid from charged liquid drops formed by electrospray ionization prior to introduction of the drops into a mass spectrometer (209). A central capillary tube (210) connects a region of the low pressure vacuum system containing the mass spectrometer (209) with a region at substantially atmospheric pressure, in which ion formation is produced by electrospray ionization. Heated, drying gas flows through a plurality of vortex forming channels (214) symmetrically disposed about the axis of the central capillary tube (210) which provides an entrance to the spectrometer (209). Gas exiting the vortex forming channels (214) enters tangentially to the inside of a vortex drying tube (222) with a small helix angle, causing the gas to swirl around the tube, forming a vortex. The vortex drying gas flows in a direction that is substantially transverse to the axis of the entrance capillary into the mass spectrometer (209). The vortex gas intersects the electrospray, separating undesired large drops from smaller drops by a vortex gas flow which imparts a centrifugal force to the drops. The largest drops are driven to the wall of the drying tube (222) and caused to fragment into smaller drops by evaporation and collision with the wall (222).

7. 发明公开

EP1051603A1 DISPOSITIF POUR LA QUALIFICATION DE PRODUITS CONTENANT DES SUBSTANCES VOLATILES 有权
标题翻译：设备为产品，方便挥发性成分资格
公开(公告)号：EP1051603A1
公开(公告)日：2000-11-15
申请号：EP99901556.3
申请日：1999-01-19
申请人： Zesiger, Thierry
发明人： Zesiger, Thierry
IPC分类号： G01N1/00 , G01N30/18
CPC分类号： G01N35/1079 , G01N30/18 , G01N30/24 , G01N2001/2229 , G01N2030/025 , H01J49/0031 , H01J49/0413 , H01J49/049 , Y10T436/25 , Y10T436/2575
摘要： The invention concerns a device for qualifying products containing volatile substances forming an analyte, comprising a measuring apparatus (2) provided with an enclosure (21a) and an electronic analysing circuit (21b) for defining said analyte characteristics, a pumping system (30) for producing a vacuum inside said enclosure, a sampling chamber (16) wherein the analyte is introduced and a capillary (22) for connecting said chamber (16) to said enclosure (21a). The invention is characterised in that the chamber (16) comprises: a first inlet (18) for introducing the analyte and provided with a sealed plug (27, 60, 62); a second inlet (17) connected to a blow-down gas (11) and provided with a valve (23); and an outlet (19) for evacuating the gas contained in the chamber (16) and likewise provided with a valve (29), and it further comprises a transfer device (35, 32) for introducing the analyte into the chamber and a programmer (15) controlling the analysing circuit (21b), the transfer device (35, 32) and the valves (23, 29), and arranged such that the purge of the chamber (16), the enclosure (21a) and the capillary (22) can be carried out automatically.

8. 发明授权

EP0452930B1 Apparatus for sample ionization and mass spectrometry 失效
标题翻译：设备Probeionisierung和质谱
公开(公告)号：EP0452930B1
公开(公告)日：1996-07-03
申请号：EP91106232.1
申请日：1991-04-18
申请人： HITACHI, LTD.
发明人： Kato, Yoshiaki
IPC分类号： H01J49/04
CPC分类号： H01J49/049 , H01J49/045 , H01J49/145

9. 发明公开

EP0465720A3 Analysenvorrichtung mit elektrothermischem Atomisator und Massenspektrometer zur Atom- und Molekülanalyse 失效
标题翻译：具有电热原子的分析装置和用于原子和分子分析的质谱仪
公开(公告)号：EP0465720A3
公开(公告)日：1992-08-19
申请号：EP90122801.5
申请日：1990-11-29
申请人： SPECTRO ANALYTICAL INSTRUMENTS Gesellschaft für analytische Messgeräte mbH
发明人： Falk, Heinz, Prof. Dr. , Wollnik, Hermann, Prof. Dr.
IPC分类号： H01J49/04
CPC分类号： H01J49/049 , G01N1/22
摘要： Die Erfindung betrifft eine Analysenvorrichtung zur Messung der Konzentrationen von Element- oder Molekülbestandteilen einer festen, flüssigen oder als Aerosol vorliegenden Probe (1), wobei die Probe von einem elektrothermischen Atomisator (2) getrocknet, erforderlichenfalls verascht, verdampft, der Probendampf ionisiert, die gebildeten Ionen in einem Ionenspeicher (7) gesammelt und die gespeicherten Ionen während einer gegen die Speicherzeit möglichst kurzen Zeit einem vorzugsweise simultan arbeitenden Massenspektrometer (8,10) zugeführt und die Häufigkeiten der jeweiligen Ionenmassen gemessen werden.

10. 发明公开

EP0465720A2 Analysenvorrichtung mit elektrothermischem Atomisator und Massenspektrometer zur Atom- und Molekülanalyse 失效
标题翻译： Atomicator和Massenspektrometer zur Atom- undMolekülanalyse。
公开(公告)号：EP0465720A2
公开(公告)日：1992-01-15
申请号：EP90122801.5
申请日：1990-11-29
申请人： SPECTRO ANALYTICAL INSTRUMENTS Gesellschaft für analytische Messgeräte mbH
发明人： Falk, Heinz, Prof. Dr. , Wollnik, Hermann, Prof. Dr.
IPC分类号： H01J49/04
CPC分类号： H01J49/049 , G01N1/22
摘要： Die Erfindung betrifft eine Analysenvorrichtung zur Messung der Konzentrationen von Element- oder Molekülbestandteilen einer festen, flüssigen oder als Aerosol vorliegenden Probe (1), wobei die Probe von einem elektrothermischen Atomisator (2) getrocknet, erforderlichenfalls verascht, verdampft, der Probendampf ionisiert, die gebildeten Ionen in einem Ionenspeicher (7) gesammelt und die gespeicherten Ionen während einer gegen die Speicherzeit möglichst kurzen Zeit einem vorzugsweise simultan arbeitenden Massenspektrometer (8,10) zugeführt und die Häufigkeiten der jeweiligen Ionenmassen gemessen werden.
摘要翻译：本发明涉及一种分析装置，用于测量固体或液体样品或气溶胶形式的样品的元素或分子成分的浓度，样品被电热雾化器干燥，如果需要焚烧并蒸发，样品蒸气被离子化，所形成的离子被收集在离子储存器中，并且储存的离子在与优选同时操作的质谱仪的存储时间尽可能短的时间内进料，离子质量的频率在特定情况下进行测量。 ... ...

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