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1. 发明公开

EP4371410A1 ANTIBACTERIAL COMPOSITION 审中-公开
公开(公告)号：EP4371410A1
公开(公告)日：2024-05-22
申请号：EP22842333.1
申请日：2022-06-29
申请人： LG Chem, Ltd.
发明人： LEE, Ji Seok , KANG, Soonhee , KIM, Sanggon , BAEK, Leehyeon , YUN, Haesung , LEE, Hwanhee , CHUNG, Da Sol , JUNG, Seonjung , CHOI, Hyungsam
IPC分类号： A01N33/12
CPC分类号： Y02A50/30 , A01N33/12 , C12Q1/18 , A01P1/00
摘要： The present specification relates to an antibacterial composition comprising at least one compound comprising a quaternary ammonium structure having an acrylate group or methacrylate group, and having an antibacterial strength A of 90% or more which are measured by the following Method 1 for at least one strain of Gram-positive bacteria and Gram-negative bacteria and an acute oral toxicity dose LD50 of 300 mg/Kg or more.

2. 发明授权

EP2766722B1 NANOSCALE MOTION DETECTOR 有权
公开(公告)号：EP2766722B1
公开(公告)日：2018-12-26
申请号：EP12797978.9
申请日：2012-10-12
申请人： École Polytechnique Fédérale de Lausanne (EPFL)
发明人： KASAS, Sandor , LONGO, Giovanni , DIETLER, Giovanni , ALONSO SARDUY LIVAN, Bladimir
IPC分类号： G01N29/036 , G01N33/543
CPC分类号： C12Q1/18 , B82Y5/00 , B82Y35/00 , C12Q1/02 , C12Q1/533 , G01N29/036 , G01N29/2418 , G01N29/46 , G01N2291/0427
摘要： Motion detector comprising a flexible support (1,5) adapted to hold at least one object (6-9), a sensor (4) for measuring the displacement of said support (1) and processing means for differentiating the fluctuations of said support (1) from those induced by said object (6-9).

3. 发明授权

EP2747578B1 THE METHOD OF OBTAINING A STRAIN OF BACTERIOPHAGE, SPECIFIC STRAINS OF BACTERIOPHAGE AND USE THEREOF 有权
公开(公告)号：EP2747578B1
公开(公告)日：2018-09-12
申请号：EP12770231.4
申请日：2012-08-09
申请人： Proteon Pharmaceuticals S.A.
发明人： DASTYCH, Jaroslaw , DZIADEK, Jaroslaw , GÓRECKA, Elzbieta , RUMIJOWSKA-GALEWICZ, Anna , WOJTASIK, Arkadiusz , WÓJCIK, Ewelina
IPC分类号： A23K10/00
CPC分类号： A23K10/18 , A23K50/75 , A61K35/76 , C12N7/00 , C12N2795/00021 , C12N2795/00032 , C12Q1/18
摘要： A method for obtaining a strain of bacteriophage specific to a selected strain of bacteria was found as well as bacteriophage strains obtained in this way. Moreover, application of bacteriophages in manufacturing of the preparation for preventing and fighting infections of farm animals, especially poultry, with pathogenic strains of bacteria sensitive to these phages was described.

4. 发明授权

EP2912193B1 PREDICTIVE MARKERS FOR POLYAMINE INHIBITOR CANCER THERAPIES 有权
公开(公告)号：EP2912193B1
公开(公告)日：2018-08-29
申请号：EP13786402.1
申请日：2013-10-29
申请人： Arizona Board of Regents on Behalf of University of Arizona
发明人： GERNER, Eugene , PAZ, Edwin , LAFLEUR, Bonnie , GARCIA-HUIDOBRO, Jenaro
IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/18 , A61K31/192 , A61K31/196 , A61K31/198 , A61K31/616 , A61K31/635 , C12Q1/6886 , A61K45/06
CPC分类号： G01N33/57496 , A61K31/192 , A61K31/196 , A61K31/198 , A61K31/616 , A61K31/635 , A61K45/06 , C12Q1/18 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/57492 , G01N2333/4703 , G01N2800/52 , A61K2300/00
摘要： The present disclosure relates to therapeutic methods and medical uses comprising the identification and use of cancer marker surrogates for increased polyamine expression. These markers may be used to identify patients who may be treated for diseases and disorders that are susceptible to polyamine synthesis inhibitors, and they can also be used to monitor therapeutic responses when such agents are used. More specifically, reduced levels of let-7 miRNA and elevated levels of LIN28 and HMGA2 proteins were found to correlate with elevated levels of polyamines and may be used for predicting the efficacy of cancer therapy using an ornithine decarboxylase (ODC1) inhibitor such as eflornithine (DFMO), suitably in combination with an NSAID such as sulindac.

5. 发明授权

EP2863875B1 MOUTH RINSE EMULSIONS 有权
公开(公告)号：EP2863875B1
公开(公告)日：2018-08-22
申请号：EP13733206.0
申请日：2013-06-20
申请人： The Procter & Gamble Company
发明人： SCOTT, Douglas, Craig , RAMJI, Niranjan , TEPPER, Bruce, Ernest
IPC分类号： C12Q1/18 , A61Q11/00 , A61K8/41 , A61K8/06 , A61Q17/00
CPC分类号： A61Q17/005 , A61K8/062 , A61K8/416 , A61Q11/00 , C12Q1/18
摘要： Disclosed are oral care mouth rinse compositions formulated as stable oil-in-water emulsions comprising: (a) at least about 0.025% by weight of a quaternary ammonium antimicrobial agent, (b) at least about 0.05% by weight of an essentially water-insoluble volatile oil, and (c) at least about 50% by weight water, wherein the emulsion comprises oil droplets having an average mean particle size of about 350 nm or less. Examples of quaternary ammonium antimicrobial agent include cetylpyridinium chloride (CPC), tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide.

6. 发明公开

EP3321371A1 NOVEL METHODS FOR RAPID DRUG SUSCEPTIBILITY TESTING AND DRUG SCREENS FOR GROWING AND NON-GROWING CELLS OF PROKARYOTIC AND EUKARYOTIC ORIGIN 审中-公开
标题翻译：用于快速药物敏感性试验和药物屏障的新方法用于生长和非生长的原核和真核生成细胞
公开(公告)号：EP3321371A1
公开(公告)日：2018-05-16
申请号：EP17159022.7
申请日：2017-03-02
申请人： Zhang, Ying , Feng, Jie , Yee, Rebecca , Zhang, Shuo , Zhang, Wenhong , Wang, Xiaodong
发明人： ZHANG, Ying , FENG, Jie , YEE, Rebecca , ZHANG, Wenhong , ZHANG, Shuo
IPC分类号： C12Q1/18 , G01N33/50
CPC分类号： G01N33/5014 , C12Q1/18 , Y02A50/57
摘要： The presently disclosed subject matter provides methods, compositions, and kits for extremely rapid assessment of drug susceptibility of growing as well as non-growing cells of prokaryotic and also eukaryotic origins, without the need for organism growth, which is in contrast to the current growth-dependent methods.This growth-independent new methodology achieves extremely rapid drug susceptibility testing results previously not possible. Methods for rapidly identifying compounds with inhibitory activity against both growing and non-growing cells in real-time continuous manner with previously unachievable efficiency in drug screens using the novel methodology are also provided. Cell cultures are incubated with a drug or test agent and with a staining mixture containing a first fluorescent dye indicative the emission of which is indicative of live cells (e.g. SYBR Green I) and a second fluorescent dye indicative emitting a different color, the emission of which is indicative of dead cells (e.g. Propidium iodide). The ratio of the intensities of the emitted fluorescence of the dyes is indicative of the percentage live and dead cells in the culture.
摘要翻译：本发明公开的主题提供了方法，组合物和试剂盒，用于非常快速评估原核生物和真核生物起源的生长以及非生长细胞的药物敏感性，而不需要生物体生长，这与目前的生长相反这种独立于生长的新方法实现了以前不可能的极快的药物敏感性测试结果。还提供了用实时连续方式迅速鉴定具有抑制生长和非生长细胞的活性的化合物的方法，以及使用新方法在药物筛选中以前无法实现的效率。将细胞培养物与药物或测试试剂以及含有第一荧光染料和第二荧光染料的染色混合物孵育，所述第一荧光染料指示其发射指示活细胞（例如SYBR Green I），第二荧光染料指示发射不同颜色，这是死细胞的指示（例如碘化丙锭）。染料荧光发射强度的比例表明培养物中活细胞和死细胞的百分比。

7. 发明授权

EP2780322B1 METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR 有权转让
标题翻译：与粒细胞集落刺激因子受体有关的方法和组合物
公开(公告)号：EP2780322B1
公开(公告)日：2018-05-16
申请号：EP12791925.6
申请日：2012-11-12
申请人： Ligand Pharmaceuticals, Inc.
发明人： PEDRAM, Bijan , ROACH, Steven, L. , GRANT, Virginia, H. , ZHI, Lin , HUDSON, Andrew, R. , PICKENS, Jason, C. , SHEN, Yixing , VALDEZ, Lino, J. , MARSCHKE, Keith , VAN OEVEREN, C., Arjan
IPC分类号： C07D209/34 , C07D231/46 , C07D403/12 , C07D405/06 , A61K31/404 , A61K31/4152 , A61P7/00
CPC分类号： A61K31/404 , A61K31/41 , A61K31/4152 , A61K31/4155 , A61K31/454 , A61K45/06 , A61N5/10 , C07D209/34 , C07D231/46 , C07D231/52 , C07D401/12 , C07D403/12 , C07D405/06 , C12Q1/18 , C12Q1/66
摘要： Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

8. 发明公开

EP3312287A1 METHOD FOR MEASURING COMPLEMENT-DEPENDENT BACTERICIDAL FUNCTION WITH RESPECT TO PNEUMOCOCCI 审中-公开
标题翻译：用于测定与气相色谱法相关的补充相关杀菌功能的方法
公开(公告)号：EP3312287A1
公开(公告)日：2018-04-25
申请号：EP16811739.8
申请日：2016-06-17
申请人： The Research Foundation for Microbial Diseases of Osaka University , Osaka University
发明人： AKEDA, Yukihiro , MIYATAKE, Hiroshi , PIAO, Zhenyu , KOIZUMI, Yuka
IPC分类号： C12Q1/02 , G01N33/15 , C07K16/12 , C12N1/20 , C12N5/078 , C12N5/0787
CPC分类号： C12Q1/18 , C07K16/12 , C12N1/20 , G01N2333/3156
摘要： The present invention relates to a measurement method for complement-dependent bactericidal activity against Streptococcus pneumoniae, and provides a measurement method capable of measuring complement-dependent bactericidal activity against Streptococcus pneumoniae of any capsular serotype. Complement-dependent bactericidal activity against Streptococcus pneumoniae is measured using capsule-deficient Streptococcus pneumoniae, that is, non-encapsulated or substantially non-encapsulated, or transparent Streptococcus pneumoniae. The measurement of the complement-dependent bactericidal activity against Streptococcus pneumoniae of any capsular serotype is enabled.
摘要翻译：本发明涉及针对肺炎链球菌的补体依赖性杀菌活性的测定方法，提供能够测定对任何荚膜血清型的肺炎链球菌的补体依赖性杀菌活性的测定方法。使用缺乏胶囊的肺炎链球菌（即未包封的或基本上未包封的）或透明的肺炎链球菌来测量对肺炎链球菌的补体依赖性杀菌活性。可以测量任何荚膜血清型对抗肺炎链球菌的补体依赖性杀菌活性。

9. 发明公开

EP3194373A4 DIAGNOSTIC SYSTEM AND PROCESS FOR RAPID BACTERIAL INFECTION DIAGNOSIS 有权
公开(公告)号：EP3194373A4
公开(公告)日：2018-04-04
申请号：EP15841956
申请日：2015-09-16
申请人： UNIV NORTHEASTERN
发明人： GOLUCH EDGAR D , SISMAET HUNTER J , WEBSTER THADDAEUS A
IPC分类号： C12Q1/02 , A61K31/496 , A61K38/12 , B01L3/00 , C12M1/34 , C12Q1/04 , C12Q1/12 , C12Q1/18 , C12Q1/22 , G01N27/327 , G01N27/48 , G01N33/487
CPC分类号： C12Q1/12 , A61K31/496 , A61K38/12 , B01L3/5027 , B01L3/502715 , B01L2300/02 , B01L2300/0636 , B01L2300/0645 , C12M1/34 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/22 , G01N27/327 , G01N27/48 , G01N33/48707 , G01N33/48735 , G01N2333/21
摘要： Methods and devices for monitoring the viability of a biofilm comprising Pseudomonas Aeruginosa bacteria are provided by detecting pyocyanin. The invention relates to electrochemical methods and devices that offer a simple and inexpensive alternative for immediate identification of bacterial infection due to the presence of Pseudomonas aeruginosa. In some embodiments, an inexpensive, disposable electrochemical sensor can be used to rapidly screen for the presence of P. aeruginosa in clinical wound effluent samples.

10. 发明公开

EP3294886A1 METHODS FOR IDENTIFYING TARGETS FOR ANTIMICROBIAL AND ANTIPROLIFERATIVE COMPOUNDS AND COMPOSITIONS THEREFROM 审中-公开
公开(公告)号：EP3294886A1
公开(公告)日：2018-03-21
申请号：EP16793387
申请日：2016-05-11
申请人： MIMETICS LLC
发明人： HARER JOHN , HAASE STEVEN B
IPC分类号： C12N15/10 , A61P31/10 , C12Q1/18 , G01N33/48
CPC分类号： C12N15/10 , A61K31/7036 , C12N15/1072 , C12Q1/18 , G01N33/5011 , G01N33/5023 , G01N33/57407
摘要： The invention is directed to methods for identifying targets for antimicrobial and antiproliferative compounds as well as methods for identifying novel compounds for treating cancer and microbial infections.

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