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    • 4. 发明公开
    • OPTICAL COHERENCE TOMOGRAPHY APPARATUS
    • OPTISCHEKOHÄRENZTOMOGRAFIEVORRICHTUNG
    • EP3088837A1
    • 2016-11-02
    • EP16167635.8
    • 2016-04-29
    • Nidek Co., Ltd.
    • HANEBUCHI, MasaakiMURATA, Keiji
    • G01B9/02G01N21/47A61B3/12
    • G01B9/02091A61B3/102A61B3/1233A61B5/0066G01B9/02019G01B9/02028G01B9/02087G01B2290/45G01B2290/70G01N21/21G01N21/4795
    • An optical coherence tomography apparatus includes: an OCT light source; a first light splitter configured to split an optical path into a first measurement optical path and a reference optical path; a light guide optical system including a second light splitter, configured to guide the measurement light to a test substance through the second light splitter, the second light splitter splitting the reflected light into the first and second measurement optical paths; a detection optical system detecting first interference between the reflected light having passed through the first measurement optical path and the reference light, and second interference between the reflected light having passed through the second measurement optical path and the reference light; and a calculation controller processing an output signal which is output from the detection optical system to obtain OCT data regarding the test substance.
    • 光学相干断层摄影装置包括:OCT光源; 第一光分路器,被配置为将光路分割成第一测量光路和参考光路; 导光光学系统,包括第二分光器,被配置为通过第二光分离器将测量光引导到测试物质,第二光分路器将反射光分成第一和第二测量光路; 一检测光学系统,检测经过第一测量光路的反射光与参考光之间的第一干涉,以及经过第二测量光路的反射光与基准光之间的第二干涉; 以及计算控制器,处理从检测光学系统输出的输出信号,以获得关于测试物质的OCT数据。
    • 6. 发明公开
    • IN VIVO OPTICAL FLOW IMAGING
    • OPTISCHE IN-VIVO-DARSTELLUNG VONSTRÖMUNGEN
    • EP2809225A4
    • 2015-12-09
    • EP13742932
    • 2013-02-01
    • UNIV OREGON HEALTH & SCIENCE
    • JIA YALIHUANG DAVIDTOKAYER JASONTAN OU
    • A61B5/02A61B6/00G01B9/02
    • A61B5/0261A61B3/102A61B5/7203G01B9/02004G01B9/02045G01B9/02077G01B9/02087G01B9/02091
    • Described herein is an optical coherence tomograph (OCT) angiography technique based on the decorrelation of OCT signal amplitude to provide flow information. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion nose. Inter-B-scan decorrelation can be determined using the individual spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range. Such images provide significant improvement of signal-to-noise ratio (SNR) for both flow detection and connectivity of microvascular networks compared to other techniques. Further, creation of isotropic resolution cells can be useful for quantifying flow having equal sensitivity to axial and transverse flow.
    • 与多普勒和其他基于相位的方法相比,幅度去相关测量对横向流动和免疫相位噪声敏感。 然而,OCT的高轴向分辨率使其对轴向方向的脉动体积运动噪声非常敏感,导致不可接受的信噪比(SNR)。 为了克服这个限制,创建了一种基于由于流动导致的OCT信号幅度的去相关的新型OCT血管造影技术。 完整的OCT光谱可以分成几个较窄的光谱带,导致每个带中的OCT分辨率单元是各向同性的,并且不易受到轴向运动噪声的影响。 可以使用较窄的频谱带分别确定B间扫描去相关,然后平均。 重新组合来自光谱带的去相关图像产生使用整个OCT光谱范围内的全部信息的血管造影。 与其他幅度 - 去相关技术相比,这些图像显示了微血管网络的流量检测和连通性的SNR的显着改善。 此外,各向同性分辨细胞的产生可用于量化具有与轴向和横向流相等的灵敏度的流动。 这种改进的非侵入性图像可用于诊断和管理各种疾病。