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1. 发明公开

EP2333522A1 Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating 审中-公开
标题翻译：用于使用动态反馈来控制聚焦特性提高图像的清晰度和灵敏度在光学相干断层成像方法和设备以及相干性控制器
公开(公告)号：EP2333522A1
公开(公告)日：2011-06-15
申请号：EP10182894.5
申请日：2002-04-30
申请人： The General Hospital Corporation
发明人： Tearney, Guillermo, J. , Bouma, Brett, Eugene
IPC分类号： G01N21/47
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/6852 , A61B5/6853 , G01B9/0205 , G01B9/02063 , G01B9/02068 , G01B9/02083 , G01B9/02085 , G01B9/02091 , G01B2290/35
摘要： Methods for optical imaging, particularly with optical coherence tomography, using a low coherence light beam reflected from a sample surface and compared to a reference light beam, wherein real time dynamic optical feedback is used to detect the surface position of a tissue sample with respect to a reference point and the necessary delay scan range. The delay is provided by a tilting/rotating mirror actuated by a voltage adjustable galvanometer. An imaging probe apparatus for implementing the method is provided. The probe initially scans along one line until it finds the tissue surface, identifiable as a sharp transition from no signal to a stronger signal. The next time the probe scans the next line it adjusts the waveform depending on the previous scan. An algorithm is disclosed for determining the optimal scan range.
摘要翻译：方法用于光学成像，特别是与光学相干断层成像，使用低相干光从样本表面反射并且与参考光束，worin实时动态光学反馈被用于检测组织样品的面位置相对于一个参考点和所需的延迟扫描范围。延迟是由通过电压调节检流计驱动的倾斜/旋转镜提供。提供探针用于实现该方法成像装置。该试验沿着一条线扫描INITIALLY直到它找到组织表面，可鉴定为来自无信号到更强的信号的急剧过渡。下一次探测扫描它bestimmt波形根据先前扫描下一行。一种算法是游离缺失盘确定性开采的最佳扫描范围。

2. 发明授权

EP2267404B1 Apparatus and method for performing polarization-based quadrature demodulation in optical coherence tomography 有权
标题翻译：的装置和方法基于光学相干断层扫描Quadraturdemulation执行偏振
公开(公告)号：EP2267404B1
公开(公告)日：2016-10-05
申请号：EP10182743.4
申请日：2006-08-09
申请人： The General Hospital Corporation
发明人： Vakoc, Benjamin, J. , Yun, Seon-Hyun , Tearney, Guillermo, J. , Bouma, Brett, Eugene
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01B9/02044 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02072 , G01B9/02081 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/45 , G01J2009/0265 , G01N21/21 , G01N21/274 , G01N21/4795

3. 发明公开

EP2436307A1 Speckle reduction in optical coherence tomography by path length encoded angular compounding 有权
标题翻译： Fle ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung
公开(公告)号：EP2436307A1
公开(公告)日：2012-04-04
申请号：EP11188120.7
申请日：2004-03-31
申请人： The General Hospital Corporation
发明人： Tearney, Guillermo, J. , Iftimia, Nicusor , Bouma, Brett, E.
IPC分类号： A61B5/00 , G01N21/47 , G02B27/48 , G01B9/02
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/6852 , G01B9/02028 , G01B9/02082 , G01B9/02087 , G01B9/02091 , G01J9/0215 , G01N21/4795 , G02B26/105 , G02B27/48
摘要： Apparatus for irradiating a sample, comprising an interferometer forwarding an electromagnetic radiation and a sample arm receiving the electromagnetic radiation, wherein the sample arm includes an arrangement which is configured to produce at least two radiations from the electromagnetic radiation so as to irradiate the sample, and to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
摘要翻译：用于照射样品的装置，包括传送电磁辐射的干涉仪和接收电磁辐射的样品臂，其中所述样品臂包括配置为从所述电磁辐射产生至少两个辐射以照射所述样品的装置，以及以相对于所述至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。

4. 发明公开

EP2272421A1 Method and apparatus for imaging of vessel segments 审中-公开
标题翻译：用于血管段成像的方法和设备
公开(公告)号：EP2272421A1
公开(公告)日：2011-01-12
申请号：EP10182301.1
申请日：2005-08-24
申请人： The General Hospital Corporation
发明人： Tearney, Guillermo, J. , Shishkov, Milen , Bouma, Brett, Eugene
IPC分类号： A61B5/00
CPC分类号： A61B5/6852 , A61B5/0062 , A61B5/0066 , A61B5/0084 , A61B5/02007
摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (208) (e.g., a housing), a fluid delivery arrangement and an imaging arrangement (204). The housing includes an aperture (221) formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated (BY A Pullback device -215) along the surface of the structure while imaging the surface of the structure.
摘要翻译：提供了用于对与不透明流体接触的结构的表面成像的设备，方法和软件布置。该设备包括制造物品（208）（例如，壳体），流体输送装置和成像装置（204）。壳体包括形成在制造物品中的孔（221）。流体输送装置构造成将大量的基本上透明的流体输送到形成在壳体中的孔。成像装置被配置为在透明流体的体积被输送到孔之后使用成像模态来成像结构的表面，其中成像装置和/或制品被平移（通过回拉装置-215）沿着结构的表面同时对结构的表面进行成像。

5. 发明公开

EP2564769A1 Apparatus for polarization-sensitive optical frequency domain imaging of a sample 有权
标题翻译： Vorrichtung zur polarisationsempfindlichen optischen Frequenzbereichsabbildung einer Probe
公开(公告)号：EP2564769A1
公开(公告)日：2013-03-06
申请号：EP12194876.4
申请日：2007-04-05
申请人： The General Hospital Corporation
发明人： Yun, Seok-Hyun , De Boer, Johannes, F. , Tearney, Guillermo, J. , Bouma, Brett, E.
IPC分类号： A61B5/00 , G01B9/02 , G01N21/47
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70
摘要： Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.
摘要翻译：提供了用于获取与样本相关联的数据的安排和方法。例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。这种辐射的频率可以在第一特征周期内随时间重复地变化。此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的极化状态可以重复地随着时间而变化，其具有比第一周期短的第二特征周期。用于成像至少一部分样品的数据可以作为偏振状态的函数提供。另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。

6. 发明公开

EP2333523A1 Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating 审中-公开
标题翻译：用于使用动态反馈来控制聚焦特性提高图像的清晰度和灵敏度在光学相干断层成像方法和设备以及相干性控制器
公开(公告)号：EP2333523A1
公开(公告)日：2011-06-15
申请号：EP10182896.0
申请日：2002-04-30
申请人： The General Hospital Corporation
发明人： Tearney, Guillermo, J. , Bouma, Brett, Eugene
IPC分类号： G01N21/47
摘要： Methods for optical imaging, particularly with optical coherence tomography, using a low coherence light beam reflected from a sample surface and compared to a reference light beam, wherein real time dynamic optical feedback is used to detect the surface position of a tissue sample with respect to a reference point and the necessary delay scan range. The delay is provided by a tilting/rotating mirror actuated by a voltage adjustable galvanometer. An imaging probe apparatus for implementing the method is provided. The probe initially scans along one line until it finds the tissue surface, identifiable as a sharp transition from no signal to a stronger signal. The next time the probe scans the next line it adjusts the waveform depending on the previous scan. An algorithm is disclosed for determining the optimal scan range.
摘要翻译：方法用于光学成像，特别是与光学相干断层成像，使用低相干光从样本表面反射并且与参考光束，worin实时动态光学反馈被用于检测组织样品的面位置相对于一个参考点和所需的延迟扫描范围。延迟是由通过电压调节检流计驱动的倾斜/旋转镜提供。提供探针用于实现该方法成像装置。该试验沿着一条线扫描INITIALLY直到它找到组织表面，可鉴定为来自无信号到更强的信号的急剧过渡。下一次探测扫描它bestimmt波形根据先前扫描下一行。一种算法是游离缺失盘确定性开采的最佳扫描范围。

7. 发明公开

EP2333521A1 Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating 审中-公开
标题翻译：用于使用动态反馈来控制聚焦特性提高图像的清晰度和灵敏度在光学相干断层成像方法和设备以及相干性控制器
公开(公告)号：EP2333521A1
公开(公告)日：2011-06-15
申请号：EP10182892.9
申请日：2002-04-30
申请人： The General Hospital Corporation
发明人： Tearney, Guillermo, J. , Bouma, Brett, Eugene
IPC分类号： G01N21/47
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/6852 , A61B5/6853 , G01B9/0205 , G01B9/02063 , G01B9/02068 , G01B9/02083 , G01B9/02085 , G01B9/02091 , G01B2290/35
摘要： Methods for optical imaging, particularly with optical coherence tomography, using a low coherence light beam reflected from a sample surface and compared to a reference light beam, wherein real time dynamic optical feedback is used to detect the surface position of a tissue sample with respect to a reference point and the necessary delay scan range. The delay is provided by a tilting/rotating mirror actuated by a voltage adjustable galvanometer. An imaging probe apparatus for implementing the method is provided. The probe initially scans along one line until it finds the tissue surface, identifiable as a sharp transition from no signal to a stronger signal. The next time the probe scans the next line it adjusts the waveform depending on the previous scan. An algorithm is disclosed for determining the optimal scan range.
摘要翻译：方法用于光学成像，特别是与光学相干断层成像，使用低相干光从样本表面反射并且与参考光束，worin实时动态光学反馈被用于检测组织样品的面位置相对于一个参考点和所需的延迟扫描范围。延迟是由通过电压调节检流计驱动的倾斜/旋转镜提供。提供探针用于实现该方法成像装置。该试验沿着一条线扫描INITIALLY直到它找到组织表面，可鉴定为来自无信号到更强的信号的急剧过渡。下一次探测扫描它bestimmt波形根据先前扫描下一行。一种算法是游离缺失盘确定性开采的最佳扫描范围。

8. 发明公开

EP2267404A1 Apparatus and method for performing polarization-based quadrature demodulation in optical coherence tomography 有权
标题翻译：用于在光学相干断层扫描中执行基于偏振的正交解调的设备和方法
公开(公告)号：EP2267404A1
公开(公告)日：2010-12-29
申请号：EP10182743.4
申请日：2006-08-09
申请人： The General Hospital Corporation
发明人： Vakoc, Benjamin, J. , Yun, Seon-Hyun , Tearney, Guillermo, J. , Bouma, Brett, Eugene
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01B9/02044 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02072 , G01B9/02081 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/45 , G01J2009/0265 , G01N21/21 , G01N21/274 , G01N21/4795
摘要： Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample and at least one second electro-magnetic radiation to a reference, such that the first and/or second electro-magnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation associated with the first radiation can be combined with a second polarization component of at least one fourth radiation associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another.
摘要翻译：能够向样本提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射的装置，方法和存储介质，使得第一和/或第二电磁辐射具有改变的谱随着时间的推移。另外，与第一辐射相关联的至少一个第三辐射的第一偏振分量可以与彼此相关联的与第二辐射相关联的至少一个第四辐射的第二偏振分量组合。第一和第二极化可以被具体控制为至少近似彼此正交。

9. 发明授权

EP2564769B1 Apparatus for polarization-sensitive optical frequency domain imaging of a sample 有权
标题翻译：一种用于样品的偏振敏感光频域成像装置
公开(公告)号：EP2564769B1
公开(公告)日：2015-06-03
申请号：EP12194876.4
申请日：2007-04-05
申请人： The General Hospital Corporation
发明人： Yun, Seok-Hyun , De Boer, Johannes, F. , Tearney, Guillermo, J. , Bouma, Brett, E.
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70

10. 发明授权

EP2319404B1 System and method for identifying tissue low-coherence interferometry 有权
标题翻译：系统和方法，用于通过低相干干涉测量的装置识别组织
公开(公告)号：EP2319404B1
公开(公告)日：2015-03-11
申请号：EP10183037.0
申请日：2004-01-26
申请人： The General Hospital Corporation
发明人： Tearney, Guillermo, J. , Shishkov, Milen, Stefanov , Iftimia, Nicursor , Bouma, Brett, Eugene , Pitman, Martha
IPC分类号： A61B5/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/6848

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