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1. 发明公开

EP3175777A1 TOMOGRAPHY DEVICE 审中-公开
标题翻译：造影装置
公开(公告)号：EP3175777A1
公开(公告)日：2017-06-07
申请号：EP15827667.5
申请日：2015-07-29
申请人： KOWA Co., Ltd.
发明人： KOBAYASHI, Naoki , NAKAGAWA, Toshiaki
IPC分类号： A61B3/10 , G01N21/17
CPC分类号： G01B9/02091 , A61B3/0058 , A61B3/102 , A61B3/13 , A61B3/15 , G01B9/02027 , G01B9/0203 , G01B9/02068 , G01B9/02077 , G01B11/02 , G01N21/17
摘要： The tomographic image capturing device of the present invention comprises a display means (18) configured to: split light from a light source (11) into measurement light and reference light and cause the measurement light and the reference light to be incident to an object (E) and a reference object (49), respectively; capture tomographic images of the object (E) on the basis of interference light generated by superposition of the measurement light reflected from the object (E) and the reference light reflected from the reference object (49); and display tomographic pictures of the object generated on the basis of the captured tomographic images. The tomographic image capturing device has a first image capturing mode and a second image capturing mode. The first image capturing mode is a mode in which the measurement light is two-dimensionally scanned by raster scan to be incident to the object (E) and the tomographic images of the object (E) are captured. The second image capturing mode is a mode in which the measurement light is two-dimensionally scanned by raster scan to be incident to the object (E) and the tomographic images of the object (E) are captured. The raster scan in the second image capturing mode is thinned from the raster scan in the first image capturing mode. The display means (18) is configured to be switchable between a first display mode and a second display mode. The first display mode is a mode in which a plurality of tomographic pictures including a region of interest of the object (E) is selected from among the tomographic pictures generated on the basis of the tomographic images captured in the second image capturing mode and only the selected plurality of tomographic pictures is displayed. The second display mode is a mode in which all of the tomographic pictures generated on the basis of the tomographic images captured in the second image capturing mode are in turn displayed. The capturing of the tomographic images in the first image capturing mode is performed after separately performing a first adjustment operation and a second adjustment operation for adjustment of an image capturing condition necessary for capturing the tomographic images in the first image capturing mode. The first adjustment operation is based on the tomographic pictures displayed in the first display mode. The second adjustment operation is based on the tomographic pictures displayed in the second display mode.
摘要翻译：本发明的断层图像拍摄装置包括：显示装置（18），其被配置为：将来自光源（11）的光分成测量光和参考光，并使测量光和参考光入射到物体（ E）和参考对象（49）; 基于由从物体（E）反射的测量光与从参考物体（49）反射的参考光的叠加产生的干涉光来捕获物体（E）的断层图像; 并且显示基于捕获的断层图像生成的对象的断层摄影图片。断层图像捕获装置具有第一图像捕获模式和第二图像捕获模式。第一图像拍摄模式是通过光栅扫描二维扫描测量光以入射到对象（E）并且拍摄对象（E）的断层图像的模式。第二图像拍摄模式是通过光栅扫描二维扫描测量光以入射到对象（E）并且拍摄对象（E）的断层图像的模式。在第一图像捕获模式下，第二图像捕获模式下的光栅扫描从光栅扫描中变细。显示装置（18）被配置为可在第一显示模式和第二显示模式之间切换。第一显示模式是这样的模式，其中从在第二图像拍摄模式下拍摄的断层图像生成的断层图像中选择包括对象（E）的感兴趣区域的多个断层图像，显示选择的多个断层图像。第二显示模式是其中依次显示基于以第二图像拍摄模式拍摄的断层图像而生成的全部断层图像的模式。在第一图像拍摄模式中拍摄断层图像是在分别执行用于调整在第一图像拍摄模式下拍摄断层图像所需的图像拍摄条件的第一调整操作和第二调整操作之后执行的。第一调整操作基于以第一显示模式显示的断层摄影图像。第二调整操作基于以第二显示模式显示的断层摄影图像。

2. 发明授权

EP2809225B1 IN VIVO OPTICAL FLOW IMAGING 有权转让
标题翻译： OPTICAL IN CURRENTS的体内表征
公开(公告)号：EP2809225B1
公开(公告)日：2017-04-05
申请号：EP13742932.0
申请日：2013-02-01
申请人： Oregon Health & Science University
发明人： JIA, Yali , HUANG, David , TOKAYER, Jason , TAN, Ou
IPC分类号： G01B9/02 , A61B5/02 , A61B6/00
CPC分类号： A61B5/0261 , A61B3/102 , A61B5/7203 , G01B9/02004 , G01B9/02045 , G01B9/02077 , G01B9/02087 , G01B9/02091
摘要： Described herein is an optical coherence tomograph (OCT) angiography technique based on the decorrelation of OCT signal amplitude to provide flow information. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion nose. Inter-B-scan decorrelation can be determined using the individual spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range. Such images provide significant improvement of signal-to-noise ratio (SNR) for both flow detection and connectivity of microvascular networks compared to other techniques. Further, creation of isotropic resolution cells can be useful for quantifying flow having equal sensitivity to axial and transverse flow.

3. 发明公开

EP3026390A1 INTERFEROMETRIC BIOLOGICAL MEASUREMENT DEVICE AND BIOLOGICAL MEASUREMENT METHOD 审中-公开
标题翻译：生物科学家生物科学
公开(公告)号：EP3026390A1
公开(公告)日：2016-06-01
申请号：EP15192032.9
申请日：2015-10-29
申请人： Panasonic Intellectual Property Management Co., Ltd.
发明人： KABETANI, Yasuhiro , OIKAZE, Hirotoshi , TAKECHI, Yohei , FURUTA, Tomotaka
IPC分类号： G01B9/02 , A61B5/00
CPC分类号： A61B5/702 , A61B5/0059 , A61B5/0064 , A61B5/0073 , A61B5/6825 , A61B2017/00557 , A61B2562/168 , G01B9/02049 , G01B9/02077 , G01B9/0209 , G01B11/14
摘要： A biological measurement device includes a phase modulation type interferometer, a first stage, a light transmitting plate, and a second stage. The first stage is able to retain a target which is a biological body. The light transmitting plate is disposed between the first stage and the interferometer in a direction of an optical axis of measurement light of the interferometer. The second stage supports the light transmitting plate. The first stage is configured to expand by a pressure of a gaseous body in the direction of the optical axis of the measurement light of the interferometer and to press the target against the light transmitting plate.
摘要翻译：生物测量装置包括相位调制型干涉仪，第一级，透光板和第二级。第一阶段能够保留作为生物体的目标。光传输板在干涉仪的测量光的光轴的方向上设置在第一级和干涉仪之间。第二级支持透光板。第一阶段被构造成通过气体的压力沿着干涉仪的测量光的光轴的方向膨胀并将目标压靠在透光板上。

4. 发明授权

EP2238430B1 SCAN ERROR CORRECTION IN LOW COHERENCE SCANNING INTERFEROMETRY 有权
标题翻译： FOR低相干ABTASTINTERFEROMETRIE校正抽样误差
公开(公告)号：EP2238430B1
公开(公告)日：2016-03-30
申请号：EP09829736.9
申请日：2009-11-23
申请人： Zygo Corporation
发明人： DAVIDSON, Mark , LIESENER, Jan , DE GROOT, Peter , COLONNA DE LEGA, Xavier , DECK, Leslie L.
IPC分类号： G01N21/45 , G01B9/02
CPC分类号： G01B9/0209 , G01B9/02007 , G01B9/0201 , G01B9/02027 , G01B9/02039 , G01B9/02057 , G01B9/02068 , G01B9/02077 , G01B11/2441 , G01B2290/45 , G01B2290/70 , Y10T29/49002

5. 发明公开

EP2209414A1 A METHOD FOR PERFORMING VISUAL ACUITY TESTING 有权转让
标题翻译：程序对听力测试的眼光和
公开(公告)号：EP2209414A1
公开(公告)日：2010-07-28
申请号：EP08846571.1
申请日：2008-11-05
申请人： OPKO Instrumentation
发明人： WEITZ, Rishard , MCLEAN, Duncan , ROGERS, John , PEDRO, Justin
IPC分类号： A61B3/113 , A61B3/028 , A61B3/032 , A61B3/12
CPC分类号： G01B9/0203 , A61B3/1025 , A61B5/0068 , G01B9/02077 , G01B9/02091
摘要： A visual acuity examination is performed on a patient by bringing a confocal imaging apparatus up to a patient's eye. Stimuli at various points in the patient's field of view are generated while the patient fixates on a point. The patient's responses to the stimuli are recorded with the movement of the eye with is tracked with the aid of the confocal imaging apparatus. The position of said stimuli on the retina is corrected to take into account any movement of the eye between stimuli.

6. 发明公开

EP2184004A1 Ophthalmic photographing apparatus 有权
标题翻译：眼科摄影设备
公开(公告)号：EP2184004A1
公开(公告)日：2010-05-12
申请号：EP09175157.8
申请日：2009-11-05
申请人： NIDEK CO., LTD
发明人： Satake, Norimasa
IPC分类号： A61B3/113 , A61B3/12
CPC分类号： G01B9/0203 , A61B3/102 , A61B5/0068 , A61B5/7207 , G01B9/02044 , G01B9/02077 , G01B9/02085 , G01B9/02087 , G01B9/02089 , G01B9/02091
摘要： An ophthalmic photographing apparatus having a photographing unit having a projection optical system having light source and a scanner changing a reflection direction of light and scanning an eye portion in X,Y-directions with measurement light, and an optical system having photodetectors and making the reflected light enter the photodetectors, a unit controlling the photographing unit to scan the given portion plural times in a scanning region and obtain image information pieces based on a photodetector signal, and a unit dividing the region in the X.Y-directions of each information into regions and obtain information on deviation between the image information pieces for each divided region, obtain image information for each divided region, in which deviation has been corrected, with reference to one of the image information pieces based on the deviation information, add and average the image information pieces for each corresponding divided region to obtain image information.
摘要翻译：一种眼科摄影设备，具有摄影单元，该摄影单元具有投影光学系统和光学系统，所述投影光学系统具有光源和扫描仪，所述扫描仪改变光的反射方向并且利用测量光在X，Y方向上扫描眼睛部分，所述光学系统具有光电检测器，光进入光电探测器，控制拍摄单元以在扫描区域内多次扫描给定部分并基于光电检测器信号获得图像信息片的单元以及将每个信息的XY方向上的区域划分成区域的单元以及获得关于每个分割区域的图像信息之间的偏差的信息，基于偏差信息参考图像信息之一获得已经校正了偏差的每个分割区域的图像信息，相加和平均图像信息对每个对应的分割区域分割图像以获得图像信息。

7. 发明公开

EP2172149A1 OPTICAL IMAGE MEASURING INSTRUMENT 审中-公开
标题翻译： OPTISCHESBILDMESSGERÄT
公开(公告)号：EP2172149A1
公开(公告)日：2010-04-07
申请号：EP08751731.4
申请日：2008-05-15
申请人： Kabushiki Kaisha TOPCON
发明人： YUMIKAKE, Kazuhiko , OKADA, Hiroaki , KIKAWA, Tsutomu
IPC分类号： A61B3/10 , A61B3/14
CPC分类号： G01B9/0203 , A61B3/0091 , A61B3/102 , A61B3/152 , G01B9/02044 , G01B9/02077 , G01B9/02083 , G01B9/02091 , G01B2290/65
摘要： A fundus oculi observation device 1 splits a low-coherence light L0 into a signal light LS and a reference light LR, generates an interference light LC from the signal light LS propagated through an eye E and the reference light LR propagated through a reference mirror 174 to detect the interference light LC and, based on the result of the detection, forms a tomographic image of a fundus oculi Ef. The device 1 includes a scan unit 141 configured to scan with the signal light LS, and an LCD and optical system that present a fixation target. The device 1 acquires an image of the fundus oculi Ef in a state that scan a fixation target is presented while scanning with the signal light LS, and based on the image, determines whether fixation is proper or not.
摘要翻译：眼底观察装置1将低相干光L0分解为信号光LS和参考光LR，从通过眼睛E传播的信号光LS和通过参考镜174传播的参考光LR产生干涉光LC 以检测干涉光LC，并且基于检测结果形成眼底Ef的断层图像。装置1包括被配置为用信号光LS扫描的扫描单元141以及呈现定影目标的LCD和光学系统。装置1在用信号光LS扫描的同时，在扫描固定目标的状态下获取眼底Ef的图像，并且基于图像确定是否适当的固定。

8. 发明公开

EP2044879A1 Optical coherence tomographic apparatus 有权
标题翻译： OptischesKohärenz-Tomographiegerät
公开(公告)号：EP2044879A1
公开(公告)日：2009-04-08
申请号：EP08017195.2
申请日：2008-09-30
申请人： Canon Kabushiki Kaisha
发明人： Hirose, Futoshi
IPC分类号： A61B3/12
CPC分类号： G01B9/02091 , A61B3/102 , G01B9/02003 , G01B9/02028 , G01B9/02077 , G01B9/02083
摘要： An optical coherence tomographic apparatus wherein a reference light path includes at least a first reference light path and a second reference light path having an optical path length shorter than that of the first reference light path, wherein first tomographic information of the object at a first inspection position based on the optical interference using the first reference light path and second tomographic information of the object at a second inspection position based on the optical interference using the second reference light path, are acquired, the second inspection position being shallower than the first inspection position with respect to a depth direction of the object, and wherein a positional deviation a tomographic image at the first inspection position obtained based on the first tomographic information is corrected using the second tomographic information.
摘要翻译：一种光学相干断层摄影装置，其中参考光路包括至少第一参考光路和具有比第一参考光路的光路长度短的光路长度的第二参考光路，其中在第一次检查时物体的第一层析信息基于使用第二参考光路的光学干涉，基于使用第一参考光路的光学干涉的位置和在第二检查位置处的物体的第二断层信息被获取，第二检查位置比第一检查位置浅相对于物体的深度方向，并且其中使用所述第二层析信息来校正基于所述第一层析信息获得的在所述第一检查位置处的断层图像的位置偏差。

9. 发明公开

EP3326152A1 LASER MULTIBEAM DIFFERENTIAL INTERFEROMETRIC SENSOR AND METHODS FOR VIBRATION IMAGING 有权
公开(公告)号：EP3326152A1
公开(公告)日：2018-05-30
申请号：EP16828514.6
申请日：2016-07-21
申请人： The University Of Mississippi
发明人： VYACHESLAV, Aranchuk
IPC分类号： G06T7/00 , G06T7/20 , G01B11/25
CPC分类号： G01B9/02083 , G01B9/02003 , G01B9/02019 , G01B9/02027 , G01B9/02028 , G01B9/02045 , G01B9/02077 , G01B11/161 , G01B2290/65 , G01B2290/70 , G01H9/004 , G01M7/025
摘要： A sensor for a vibration imaging system is provided. The sensor includes a transmitter configured to project an array of laser beams onto a surface of an object such that neighboring beams in the array of laser beams are frequency shifted relative to each other, an interferometer configured to mix radiations reflected from neighboring points on the surface of the object such that the radiations from neighboring points interfere with one another, a photodetector array configured to produce output signals representative of the interfering beams, a demodulator configured to demodulate the output signals, and a computing device configured to calculate a deformation profile for the object based on the demodulated output signals.

10. 发明授权

EP1838213B1 METHOD OF MOTION CORRECTION IN OPTICAL COHERENCE TOMOGRAPHY IMAGING 有权
公开(公告)号：EP1838213B1
公开(公告)日：2018-05-23
申请号：EP06706294.3
申请日：2006-01-19
申请人： Carl Zeiss Meditec AG
发明人： EVERETT, Matthew, J. , O'HARA, Keith, E.
IPC分类号： A61B5/00 , A61B3/12 , G01B9/02
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/113 , A61B3/1233 , A61B5/0059 , A61B5/0066 , G01B9/02048 , G01B9/02077 , G01B9/02087 , G01B9/02091 , G01N21/4795 , G01N2021/1787
摘要： An image data set acquired by an optical coherence tomography (OCT) system is corrected for effects due to motion of the sample. A first set of A-scans is acquired within a time short enough to avoid any significant motion of the sample. A second more extensive set of A-scans is acquired over an overlapping region on the sample. Significant sample motion may occur during acquisition of the second set. A-scans from the first set are matched with A-scans from the second set, based on similarity between the longitudinal optical scattering profiles they contain. Such matched pairs of A-scans are likely to correspond to the same region in the sample. Comparison of the OCT scanner coordinates that produced each A-scan in a matching pair, in conjunction with any shift in the longitudinal scattering profiles between the pair of A-scans, reveals the displacement of the sample between acquisition of the first and second A-scans in the pair. Estimates of the sample displacement are used to correct the transverse and longitudinal coordinates of the A-scans in the second set, to form a motion-corrected OCT data set.

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