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1. 发明公开

EP3303274A1 PROCESS FOR THE SYNTHESIS OF 9,9-BIS(HYDROXYMETHYL)FLUORENE 有权转让
标题翻译：合成9,9-双（羟甲基）芴的方法
公开(公告)号：EP3303274A1
公开(公告)日：2018-04-11
申请号：EP16727414.1
申请日：2016-05-30
申请人： SABIC Global Technologies B.V.
发明人： SAINANI, Jaiprakash Brijlal
IPC分类号： C07C29/38
CPC分类号： C07C29/36 , C07B2200/13 , C07C2603/18 , C07C33/36
摘要： The present invention relates to a novel process for the synthesis of 9,9-bis(hydroxymethyl)fluorene. The syntheses from fluorene to 9,9-bis(hydroxymethyl)fluorene via a hydroxymethylation and further to 9,9-bis(methoxymethyl)fluorene via a etherification are known. 9,9-bis(methoxymethyl)fluorene is a compound that is used as an electron donor for Ziegler-Natta catalysts. The present invention is related to an improvement in the synthesis of 9,9-bis(hydroxymethyl)fluorene leading to a decrease in the amount of solvent used and an easier work up while achieving high yield and purity.

2. 发明公开

EP2892866A1 VERFAHREN ZUR HERSTELLUNG VON 2-METHYL-4-PHENYL-BUTAN-2-OL 有权
标题翻译：用于生产2-甲基-4-苯基-2- OL-BUTANE
公开(公告)号：EP2892866A1
公开(公告)日：2015-07-15
申请号：EP13758882.8
申请日：2013-09-06
申请人： BASF SE
发明人： RÜDENAUER, Stefan
IPC分类号： C07C29/36 , C07C33/20
CPC分类号： C07C29/36 , C07C33/20
摘要： The invention relates to a method for preparing 2-Methyl-4-phenylbutan-2-ol by reacting a benzylmagnesium halide with isobutylene oxide. 2-Methyl-4-phenylbutan-2-ol can be used as an odorant.

3. 发明公开

EP2890672A1 NEW PROCESS 有权
标题翻译：新工艺
公开(公告)号：EP2890672A1
公开(公告)日：2015-07-08
申请号：EP13832514.7
申请日：2013-09-02
申请人： Novartis AG
发明人： ZHU, Guoliang , YE, Wenfa , ZHENG, Hui , QIAN, Lingfeng , WEI, Junhui , YANG, Lijun , LI, Yunguang , LUO, Lijun
IPC分类号： C07C215/20 , C07C213/00
CPC分类号： C07C269/04 , C07B2200/07 , C07C29/36 , C07C41/30 , C07C213/00 , C07C213/02 , C07C269/06 , C07C215/28 , C07C271/16 , C07C271/22 , C07C33/46 , C07C43/1782
摘要： Provided is a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ -amino- δ -biphenyl- a -methylalkanoic acid, or acid ester, backbone.

4. 发明公开

EP2794532A1 PROCEDE DE PREPARATION D'UN MELANGE D'ALCOOLS 审中-公开
标题翻译：用于生产醇的混合物
公开(公告)号：EP2794532A1
公开(公告)日：2014-10-29
申请号：EP12813831.0
申请日：2012-12-20
申请人： Rhodia Operations
发明人： BELLIERE-BACCA, Virginie , MORVAN, Didier , BAUSSARON, Loïc , BOCQUENET, Gérald , JACQUOT, Roland , MARION, Philippe , KUBO, Jun , YOSHIOKA, Tetsuya
IPC分类号： C07C29/34 , C07C31/12
CPC分类号： C07C29/36 , C07C29/34 , C07C31/12
摘要： The present invention relates to a method for preparing a mixture (M) including at least one alcohol (Aj), wherein said method includes a gas-phase oligomerization reaction of at least one alcohol (Ai) with a solid acid-base catalyst doped with one or more metals, said reaction being carried out in the presence of hydrogen and at a temperature of no less than 50°C and strictly less than 200°C.

5. 发明公开

EP2669265A3 Improved method for preparing dipeptidyl peptidase-IV inhibitor and intermediate 审中-公开
标题翻译：对于二肽基肽酶IV抑制剂中的用途和中间的改进的方法
公开(公告)号：EP2669265A3
公开(公告)日：2014-03-26
申请号：EP13175341.0
申请日：2010-03-30
申请人： Dong-A Pharmaceutical Co., Ltd.
发明人： Kwak, Woo Young , Kim, Heung Jae , Min, Jong Pil , Yoon, Tae Hyan , Yoo, Moohi , Lim, Geun Gho , Chang, San Ki
IPC分类号： C07C213/00 , C07C219/10 , C07C219/18 , C07D203/06 , C07C29/36 , C07C247/10 , C07C255/44 , C07C271/22 , C07D203/08 , C07D241/08 , C07C269/06 , C07D203/18
CPC分类号： C07D241/08 , C07C29/106 , C07C29/36 , C07C227/02 , C07C241/00 , C07C247/10 , C07C253/00 , C07C255/42 , C07C255/44 , C07C269/06 , C07C271/22 , C07D203/08 , C07D203/10 , C07D203/18 , Y02P20/55 , C07C33/46
摘要： The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor which is able to reduce preparations costs by using low cost reagents in the reaction steps and is able to be used in mass production by improving yield.

6. 发明公开

EP2557084A1 ROSUVASTATIN CALCIUM INTERMEDIATE AND PREPARATION METHOD THEREOF 有权
标题翻译： ROSUVASTATIN钙中间体及其制备方法
公开(公告)号：EP2557084A1
公开(公告)日：2013-02-13
申请号：EP10849287.7
申请日：2010-07-28
申请人： Porton Fine Chemicals Ltd
发明人： LIN, Wenqing , ZHENG, Hongjie , LIU, Xiaobo
IPC分类号： C07F9/535 , C07F7/02 , C07C69/716 , C07C69/738 , C07C69/732
CPC分类号： C07F9/5352 , C07C29/36 , C07C67/22 , C07C67/29 , C07C67/31 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/78 , Y02P20/55 , C07C33/423
摘要： A rosuvastatin calcium intermediate as shown by Formula I is prepared as follow: a) subjecting chloroethylene, magnesium and R-epoxy chloropropane to Grignard reaction, b) adding sodium cyanide for nucleophilic substitution reaction, c) adding alcohol for alcoholysis reaction, d) adding alkaline solvent for hydroxyl protection, e) subjecting the mixture to oxidation reaction, f) adding triphenyl phosphorus and subjecting to Wittig reaction in the presence of alkali to obtain the compound of formula I. The method has moderate reaction conditions, is convenient and stable and can be applied to industrial production.
摘要翻译：式I所示的瑞舒伐他汀钙中间体如下制备：a）使氯乙烯，镁和R-环氧氯丙烷进行格氏反应，b）加入氰化钠进行亲核取代反应，c）加入醇进行醇解反应，d）加入 e）将混合物进行氧化反应，f）加入三苯基磷并在碱存在下进行维g希反应，得到式I化合物。该方法反应条件温和，方便稳定，可以应用于工业生产。

7. 发明公开

EP1055654A4 PROCESS FOR THE PREPARATION OF ORGANIC COMPOUNDS WITH IMIDE CATALYSTS 有权
标题翻译：用于生产有机化合物IMID催化剂
公开(公告)号：EP1055654A4
公开(公告)日：2004-09-08
申请号：EP99959710
申请日：1999-12-09
申请人： DAICEL CHEM
发明人： ISHII YASUTAKA , IWAHAMA TAKAHIRO , NAKANO TATSUYA
IPC分类号： B01J31/02 , C07C2/76 , C07C29/36 , C07C45/33 , C07C45/34 , C07C45/39 , C07C49/323 , C07C49/345 , C07C67/347 , C07D307/33 , C07D315/00 , C07D317/30 , C08F20/30 , C07B37/02 , C07B37/04 , C07B41/00 , C07C2/82 , C07C13/615 , C07C29/32 , C07C31/137 , C07C67/333 , C07C69/675 , C07C69/716 , C07C69/732 , C07D307/32 , C07D307/94
CPC分类号： C07D307/33 , B01J31/0247 , C07B2200/09 , C07C2/76 , C07C29/36 , C07C45/33 , C07C45/34 , C07C45/39 , C07C49/323 , C07C49/345 , C07C67/347 , C07C2603/28 , C07C2603/68 , C07C2603/74 , C07D315/00 , C07D317/30 , C08F20/30 , C07C13/615 , C07C69/716 , C07C69/608 , C07C69/675 , C07C69/732 , C07C31/137 , C07C35/36 , C07C35/37
摘要： A process of reacting (A) a compound capable of forming a stable radical which is selected from among (A1) oxygen compounds having carbon-hydrogen bonds at the position adjacent to the oxygen atom, (A2) carbonyl compounds and (A3) compounds having hydrocarbon groups bearing methyne carbon with (B) a radical-scavenging compound selected from among (B1) unsaturated compounds, (B2) compounds having hydrocarbon groups bearing methyne carbon, and so on in the presence of molecular oxygen by the use of an imide catalyst represented by general formula (1) or the like to thereby obtain an adduct of the compound (B) with the compound (A), a product of substitution of the compound (B) with the compound (A), or oxides of both. In said formula, R?1 and R2¿ are each hydrogen or the like, or alternatively R?1 and R2¿ may be united to form a double bond or an aromatic or nonaromatic ring; and X is oxygen or hydroxyl. This process makes it possible to efficiently produce various organic compounds under mild conditions through addition or substitution by the use of molecular oxygen.

8. 发明公开

EP1265833A1 PROCESS FOR PREPARING A 1,3-DIOL 有权
标题翻译：用于生产1,3-二醇
公开(公告)号：EP1265833A1
公开(公告)日：2002-12-18
申请号：EP01917105.7
申请日：2001-03-22
申请人： SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V.
发明人： LANGE, Jean-Paul
IPC分类号： C07C29/141 , C07C29/36 , C07C31/20 , C07C45/50 , C07C47/26
CPC分类号： C07C45/58 , C07C29/141 , C07C29/36 , C07C47/19 , C07C31/205
摘要： A process for preparing a 1,3-diol by hydrogenating a feed comprising a 3-hydroxyaldehyde in the presence of a catalyst and a hydrogen source, wherein syngas is used as hydrogen source, and the catalyst is a heterogeneous catalyst comprising copper on a support, and a process for preparing a 1,3-alkanediol by conversion of an oxirane in a process comprising hydroformylation and hydrogenation, which steps may optionally be conducted, simultaneously, in a single reaction vessel.

9. 发明授权

EP0950652B1 Cis-configurational unsaturated ester, process for producing the same, and fragrance composition containing the same 有权
标题翻译：与顺式结构的不饱和酯，其制备方法，以及含有它们的加臭剂的组合物
公开(公告)号：EP0950652B1
公开(公告)日：2002-07-03
申请号：EP99106205.0
申请日：1999-04-12
申请人： Kuraray Co., Ltd.
发明人： Mayahara, Kunio, c/o KURARAY CO., LTD. , Mori, Toshiki, c/o KURARAY CO., LTD. , Tamai, Yoshin, c/o KURARAY CO., LTD.
IPC分类号： C07C69/145 , C11B9/00 , C07C67/08 , C07C29/36 , C07C33/30 , A61K7/46
CPC分类号： C11B9/0061 , C07B2200/09 , C07C29/36 , C07C33/30 , C07C69/007 , C11B9/0019 , C07C33/025

10. 发明公开

EP0950652A1 Cis-configurational unsaturated ester, process for producing the same, and fragrance composition containing the same 有权
标题翻译：与顺式结构的不饱和酯，其制备方法，以及含有它们的加臭剂的组合物
公开(公告)号：EP0950652A1
公开(公告)日：1999-10-20
申请号：EP99106205.0
申请日：1999-04-12
申请人： Kuraray Co., Ltd.
发明人： Mayahara, Kunio, c/o KURARAY CO., LTD. , Mori, Toshiki, c/o KURARAY CO., LTD. , Tamai, Yoshin, c/o KURARAY CO., LTD.
IPC分类号： C07C69/145 , C11B9/00 , C07C67/08 , C07C29/36 , C07C33/30 , A61K7/46
CPC分类号： C11B9/0061 , C07B2200/09 , C07C29/36 , C07C33/30 , C07C69/007 , C11B9/0019 , C07C33/025
摘要： The present invention provides a cis -configurational unsaturated ester represented by the formula (1)
(where R is a methyl group or a phenyl group, and n is 1 or 2)
and also provides a fragrance composition containing the cis -configurational unsaturated ester in an effective amount. The cis -configurational unsaturated ester represented by the formula (1) can be produced by

reacting a cyclic vinyl ether represented by the formula (2a)
(where n is defined as above) with a Grignard reagent represented by the formula (3a)

RMgX (3a)

(where R is defined as above, and X is a chlorine atom, a bromine atom or an iodine atom)
in the presence of a triarylphosphine and not more than 0.05 mol of a nickel compound per one mole of the cyclic vinyl ether represented by the formula (2a) to give a cis -configurational unsaturated alcohol represented by the formula (4a)
(where n and R are defined as above); and
subjecting this cis -configurational unsaturated alcohol to acylation with acetic acid or a derivative thereof to give the cis -configurational unsaturated esters represented by the formula (1).
摘要翻译：本发明提供由式（1）（其中R是甲基或苯基，和n是1或2>，因此提供的香料组合物包含顺式构型为代表的顺式构型不饱和酯在有效量的不饱和酯。该顺式构型不饱和酯由下式表示（1）可以通过与格氏起反应由式（2a）（其中n如上所定义）表示的环状乙烯醚产生试剂由式（3a）表示MGX（其中R如上所定义，并且X是氯原子，在三芳基膦的存在下，溴原子或碘原子>的并且不大于12:05摩尔镍化合物，并选择一个由式（2a）所示的环状乙烯醚的摩尔，得到一种由式（4a）代表的顺式构型不饱和醇（其中n和R如上所定义）;以及使该顺式构型不饱和醇与酰化化醋 C酸或其衍生物，得到由式（1）表示的顺式构型不饱和酯。

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