发明公开
EP0950652A1 Cis-configurational unsaturated ester, process for producing the same, and fragrance composition containing the same
有权
基本信息:
- 专利标题： Cis-configurational unsaturated ester, process for producing the same, and fragrance composition containing the same
- 专利标题（中）：与顺式结构的不饱和酯，其制备方法，以及含有它们的加臭剂的组合物
- 申请号：EP99106205.0 申请日：1999-04-12
- 公开(公告)号：EP0950652A1 公开(公告)日：1999-10-20
- 发明人： Mayahara, Kunio, c/o KURARAY CO., LTD. , Mori, Toshiki, c/o KURARAY CO., LTD. , Tamai, Yoshin, c/o KURARAY CO., LTD.
- 申请人： Kuraray Co., Ltd.
- 申请人地址： 1621 Sakazu Kurashiki-City, Okayama 710-8622 JP
- 专利权人： Kuraray Co., Ltd.
- 当前专利权人： Kuraray Co., Ltd.
- 当前专利权人地址： 1621 Sakazu Kurashiki-City, Okayama 710-8622 JP
- 代理机构： Müller-Boré & Partner Patentanwälte
- 优先权： JP11787298 19980413; JP34567098 19981204
- 主分类号： C07C69/145
- IPC分类号： C07C69/145 ; C11B9/00 ; C07C67/08 ; C07C29/36 ; C07C33/30 ; A61K7/46
摘要：
The present invention provides a cis -configurational unsaturated ester represented by the formula (1)
(where R is a methyl group or a phenyl group, and n is 1 or 2)
and also provides a fragrance composition containing the cis -configurational unsaturated ester in an effective amount. The cis -configurational unsaturated ester represented by the formula (1) can be produced by
reacting a cyclic vinyl ether represented by the formula (2a)
(where n is defined as above) with a Grignard reagent represented by the formula (3a)
RMgX (3a)
(where R is defined as above, and X is a chlorine atom, a bromine atom or an iodine atom)
in the presence of a triarylphosphine and not more than 0.05 mol of a nickel compound per one mole of the cyclic vinyl ether represented by the formula (2a) to give a cis -configurational unsaturated alcohol represented by the formula (4a)
(where n and R are defined as above); and
subjecting this cis -configurational unsaturated alcohol to acylation with acetic acid or a derivative thereof to give the cis -configurational unsaturated esters represented by the formula (1).
摘要（中）：
(where R is a methyl group or a phenyl group, and n is 1 or 2)
and also provides a fragrance composition containing the cis -configurational unsaturated ester in an effective amount. The cis -configurational unsaturated ester represented by the formula (1) can be produced by
reacting a cyclic vinyl ether represented by the formula (2a)
(where n is defined as above) with a Grignard reagent represented by the formula (3a)
RMgX (3a)
(where R is defined as above, and X is a chlorine atom, a bromine atom or an iodine atom)
in the presence of a triarylphosphine and not more than 0.05 mol of a nickel compound per one mole of the cyclic vinyl ether represented by the formula (2a) to give a cis -configurational unsaturated alcohol represented by the formula (4a)
(where n and R are defined as above); and
subjecting this cis -configurational unsaturated alcohol to acylation with acetic acid or a derivative thereof to give the cis -configurational unsaturated esters represented by the formula (1).
本发明提供由式（1）（其中R是甲基或苯基，和n是1或2>，因此提供的香料组合物包含顺式构型为代表的顺式构型不饱和酯 在有效量的不饱和酯。该顺式构型不饱和酯由下式表示（1）可以通过与格氏起反应由式（2a）（其中n如上所定义）表示的环状乙烯醚产生 试剂由式（3a）表示MGX（其中R如上所定义，并且X是氯原子，在三芳基膦的存在下，溴原子或碘原子>的并且不大于12:05摩尔镍化合物，并选择一个 由式（2a）所示的环状乙烯醚的摩尔，得到一种由式（4a）代表的顺式构型不饱和醇（其中n和R如上所定义）;以及使该顺式构型不饱和醇 与酰化化醋 C酸或其衍生物，得到由式（1）表示的顺式构型不饱和酯。
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C69/00 | 羧酸酯；碳酸酯或卤甲酸酯 |
| --------C07C69/02 | .无环饱和一元羧酯，其含有羧基连接非环碳原子或氢 |
| ----------C07C69/04 | ..甲酸酯 |
| ------------C07C69/14 | ...一元羟基化合物的 |
| --------------C07C69/145 | ....不饱和醇的 |