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1. 发明授权

EP2966179B1 METHOD FOR DETECTING METHYLATED DNA 有权
公开(公告)号：EP2966179B1
公开(公告)日：2019-05-08
申请号：EP14761083.6
申请日：2014-03-07
申请人： Sekisui Medical Co., Ltd. , Mie University
发明人： YOTANI, Takuya , NOBORI, Tsutomu
IPC分类号： C12Q1/686 , C12Q1/6827

2. 发明公开

EP3360959A1 TUMOR DETERMINATION METHOD 审中-公开
公开(公告)号：EP3360959A1
公开(公告)日：2018-08-15
申请号：EP16853760.3
申请日：2016-10-07
申请人： Japanese Foundation For Cancer Research , Sekisui Medical Co., Ltd.
发明人： ARAI, Masami , NOMURA, Sachio , NEMOTO, Yuriko , YOTANI, Takuya
IPC分类号： C12N15/00 , C12N15/09 , C12Q1/68 , G01N30/02 , G01N30/88
CPC分类号： C12N15/00 , C12N15/09 , C12Q1/68 , G01N30/02 , G01N30/88
摘要： It is intended to provide a method for determining a tumor. The method for determining a tumor comprises: (1) treating genomic DNA prepared from a subject tissue or cell with bisulfite (the subject tissue or cell is derived from a patient who is affected by a tumor and is determined as (i) having MSI-H of the tumor in MSI examination and/or no or reduced expression of MLH1 in the tumor in immunohistochemical examination, and (ii) having no mutation in MLH1 in genetic examination); 2) amplifying, by PCR, DNA comprising a portion or the whole of MLH1 promoter region from the bisulfite-treated DNA; 3) subjecting the PCR amplification product to ion exchange chromatography to obtain a detection signal; 4) determining whether or not the peak of the detection signal is a peak indicating highly methylated DNA; and 5) determining the tumor as a tumor derived from a patient without Lynch syndrome when the peak is determined as a peak indicating highly methylated DNA.

3. 发明公开

EP3346015A1 PROGNOSIS METHOD FOR RENAL CELL CANCER 有权
公开(公告)号：EP3346015A1
公开(公告)日：2018-07-11
申请号：EP16842012.3
申请日：2016-09-02
申请人： National Cancer Center , Sekisui Medical Co., Ltd.
发明人： KANAI, Yae , ARAI, Eri , NEMOTO, Yuriko , YOTANI, Takuya
IPC分类号： C12Q1/68 , C12N15/00 , G01N30/88
CPC分类号： C12N15/00 , C12Q1/68 , G01N30/88
摘要： It is intended to provide a rapid, convenient, and highly accurate method for determining the prognosis of cancer. The present invention provides a method for determining a tissue having renal cell carcinoma, comprising: (1) subjecting sample DNA to ion exchange chromatography, wherein the sample DNA is obtained by treating target genomic DNA prepared from a renal tissue of a subject with bisulfite, followed by PCR amplification; (2) calculating a derivative value of a detection signal of the chromatography; and (3) determining the renal tissue as being a tissue having renal cell carcinoma having poor prognosis when the derivative value calculated in the step (2) has two or more maximums.

4. 发明授权

EP2990791B1 SWITCHING VALVE FOR A FLOW-TYPE ANALYSIS DEVICE 有权
标题翻译：流量型分析装置的开关阀
公开(公告)号：EP2990791B1
公开(公告)日：2018-03-21
申请号：EP14788272.4
申请日：2014-04-22
申请人： Sekisui Medical Co., Ltd.
发明人： YOTANI, Takuya , TAIRA, Hiroaki , OKA, Takayuki , MURAKI, Hideki
IPC分类号： G01N30/26 , G01N1/00 , G01N30/20 , G01N35/10
CPC分类号： G01N30/20 , G01N33/491 , G01N35/1097 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： Provided is a switching valve including the following (A) to (C): (A) a rotor including the following (1) to (3): (1) a center pipe connection port, (2) a first in-valve flow path in communication with the center pipe connection port, and (3) an arc-like second in-valve flow path; (B) a stator including the following (4) and (5): (4) a first pipe connection port group which is brought into communication independently with the center pipe connection port via the first in-valve flow path when the rotor is turned, and (5) a second pipe connection port group which is brought into mutual communication via the second in-valve flow path when the rotor is turned; and (C) an arrangement of the rotor and the stator which satisfies the following relationship: the state of communication or non-communication among the second pipe connection port group via the second in-valve flow path is switched in accordance with the state of communication between the first pipe connection port group and the center pipe connection port.

5. 发明公开

EP2966179A1 METHOD FOR DETECTING METHYLATED DNA 有权
标题翻译： VERFAHREN ZUM NACHWEIS METHYLIERTER DNA
公开(公告)号：EP2966179A1
公开(公告)日：2016-01-13
申请号：EP14761083.6
申请日：2014-03-07
申请人： Sekisui Medical Co., Ltd. , Mie University
发明人： YOTANI, Takuya , NOBORI, Tsutomu
IPC分类号： C12Q1/68 , C12M1/34 , C12N15/09
CPC分类号： C12Q1/6848 , C12Q1/6827 , C12Q1/686 , G01N30/96 , C12Q2523/125 , C12Q2565/137 , G01N2030/8827
摘要： Provided is a rapid and simple method of detecting methylated DNA. The method of detecting methylated DNA includes the following steps of: (1) treating sample DNA with a hydrogen sulfite; (2) amplifying the sample DNA treated with the hydrogen sulfite by PCR; and (3) subjecting the resultant PCR amplification product to ion-exchange chromatography.
摘要翻译：提供了检测甲基化DNA的快速和简单的方法。检测甲基化DNA的方法包括以下步骤：（1）用亚硫酸氢盐处理样品DNA; （2）通过PCR扩增用亚硫酸氢亚硫酸氢盐处理的样品DNA; 和（3）使得到的PCR扩增产物进行离子交换层析。

6. 发明授权

EP3023782B1 SAMPLE ANALYSIS DEVICE AND GRADIENT LIQUID FEED DEVICE 有权
公开(公告)号：EP3023782B1
公开(公告)日：2018-05-30
申请号：EP14826856.8
申请日：2014-07-17
申请人： Sekisui Medical Co., Ltd.
发明人： YOTANI, Takuya , TAIRA, Hiroaki , OKA, Takayuki , MURAKI, Hideki
IPC分类号： G01N30/34 , G01N30/26 , G01N30/32 , G01N30/88
CPC分类号： G01N30/34 , G01N30/16 , G01N30/88 , G01N33/491 , G01N2030/027 , G01N2030/347 , G01N2030/8822
摘要： A gradient liquid feed device allows reduction in size of a high performance liquid chromatography type sample analyzer. The gradient liquid feed device includes a plurality of carrier liquid reservoir tanks (51,52) configured to store carrier liquids of mutually different compositions, a plurality of single plunger pumps (1,2) capable of drawing and discharging the carrier liquid from the plurality of carrier liquid reservoir tanks, a mixer (3) configured to mix the carrier liquids discharged from the plurality of liquid feed pumps and feed the mixed carrier liquid, and a pulse damper (4) in communication with the mixer and configured to absorb pulsation that may occur during liquid feeding. The single plunger pumps (1,2) have a function for variably setting a length of stroke for drawing and discharging the carrier liquid and a function for variably setting a ratio between the carrier liquid drawing time and the carrier liquid discharge time.

7. 发明授权

EP2778674B1 SAMPLE INJECTION DEVICE FOR BIOCHEMICAL ANALYSIS, FLOW-TYPE BIOCHEMICAL ANALYSIS DEVICE, AND MEASUREMENT METHOD FOR HEMOGLOBIN COMPONENT 有权
标题翻译：样装置生化分析，源源不绝生化分析设备和血红蛋白测定成分分析法
公开(公告)号：EP2778674B1
公开(公告)日：2016-11-09
申请号：EP12848233.8
申请日：2012-11-09
申请人： Sekisui Medical Co., Ltd.
发明人： OKA, Takayuki , YOTANI, Takuya , MURAKI, Hideki
IPC分类号： G01N30/18 , G01N30/88 , G01N1/14
CPC分类号： G01N1/14 , G01N30/18 , G01N30/20 , G01N2030/8822
摘要： When injecting a sample into carrier-liquid channels (3A and 3B), injection shock is prevented. Septa 13 and 14 constitute the upper wall and the lower wall of a sample injection part (11) of the carrier-liquid channels (3A and 3B). A needle (27) can vertically penetrate the septum (13) on the upper wall side and also penetrate the septum (14) on the lower wall side. A needle moving unit (28) induces the needle (27) to penetrate the septum (14) on the lower wall side and induces the tip of the needle to face the inside of a sample vessel (26). A measurement pump (29) is operated for drawing and as a result a sample is drawn into the needle (27). Next, the needle (27) is extracted from the septum (14) on the lower wall side, the tip of the needle is induced to face the inside of the sample injection part (11), the measurement pump (29) is caused to discharge and as a result the sample within the needle (27) is injected.
摘要翻译：当将样品注射到载体液体通道（3A和3B），注射冲击防止。隔片13和14构成上壁和所述载体液体通道（3A和3B）的样品注入部（11）的下壁。的针（27）可以垂直地贯穿在上壁侧的隔膜（13），并且因此穿透的下侧壁隔膜（14）。的针移动单元（28）诱导的针（27），以在所述下侧壁穿透隔膜（14）并诱导针的尖端面对的样品容器（26）的内部。的测量泵（29）被用于绘图操作，并且作为结果的试样被抽吸到针（27）。接着，将针（27）从下壁侧的隔膜（14）萃取，将针的尖端被感应到面对样品注入部（11）的内部，测量泵（29）被导致放电，其结果，针（27）内的样品被注入。

8. 发明公开

EP3023782A1 SAMPLE ANALYSIS DEVICE AND GRADIENT LIQUID FEED DEVICE 有权
标题翻译：样品分析装置和渐变液体进料装置
公开(公告)号：EP3023782A1
公开(公告)日：2016-05-25
申请号：EP14826856.8
申请日：2014-07-17
申请人： Sekisui Medical Co., Ltd.
发明人： YOTANI, Takuya , TAIRA, Hiroaki , OKA, Takayuki , MURAKI, Hideki
IPC分类号： G01N30/34 , G01N30/26 , G01N30/32 , G01N30/88
CPC分类号： G01N30/34 , G01N30/16 , G01N30/88 , G01N33/491 , G01N2030/027 , G01N2030/347 , G01N2030/8822
摘要： A gradient liquid feed device allows reduction in size of a high performance liquid chromatography type sample analyzer. The gradient liquid feed device includes a plurality of carrier liquid reservoir tanks (51,52) configured to store carrier liquids of mutually different compositions, a plurality of single plunger pumps (1,2) capable of drawing and discharging the carrier liquid from the plurality of carrier liquid reservoir tanks, a mixer (3) configured to mix the carrier liquids discharged from the plurality of liquid feed pumps and feed the mixed carrier liquid, and a pulse damper (4) in communication with the mixer and configured to absorb pulsation that may occur during liquid feeding. The single plunger pumps (1,2) have a function for variably setting a length of stroke for drawing and discharging the carrier liquid and a function for variably setting a ratio between the carrier liquid drawing time and the carrier liquid discharge time.
摘要翻译：梯度液体供给装置允许高效液相色谱型样品分析仪的尺寸减小。梯度液体供给装置包括：多个载液储存罐（51,52），其被配置为储存彼此不同组成的载液;多个单柱塞泵（1,2），其能够从多个（3），其被配置为混合从所述多个液体供给泵排出的载液并且供给混合的载液;以及脉冲阻尼器（4），其与所述混合器连通并且被配置为吸收脉冲，所述脉动可能会发生液体喂养。单柱塞泵（1,2）具有用于可变地设定用于抽取和排出载液的行程长度的功能和用于可变地设定载液抽取时间与载液排出时间之间的比率的功能。

9. 发明公开

EP3783359A1 HAEMOGLOBIN ANALYSIS METHOD 有权
公开(公告)号：EP3783359A1
公开(公告)日：2021-02-24
申请号：EP19788856.3
申请日：2019-04-18
申请人： Sekisui Medical Co., Ltd.
发明人： TAIRA, Hiroaki , SUNAMURA, Ei-ichiro , MATSUDA, Kohei , YOTANI, Takuya
IPC分类号： G01N30/88 , G01N30/02 , G01N30/34
摘要： Provided is a method for separating and detecting various hemoglobins including abnormal hemoglobins and thalassemia markers. A method for analyzing hemoglobins, comprising separating hemoglobins in a sample by cation exchange chromatography, wherein an eluent having a pH of 8.1 or more and an osmotic pressure of 40 mOsm/kg or less is used for separation of the hemoglobins.

10. 发明授权

EP3112475B1 METHOD FOR DETERMINING PROGNOSIS OF RENAL CELL CARCINOMA 有权转让
公开(公告)号：EP3112475B1
公开(公告)日：2018-08-15
申请号：EP15755821.4
申请日：2015-03-02
申请人： National Cancer Center , Sekisui Medical Co., Ltd.
发明人： KANAI, Yae , ARAI, Eri , NEMOTO, Yuriko , YOTANI, Takuya
IPC分类号： C12Q1/68 , G01N30/88 , C12N15/09
CPC分类号： C12Q1/6886 , B01D15/362 , C12Q1/6827 , C12Q2600/118 , C12Q2600/154 , G01N30/88 , G01N30/96 , G01N2030/8813 , C12Q2523/125 , C12Q2565/137
摘要： It is intended to provide a rapid, convenient, and highly accurate method for determining the prognosis of cancer. The present invention provides a method for determining the prognosis of a renal cell carcinoma patient, comprising: (1) treating genomic DNA prepared from a renal tissue of a subject with bisulfite; (2) amplifying the bisulfite-treated DNA by PCR; (3) subjecting the obtained PCR amplification product to ion exchange chromatography; (4) obtaining the retention time of a detection signal obtained by the chromatography; and (5) determining the renal cell carcinoma of the subject as having poor prognosis when the result of the step (4) is shorter than a retention time serving as a reference.

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