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    • 3. 发明公开
    • ON-LINE BIOMOLECULAR INTERACTION ANALYSIS FOR MONITORING OR CONTROLLING BIOPROCESSES
    • EP4155709A1
    • 2023-03-29
    • EP21199383.7
    • 2021-09-28
    • Bayer AG
    • The designation of the inventor has not yet been filed
    • G01N1/14G01N1/18B01L3/00C12M1/32G01N1/00G01N21/77G01N35/00G01N1/10
    • The invention relates to a system for measuring one or more analytes in discrete fluid samples from a vessel adapted to contain a fluid comprising one or more sensors (5) for the measurement of the analytes (53) in a contact volume of the fluid sample, an analysis module (55) comprising at least one main sampling line in fluidic connection with the vessel and one or more pumps in fluidic connection with said main sampling line(s) and adapted to selectively pump fluid from in the main sampling line away from the vessel, at least one fluid distribution tubing (30) in fluidic connection with the analysis module, a manifold (20) comprising a body (25), and in the body (25), for each sensor (5), one fluidic cell comprising one fluid distribution channel (21) and a collecting channel (22a, 22b) in fluidic communication with the fluid distribution channel (21), wherein the fluid distribution tubing (30) is fitted in the fluid distribution channel (21) so that it is emerging in the collecting channel (22) and so that the sensor (5) can be contacted with at least a drop (10) of the fluid sample emerging at the top of the fluid distribution tubing (30) as the contact volume or wherein the fluid distribution tubing (30) is fitted in the fluid distribution channel (21) in fluidic connection with a measurement well (40), so the measurement well (40) can be filled with the fluid sample to create the contact volume and the sensor (5) can be dipped in the contact volume for measurement, and wherein said collecting channels (22a, 22b) are plunging so the fluid sample is collected per gravity.