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1. 发明公开

EP3608669A1 FLUORESCENT PREMIX PARTICLES, FLUORESCENT STAIN CONTAINING SAME, AND FLUORESCENT STAINING METHOD IN WHICH THESE ARE USED 审中-公开
公开(公告)号：EP3608669A1
公开(公告)日：2020-02-12
申请号：EP17904947.3
申请日：2017-04-07
申请人： Konica Minolta, Inc.
发明人： ISODA, Takeshi , TOMIOKA, Daisuke
IPC分类号： G01N33/543
摘要： The present invention relates to fluorescent premix particles, a fluorescent stain containing the same, and a fluorescent staining method in which these are used, and the fluorescent premix particles are particles including: phosphor integrated particles that are modified with a first reactive substance; and at least one target protein-binding substance that is modified with a second reactive substance and is selected from the group consisting of an antibody and an aptamer, wherein the phosphor integrated particles and the at least one target protein-binding substance are linked by interaction between the first reactive substance and the second reactive substance.

2. 发明授权

EP2930514B1 METHOD FOR SUPPRESSING NONSPECIFIC SIGNALS FROM CONTAMINANTS IN AN IMMUNOASSAY USING SURFACE PLASMON-FIELD ENHANCED FLUORESCENCE SPECTROSCOPY (SPFS) 失效
公开(公告)号：EP2930514B1
公开(公告)日：2019-08-28
申请号：EP13859978.2
申请日：2013-11-08
申请人： Konica Minolta, Inc.
发明人： KANEKO, Tomonori , ISODA, Takeshi
IPC分类号： G01N33/543 , G01N21/64 , G01N33/53

3. 发明授权

EP3124969B1 BIOLOGICAL-MATERIAL QUANTITATION METHOD BASED ON MULTIPLE-ANTIGEN IMMUNOSTAINING 有权
公开(公告)号：EP3124969B1
公开(公告)日：2019-05-01
申请号：EP15770205.1
申请日：2015-03-23
申请人： Konica Minolta, Inc.
发明人： GOUDA, Hideki , ISODA, Takeshi , WATANABE, Yasuhiro , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N33/53 , G01N21/64 , G01N33/48 , G01N33/536 , A61B5/00 , G01N33/58 , G01N33/68

4. 发明公开

EP3121291A1 PROBE REAGENT AND FISH USING PROBE REAGENT 审中-公开
标题翻译： SONDENREAGENS UND FISCH MIT VERWENDUNG DER SONDENREAGENS
公开(公告)号：EP3121291A1
公开(公告)日：2017-01-25
申请号：EP15765414.6
申请日：2015-03-20
申请人： Konica Minolta, Inc.
发明人： ISODA, Takeshi , SEKIGUCHI, Mitsuru , HATANAKA, Yutaka , KURIHARA, Yoshikazu
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6841 , C12Q2525/197 , C12Q2563/155
摘要： Provided are: a probe reagent which is capable of stably yielding a fluorescence signal in FISH while inhibiting non-specific adsorption by the use of a nucleic acid molecule having a smaller number of bases than a BAC probe; and FISH using the probe reagent. The probe reagent is for in situ hybridization and comprises: phosphor-integrated nanoparticles containing phosphors integrated therein; and a nucleic acid molecule having a prescribed nucleic acid sequence, which phosphor-integrated nanoparticles and nucleic acid molecule are bound with each other. This probe reagent enables to not only improve the accuracy of detecting a specific gene by inhibiting non-specific adsorption in FISH where a specific region of a chromosome is stained, but also obtain a fluorescence signal of a sufficient intensity for observation under a confocal microscope. When phosphor nanoparticles are used in the probe reagent, bright spots that are located at different depths of a tissue section can be detected simultaneously in a single field of view even when the tissue section is observed under a fluorescence microscope. Furthermore, the probe reagent enables to maintain a tissue section slide subjected to FISH in a state where bright spots are detectable over a longer period of time.
摘要翻译：提供：能够在FISH中稳定产生荧光信号的探针试剂，同时通过使用碱基少于BAC探针的核酸分子来抑制非特异性吸附; 和使用探针试剂的FISH。探针试剂用于原位杂交，并包含：含有荧光体的纳米磷光体; 和具有规定的核酸序列的核酸分子，磷光体整合的纳米粒子和核酸分子彼此结合。该探针试剂不仅可以通过抑制染色体的特定区域染色的FISH中的非特异性吸附来提高检测特异性基因的准确性，而且可以获得足够强度的荧光信号，以在共焦显微镜下观察。当在探针试剂中使用荧光体纳米颗粒时，即使在荧光显微镜下观察组织切片时，也可以在单一视野中同时检测位于组织切片不同深处的亮点。此外，探针试剂能够在更长的时间段内能够检测到亮点的状态下保持经受FISH的组织切片。

5. 发明公开

EP2966445A1 STAINING AGENT FOR STAINING TISSUE, PRODUCTION METHOD FOR STAINING AGENT FOR STAINING TISSUE, AND TISSUE STAINING KIT INCLUDING STAINING AGENT FOR STAINING TISSUE 有权
标题翻译：对印染布，方法着色剂用于织物和GEWEBEFÄRBUNGSKIT着色剂织物染料着色剂
公开(公告)号：EP2966445A1
公开(公告)日：2016-01-13
申请号：EP14761085.1
申请日：2014-03-06
申请人： Konica Minolta, Inc.
发明人： TAKANASHI, Kensaku , NAKANO, Yasushi , ISODA, Takeshi , GOUDA, Hideki
IPC分类号： G01N33/48
CPC分类号： G01N1/30 , G01N33/52 , G01N2001/302
摘要： An object of the present invention is to provide: a staining agent for tissue staining which has an improved fluorescence signal evaluation accuracy; and a tissue staining kit comprising the staining agent. The staining agent for tissue staining contains, as a staining component, dye-resin particles comprising thermosetting resin particles and a fluorescent dye immobilized on the resin particles, wherein the resin particles contains a substituent having an electric charge opposite to that of the fluorescent dye and forms an ionic bond or a covalent bond with the fluorescent dye, and the dye-resin particles have a particle size variation coefficient of 15% or less.
摘要翻译：本发明的目的是提供：一种染色剂染色组织其中具有改进荧光信号评估准确性; 和组织染色试剂盒，包括染色剂。用于组织染色的染色剂含有作为染色组分，其包含热固性树脂粒子和固定在树脂粒子的荧光染料，worin树脂粒子染料类树脂颗粒包含具有到电荷相反的做了荧光染料的和取代基离子键或与荧光染料共价键，和染料树脂颗粒的形式具有15％或更小的粒度变异系数。

6. 发明公开

EP3477304A1 METHOD RELATING TO EVALUATION OF TUMOR TISSUE OF EXPERIMENTAL ANIMAL 审中-公开
公开(公告)号：EP3477304A1
公开(公告)日：2019-05-01
申请号：EP17839266.8
申请日：2017-07-31
申请人： Konica Minolta, Inc.
发明人： KURIHARA, Yoshikazu , GOUDA, Hideki , ISODA, Takeshi , SHIRAISHI, Takeshi
IPC分类号： G01N33/574 , G01N33/48 , G01N33/53 , G01N33/536
摘要： The present invention relates to a method relating the evaluation of tumor tissue from an experimental animal, the method including the step of measuring an amount of a substance, except for human-derived tumor cells, contained in a sample collected from a region in an experimental animal into which a human-derived tumor tissue ortumor cells have been transplanted, wherein the region contains the tumor tissue or the tumor cells.

7. 发明公开

EP3418744A1 NON-CLINICAL TEST METHOD CHARACTERIZED BY QUANTITATIVE EVALUATION OF EXPERIMENTAL ANIMAL SPECIMEN 审中-公开
公开(公告)号：EP3418744A1
公开(公告)日：2018-12-26
申请号：EP17753243.9
申请日：2017-02-15
申请人： Konica Minolta, Inc.
发明人： GOUDA, Hideki , SHIRAISHI, Takeshi , ISODA, Takeshi , KOYAMA, Noboru , OKADA, Hisatake
IPC分类号： G01N33/574 , C12Q1/02 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/50 , G01N33/58
CPC分类号： G01N33/5088 , G01N33/574 , G01N33/588
摘要： An object of the present invention is to provide a non-clinical test method which allows for the quality control of experimental animals having a transplanted tumor site, such as tumor-bearing mice, or experimental animals having a lesion site other than a transplanted a tumor site, and which is characterized by including the step of identifying, using a specimen collected from such an experimental animal, the profile of a lesion site, for example, a transplanted tumor site, of the experimental animal, by a quantitative technique.

8. 发明授权

EP2908133B1 METHOD FOR DETECTING SQUAMOUS CELL CARCINOMA 有权
公开(公告)号：EP2908133B1
公开(公告)日：2018-07-04
申请号：EP12886166.3
申请日：2012-10-09
申请人： Konica Minolta, Inc. , Chugai Seiyaku Kabushiki Kaisha
发明人： ISODA, Takeshi , NORO, Nao , KANEKO, Tomonori
IPC分类号： G01N33/53 , C07K14/705 , C07K16/28 , C12N15/09 , G01N33/574
CPC分类号： G01N33/57492 , C07K14/705 , C07K16/28 , G01N33/57423 , G01N2333/705
摘要： The present invention provides a method by which lung squamous cell carcinoma can be detected in a simple and prompt manner with high detection performance; and the like. The method according to the present invention detects lung squamous cell carcinoma by an assessment including the steps of: (1) performing measurement of the desmoglein 3 content in a blood sample collected from a subject; and (2) comparing the desmoglein 3 content determined by the measurement with the desmoglein 3 content in a blood sample collected from a healthy individual so as to estimate the presence of lung squamous cell carcinoma in the subject when the desmoglein 3 content is higher in the blood sample collected from the subject.

9. 发明公开

EP3249401A1 BIOLOGICAL SUBSTANCE QUANTITATION METHOD, PATHOLOGICAL DIAGNOSIS SUPPORT SYSTEM, AND PROGRAM 有权
标题翻译：生物物质定量方法，病理诊断支持系统和程序
公开(公告)号：EP3249401A1
公开(公告)日：2017-11-29
申请号：EP16740073.8
申请日：2016-01-15
申请人： Konica Minolta, Inc.
发明人： ISODA, Takeshi , FURUSAWA, Naoko , MOTOKUI, Yasuyuki , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N33/53 , G01N33/48 , G01N33/536 , G01N33/58 , G01N33/68
摘要： Provided are: a biological substance quantitation method with which the expression level of a nucleoprotein in a specimen can be accurately quantitated; a pathological diagnosis support system; and a program. This biological substance quantitation method, in which a biological substance is quantitated, on the basis of the fluorescence of a fluorescent substance, from a specimen that has been stained using a staining reagent that includes fluorescent particles containing said fluorescent substance, is characterized by including an input step for inputting a fluorescent image that represents the expression of the biological substance in the specimen using a fluorescent bright spot, and a quantitation step for quantitating the expression level of the biological substance on the basis of the fluorescence of the fluorescent bright spot, wherein the biological substance is a nucleoprotein that is expressed in a cell nucleus, and the fluorescent particles bind to the biological substance via a primary antibody for which the biological substance serves as an antigen.
摘要翻译：本发明提供一种生物物质定量方法，能够准确地定量样本中的核蛋白的表达量，病理诊断支持系统; 和一个程序。该基于荧光物质的荧光定量生物物质的生物物质定量方法，其特征在于，使用包含含有所述荧光物质的荧光粒子的染色试剂对已被染色的样本进行定量，其特征在于，输入步骤，用于使用荧光亮点输入表示生物物质在样本中的表达的荧光图像;以及定量步骤，用于基于荧光亮点的荧光来定量生物物质的表达水平，其中生物物质是在细胞核中表达的核蛋白，荧光颗粒经由生物物质作为抗原的一次抗体与生物物质结合。

10. 发明公开

EP2908133A1 METHOD FOR DETECTING SQUAMOUS CELL CARCINOMA 有权
标题翻译： VERFAHREN ZUM NACHWEIS VON PLATTENEPITHELKARZINOMEN
公开(公告)号：EP2908133A1
公开(公告)日：2015-08-19
申请号：EP12886166.3
申请日：2012-10-09
申请人： Konica Minolta, Inc. , Forerunner Pharma Research Co., Ltd.
发明人： ISODA, Takeshi , NORO, Nao , KANEKO, Tomonori
IPC分类号： G01N33/53 , C07K14/705 , C07K16/28 , C12N15/09
CPC分类号： G01N33/57492 , C07K14/705 , C07K16/28 , G01N33/57423 , G01N2333/705
摘要： The present invention provides a method by which lung squamous cell carcinoma can be detected in a simple and prompt manner with high detection performance; and the like. The method according to the present invention detects lung squamous cell carcinoma by an assessment including the steps of: (1) performing measurement of the desmoglein 3 content in a blood sample collected from a subject; and (2) comparing the desmoglein 3 content determined by the measurement with the desmoglein 3 content in a blood sample collected from a healthy individual so as to estimate the presence of lung squamous cell carcinoma in the subject when the desmoglein 3 content is higher in the blood sample collected from the subject.
摘要翻译：本发明提供了一种能够以高检测性能简单快速地检测肺鳞状细胞癌的方法; 等等。根据本发明的方法通过评估包括以下步骤来检测肺鳞状细胞癌：（1）进行从受试者收集的血液样品中的骨髓蛋白3含量的测量; 和（2）将由测量确定的脱骨髓素3含量与从健康个体收集的血液样品中的骨髓来蛋白3含量进行比较，以便当骨髓基蛋白3含量较高时估计受试者中肺鳞状细胞癌的存在从受试者收集的血液样本。

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