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1. 发明公开

EP4453183A2 METHODS AND SYSTEMS FOR OPTIMIZING CULTURE CONDITIONS IN A CULTURE PROCESS 失效
公开(公告)号：EP4453183A2
公开(公告)日：2024-10-30
申请号：EP22912457.3
申请日：2022-12-21
申请人： Pow Genetic Solutions, Inc.
发明人： HALL, Shannon , WANG, Ouwei , LEE, Brian , EMRICH, Charles
IPC分类号： C12N5/02 , C12N5/00 , C12Q1/02 , G06N3/12 , G16B5/00 , G06N3/00
CPC分类号： G16B20/00 , C12N5/0062

2. 发明授权

EP3786279B1 METHOD FOR MEASURING INTRACELLULAR POTENTIAL BY CAPACITANCE TYPE POTENTIAL MEASUREMENT DEVICE 有权转让
公开(公告)号：EP3786279B1
公开(公告)日：2024-10-23
申请号：EP19793819.4
申请日：2019-04-26
IPC分类号： C12Q1/02 , C12M1/34 , G01N27/00 , C12N15/09 , G01N33/487 , G01N33/543
CPC分类号： C12Q1/025 , G01N33/54326 , G01N33/48728 , C12M41/46

4. 发明公开

EP4442825A1 RNA MOLECULE 审中-实审
公开(公告)号：EP4442825A1
公开(公告)日：2024-10-09
申请号：EP22901386.7
申请日：2022-11-30
申请人： Kyoto University
发明人： SAITO, Hirohide , KAWASAKI, Shunsuke , KUWABARA, Takeru
IPC分类号： C12N15/11 , C12N15/113 , C12N15/115 , C12Q1/02 , C12Q1/68 , C12Q1/6897
CPC分类号： C12Q1/68 , C12Q1/02 , C12N15/11 , C12N15/113 , C12N15/115 , C12Q1/6897
摘要： An object of the present invention is to provide an RNA molecule that can be translationally activated by specifically responding to a wide range of target substances, and an RNA molecule that can specifically detect a target molecule without translation, and a translational regulation method, and a method for detecting a target substance using these RNA molecules. The present invention provides an RNA molecule comprising: (a) a recognition region that specifically recognizes a target substance; (b) a cap-independent translational activation region positioned on the 3' terminal side of the recognition region; and (c) a coding region positioned on the 3' terminal side of the translational activation region, the coding region being translated by the translational activation region, in which the RNA molecule does not contain a 5' cap structure, or an RNA molecule comprising: (A) a recognition region that specifically recognizes a target substance; and (B) a reporter region positioned on the 3' terminal side of the recognition region, in which the RNA molecule does not contain a 5' cap structure, and a translational regulation method and a method for detecting a target substance using these RNA molecules.

5. 发明公开

EP4422656A1 COMPOSITION FROM ARONIA MELANOCARPA 审中-实审
公开(公告)号：EP4422656A1
公开(公告)日：2024-09-04
申请号：EP22805795.6
申请日：2022-10-14
申请人： Givaudan SA
发明人： LECOMTE, Manon , FANÇA-BERTHON, Pascale Elizabeth Renée , FROMENTIN, Emilie Annie Claudie , LE SAYEC, Melanie Marie-Lou , RODRIGUEZ MATEOS, Ana Maria
IPC分类号： A61K36/73 , A61P9/00 , A61P9/10 , A61P9/12 , C12N1/20 , C12Q1/02
CPC分类号： A61K36/73 , A61P9/00 , A61P9/10 , A61P9/12 , C12Q1/025 , G01N33/56911 , G01N2333/21220130101 , G01N2333/3320130101

6. 发明授权

EP3733076B1 METHOD FOR DETERMINING ULTRAVIOLET LIGHT SENSITIVITY 有权转让
公开(公告)号：EP3733076B1
公开(公告)日：2024-08-28
申请号：EP18895200.6
申请日：2018-12-28
IPC分类号： G01N21/76 , A61B10/00 , A61B5/00 , C12Q1/02 , G01N33/50 , G01N33/68 , G01N21/64 , G01N33/15
CPC分类号： G01N33/15 , G01N21/763 , G01N21/6408 , G01N33/5044 , G01N2800/2020130101 , G01N33/6881 , A61B5/0075 , A61B5/445

7. 发明公开

EP4411348A1 A METHOD FOR IDENTIFYING A METABOLIC STATE OF A MICROBE 审中-实审
公开(公告)号：EP4411348A1
公开(公告)日：2024-08-07
申请号：EP23154460.2
申请日：2023-02-01
申请人： Mibic GmbH & Co KG
发明人： VALET, Oliver , LANKERS, Markus
IPC分类号： G01N21/65 , G01N21/64 , C12Q1/02
CPC分类号： G01N21/65 , G01N21/6428 , G01N21/6458 , C12Q1/04
摘要： The invention relates to a method for identifying a metabolic state of microbes based on a Raman-spectroscopic signal, the method comprising the steps of:
a. Acquiring a sample comprising the microbes,
b. Exposing the sample to a solution comprising a Raman-active compound comprising a Raman-active isotope, wherein said compound is ingestible by the microbes by way of their metabolism,
c. Filtering the sample onto a filter that is designed and configured to retain the microbes on a surface of the filter and to clear the sample from the solution,
d. Imaging the filter surface with the microbes by means of an optical imaging method so as to obtain from the detected signal of the filter surface locations on the filter at which at least microbic residues or microbes are located,
e. On the filter, at least at one obtained location, performing a Raman-spectroscopic measurement configured to be sensitive to the Raman-active isotope and recording a Raman spectrum at the at least one obtained location,
f. From the recorded Raman spectrum recorded at the obtained location, differentiating between at least two metabolic states of the microbe at the time of exposure of the sample to the Raman active isotope by means of analysis of the Raman spectrum with regard to a corresponding signal in the Raman spectrum.

8. 发明公开

EP4403640A1 METHOD FOR EVALUATING MIGRATORY ABILITY OF MIGRATORY CELLS 审中-实审
公开(公告)号：EP4403640A1
公开(公告)日：2024-07-24
申请号：EP22867262.2
申请日：2022-08-31
申请人： Toppan Holdings Inc.
发明人： NADA, Isana , MORIMURA, Rii , KITANO, Shiro
IPC分类号： C12Q1/02 , C12N5/071 , C12N5/0783 , C12N5/09
CPC分类号： C12Q1/02 , C12N5/06
摘要： The method for evaluating the migration ability of migratory cells includes: a culture step of culturing a cell structure having a stromal cell layer containing migratory cells and stromal cells, and a migratory cell-free cell layer containing no migratory cells on a top surface of the stromal cell layer; and an evaluation step of evaluating the migration ability of the migratory cells based on the mobility of the migratory cells in the cell structure after the culture step, the mobility of the migratory cells being a ratio of a height Hm of the migratory cells in the cell structure to a height Hs of the cell structure, the height Hm of the migratory cells in the cell structure being the distance between a point Pb and the migratory cells, the point Pb being an intersection where a perpendicular line down from the migratory cells to a bottom of the cell structure intersects the bottom of the cell structure, and the height Hs of the cell structure being the distance between the point Pb and a point Pt, the point Pt being an intersection where a straight line obtained by extending the perpendicular line to a top surface of the cell structure intersects the top surface of the cell structure.

9. 发明公开

EP4400585A1 SYSTEM FOR REGULATING PROTEIN TRANSLATION 审中-实审
公开(公告)号：EP4400585A1
公开(公告)日：2024-07-17
申请号：EP22861458.2
申请日：2022-08-26
申请人： National University Corporation Tokyo Medical and Dental University
发明人： NAKANISHI, Hideyuki , ITAKA, Keiji , SAITO, Hirohide
IPC分类号： C12N15/09 , C07K14/01 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/62 , C12Q1/02
CPC分类号： C12Q1/02 , C07K14/01 , C12N15/80 , C12N15/81 , C12N15/09 , C12N15/62 , C12N15/74 , C12N5/10
摘要： The present invention provides a system capable of translational regulation of a protein of interest specifically in accordance with the type of cell. The system for regulating protein translation contains the following mRNAs (a), (b), and (c), or DNAs encoding these mRNAs:
(a) an mRNA that expresses a first fusion protein containing a first target-binding molecule specifically recognizing a first site of a target molecule, an N-terminal domain of a caged intein, and an N-terminal domain of a translational regulator;
(b) an mRNA that expresses a second fusion protein containing a second target-binding molecule specifically recognizing a second site of the target molecule, a C-terminal domain of a caged intein, and a C-terminal domain of the translational regulator; and
(c) a switch mRNA containing one or more binding motifs specifically recognizing the translational regulator, and a nucleic acid sequence encoding a protein of interest, and
the translational regulator contains an RNA-binding protein.

10. 发明公开

EP4365912A3 FLEXIBLE ANALYTE SENSORS 审中-实审
公开(公告)号：EP4365912A3
公开(公告)日：2024-07-17
申请号：EP24151950.3
申请日：2018-01-18
申请人： DexCom, Inc.
发明人： Wang, Shanger , Headen, Devon, M. , Böhm, Sebastian , Lee, Ted Tang , Hughes, Jonathan , Simpson, Peter C. , Zou, Jiong
IPC分类号： A61B5/145 , A61B5/1486 , C12Q1/02 , A61B5/00 , C12Q1/00 , G01N27/327 , G16H40/67
CPC分类号： A61B5/14865 , G01N27/3271 , A61B5/0022 , C12Q1/006 , A61B2562/12520130101 , C12Q1/002 , A61B5/14532 , A61B2562/16420130101 , A61B5/14546 , G16H40/67 , Y02A90/10
摘要： Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose. The flexible analyte sensor may have a relatively flexible conductive or non-conductive core, may be formed from a plurality of substantially planar layers, or may be configured to transform from a freestanding sensor ex vivo to a non-freestanding sensor in vivo.

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