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1. 发明公开

EP2833138A1 MEDICAL IMAGE PROCESSOR AND PROGRAM 有权
标题翻译： MEDIZINISCHER BILDPROZESSOR UND PROGRAMM
公开(公告)号：EP2833138A1
公开(公告)日：2015-02-04
申请号：EP13769898.1
申请日：2013-03-27
申请人： Konica Minolta, Inc. , Tohoku University
发明人： TSUNOMORI, Akinori , OKADA, Hisatake , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N33/48 , G01N21/64
CPC分类号： G06K9/0014 , G01N21/6458 , G06K9/00147 , G06T7/0012 , G06T2207/10061 , G06T2207/10064 , G06T2207/20221 , G06T2207/30024 , G06T2207/30096
摘要： The aim of the present invention lies in making it possible to efficiently discern a cancerous region in which a specified protein is overexpressed from within a whole tissue section image. A control unit (21) of an image processor (2A) extracts a cell nucleus region from a bright-field image in which a tissue section slide is captured, and estimates, as the cell region, a circular region having a predetermined radius including the expression region of the specified protein around a cell membrane from the centre of gravity of each cell nucleus region extracted. Furthermore, the control unit (21) extracts a fluorescent bright point from a fluorescent image captured in the same field of vision. The control unit (21) then calculates and outputs a feature value relating to each cell region on the basis of the fluorescent bright point and the cell nucleus contained in each estimated cell region, determines whether or not each estimated cell region is cancerous and determines the state of expression of the specified protein in a region which is deemed to be cancerous, on the basis of the calculated feature value, and outputs a determination result.
摘要翻译：本发明的目的在于能够从整个组织切片图像中有效地辨别特定蛋白质过度表达的癌性区域。图像处理器（2A）的控制单元（21）从拍摄组织部分的幻灯片的亮场图像中提取细胞核区域，并且将作为细胞区域的具有预定半径的圆形区域估计为包括从提取的每个细胞核区域的重心的细胞膜周围的指定蛋白质的表达区域。此外，控制单元（21）从在相同视野中捕获的荧光图像中提取荧光亮点。控制单元（21）然后基于包含在每个估计的单元区域中的荧光亮点和单元核心来计算和输出与每个单元区域有关的特征值，确定每个估计的单元格区域是否是癌变的，并且确定根据计算出的特征值，在被认为是癌症的区域中指定蛋白质的表达状态，并输出确定结果。

2. 发明公开

EP2833123A1 MEDICAL IMAGE PROCESSOR AND PROGRAM 审中-公开
标题翻译：医学图像处理器和程序
公开(公告)号：EP2833123A1
公开(公告)日：2015-02-04
申请号：EP13767991.6
申请日：2013-03-27
申请人： Konica Minolta, Inc. , Tohoku University
发明人： TSUNOMORI, Akinori , OKADA, Hisatake , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N21/64 , G01N33/53 , G01N33/543
CPC分类号： G06K9/0014 , G01N21/6456 , G01N21/6458 , G06K9/4661 , G06T7/0012 , G06T2207/10064 , G06T2207/20021 , G06T2207/20104 , G06T2207/20221 , G06T2207/30024 , G06T2207/30096
摘要： The aim of the present invention lies in enabling a practitioner to quantitatively ascertain the amount of expression of a specified protein in a tissue section. An image processor (2A) comprises a control unit (21), and when a ROI of an object being analysed is specified by means of an operating unit (22) from a cell form image showing the form of cells in a tissue section (bright-field image or fluorescent image), the control unit (21) extracts the cell nucleus region from the bright-field image or fluorescent image, and extracts a fluorescent bright point showing expression of the specified protein from the fluorescent image. A feature value showing the amount of expression of the specified protein in the designated ROI is then calculated and output on the basis of the fluorescent bright point and the region of the cell nucleus present in the ROI designated by the operating unit (22).
摘要翻译：本发明的目的在于使从业者能够定量确定组织切片中特定蛋白质的表达量。图像处理装置（2A）由控制部（21）构成，在通过操作部（22）从表示组织切片内的细胞的形态的细胞形态图像（明亮的场图像或荧光图像），控制单元（21）从明视野图像或荧光图像中提取细胞核区域，并从荧光图像中提取显示指定蛋白质的表达的荧光亮点。然后，基于由操作单元（22）指定的ROI中存在的荧光亮点和细胞核的区域，计算并输出表示特定蛋白质在指定ROI中的表达量的特征值。

3. 发明授权

EP2833138B1 MEDICAL IMAGE PROCESSOR AND PROGRAM 有权
标题翻译：医学图像处理器和程序
公开(公告)号：EP2833138B1
公开(公告)日：2017-08-09
申请号：EP13769898.1
申请日：2013-03-27
申请人： Konica Minolta, Inc.
发明人： TSUNOMORI, Akinori , OKADA, Hisatake , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N33/48 , G01N21/64 , G06K9/00 , G06T7/00
CPC分类号： G06K9/0014 , G01N21/6458 , G06K9/00147 , G06T7/0012 , G06T2207/10061 , G06T2207/10064 , G06T2207/20221 , G06T2207/30024 , G06T2207/30096

4. 发明公开

EP2755026A1 METHOD FOR STAINING TISSUE 有权转让
标题翻译： VERFAHREN ZUMFÄRBENVON GEWEBEN
公开(公告)号：EP2755026A1
公开(公告)日：2014-07-16
申请号：EP12829474.1
申请日：2012-09-04
申请人： Konica Minolta, Inc. , Tohoku University
发明人： GOUDA, Hideki , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N33/48 , G01N1/30 , G01N21/78 , G01N33/53 , G01N33/536
CPC分类号： G01N33/569 , G01N1/30
摘要： It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected.
摘要翻译：本发明的目的是提供一种组织染色方法，其可以在单个部分和单个部分上观察关于组织形态的信息和关于待检测的抗原分子的生物物质的信息查看字段。本发明提供一种组织染色方法，其包括在单个组织切片上连续进行（A）HE（苏木精 - 伊红）染色和（B）组织化学染色，其中组织化学染色定义为组织化学技术通过使用待检测的生物物质和能够特异性结合待检测的生物物质的探针生物物质之间的结合反应，以可见的方式检测待检测的生物物质。

5. 发明公开

EP3418744A1 NON-CLINICAL TEST METHOD CHARACTERIZED BY QUANTITATIVE EVALUATION OF EXPERIMENTAL ANIMAL SPECIMEN 审中-公开
公开(公告)号：EP3418744A1
公开(公告)日：2018-12-26
申请号：EP17753243.9
申请日：2017-02-15
申请人： Konica Minolta, Inc.
发明人： GOUDA, Hideki , SHIRAISHI, Takeshi , ISODA, Takeshi , KOYAMA, Noboru , OKADA, Hisatake
IPC分类号： G01N33/574 , C12Q1/02 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/50 , G01N33/58
CPC分类号： G01N33/5088 , G01N33/574 , G01N33/588
摘要： An object of the present invention is to provide a non-clinical test method which allows for the quality control of experimental animals having a transplanted tumor site, such as tumor-bearing mice, or experimental animals having a lesion site other than a transplanted a tumor site, and which is characterized by including the step of identifying, using a specimen collected from such an experimental animal, the profile of a lesion site, for example, a transplanted tumor site, of the experimental animal, by a quantitative technique.

6. 发明公开

EP3321682A1 TEST SUPPORT METHOD FOR SUPPORTING PREDICTION OF PATHOLOGICAL COMPLETE RESPONSE (PCR) USING FLUORESCENT NANOPARTICLES 有权
标题翻译：支持使用荧光纳米粒子预测病理完全反应（PCR）的测试支持方法
公开(公告)号：EP3321682A1
公开(公告)日：2018-05-16
申请号：EP17200777.5
申请日：2017-11-09
申请人： Konica Minolta, Inc.
发明人： GOUDA, Hideki , TAKAHASHI, Masaru , TAKANASHI, Kensaku , OKADA, Hisatake , OZAKI, Yuichi , YOSHIHARA, Yuka , NAKANO, Yasushi , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika , MASUDA, Norikazu , TOI, Masakazu , TADA, Hiroshi , MIYASHITA, Minoru
IPC分类号： G01N33/50 , G01N1/30 , G01N33/58
CPC分类号： G01N33/57415 , G01N1/30 , G01N33/5023 , G01N33/582 , G01N2333/71 , G06K9/00134 , G06K9/0014 , G06K9/00147
摘要： The present invention relates to a test support method for supporting the prediction of pathological complete response (pCR) to preoperative therapy in breast cancer by using a human breast cancer tissue section, and the test support method includes Step [1]: the step of acquiring a fluorescence image of the breast cancer tissue section, which fluorescence image shows bright spots of fluorescent nanoparticles labeling two or more kinds of breast cancer-related proteins including at least HER2; Step [2]: the step of acquiring numerical values representing the expression levels of each of the two or more kinds of breast cancer-related proteins including HER2 on the basis of the bright spots of the fluorescence image, and calculating, as an index, the value of a ratio of numerical value representing the expression level of HER2/numerical value representing the expression level of a breast cancer protein other than HER2; and Step [3]: the step of acquiring information for predicting pCR by performing an analysis using the value of the ratio.
摘要翻译：本发明涉及一种支持通过使用人乳腺癌组织切片来预测对乳腺癌的术前治疗的病理完全应答（pCR）的测试支持方法，并且该测试支持方法包括步骤[1]：获取所述荧光图像显示荧光纳米颗粒的亮点，所述荧光纳米颗粒标记了至少包括HER2的两种或更多种乳腺癌相关蛋白; 步骤[2]：基于荧光图像的亮点获取表示两种或更多种包括HER2的乳腺癌相关蛋白质中的每一种的表达水平的数值的步骤，并且作为指标，代表HER2的表达水平的数值/代表HER2以外的乳腺癌蛋白的表达水平的数值的比值的值; 和步骤[3]：通过使用该比率的值执行分析来获取用于预测pCR的信息的步骤。

7. 发明授权

EP2613145B1 TISSUE STAINING METHOD, TISSUE EVALUATION METHOD AND BIOSUBSTANCE DETECTION METHOD 有权
标题翻译：组织染色法，组织评估法和生物检测方法
公开(公告)号：EP2613145B1
公开(公告)日：2017-06-28
申请号：EP11821360.2
申请日：2011-03-15
申请人： Konica Minolta, Inc.
发明人： AIMIYA, Takuji , GOUDA, Hideki , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： G01N33/48 , G01N1/28 , G01N1/30 , G01N21/64 , G01N33/53 , G01N33/574 , B82Y15/00 , B82Y30/00 , G01N33/58 , G01N33/74
CPC分类号： G01N1/30 , B82Y15/00 , B82Y30/00 , G01N21/6428 , G01N33/582 , G01N33/588 , G01N33/74 , G01N33/743 , G01N2001/302 , G01N2021/6441 , G01N2333/71 , G01N2333/723 , G01N2333/91205

8. 发明公开

EP3418745A1 INFORMATION ACQUISITION METHOD FOR DIAGNOSIS OR TREATMENT OF CANCER OR IMMUNE SYSTEM-RELATED DISEASES 审中-公开
公开(公告)号：EP3418745A1
公开(公告)日：2018-12-26
申请号：EP17753244.7
申请日：2017-02-15
申请人： Konica Minolta, Inc.
发明人： TAKAHASHI, Masaru , FUTAYA, Etsuko , OKADA, Hisatake , KOYAMA, Noboru
IPC分类号： G01N33/574 , G01N33/68 , C12Q1/68 , G01N21/64 , G01N33/58
CPC分类号： C12Q1/68 , G01N21/64 , G01N33/574 , G01N33/58 , G01N33/68
摘要： Provided is a method for acquiring information for the diagnosis or treatment of mainly cancer or immune system-related diseases, said method being characterized by including a step in which the expression level of a cancer-related protein or nucleic acid in a tumor cell is quantitated using a specimen derived from human or other tumor tissue, and/or a step in which the expression level of a protein or nucleic acid in an immunocyte is quantitated.

9. 发明授权

EP2755019B1 BIOLOGICAL SUBSTANCE DETECTION METHOD 有权转让
标题翻译：生物物质检测方法
公开(公告)号：EP2755019B1
公开(公告)日：2018-01-03
申请号：EP12829813.0
申请日：2012-09-04
申请人： Konica Minolta, Inc.
发明人： TAKANASHI, Kensaku , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N21/64
CPC分类号： G01N33/582 , G01N21/6428 , G01N33/56966 , G01N33/57492 , G01N2021/6439 , G01N2333/70596
摘要： The present invention provides a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The biological substance detection method according to the present invention is characterized in that the brightness retention rate of an immunostained part is in a range of 80% to 120% in relation to the brightness retention rate of a part stained for morphological observation when the fluorescent label used for the immunostaining is observed.

10. 发明公开

EP2755019A1 BIOLOGICAL SUBSTANCE DETECTION METHOD 有权转让
标题翻译： VERFAHREN ZUM NACHWEIS生物学家STOFFE
公开(公告)号：EP2755019A1
公开(公告)日：2014-07-16
申请号：EP12829813.0
申请日：2012-09-04
申请人： Konica Minolta, Inc. , Tohoku University
发明人： TAKANASHI, Kensaku , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N21/64
CPC分类号： G01N33/582 , G01N21/6428 , G01N33/56966 , G01N33/57492 , G01N2021/6439 , G01N2333/70596
摘要： The present invention provides a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The biological substance detection method according to the present invention is characterized in that the brightness retention rate of an immunostained part is in a range of 80% to 120% in relation to the brightness retention rate of a part stained for morphological observation when the fluorescent label used for the immunostaining is observed.
摘要翻译：本发明提供了一种用于特异性检测来自病理标本的生物物质的生物物质检测方法，通过该方法，当使用荧光标记物进行免疫染色并同时进行用于形态学观察的染色剂的形态观察染色时，荧光检测结果即使通过用激发光照射使荧光标记和/或染色剂劣化，也可以适当地评价观察和免疫染色。根据本发明的生物物质检测方法的特征在于，当荧光标记物的形态学观察时，与染色的部分的亮度保持率相比，免疫染色部分的亮度保持率在80％至120％的范围内用于免疫染色观察。

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