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1. 发明授权

EP0098392B1 Filtration membrane and process for producing the membrane 有权转让
标题翻译：过滤膜和生产膜的方法
公开(公告)号：EP0098392B1
公开(公告)日：1987-12-09
申请号：EP83105534.8
申请日：1983-06-06
申请人： Gambro Dialysatoren GmbH & Co. KG , Gambro Lundia AB
发明人： Göhl, Hermann Joseph , Geiling, Günther Friedrich , Mayer, Georg Bernhard , Gullberg, Claes-Ake
IPC分类号： B01D13/04 , A61M1/34
CPC分类号： D01D5/24 , B01D69/02 , B01D69/08 , B01D71/56

2. 发明公开

EP0098392A2 Filtration membrane and process for producing the membrane 有权转让
标题翻译： Membran und Verfahren zu ihrer Herstellung。
公开(公告)号：EP0098392A2
公开(公告)日：1984-01-18
申请号：EP83105534.8
申请日：1983-06-06
申请人： Gambro Dialysatoren GmbH & Co. KG , Gambro Lundia AB
发明人： Göhl, Hermann Joseph , Geiling, Günther Friedrich , Mayer, Georg Bernhard , Gullberg, Claes-Ake
IPC分类号： B01D13/04 , A61M1/34
CPC分类号： D01D5/24 , B01D69/02 , B01D69/08 , B01D71/56
摘要： Filtration membrane, especially adapted for use in hemofiltration as well as filtration of infusion solutions.
The membrane, preferably in the form of a hollow fiber, is made of a polymer which is soluble in a polar, non-protonic organic solvent. The most preferred polymer for the membrane material is polyamide. Characterizing for the membrane is high ultrafiltration rates (permeabilities to water) of up to 500 x 10- 4 ml/sec. x cm2 x atm., and impermeability to albumin (M w 68,000).
The membrane is prepared by extruding a polymer solution with a center liquid under conditions such that the volume of polymer solution to volume of center liquid ratio is within the range of from 2 : 1 to 4 : 1. Simultaneously, the inner diameter to wall thickness ratio of the hollow fiber is preferably correlated to the polymer concentration and is set to 150:75 to 280:75 at a polymer concentration of 5-20%. The most preferred such correlation is 220 : 75 at a polymer concentration of 11 %.
摘要翻译：过滤膜，特别适用于血液滤过以及过滤输液。优选为中空纤维形式的膜由可溶于极性非质子有机溶剂的聚合物制成。用于膜材料的最优选的聚合物是聚酰胺。膜的特征在于高达500×10 -4毫升/秒的超滤速率（渗透水）。 x cm 2 x大气压和对白蛋白的不渗透性（Mw 68,000）。 ...通过在聚合物溶液体积与中心液体积比为2:1至4:1的条件下将中心液挤出聚合物溶液制备膜。同时，中空纤维的内径与壁厚比优选与聚合物浓度相关，并且在聚合物浓度为5-20％时设定为150:75至280:75。在聚合物浓度为11％时，最优选的相关性为220:75。

3. 发明授权

EP0193725B1 Process for spinning hollow fiber membranes 有权转让
标题翻译：纺丝中空纤维膜的工艺
公开(公告)号：EP0193725B1
公开(公告)日：1991-03-27
申请号：EP86100985.0
申请日：1986-01-24
申请人： Gambro Dialysatoren GmbH & Co. KG
发明人： Buck, Reinhold Johann , Göhl, Hermann Joseph , Harttig, Erich Herbert
IPC分类号： D01D5/24 , B01D61/00
CPC分类号： D01D5/24 , B01D69/087 , B01D71/50 , B01D71/52 , B01D71/80

4. 发明授权

EP0305787B1 A process for manufacturing permselective asymmetric membranes suitable for haemodialysis and the so prepared membranes 有权转让
标题翻译：一种制备适用于肝细胞分析的选择性不对称膜的方法及其制备的膜
公开(公告)号：EP0305787B1
公开(公告)日：1992-10-07
申请号：EP88113098.3
申请日：1988-08-12
申请人： GAMBRO DIALYSATOREN GMBH & CO. KG
发明人： Buck, Reinhold Johannes , Göhl, Hermann Joseph
IPC分类号： B01D69/00
CPC分类号： B01D69/08 , B01D67/0009 , B01D67/0011 , B01D69/02 , B01D69/12 , B01D2325/022 , B01D2325/026 , B01D2325/20 , B01D2325/36 , B01D2325/38

5. 发明公开

EP0193725A2 Process for spinning hollow fiber membranes 有权转让
标题翻译： Verfahren zum Spinnen von Hohlfasermembranen。
公开(公告)号：EP0193725A2
公开(公告)日：1986-09-10
申请号：EP86100985.0
申请日：1986-01-24
申请人： Gambro Dialysatoren GmbH & Co. KG
发明人： Buck, Reinhold Johann , Göhl, Hermann Joseph , Harttig, Erich Herbert
IPC分类号： D01D5/24 , B01D61/00
CPC分类号： D01D5/24 , B01D69/087 , B01D71/50 , B01D71/52 , B01D71/80
摘要： Process for producing a semipermeable hollow fiber, which comprises extruding a solution of polymer to form a hollow fiber extrudate, while simultaneously injecting a center medium into the bore of the hollow fiber extrudate, and coagulating the so formed extrudate.
Gases and/or vapors are used as said center medium, for example air or components thereof.
The polymer is preferably chosen among block copolymers comprising at least one hydrophilic polymer block and at least one hydrophobic polymer block. A polyethyleneoxide-polycarbonate block copolymer is particularly preferred.
摘要翻译：制造半透空心纤维的方法，其包括挤出聚合物溶液以形成中空纤维挤出物，同时将中心介质注入中空纤维挤出物的孔中，并凝固如此形成的挤出物。气体和/或蒸汽用作所述中心介质，例如空气或其组分。聚合物优选选自包含至少一个亲水性聚合物嵌段和至少一个疏水性聚合物嵌段的嵌段共聚物。聚环氧乙烷 - 聚碳酸酯嵌段共聚物是特别优选的。

6. 发明授权

EP0305787B2 A process for manufacturing permselective asymmetric membranes suitable for haemodialysis and the so prepared membranes 有权转让
标题翻译：如此制备一种用于制造适于血液透析选择性渗透非对称膜和膜过程
公开(公告)号：EP0305787B2
公开(公告)日：1997-09-03
申请号：EP88113098.3
申请日：1988-08-12
申请人： GAMBRO DIALYSATOREN GMBH & CO. KG
发明人： Buck, Reinhold Johannes , Göhl, Hermann Joseph
IPC分类号： B01D69/00
CPC分类号： B01D69/08 , B01D67/0009 , B01D67/0011 , B01D69/02 , B01D69/12 , B01D2325/022 , B01D2325/026 , B01D2325/20 , B01D2325/36 , B01D2325/38

7. 发明公开

EP0305787A1 A process for manufacturing permselective asymmetric membranes suitable for haemodialysis and the so prepared membranes 有权转让
标题翻译：一种用于生产适合于血液透析和这样产生的膜选择性渗透非对称膜工艺。
公开(公告)号：EP0305787A1
公开(公告)日：1989-03-08
申请号：EP88113098.3
申请日：1988-08-12
申请人： GAMBRO DIALYSATOREN GMBH & CO. KG
发明人： Buck, Reinhold Johannes , Göhl, Hermann Joseph
IPC分类号： B01D69/00
CPC分类号： B01D69/08 , B01D67/0009 , B01D67/0011 , B01D69/02 , B01D69/12 , B01D2325/022 , B01D2325/026 , B01D2325/20 , B01D2325/36 , B01D2325/38
摘要： A permselective asymmetric membrane suitable for hemodialysis, hemodiafiltration and hemofiltration of blood, comprised of a hydrophobic first polymer, a hydrophilic second polymer and suitable additives.
The membrane is characterized by a three-layer structure, comprising a first layer in the form of dense rather thin skin, responsible for the sieving properties, a second layer in the form of a sponge structure, having a high diffusive permeability and serving as a support for said first layer, and a third layer in the form of a finger structure, giving the membrane a mechanical stability.
A process for the manufacturing of the above membrane is also described.
摘要翻译：选择性渗透非对称膜适合于血液透析，血液透析滤过和血液滤过，由疏水第一聚合物，亲水性的第二聚合物和适当的添加剂的。所述的膜是由三层结构，其特征，它包括在致密而薄皮的形式的第一层，负责筛分性质，在海绵状结构的形式的第二层，具有高扩散渗透率和作为为所述第一层，并且在手指结构的形式的第三层，得到膜的机械稳定性支持。因此描述了一种用于制造上述膜的方法。

8. 发明公开

EP0098392A3 Filtration membrane and process for producing the membrane 有权转让
标题翻译：过滤膜和生产膜的方法
公开(公告)号：EP0098392A3
公开(公告)日：1984-03-07
申请号：EP83105534
申请日：1983-06-06
申请人： GAMBRO DIALYSATOREN K.G. , Gambro Lundia AB
发明人： Göhl, Hermann Joseph , Geiling, Günther Friedrich , Mayer, Georg Bernhard , Gullberg, Claes-Ake
IPC分类号： B01D13/04 , A61M01/03
CPC分类号： D01D5/24 , B01D69/02 , B01D69/08 , B01D71/56
摘要： Filtration membrane, especially adapted for use in hemofiltration as well as filtration of infusion solutions. The membrane, preferably in the form of a hollow fiber, is made of a polymer which is soluble in a polar, non-protonic organic solvent. The most preferred polymer for the membrane material is polyamide. Characterizing for the membrane is high ultrafiltration rates (permeabilities to water) of up to 500 x 10- 4 ml/sec. x cm2 x atm., and impermeability to albumin (M w 68,000). The membrane is prepared by extruding a polymer solution with a center liquid under conditions such that the volume of polymer solution to volume of center liquid ratio is within the range of from 2 : 1 to 4 : 1. Simultaneously, the inner diameter to wall thickness ratio of the hollow fiber is preferably correlated to the polymer concentration and is set to 150:75 to 280:75 at a polymer concentration of 5-20%. The most preferred such correlation is 220 : 75 at a polymer concentration of 11 %.

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