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1. 发明授权

EP0013403B1 Process and apparatus for the removal of waste metabolites from a metabolite-containing solution 有权转让
标题翻译：从含有代谢物的溶液中去除废弃代谢物的方法和装置
公开(公告)号：EP0013403B1
公开(公告)日：1984-11-14
申请号：EP79105308.5
申请日：1979-12-21
申请人： Gambro Dialysatoren K.G. , Gambro Lundia AB
发明人： Lehmann, Hans-Dieter , Larsson, Lars-Ake, Lennart
IPC分类号： A61M1/03 , B01D15/00
CPC分类号： A61M1/1696 , B01D15/00

2. 发明授权

EP0026333B1 Transferring means for use in a device for separating of liquids, especially whole blood 有权转让
标题翻译：用于分离液体，特别是全血的装置中的传送装置
公开(公告)号：EP0026333B1
公开(公告)日：1983-09-21
申请号：EP80105144.2
申请日：1980-08-29
申请人： Gambro Dialysatoren K.G.
发明人： Rosemeier, Friedrich , Kerber, Helmut
IPC分类号： B04B5/04
CPC分类号： B04B5/0442 , B04B11/06

3. 发明授权

EP0026334B1 Separation unit for use in a device for separating of liquids, especially whole blood 有权转让
标题翻译：用于分离液体，特别是全血的装置中的分离单元
公开(公告)号：EP0026334B1
公开(公告)日：1983-08-17
申请号：EP80105145.9
申请日：1980-08-29
申请人： Gambro Dialysatoren K.G.
发明人： Rosemeier, Friedrich , Kerber, Helmut
IPC分类号： B04B5/04
CPC分类号： B04B5/0442 , B04B2005/045

4. 发明授权

EP0022922B1 Method of forming an aqueous dialysis solution 有权转让
标题翻译：形成水溶性透析溶液的方法
公开(公告)号：EP0022922B1
公开(公告)日：1983-05-11
申请号：EP80103136.0
申请日：1980-06-06
申请人： Gambro Dialysatoren K.G.
发明人： Gullberg, Claes-Ake , von Dobrogoiski, Alexander
IPC分类号： A61M1/03
CPC分类号： A61M1/1654

5. 发明公开

EP0131143A1 A method of treating a cellulosic hollow fiber 失效
标题翻译： Verfahren zur Behandlung von Cellulosischen Hohlfasern。
公开(公告)号：EP0131143A1
公开(公告)日：1985-01-16
申请号：EP84106322.5
申请日：1984-06-02
申请人： GAMBRO DIALYSATOREN K.G.
发明人： Spranger, Kurt , Beck, Bernd Andreas Walter
IPC分类号： B01D13/04 , A61M1/18 , A61L2/00
CPC分类号： B01D67/0088 , A61L2/07 , A61L2/08 , A61L2/20 , B01D65/022 , B01D67/0095 , B01D2321/08 , B01D2321/34
摘要： A cellulosic hollow fiber which is being particularly adapted for use in hemodialysis or a similar extracorporeal treatment of blood, is possibly after rinsing with an alcoholic solution or fluorinated hydrocarbons- exposed to swelling with use of an aqueous solution prior to drying and/steriliza- tion of the hollow fiber.
Examples of aqueous solutions can be water, water/ glycerol, and water/glycerol/alcohol. Preferably said aqueous solution contains glycerol in an amount of4-35%, such as 12-35%, preferably 16-35%.
The aqueous solution can be applied to the inside and/or the outside of the hollow fiber so as to bring about a diffusive and/or a convective transport of water and/or glycerol into the hollow fiber wall. The rate of diffusion can be increased by increasing the temperature of the aqueous solution, by increasing the contact time between the aqueous solution and the hollow fiber, or by increasing the glycerol content of the aqueous solution, and the convective transport of said substances is achieved by applying the aqueous solution under pressure.
After drying, the hollow fiber can be sterilized either by temperature or by radiation without any substantial loss of permeability characteristics.
摘要翻译：特别适合用于血液透析或血液类似体外处理的纤维素中空纤维可能在用醇水溶液或氟化烃漂洗之前，在使用水溶液暴露于溶胀之前，在干燥和/灭菌之前中空纤维。水溶液的实例可以是水，水/甘油和水/甘油/醇。所述水溶液优选含有4-35％的甘油，例如12-35％，优选16-35％的甘油。 ...水溶液可以施加到中空纤维的内部和/或外部，以便使水和/或甘油扩散和/或对流地输送到中空纤维壁中。可以通过增加水溶液的温度，通过增加水溶液和中空纤维之间的接触时间，或通过增加水溶液的甘油含量来增加扩散速率，并且实现所述物质的对流运输通过在压力下施加水溶液。干燥后，可以通过温度或辐射对中空纤维进行灭菌，而不会明显地损失渗透性。

6. 发明公开

EP0098392A3 Filtration membrane and process for producing the membrane 有权转让
标题翻译：过滤膜和生产膜的方法
公开(公告)号：EP0098392A3
公开(公告)日：1984-03-07
申请号：EP83105534
申请日：1983-06-06
申请人： GAMBRO DIALYSATOREN K.G. , Gambro Lundia AB
发明人： Göhl, Hermann Joseph , Geiling, Günther Friedrich , Mayer, Georg Bernhard , Gullberg, Claes-Ake
IPC分类号： B01D13/04 , A61M01/03
CPC分类号： D01D5/24 , B01D69/02 , B01D69/08 , B01D71/56
摘要： Filtration membrane, especially adapted for use in hemofiltration as well as filtration of infusion solutions. The membrane, preferably in the form of a hollow fiber, is made of a polymer which is soluble in a polar, non-protonic organic solvent. The most preferred polymer for the membrane material is polyamide. Characterizing for the membrane is high ultrafiltration rates (permeabilities to water) of up to 500 x 10- 4 ml/sec. x cm2 x atm., and impermeability to albumin (M w 68,000). The membrane is prepared by extruding a polymer solution with a center liquid under conditions such that the volume of polymer solution to volume of center liquid ratio is within the range of from 2 : 1 to 4 : 1. Simultaneously, the inner diameter to wall thickness ratio of the hollow fiber is preferably correlated to the polymer concentration and is set to 150:75 to 280:75 at a polymer concentration of 5-20%. The most preferred such correlation is 220 : 75 at a polymer concentration of 11 %.

7. 发明公开

EP0095554A2 Microporous hollow fiber membrane for plasmapheresis and process for the preparation of the membrane 失效
标题翻译：微孔中空纤维膜用于血浆置换，使该膜的方法。
公开(公告)号：EP0095554A2
公开(公告)日：1983-12-07
申请号：EP83101310.7
申请日：1983-02-11
申请人： GAMBRO DIALYSATOREN K.G. , GAMBRO, INC.
发明人： Göhl, Hermann Joseph , Ohmayer, Maria Theresia , Gullberg, Claes-Ake , Konstantin, Peter
IPC分类号： B01D13/04 , A61M1/03 , D01D5/24
CPC分类号： D01D5/24 , B01D63/021 , B01D69/08 , B01D71/50 , B01D71/52 , B01D71/80
摘要： Plasmapheresis hollow fiber membrane of a hydorphilic polyether-polycarbonate block copolymer of the general formula:
wherein R is designating CH 2 CH 2 or combinations of CH 2 -CH=CH and CH=CH, preferably CH 2 CH 2 , m = 40-100, preferably 80, n = 10-155, preferably 152, and p = 0.5-3, preferably 1.
The hollow fiber membrane, which may be prepared without any wetting, hydrophilizing or plasticizing agent and therefore need not be washed prior to use, has pores having an average pore size which can be freely set within the range of from 0.008 µm to 0.8 µm corresponding to a similarly freely set cut-off of the hollow fiber membrane of from 10 5 Daltons to 3 x 10 6 Daltons. The porosity of the hollow fiber membrane is above 65%, and the membrane thickness is usually 20-300 µm, preferably 40-80 µm.
Said holow fiber membrane is prepared by extruding a solution containing the hydrophilic polyether-polycarbonate block copolymer togehter with a center liquid in the form of a hollow fiber into a gelling medium having the capability
of only slowly transferring the extruded hollow fiber into a solid state.
Examples of preferred gelling media are acetone/ alcohol mixtures, and polar solvent/alcohol mixtures. Examples of said center liquid may be paraffin, or a liquid of the same composition as the used gelling medium.
摘要翻译：通式的hydorphilic聚醚 - 聚碳酸酯嵌段共聚物的血浆去除空心纤维膜： worin R为指定CH 2 CH 2或组合CH 2 CH = CH和CH = CH，优选CH 2 CH，M = 40-100，优选为80， N = 10至155，优选152，和p = 0.5〜3，优选为1所述的中空纤维膜，其可以在没有任何润湿剂，亲水化或塑化剂来制备，因此无需在使用之前清洗，有孔具有平均孔径sizewhich可以从0.008微米至0.8微米对应于中空纤维膜的类似自由地设定截止的范围内自由地设定为10 <5>道尔顿至3×10 <6> 道尔顿。中空纤维膜的孔隙率是65％以上，膜厚度为20-300一般微米，优选40-80微米所述holow纤维膜是通过用挤压togehter含有亲水性聚醚 - 聚碳酸酯嵌段共聚物的溶液制备中心液体在中空纤维的形式为具有仅缓慢转移环的挤出的中空纤维成固体状态的能力的胶凝平台。优选的胶凝介质的实例为丙酮/醇混合物，和极性溶剂/醇混合物。所述中心液体的实例可以是石蜡，或相同的组成所使用的凝胶化介质的液体。

8. 发明公开

EP0052365A1 Method of binding a biologically active material, e.g. a protein to a carrier containing hydroxyl groups 有权
标题翻译：的含蛋白的载体结合的生物活性物质，例如为羟基的方法。
公开(公告)号：EP0052365A1
公开(公告)日：1982-05-26
申请号：EP81109709.6
申请日：1981-11-16
申请人： GAMBRO DIALYSATOREN K.G.
发明人： Lehmann, Hans-Dieter , Krisam, Gerd Gustav , Golla, Ruth Sibylle
IPC分类号： C12N11/02 , C07G7/00
CPC分类号： C08G18/6446 , C12N11/02
摘要： Methods of binding a biologically active material containing hydroxyl groups are disclosed in which an isocyanate compound is bound to the carrier and the protein is bound to the so bound isocyanate compound. The binding of the isocyanate compound to the carrier is achieved with the use of an agent, having the capability of catalytically forming urethane. Examples of such agents may be non-toxic agents on the basis of titanium, for example, orthotitanium acid esters, and preferably tetrabutyltitanate.
摘要翻译：结合含羟基基团的生物活性材料的方法是在光盘中的异氰酸酯化合物，其异氰酸酯化合物游离缺失结合到载体和蛋白质结合至这样界。异氰酸酯化合物与载体的结合，实现与使用的试剂，具有催化地形成聚氨酯的能力。搜索剂的实例可以是钛的基础上无毒的试剂，例如，邻钛酸酯，和四丁基优选。

9. 发明授权

EP0010087B1 Verfahren zur katalytischen Aushärtung von Polyurethanformmassen 失效
标题翻译：聚氨酯模塑料的催化硬化工艺
公开(公告)号：EP0010087B1
公开(公告)日：1982-02-10
申请号：EP78900124.5
申请日：1978-08-07
申请人： Gambro Dialysatoren K.G.
发明人： LEHMANN, Hans-Dieter
IPC分类号： C08G18/16
CPC分类号： C08G18/168
摘要： During the catalytic hardening of polyurethanic moulding masses, which contain diisocyanates and polyalcohols and/or polyurethanic prepolymers, sorbic acid or cinnamic acid is used as catalyser. These acids produce a quick prehardening and hence a good withdrawing from the mould, which allows to increase the rate of production. Furthermore, these acids are physiologically acceptable, which enables to apply this process of preparation to the shaping of medical instruments. These acids can also be used in a physiologically acceptable mixture with a catalyst containing metals having a high atomic weight.

10. 发明公开

EP0193725A3 Process for spinning hollow fiber membranes 有权转让
标题翻译：纺丝中空纤维膜的工艺
公开(公告)号：EP0193725A3
公开(公告)日：1987-12-16
申请号：EP86100985
申请日：1986-01-24
申请人： GAMBRO DIALYSATOREN K.G.
发明人： Buck, Reinhold Johann , Göhl, Hermann Joseph , Harttig, Erich Herbert
IPC分类号： D01D05/24 , B01D13/04
CPC分类号： D01D5/24 , B01D69/087 , B01D71/50 , B01D71/52 , B01D71/80
摘要： Process for producing a semipermeable hollow fiber, which comprises extruding a solution of polymer to form a hollow fiber extrudate, while simultaneously injecting a center medium into the bore of the hollow fiber extrudate, and coagulating the so formed extrudate. Gases and/or vapors are used as said center medium, for example air or components thereof. The polymer is preferably chosen among block copolymers comprising at least one hydrophilic polymer block and at least one hydrophobic polymer block. A polyethyleneoxide-polycarbonate block copolymer is particularly preferred.

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